Lærke Smidt Gasbjerg
Postdoc, Assistant Professor
Molecular and Translational Pharmacology
Blegdamsvej 3, 2200 København N.
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
- 2024
- Accepted/In press
Effects of exogenous GIP and GLP-2 on bone turnover in individuals with type 2 diabetes
Skov-Jeppesen, Kirsa, Christiansen, Charlotte Bayer, Hansen, L. S., Windeløv, Johanne Agerlin, Hedbäck, N., Gasbjerg, Lærke Smidt, Hindsø, M., Svane, M. S., Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2024, (Accepted/In press) In: The Journal of clinical endocrinology and metabolism.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
Intestinal expression profiles and hepatic expression of LEAP2, ghrelin and their common receptor, GHSR, in humans
Englund, A., Gilliam-Vigh, H., Suppli, M. P., Gasbjerg, Lærke Smidt, Vilsbøll, Tina & Knop, Filip Krag, 2024, In: Peptides. 177, 7 p., 171227.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Safety of native glucose-dependent insulinotropic polypeptide in humans
Helsted, M. M., Schaltz, N. L., Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring, Vilsbøll, Tina & Knop, Filip Krag, 2024, In: Peptides. 177, 14 p., 171214.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Biased GLP-2 agonist with strong G protein-coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice
Gabe, M. B. N., Christensen, Liv von Voss, Dal, Jenna Elizabeth Hunt, Gadgaard, S., Gasbjerg, Lærke Smidt, Holst, Jens Juul, Kissow, Hannelouise, Hartmann, Bolette & Rosenkilde, Mette, Jan 2023, In: British Journal of Pharmacology. 180, 13, p. 1674-1689Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acarbose diminishes postprandial suppression of bone resorption in patients with type 2 diabetes
Dalsgaard, N. B., Gasbjerg, Lærke Smidt, Helsted, M. M., Hansen, L. S., Hansen, N. L., Skov-Jeppesen, Kirsa, Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2023, In: Bone. 170, 116687.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protocol for assessing the effects of exogenous hormone administration on human postprandial glucose metabolism, appetite sensations, and food intake
Hagemann, C. A., Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring & Knop, Filip Krag, 2023, In: STAR Protocols. 4, 1, 10 p., 102070.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes
Melchiorsen, Josefine Ulrikke, Sørensen, Kimmie Vestergaard, Bork-Jensen, J., Kizilkaya, Hüsün Sheyma, Gasbjerg, Lærke Smidt, Hauser, Alexander Sebastian, Rungby, Jørgen, Sørensen, H. T., Vaag, Allan, Nielsen, J. S., Pedersen, Oluf Borbye, Linneberg, Allan René, Hartmann, Bolette, Gjesing, A. P., Holst, Jens Juul, Hansen, Torben, Rosenkilde, Mette & Grarup, Niels, 2023, In: Journal of Clinical Endocrinology and Metabolism. 108, 11, p. 2821–2833 38 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Separate and combined effects of long-term GIP and GLP-1 receptor activation in patients with type 2 diabetes: a structured summary of a study protocol for a double-blind, randomised, placebo-controlled clinical trial
Helsted, M. M., Gasbjerg, Lærke Smidt, Vilsbøll, Tina, Nielsen, C. K., Forman, Julie Lyng, Christensen, Mikkel Bring & Knop, Filip Krag, 2023, In: BMJ Open. 13, 2, 5 p., e065736.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Gut-Bone Axis in Diabetes
Maagensen, H., Helsted, M. M., Gasbjerg, Lærke Smidt, Vilsbøll, Tina & Knop, Filip Krag, 2023, In: Current Osteoporosis Reports. 21, p. 21–31 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The impact of type 2 diabetes and glycaemic control on mortality and clinical outcomes in hospitalized patients with COVID-19 in the capital region of Denmark
