Thomas Andrew Qvistgaard Jepps
Associate Professor
Physiology of circulation, kidney and lung
Blegdamsvej 3
2200 København N.
- 2024
- Published
Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation
Mozzicato, Anthony Michael, Bastrup, Joakim Armstrong, Sanchez-Alonso, J. L., van der Horst, Jennifer, Gorelik, J., Hägglund, Per Mårten & Jepps, Thomas Andrew Qvistgaard, 2024, In: The Biochemical journal. 481, 5, p. 387-403Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Acute, pro-contractile effects of prorenin on rat mesenteric arteries
Rognant, Salomé, Baldwin, S. N., Pritchard, H. A. T., Greenstein, A., Callø, Kirstine, Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, 2023, In: FASEB Journal. 37, 12, 18 p., e23282.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Colchicine enhances β adrenoceptor-mediated vasodilation in men with essential hypertension
Ehlers, T. S., van der Horst, Jennifer, Møller, S., Piil, P. K., Gliemann, Lasse, Aalkjær, Christian, Jepps, Thomas Andrew Qvistgaard & Hellsten, Ylva, 2023, In: British Journal of Clinical Pharmacology. 89, 7, p. 2179-2189 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cycling matters: Sex hormone regulation of vascular potassium channels
Baldwin, S. N., Jepps, Thomas Andrew Qvistgaard & Greenwood, I. A., 2023, In: Channels. 17, 1, 19 p., 2217637.Research output: Contribution to journal › Review › Research › peer-review
- Published
Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels
Manville, R. W., Baldwin, S. N., Eriksen, E. Ø., Jepps, Thomas Andrew Qvistgaard & Abbott, G. W., 2023, In: FASEB Journal. 37, 9, p. 1-15 e23125.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomic mapping reveals dysregulated angiogenesis in the cerebral arteries of rats with early-onset hypertension
Bastrup, Joakim Armstrong & Jepps, Thomas Andrew Qvistgaard, 2023, In: Journal of Biological Chemistry. 299, 10, p. 1-16 105221.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vascular smooth muscle-specific YAP/TAZ deletion triggers aneurysm development in mouse aorta
Arévalo Martínez, M., Ritsvall, O., Bastrup, Joakim Armstrong, Celik, S., Jakobsson, G., Daoud, F., Winqvist, C., Aspberg, A., Rippe, C., Maegdefessel, L., Schiopu, A., Jepps, Thomas Andrew Qvistgaard, Holmberg, J., Swärd, K. & Albinsson, S., 2023, In: JCI insight. 8, 17, 25 p., e170845.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Dynein coordinates β2-adrenoceptor-mediated relaxation in normotensive and hypertensive rat mesenteric arteries
van der Horst, Jennifer, Rognant, Salomé, Hellsten, Ylva, Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, 2022, In: Hypertension. 79, 10, p. 2214-2227 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of novel proteins and mechanistic pathways associated with early-onset hypertension by deep proteomic mapping of resistance arteries
Bastrup, Joakim Armstrong, Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, 2022, In: Journal of Biological Chemistry. 298, 1, 17 p., 101512.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNQ5 activation by tannins mediates vasorelaxant effects of barks used in Native American botanical medicine
Manville, R. W., Redford, K. E., van der Horst, Jennifer, Hogenkamp, D. J., Jepps, Thomas Andrew Qvistgaard & Abbott, G. W., 2022, In: FASEB Journal. 36, 9, 15 p., e22457.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The impact of an atrial septal defect on the progression of atrial tachypacing-induced atrial fibrillation in a Danish Landrace pig: A case report
Saljic, Arnela, Hertel, Julie Norup, Leonhardt, C., Nissen, Sarah Dalgas, Dobrev, D., Jepps, Thomas Andrew Qvistgaard, Jespersen, Thomas & Sattler, Stefan M, 2022, In: IJC Heart and Vasculature. 40, 3 p., 101054.Research output: Contribution to journal › Letter › Research › peer-review
- Published
The microtubule network enables Src kinase interaction with the Na,K-ATPase to generate Ca2+ flashes in smooth muscle cells
