Downregulation of Kv7.4 channel activity in primary and secondary hypertension

Research output: Contribution to journalJournal articleResearchpeer-review

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Downregulation of Kv7.4 channel activity in primary and secondary hypertension. / Jepps, Thomas Andrew; Chadha, Preet S; Davis, Alison J; Harhun, Maksym I; Cockerill, Gillian W; Olesen, Søren Peter; Hansen, Rie S; Greenwood, Iain A.

In: Circulation, Vol. 124, No. 5, 02.08.2011, p. 602-11.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jepps, TA, Chadha, PS, Davis, AJ, Harhun, MI, Cockerill, GW, Olesen, SP, Hansen, RS & Greenwood, IA 2011, 'Downregulation of Kv7.4 channel activity in primary and secondary hypertension', Circulation, vol. 124, no. 5, pp. 602-11. https://doi.org/10.1161/CIRCULATIONAHA.111.032136

APA

Jepps, T. A., Chadha, P. S., Davis, A. J., Harhun, M. I., Cockerill, G. W., Olesen, S. P., ... Greenwood, I. A. (2011). Downregulation of Kv7.4 channel activity in primary and secondary hypertension. Circulation, 124(5), 602-11. https://doi.org/10.1161/CIRCULATIONAHA.111.032136

Vancouver

Jepps TA, Chadha PS, Davis AJ, Harhun MI, Cockerill GW, Olesen SP et al. Downregulation of Kv7.4 channel activity in primary and secondary hypertension. Circulation. 2011 Aug 2;124(5):602-11. https://doi.org/10.1161/CIRCULATIONAHA.111.032136

Author

Jepps, Thomas Andrew ; Chadha, Preet S ; Davis, Alison J ; Harhun, Maksym I ; Cockerill, Gillian W ; Olesen, Søren Peter ; Hansen, Rie S ; Greenwood, Iain A. / Downregulation of Kv7.4 channel activity in primary and secondary hypertension. In: Circulation. 2011 ; Vol. 124, No. 5. pp. 602-11.

Bibtex

@article{90e41fc87ca046bc9f2d33194ac098d3,
title = "Downregulation of Kv7.4 channel activity in primary and secondary hypertension",
abstract = "Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.",
keywords = "Angiotensin II, Animals, Aorta, Thoracic, Blood Pressure, Carbamates, Down-Regulation, Hypertension, Indoles, KCNQ Potassium Channels, Male, Membrane Potentials, Mesenteric Arteries, Mice, Phenylenediamines, Rats, Rats, Inbred SHR, Rats, Wistar, Vasoconstrictor Agents",
author = "Jepps, {Thomas Andrew} and Chadha, {Preet S} and Davis, {Alison J} and Harhun, {Maksym I} and Cockerill, {Gillian W} and Olesen, {S{\o}ren Peter} and Hansen, {Rie S} and Greenwood, {Iain A}",
year = "2011",
month = "8",
day = "2",
doi = "10.1161/CIRCULATIONAHA.111.032136",
language = "English",
volume = "124",
pages = "602--11",
journal = "Circulation",
issn = "0009-7322",
publisher = "AHA/ASA",
number = "5",

}

RIS

TY - JOUR

T1 - Downregulation of Kv7.4 channel activity in primary and secondary hypertension

AU - Jepps, Thomas Andrew

AU - Chadha, Preet S

AU - Davis, Alison J

AU - Harhun, Maksym I

AU - Cockerill, Gillian W

AU - Olesen, Søren Peter

AU - Hansen, Rie S

AU - Greenwood, Iain A

PY - 2011/8/2

Y1 - 2011/8/2

N2 - Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.

AB - Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.

KW - Angiotensin II

KW - Animals

KW - Aorta, Thoracic

KW - Blood Pressure

KW - Carbamates

KW - Down-Regulation

KW - Hypertension

KW - Indoles

KW - KCNQ Potassium Channels

KW - Male

KW - Membrane Potentials

KW - Mesenteric Arteries

KW - Mice

KW - Phenylenediamines

KW - Rats

KW - Rats, Inbred SHR

KW - Rats, Wistar

KW - Vasoconstrictor Agents

U2 - 10.1161/CIRCULATIONAHA.111.032136

DO - 10.1161/CIRCULATIONAHA.111.032136

M3 - Journal article

C2 - 21747056

VL - 124

SP - 602

EP - 611

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 5

ER -

ID: 108539339