Kliim-Hansen, V., Johansson, K. S., Gasbjerg, Lærke Smidt, Solem, Espen Victor Jimenez, Petersen, Tonny Studsgaard, Nyeland, M. E., Winther-Jensen, M., Ankarfeldt, Mikkel Zöllner, Pedersen, M. G., Ellegaard, A. M., Knop, Filip Krag & Christensen, Mikkel Bring, 2023, In: Diabetes, Obesity and Metabolism. 26, 1, p. 160-168 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The importance of endogenously secreted GLP-1 and GIP for postprandial glucose tolerance and β-cell function after Roux-en-Y gastric bypass and sleeve gastrectomy surgery
Hindsø, M., Hedbäck, N., Svane, M. S., Møller, A., Martinussen, C., Jørgensen, N. B., Dirksen, C., Gasbjerg, Lærke Smidt, Kristiansen, V. B., Hartmann, Bolette, Rosenkilde, Mette, Holst, Jens Juul, Madsbad, Sten & Bojsen-Møller, K. N., 2023, In: Diabetes. 72, 3, p. 336–347Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The importance of glucose-dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide
Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Meier, J. J., Holst, Jens Juul & Knop, Filip Krag, 2023, In: Diabetes, Obesity and Metabolism. 25, 11, p. 3079-3092Research output: Contribution to journal › Review › Research › peer-review
- Published
The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans
Krogh, L. S. L., Henriksen, K., Stensen, S., Skov-Jeppesen, Kirsa, Bergmann, N. C., Størling, Joachim, Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2023, In: European Journal of Endocrinology. 188, 1, lvac015.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Acute concomitant GIP receptor antagonism during GLP-1 receptor agonism does not affect appetite, resting energy expenditure or food intake in patients with type 2 diabetes and overweight/obesity
Stensen, S., Krogh, L. L., wbf943, wbf943, Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, Mikkel Bring, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2022, In: Diabetes, Obesity and Metabolism. 24, 9, p. 1882-1887Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in Beta Cell Function in Patients with Type 2 Diabetes
Stensen, S., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Vilsbøll, Tina, Holst, Jens Juul, Hartmann, Bolette, Christensen, Mikkel Bring & Knop, Filip Krag, 2022, In: Diabetes. 71, 10, p. 2209-2221Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fibroblast growth factor 21 is the main alcohol responsive peptide hormone in humans and individuals with alcohol use disorder exihibit increased plasma concentrations after alcohol intake
Lanng, A., Gasbjerg, Lærke Smidt, Sucksdorff, A., Svenningsen, J., Trammell, Sam, Vilsbøll, Tina, Gillum, M. & Knop, Filip Krag, 2022, In: Journal of Hepatology. 77, S1, p. S121-S121 1 p., THU006.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
GIP and GLP-2 together improve bone turnover in humans supporting GIPR-GLP-2R co-agonists as future osteoporosis treatment
Gabe, M. B. N., Skov-Jeppesen, Kirsa, Gasbjerg, Lærke Smidt, Schiellerup, S. P., Martinussen, C., Gadgaard, S., Boer, G. A., Oeke, J., Pedersen, Lola Julie Torz, Veedfald, Simon, Svane, M. S., Bojsen-Møller, K. N., Madsbad, Sten, Holst, Jens Juul, Hartmann, Bolette & Rosenkilde, M. M., 2022, In: Pharmacological Research. 176, 106058.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1 and GIP receptor signaling in beta cells – A review of receptor interactions and co-stimulation
Mayendraraj, A., Rosenkilde, Mette & Gasbjerg, Lærke Smidt, 2022, In: Peptides. 151, p. 1-10 170749.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gastric Aspiration Improves Postprandial Glucose Tolerance Without Causing a Compensatory Increase in Appetite and Food Intake
Gether, I. M., Jensen, M. M., Nexøe-Larsen, C. C., Jorsal, T., Gasbjerg, Lærke Smidt, Naver, L., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2022, In: Obesity Surgery. 32, p. 1385–1390Research output: Contribution to journal › Journal article › Research › peer-review
- Published
LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men