Rognant, Salomé, Kravtsova, V. V., Bouzinova, E. V., Melnikova, E. V., Krivoi, I. I., Pierre, S. V., Aalkjær, Christian, Jepps, Thomas Andrew Qvistgaard & Matchkov, V. V., 2022, In: Frontiers in Physiology. 13, 14 p., 1007340.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Dynein regulates Kv7.4 channel trafficking from the cell membrane
van der Horst, Jennifer, Rognant, Salomé, Abbott, G. W., Ozhathil, Lijo Cherian, Hägglund, Per Mårten, Barrese, V., Chuang, Christine, Jespersen, Thomas, Davies, Michael J., Greenwood, I. A., Gourdon, Pontus Emanuel, Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, 2021, In: Journal of General Physiology. 153, 3, 19 p., e202012760.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Editorial: Kv7 Channels: Structure, Physiology, and Pharmacology
Jepps, Thomas Andrew Qvistgaard, Barrese, V. & Miceli, F., 2021, In: Frontiers in Physiology. 12, 4 p., 679317.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Functional sympatholysis in mouse skeletal muscle involves sarcoplasmic reticulum swelling in arterial smooth muscle cells
van der Horst, Jennifer, Møller, S., Kjeldsen, Sasha Alexandra Sampson, Wojtaszewski, Jørgen F P, Hellsten, Ylva & Jepps, Thomas Andrew Qvistgaard, 2021, In: Physiological Reports. 9, 23, 10 p., e15133.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea
Redford, K. E., Rognant, Salomé, Jepps, Thomas Andrew Qvistgaard & Abbott, G. W., 2021, In: Cellular Physiology and Biochemistry. 55, S3, p. 46-64 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Kv7 channel trafficking by the microtubule network in vascular smooth muscle
Jepps, Thomas Andrew Qvistgaard, 2021, In: Acta Physiologica. 232, 3, 12 p., e13692.Research output: Contribution to journal › Review › Research › peer-review
- 2020
- Published
Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly
van der Horst, Jennifer, Manville, R. W., Hayes, K., Thomsen, M. B., Abbott, G. W. & Jepps, Thomas Andrew Qvistgaard, 2020, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 40, 5, p. 1207-1219 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels
van der Horst, Jennifer, Greenwood, I. A. & Jepps, Thomas Andrew Qvistgaard, 2020, In: Frontiers in Physiology. 11, 12 p., 727.Research output: Contribution to journal › Review › Research › peer-review
- Published
Effects of a novel selenium substituted-sugar (1,4-anhydro-4-seleno-D-talitol, SeTal) on human coronary artery cell lines and mouse aortic rings
Zacharias, T., Flouda, K., Jepps, Thomas Andrew Qvistgaard, Gammelgaard, Bente, Schiesser, C. H. & Davies, Michael J., 2020, In: Biochemical Pharmacology. 173, 14 p., 113631.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse
lvs502, lvs502, Andreasen, Laura Korsholm, Hagen, C. M., Ahlberg, G., Ghouse, Jonas, Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hougaard, D. M., Hedley, P., Haunsø, Stig, Svendsen, Jesper Hastrup, Kanters, Jørgen K., Jepps, Thomas Andrew Qvistgaard, Skov, M. W., Christiansen, M. & Olesen, Morten Steen Salling, 2020, In: Cardiovascular Research. 116, 1, p. 138-148Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension
Askew Page, H. R., Dalsgaard, T., Baldwin, S. N., Jepps, Thomas Andrew Qvistgaard, Povstyan, O., Olesen, Søren-Peter & Greenwood, I. A., Jun 2019, In: British Journal of Pharmacology. 176, 11, p. 1635-1648Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Kcne4 deletion sex dependently inhibits the RISK pathway response and exacerbates hepatic ischemia-reperfusion injury in mice
Hu, Z., Jepps, Thomas Andrew Qvistgaard, Zhou, L., Liu, J., Li, M. & Abbott, G. W., 1 May 2019, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 316, 5, p. R552-R562Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia
David, J., Lisewski, U., Crump, S. M., Jepps, Thomas Andrew Qvistgaard, Bocksteins, E., Wilck, N., Lossie, J., Roepke, T. K., Schmitt, Nicole & Abbott, G. W., Feb 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 2, p. 2537-2552 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of the first genome-wide significant risk loci for syncope and collapse: [Meeting Abstract]
