Downregulation of Kv7.4 channel activity in primary and secondary hypertension

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Downregulation of Kv7.4 channel activity in primary and secondary hypertension. / Jepps, Thomas Andrew; Chadha, Preet S; Davis, Alison J; Harhun, Maksym I; Cockerill, Gillian W; Olesen, Søren Peter; Hansen, Rie S; Greenwood, Iain A.

In: Circulation, Vol. 124, No. 5, 02.08.2011, p. 602-11.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jepps, TA, Chadha, PS, Davis, AJ, Harhun, MI, Cockerill, GW, Olesen, SP, Hansen, RS & Greenwood, IA 2011, 'Downregulation of Kv7.4 channel activity in primary and secondary hypertension', Circulation, vol. 124, no. 5, pp. 602-11. https://doi.org/10.1161/CIRCULATIONAHA.111.032136

APA

Jepps, T. A., Chadha, P. S., Davis, A. J., Harhun, M. I., Cockerill, G. W., Olesen, S. P., Hansen, R. S., & Greenwood, I. A. (2011). Downregulation of Kv7.4 channel activity in primary and secondary hypertension. Circulation, 124(5), 602-11. https://doi.org/10.1161/CIRCULATIONAHA.111.032136

Vancouver

Jepps TA, Chadha PS, Davis AJ, Harhun MI, Cockerill GW, Olesen SP et al. Downregulation of Kv7.4 channel activity in primary and secondary hypertension. Circulation. 2011 Aug 2;124(5):602-11. https://doi.org/10.1161/CIRCULATIONAHA.111.032136

Author

Jepps, Thomas Andrew ; Chadha, Preet S ; Davis, Alison J ; Harhun, Maksym I ; Cockerill, Gillian W ; Olesen, Søren Peter ; Hansen, Rie S ; Greenwood, Iain A. / Downregulation of Kv7.4 channel activity in primary and secondary hypertension. In: Circulation. 2011 ; Vol. 124, No. 5. pp. 602-11.

Bibtex

@article{90e41fc87ca046bc9f2d33194ac098d3,
title = "Downregulation of Kv7.4 channel activity in primary and secondary hypertension",
abstract = "Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.",
keywords = "Angiotensin II, Animals, Aorta, Thoracic, Blood Pressure, Carbamates, Down-Regulation, Hypertension, Indoles, KCNQ Potassium Channels, Male, Membrane Potentials, Mesenteric Arteries, Mice, Phenylenediamines, Rats, Rats, Inbred SHR, Rats, Wistar, Vasoconstrictor Agents",
author = "Jepps, {Thomas Andrew} and Chadha, {Preet S} and Davis, {Alison J} and Harhun, {Maksym I} and Cockerill, {Gillian W} and Olesen, {S{\o}ren Peter} and Hansen, {Rie S} and Greenwood, {Iain A}",
year = "2011",
month = aug,
day = "2",
doi = "10.1161/CIRCULATIONAHA.111.032136",
language = "English",
volume = "124",
pages = "602--11",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams & Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Downregulation of Kv7.4 channel activity in primary and secondary hypertension

AU - Jepps, Thomas Andrew

AU - Chadha, Preet S

AU - Davis, Alison J

AU - Harhun, Maksym I

AU - Cockerill, Gillian W

AU - Olesen, Søren Peter

AU - Hansen, Rie S

AU - Greenwood, Iain A

PY - 2011/8/2

Y1 - 2011/8/2

N2 - Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.

AB - Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.

KW - Angiotensin II

KW - Animals

KW - Aorta, Thoracic

KW - Blood Pressure

KW - Carbamates

KW - Down-Regulation

KW - Hypertension

KW - Indoles

KW - KCNQ Potassium Channels

KW - Male

KW - Membrane Potentials

KW - Mesenteric Arteries

KW - Mice

KW - Phenylenediamines

KW - Rats

KW - Rats, Inbred SHR

KW - Rats, Wistar

KW - Vasoconstrictor Agents

U2 - 10.1161/CIRCULATIONAHA.111.032136

DO - 10.1161/CIRCULATIONAHA.111.032136

M3 - Journal article

C2 - 21747056

VL - 124

SP - 602

EP - 611

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 5

ER -

ID: 108539339