Hagemann, C. A., Jensen, M. S., Holm, Stephanie Kjærulff, Gasbjerg, Lærke Smidt, Byberg, Sarah, Skov-Jeppesen, Kirsa, Hartmann, Bolette, Holst, Jens Juul, Dela, Flemming, Vilsbøll, Tina, Christensen, Mikkel Bring, Holst, Birgitte & Knop, Filip Krag, 2022, In: Cell Reports Medicine. 3, 4, 100582.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards more GLP-1 receptor interaction
Gabe, M. B. N., Gasbjerg, Lærke Smidt, Gadgaard, S., Lindquist, Peter, Holst, Jens Juul & Rosenkilde, Mette, 2022, In: British Journal of Pharmacology. 179, 18, p. 4473-4485Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protocol for a 30-day randomised, parallel-group, non-inferiority, controlled trial investigating the effects of discontinuing renin-angiotensin system inhibitors in patients with and without COVID-19: The RASCOVID-19 trial
Kliim-Hansen, V., Gasbjerg, Lærke Smidt, Ellegaard, A. M., Lorentsson, H. J. N., Lynggaard, M. B., Hagemann, C. A., Legart, C., Mathiesen, D. S., Sivapalan, P., Jensen , Jens-Ulrik Stæhr , Vilsbøll, Tina, Christensen, Mikkel Bring & Knop, Filip Krag, 2022, In: BMJ Open. 12, 11, e062895.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Glucagon Receptor Antagonist LY2409021 has No Effect on Postprandial Glucose in Type 2 Diabetes
Hædersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Forman, Julie Lyng, van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: European Journal of Endocrinology. 186, 2, p. 207-221 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection
Lindquist, Peter, Gasbjerg, Lærke Smidt, Mokrosinski, J., Holst, Jens Juul, Hauser, Alexander Sebastian & Rosenkilde, Mette, 2022, In: Frontiers in Endocrinology. 13, 14 p., 891586.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Worsening Postural Tachycardia Syndrome Is Associated With Increased Glucose-Dependent Insulinotropic Polypeptide Secretion
Breier, N. C., Paranjape, S. Y., Scudder, S., Mehr, S. E., Diedrich, A., Flynn, C. R., Okamoto, L. E., Hartmann, Bolette, Gasbjerg, Lærke Smidt & Shibao, C. A., 2022, In: Hypertension. 79, 5, p. e89-e99Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Effects of endogenous GIP in patients with type 2 diabetes
Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., Skov-Jeppesen, Kirsa, wbf943, wbf943, Jensen, M. H., Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, Mikkel Bring & Knop, Filip Krag, Apr 2021, In: European Journal of Endocrinology. 185, 1, p. 33-45Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic effects of one-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults
Demant, Mia Grønlund, Suppli, M. P., Foghsgaard, S., Gether, L., Grøndahl, M. F. G., Dalsgaard, N. B., Bergmann, S. S., Lanng, A. R., Gasbjerg, Lærke Smidt, Thomasen, M., Bagger, J. I., Strandberg, C., Kønig, M. J., Grønbæk, H., Becker, U., Holst, Jens Juul, Knop, J., Gillum, M. P., Vilsbøll, Tina & Knop, Filip Krag, Apr 2021, In: European Journal of Endocrinology. 185, 1, p. 23-32Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dose-dependent efficacy of the glucose-dependent insulinotropic polypeptide (GIP)receptor antagonistGIP(3-30)NH2 on GIP actions in humans
Gasbjerg, Lærke Smidt, Bari, E. J., Stensen, S., Hoe, B., Lanng, A. R., Mathiesen, D. S., Christensen, Mikkel Bring, Hartmann, Bolette, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2021, In: Diabetes, Obesity and Metabolism. 23, 1, p. 68-74Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exendin(9-39)NH2: Recommendations for clinical use based on a systematic literature review
Gasbjerg, Lærke Smidt, Bari, E. J., Christensen, Mikkel Bring & Knop, Filip Krag, 2021, In: Diabetes, Obesity and Metabolism. 23, 11, p. 2419-2436Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exogenous LEAP2 improves postprandial glucose tolerance and reduces ad libitum food intake in men
