Downregulation of Kv7.4 channel activity in primary and secondary hypertension

Research output: Contribution to journalJournal articleResearchpeer-review

Thomas Andrew Jepps, Preet S Chadha, Alison J Davis, Maksym I Harhun, Gillian W Cockerill, Søren Peter Olesen, Rie S Hansen, Iain A Greenwood

Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.
Original languageEnglish
JournalCirculation
Volume124
Issue number5
Pages (from-to)602-11
Number of pages10
ISSN0009-7322
DOIs
Publication statusPublished - 2 Aug 2011

    Research areas

  • Angiotensin II, Animals, Aorta, Thoracic, Blood Pressure, Carbamates, Down-Regulation, Hypertension, Indoles, KCNQ Potassium Channels, Male, Membrane Potentials, Mesenteric Arteries, Mice, Phenylenediamines, Rats, Rats, Inbred SHR, Rats, Wistar, Vasoconstrictor Agents

ID: 108539339