Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related Peptide-induced cerebral reactivity

Research output: Contribution to journalJournal articleResearchpeer-review

Preet S Chadha, Thomas A Jepps, Georgina Carr, Jennifer B Stott, Hei-Lei Zhu, William C Cole, Iain A Greenwood

Middle cerebral artery (MCA) diameter is regulated by inherent myogenic activity and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP). Previous studies showed that MCAs express KCNQ1, 4, and 5 potassium channel genes, and the expression products (Kv7 channels) participate in the myogenic control of MCA diameter. The present study investigated the contribution of Kv7.4 and Kv7.5 isoforms to myogenic and CGRP regulation of MCA diameter and determined whether they were affected in hypertensive animals.
Original languageEnglish
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume34
Issue number4
Pages (from-to)887-93
Number of pages7
ISSN1079-5642
DOIs
Publication statusPublished - Apr 2014

ID: 104942948