Hagemann, C. A., Jensen, M. S., Holm, Stephanie Kjærulff, Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring, Heimburger, S. M. N., Dela, Flemming, Vilsbøll, Tina, Holst, Birgitte & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 23-23 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Glucose-dependent insulinotropic polypeptide (GIP) contributes to sitagliptin-mediated improvement of beta cell function in patients with type 2 diabetes
Stensen, S., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Christensen, M. B. & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 95-95 179.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Importance of endogenous GLP-1 and GIP for postprandial glucose tolerance after Roux-en-Y gastric bypass and sleeve gastrectomy surgery
Hindso, M., Hedback, N., Moller, A., Svane, M. S., Martinussen, C., Jorgensen, N. B., Dirksen, C., Gasbjerg, Lærke Smidt, Kristiansen, V. B., Hartmann, Bolette, Rosenkilde, Mette, Holst, Jens Juul, Madsbad, Sten & Bojsen-Moller, K. N., 2021, In: Diabetologia. 64, SUPPL 1, p. 200-201 387.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes
Kizilkaya, Hüsün Sheyma, Sørensen, Kimmie Vestergaard, Kibsgaard, C. J., Gasbjerg, Lærke Smidt, Hauser, Alexander Sebastian, wbf943, wbf943, Grarup, Niels & Rosenkilde, Mette, 2021, In: Frontiers in Cell and Developmental Biology. 9, 12 p., 749607.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of GLP-1 in the postprandial effects of acarbose in type 2 diabetes
Dalsgaard, N. B., Gasbjerg, Lærke Smidt, Hansen, L. S., Hansen, N. L., Stensen, S., Hartmann, Bolette, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2021, In: European Journal of Endocrinology. 184, 3, p. 387-398 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of incretins on insulin function and glucose homeostasis
Holst, Jens Juul, Gasbjerg, Lærke Smidt & Rosenkilde, Mette, 2021, In: Endocrinology. 162, 7, 10 p., bqab065.Research output: Contribution to journal › Review › Research › peer-review
- 2020
- Published
GIP's involvement in the pathophysiology of type 2 diabetes
Christensen, Mikkel Bring, Gasbjerg, Lærke Smidt, Heimbürger, S. M., Stensen, S., Vilsbøll, Tina & Knop, Filip Krag, Mar 2020, In: Peptides. 125, 10 p., 170178.Research output: Contribution to journal › Review › Research › peer-review
- Published
Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists
Gasbjerg, Lærke Smidt, Bergmann, N. C., Stensen, S., Christensen, Mikkel Bring, Rosenkilde, Mette, Holst, Jens Juul, Nauck, M. & Knop, Filip Krag, 2020, In: Peptides. 125, 10 p., 170183.Research output: Contribution to journal › Review › Research › peer-review
- Published
GIP and GLP-1 Receptor Antagonism During a Meal in Healthy Individuals
Gasbjerg, Lærke Smidt, Helsted, M. M., Hartmann, Bolette, wbf943, wbf943, Veedfald, Simon, Stensen, S., Lanng, A. R., Bergmann, N. C., Christensen, Mikkel Bring, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 3, p. e725-e738 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GIP and the gut-bone axis – Physiological, pathophysiological and potential therapeutic implications
Stensen, S., Gasbjerg, Lærke Smidt, Helsted, M. M., Hartmann, Bolette, Christensen, Mikkel Bring & Knop, Filip Krag, 2020, In: Peptides. 125, 7 p., 170197.Research output: Contribution to journal › Review › Research › peer-review
- Published
GIP's effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP(3-30)NH2
Gasbjerg, Lærke Smidt, Hartmann, Bolette, Christensen, Mikkel Bring, Lanng, A. R., Vilsbøll, Tina, Jørgensen, Niklas Rye, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Bone. 130, 6 p., 115079 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GIP(3-30)NH2 – a tool for the study of GIP physiology