Ahlberg, G., lvs502, lvs502, Andreasen, L., Hagen, C. M., Ghouse, Jonas, Baekvad-Hansen, M., Bybjerg-Grauholm, J., Hougaard, D. M., Hedley, P., Haunsø, Stig, Svendsen, Jesper Hastrup, Jepps, Thomas Andrew Qvistgaard, Skov, M. W., Christiansen, M. & Olesen, Morten Steen Salling, 2019, In: European Heart Journal. 40, S1, p. 2539-2539 4259 .Research output: Contribution to journal › Conference abstract in journal › Research
- Published
KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines
Manville, R. W., van der Horst, Jennifer, Redford, K. E., Katz, B. B., Jepps, Thomas Andrew Qvistgaard & Abbott, G. W., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 42, p. 21236-21245Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Impaired Kv7 channel function in cerebral arteries of a tauopathy mouse model (rTg4510)
de Jong, I. E. M. & Jepps, Thomas Andrew Qvistgaard, Dec 2018, In: Physiological Reports. 6, 23, 10 p., e13920 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Contractile responses in intact and mucosa-denuded human ureter: a comparison with urinary bladder detrusor preparations
Roedel, M., Ravens, U., Kasper, M., Wirth, M. P., Jepps, Thomas Andrew Qvistgaard & Propping, S., 1 Aug 2018, In: Naunyn-Schmiedeberg's Archives of Pharmacology. 391, 8, p. 773-782 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Angiotensin II Promotes KV7.4 Channels Degradation Through Reduced Interaction With HSP90 (Heat Shock Protein 90)
Barrese, V., Stott, J. B., Figueiredo, H. B., Aubdool, A. A., Hobbs, A. J., Jepps, Thomas Andrew Qvistgaard, McNeish, A. J. & Greenwood, I. A., Jun 2018, In: Hypertension. 71, 6, p. 1091-1100 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances K7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries
Khammy, M. M., Kim, S., Bentzen, Bo Hjorth, Lee, S., Choi, I., Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, Feb 2018, In: British Journal of Pharmacology. 175, 3, p. 501-516 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microtubule Regulation of Kv7 Channels Orchestrates cAMP-Mediated Vasorelaxations in Rat Arterial Smooth Muscle
Lindman, J., Khammy, M. M., Lundegaard, Pia Rengtved, Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, Feb 2018, In: Hypertension. 71, 2, p. 336-345 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Unravelling the complexities of vascular smooth muscle ion channels: Fine tuning of activity by ancillary subunits
Jepps, Thomas Andrew Qvistgaard, Oct 2017, In: Pharmacology & Therapeutics. 178, p. 57-66 10 p.Research output: Contribution to journal › Review › Research › peer-review
- 2016
- Published
Kcne4 Deletion Sex-Dependently Alters Vascular Reactivity
Abbott, G. W. & Jepps, Thomas Andrew Qvistgaard, 7 Oct 2016, In: Journal of Vascular Research. 53, 3-4, p. 138-148 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MicroRNA-153 targeting of KCNQ4 contributes to vascular dysfunction in hypertension
Carr, G., Barrese, V., Stott, J. B., Povstyan, O. V., Jepps, Thomas Andrew Qvistgaard, Figueiredo, H. B., Zheng, D., Jamshidi, Y. & Greenwood, I. A., 7 Jul 2016, In: Cardiovascular Research. 112, p. 581-589 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular and functional characterization of Kv 7 channels in penile arteries and corpus cavernosum of healthy and metabolic syndrome rats
Jepps, Thomas Andrew Qvistgaard, Olesen, Søren-Peter, Greenwood, I. A. & Dalsgaard, T., May 2016, In: British Journal of Pharmacology. 173, 9, p. 1478-1490 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts
Skarsfeldt, M. A., Jepps, Thomas Andrew Qvistgaard, Bomholtz, Sofia Hammami, Abildgaard, L., Sørensen, U. S., Gregers, E., Svendsen, Jesper Hastrup, Diness, J. G., Grunnet, M., Schmitt, Nicole, Olesen, Søren-Peter & Bentzen, Bo Hjorth, Apr 2016, In: Pfluegers Archiv. 468, 4, p. 643-654 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Fundamental role for the KCNE4 ancillary subunit in Kv7.4 regulation of arterial tone
Jepps, Thomas Andrew Qvistgaard, Carr, G., Lundegaard, Pia Rengtved, Olesen, Søren-Peter & Greenwood, I. A., 15 Dec 2015, In: Journal of Physiology. 593, 24, p. 5325-40 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats
Stott, J. B., Barrese, V., Jepps, Thomas Andrew Qvistgaard, Leighton, E. V. & Greenwood, I. A., Mar 2015, In: Hypertension. 65, 3, p. 676-82 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
KV7 potassium channels: a new therapeutic target in smooth muscle disorders
Stott, J. B., Jepps, Thomas Andrew Qvistgaard & Greenwood, I. A., 12 Dec 2014, In: Drug Discovery Today. 19, 4, p. 413-424 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vasorelaxant effects of novel Kv7.4 channel enhancers ML213 and NS15370
Jepps, Thomas Andrew Qvistgaard, Bentzen, Bo Hjorth, Stott, J. B., Povstyan, O. V., Sivaloganathan, K., Dalby-Brown, W. & Greenwood, I. A., 9 Jun 2014, In: British Journal of Pharmacology. 171, 19, p. 4413-4424 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related Peptide-induced cerebral reactivity
Chadha, P. S., Jepps, Thomas Andrew Qvistgaard, Carr, G., Stott, J. B., Zhu, H., Cole, W. C. & Greenwood, I. A., Apr 2014, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 34, 4, p. 887-93 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Contribution of KV7 Channels to Basal Coronary Flow and Active Response to Ischemia
Khanamiri, S., Soltysinska, E., Jepps, Thomas Andrew Qvistgaard, Bentzen, Bo Hjorth, Chadha, P. S., Schmitt, Nicole, Greenwood, I. A. & Olesen, Søren-Peter, 30 Sep 2013, In: Hypertension. 62, 6, p. 1090-1097 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders
Jepps, Thomas Andrew Qvistgaard, Olesen, Søren-Peter & Greenwood, I. A., 2013, In: British Journal of Pharmacology. 168, 1, p. 19-27 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries
Chadha, P. S., Zunke, F., Davis, A. J., Jepps, Thomas Andrew Qvistgaard, Linders, J. T. M., Schwake, M., Towart, R. & Greenwood, I. A., Jun 2012, In: British Journal of Pharmacology. 166, 4, p. 1377-87 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired ß-adrenoceptor-mediated relaxation of renal arteries in hypertension
Chadha, P. S., Zunke, F., Zhu, H., Davis, A. J., Jepps, Thomas Andrew Qvistgaard, Olesen, Søren-Peter, Cole, W. C., Moffatt, J. D. & Greenwood, I., 2012, In: Hypertension. 59, 4, p. 877-84 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Downregulation of Kv7.4 channel activity in primary and secondary hypertension
Jepps, Thomas Andrew Qvistgaard, Chadha, P. S., Davis, A. J., Harhun, M. I., Cockerill, G. W., Olesen, S. P., Hansen, R. S. & Greenwood, I. A., 2 Aug 2011, In: Circulation. 124, 5, p. 602-11 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression and function of the K+ channel KCNQ genes in human arteries
Ng, F. L., Davis, A. J., Jepps, Thomas Andrew Qvistgaard, Harhun, M. I., Yeung, S. Y., Wan, A., Reddy, M., Melville, D., Nardi, A., Khong, T. K. & Greenwood, I. A., Jan 2011, In: British Journal of Pharmacology. 162, 1, p. 42-53 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Expression profile and protein translation of TMEM16A in murine smooth muscle
Davis, A. J., Forrest, A. S., Jepps, Thomas Andrew Qvistgaard, Valencik, M. L., Wiwchar, M., Singer, C. A., Sones, W. R., Greenwood, I. A. & Leblanc, N., Nov 2010, In: A J P: Cell Physiology (Online). 299, 5, p. C948-59Research output: Contribution to journal › Journal article › Research
- 2009
- Published
Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles
Jepps, Thomas Andrew Qvistgaard, Greenwood, I. A., Moffatt, J. D., Sanders, K. M. & Ohya, S., Jul 2009, In: A J P: Gastrointestinal and Liver Physiology (Online). 297, 1, p. G107-15Research output: Contribution to journal › Journal article › Research
ID: 51475012
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353
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MicroRNA-153 targeting of KCNQ4 contributes to vascular dysfunction in hypertension
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
131
downloads
Impaired Kv7 channel function in cerebral arteries of a tauopathy mouse model (rTg4510)
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
93
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Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse
Research output: Contribution to journal › Journal article › Research › peer-review
Published