Lynggaard, M. B., Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring & Knop, Filip Krag, 2020, In: Current Opinion in Pharmacology. 55, p. 31-40 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Glucose-dependent insulinotropic polypeptide (GIP) and cardiovascular disease
Heimbürger, S. M., Bergmann, N. C., Augustin, R., Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring & Knop, Filip Krag, 2020, In: Peptides. 125, 8 p., 170174.Research output: Contribution to journal › Review › Research › peer-review
- Published
Molecular interactions of full-length and truncated GIP peptides with the GIP receptor - A comprehensive review
Gabe, M. B. N., van der Velden, W. J. C., Smit, F. X., Gasbjerg, Lærke Smidt & Rosenkilde, Mette, 2020, In: Peptides. 125, 8 p., 170224.Research output: Contribution to journal › Review › Research › peer-review
- Published
No Acute Effects of Exogenous Glucose-Dependent Insulinotropic Polypeptide on Energy Intake, Appetite, or Energy Expenditure When Added to Treatment With a Long-Acting Glucagon-Like Peptide 1 Receptor Agonist in Men With Type 2 Diabetes
Bergmann, N. C., Gasbjerg, Lærke Smidt, Heimbürger, S. M., Krogh, L. S. L., Dela, Flemming, Hartmann, Bolette, Holst, Jens Juul, Jessen, L., Christensen, Mikkel Bring, Vilsbøll, Tina, Lund, A. & Knop, Filip Krag, 2020, In: Diabetes Care. 43, 3, p. 588-596 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of acute intragastric vs. intravenous alcohol administration on inflammation markers, blood lipids and gallbladder motility in healthy men
Lanng, A. R., Gasbjerg, Lærke Smidt, Bergmann, N. C., Gillum, M. P., Rehfeld, Jens Frederik, Helsted, M. M., Møller, H. J., Grønbæk, H., Vilsbøll, Tina & Knop, Filip Krag, 2020, In: Alcohol. 87, p. 29-37 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of endogenous GIP and GLP-1 in postprandial bone homeostasis
Helsted, M. M., Gasbjerg, Lærke Smidt, Lanng, A. R., Bergmann, N. C., Stensen, S., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Bone. 140, 7 p., 115553.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Separate and Combined Effects of GIP and GLP-1 Infusions on Bone Metabolism in Overweight Men without Diabetes
Bergmann, N. C., Lund, A., Gasbjerg, Lærke Smidt, Jørgensen, N. R., Jessen, L., Hartmann, Bolette, Holst, Jens Juul, Christensen, Mikkel Bring, Vilsbøll, Tina & Knop, Filip Krag, Jul 2019, In: The Journal of clinical endocrinology and metabolism. 104, 7, p. 2953–2960Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of combined GIP and GLP-1 infusion on energy intake, appetite and energy expenditure in overweight/obese individuals: a randomised, crossover study
Bergmann, N. C., Lund, A., Gasbjerg, Lærke Smidt, Meessen, E. C. E., Andersen, M. M., Bergmann, S., Hartmann, Bolette, Holst, Jens Juul, Jessen, L., Christensen, Mikkel Bring, Vilsbøll, Tina & Knop, Filip Krag, 2019, In: Diabetologia. 62, 4, p. 665-675 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Endogenous glucose-dependent insulinotropic polypeptide exerts diverging and tissue specific in obese patients with type 2 diabetes
Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., wbf943, wbf943, Skov-Jeppesen, Kirsa, Jensen, M. H., Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, M. B. & Knop, Filip Krag, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S270-S271 2 p., 560.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men
Skov-Jeppesen, Kirsa, Svane, M. S., Martinussen, C., Gabe, M. B. N., Gasbjerg, Lærke Smidt, Veedfald, Simon, Bojsen-Møller, K. N., Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2019, In: Bone. 125, p. 178-185Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gluco-metabolic effects of oral and intravenous alcohol administration in men
Lanng, A. R., Gasbjerg, Lærke Smidt, Bergmann, N. C., Bergmann, S., Heisted, M. M., Gillum, M. P., Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2019, In: Endocrine Connections. 8, 10, p. 1372-1382Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats
Baidassano, S., Gasbjerg, Lærke Smidt, Kizilkaya, Hüsün Sheyma, Rosenkilde, Mette, Holst, Jens Juul & Hartmann, Bolette, 2019, In: Frontiers in Endocrinology. 10, 11 p., 492.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Separate and Combined Glucometabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide 1 in Healthy Individuals
Gasbjerg, Lærke Smidt, Helsted, M. M., Hartmann, Bolette, Jensen, M. H., Gabe, M. B. N., wbf943, wbf943, Veedfald, Simon, Stensen, S., Lanng, A. R., Bergmann, N. C., Christensen, Mikkel Bring, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2019, In: Diabetes. 68, 3, p. 906-917Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
The bile acid-sequestering resin sevelamer eliminates the acute GLP-1 stimulatory effect of endogenously released bile acids in patients with type 2 diabetes
Brønden, A., Albér, A., Rohde, U., Gasbjerg, Lærke Smidt, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Feb 2018, In: Diabetes, Obesity and Metabolism. 20, 2, p. 362-369Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GIP(3-30)NH2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study
Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring, Hartmann, Bolette, Lanng, A. R., wbf943, wbf943, Gabe, M. B. N., Dela, Flemming, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, Feb 2018, In: Diabetologia. 61, 2, p. 413-423Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents
Gasbjerg, Lærke Smidt, Gabe, M. B. N., Hartmann, Bolette, Christensen, Mikkel Bring, Knop, Filip Krag, Holst, Jens Juul & Rosenkilde, Mette, Feb 2018, In: Peptides. 100, p. 173-181Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human GIP(3-30)NH inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors
Gabe, M. B. N., Sparre-Ulrich, A. H., Pedersen, M. F., Gasbjerg, Lærke Smidt, Inoue, A., Bräuner, Hans, Hartmann, Bolette & Rosenkilde, M. M., 31 Jan 2018, In: Biochemical Pharmacology. 150, p. 97-107 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mono- and co-activation of the GIP and GLP-1 receptors inhibits bone resorption
Bergmann, N. C., Lund, A., Heimburger, S. M., Gasbjerg, Lærke Smidt, Jørgensen, Niklas Rye, Jessen, L., Hartmann, Bolette, Holst, Jens Juul, Christensen, Mikkel Bring, Vilsbøll, Tina & Knop, Filip Krag, 2018, In: Diabetologia. 61, S.1, p. S348-S348 717.Research output: Contribution to journal › Conference abstract in journal › Research
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Postprandial effects of individual and combined GIP and GLP-1 receptor antagonism in healthy subjects
Gasbjerg, Lærke Smidt, Helsted, M. M., wbf943, wbf943, Lanng, A. R., Stensen, S., Jakobsen, M. H., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, M. M. & Knop, Filip Krag, 2018, In: Diabetologia. 61, S1, p. S246-S246 503.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Separate effects of glucagon like peptide-2 (GLP-2) and glucose-dependent insulinotropic polypeptide (GIP) on bone remodelling
Skov-Jeppesen, Kirsa, Svane, M., Martinussen, C., Gabe, M., Gasbjerg, Lærke Smidt, Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2018, In: Diabetologia. 61, S1, p. S245-S245 501.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
The Combination of Fosfomycin, Metronidazole, and Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor is Stable in vitro and Has Maintained Antibacterial Activity
Fonnes, S., Holzknecht, Barbara Juliane, Gasbjerg, Lærke Smidt, Weisser, J. J., Hallberg, H. W., Arpi, M. & Rosenberg, Jacob, 2018, In: Drug Research. 68, 6, p. 349-354Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Effect of Ethanol on Inflammation Markers and FGF-21 in Healthy Individuals
Lanng, A. R., Gasbjerg, Lærke Smidt, Bergmann, N. C., Møller, H., Gillum, M., Gronbaek, H., Vilsbøll, Tina & Knop, Filip Krag, 2018, In: Diabetes. 67, Supplement 1, 2415-PUB.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of the incretins in the postprandial bone remodelling
Helsted, M. M., Gasbjerg, Lærke Smidt, Lanng, A. R., Stensen, S., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, M. M. & Knop, Filip Krag, 2018, In: Diabetologia. 61, S1, p. S221-S221 449.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- 2017
- Published
Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial
Ekeloef, S., Halladin, N., Fonnes, S., Jensen, S. E., Zaremba, T., Rosenberg, Jacob, Jonsson, G., Aarøe, J., Gasbjerg, Lærke Smidt, Rosenkilde, Mette & Gögenur, Ismail, Dec 2017, In: Journal of Cardiovascular Translational Research. 10, 5-6, p. 470-479 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N. & 9 others, , Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor
Asmar, M., Asmar, A., Simonsen, L., Gasbjerg, Lærke Smidt, wbf943, wbf943, Rosenkilde, Mette, Hartmann, Bolette, Dela, Flemming, Holst, Jens Juul & Bülow, J., Sep 2017, In: Diabetes. 66, 9, p. 2363-2371 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Signaling via G proteins mediates tumorigenic effects of GPR87
Arfelt, K. N., Fares, S., wbf943, wbf943, Hjortø, Gertrud Malene, Gasbjerg, Lærke Smidt, Molleskov-Jensen, A., Benned-Jensen, T. & Rosenkilde, Mette, Jan 2017, In: Cellular Signalling. 30, p. 9-18Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release
wbf943, wbf943, Gabe, M. N., Gasbjerg, Lærke Smidt, Christiansen, Charlotte Bayer, Svendsen, B., Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, 2017, In: Biochemical Pharmacology. 131, p. 78-88Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Species-specific action of (Pro3)GIP - an efficacious agonist on human GIP receptor, but partial agonist and competitive antagonist on rat and mouse GIP receptors
wbf943, wbf943, Gasbjerg, Lærke Smidt, Svendsen, B., Christensen, M., Knop, Filip Krag, Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, Jan 2016, In: British Journal of Pharmacology. 173, 1, p. 27-38 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Extracellular Disulfide Bridges Serve Different Purposes in Two Homologous Chemokine Receptors, CCR1 and CCR5
Rummel, P. C., Thiele, S., Gasbjerg, Lærke Smidt, Petersen, T. P., wbf943, wbf943, Ulven, T. & Rosenkilde, Mette, 13 Jun 2013, In: Current Molecular Pharmacology. 84, 3, p. 335-345 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biased and Constitutive Signaling in the CC-Chemokine Receptor CCR5 by manipulating the Interface between Transmembrane Helix 6 and 7
Steen, A., Thiele, S., Guo, D., Gasbjerg, Lærke Smidt, Frimurer, Thomas Michael & Rosenkilde, Mette, 3 May 2013, In: Journal of Biological Chemistry. 288, 18, p. 12511-12521 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice
Kissow, Hannelouise, Hartmann, Bolette, Holst, Jens Juul, Viby, N., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hare, K. J. & Poulsen, Steen Seier, 10 Nov 2012, In: Regulatory Peptides. 179, 1-3, p. 91-100 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 37775779
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Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
Research output: Contribution to journal › Journal article › Research › peer-review
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297
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GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release
Research output: Contribution to journal › Journal article › Research › peer-review
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139
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Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats
Research output: Contribution to journal › Journal article › Research › peer-review
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