Jens Juul Holst
Professor
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
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Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study
Samocha-Bonet, D., Chisholm, D. J., Gribble, F. M., Coster, A. C. F., Carpenter, K. H., Jones, G. R. D., Holst, Jens Juul & Greenfield, J. R., 2014, In: PloS one. 9, 11, p. 1-7 7 p., e113366.Research output: Contribution to journal › Journal article › Research › peer-review
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Glutamine reduces postprandial glycemia and augments the glucagon-like peptide-1 response in type 2 diabetes patients
Samocha-Bonet, D., Wong, O., Synnott, E., Piyaratna, N., Douglas, A., Gribble, F. M., Holst, Jens Juul, Chisholm, D. J. & Greenfield, J. R., Jul 2011, In: Journal of Nutrition. 141, 7, p. 1233-1238 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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L-glutamine and whole protein restore first-phase insulin response and increase glucagon-like Peptide-1 in type 2 diabetes patients
Samocha-Bonet, D., Chisholm, D. J., Holst, Jens Juul & Greenfield, J. R., 2015, In: Nutrients. 7, 4, p. 2101-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Acute effects of dietary carbohydrate restriction on glycemia, lipemia and appetite regulating hormones in normal-weight to obese subjects
Samkani, A. A., fbg982, fbg982, Thomsen, M. N., Astrup, A., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Rehfeld, Jens Frederik, Krarup, T. & Haugaard, Steen Bendix, 2018, In: Nutrients. 10, 9, 14 p., 1285.Research output: Contribution to journal › Journal article › Research › peer-review
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The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial
Samkani, A., fbg982, fbg982, Anholm, C., Astrup, A., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, S., Boston, R., Krarup, T. & Haugaard, Steen Bendix, 2018, In: Lipids in Health and Disease. 17, 9 p., 295.Research output: Contribution to journal › Journal article › Research › peer-review
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A carbohydrate-reduced high-protein diet acutely decreases postprandial and diurnal glucose excursions in type 2 diabetes patients
Samkani, A., fbg982, fbg982, Kandel, D., Kjaer, S., Astrup, A., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Rehfeld, Jens Frederik, Haugaard, Steen Bendix & Krarup, T., 2018, In: British Journal of Nutrition. 119, 8, p. 910-917 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sweet Taste Receptor Activation in the Gut Is of Limited Importance for Glucose-Stimulated GLP-1 and GIP Secretion
Saltiel, M. Y., Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Eliasen, R., Conde-Frieboes, K. W., Rosenkilde, Mette & Holst, Jens Juul, 2017, In: Nutrients. 9, 4, 15 p., 418.Research output: Contribution to journal › Journal article › Research › peer-review
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The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells
Salehi, A., Gunnerud, U., Muhammed, S. J., Ostman, E., Holst, Jens Juul, Björck, I. & Rorsman, P., 2012, In: Nutrition & Metabolism. 9, 1, p. 48Research output: Contribution to journal › Journal article › Research › peer-review
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Mathematical Modelling of Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide-1 following Ingestion of Glucose
Røge, R. M., Bagger, J. I., Alskär, O., Kristensen, N. R., Klim, S., Holst, Jens Juul, Ingwersen, S. H., Karlsson, M. O., Knop, Filip Krag, Vilsbøll, Tina & Kjellsson, M. C., Oct 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 4, p. 290-297 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake
Ryskjaer, J., Deacon, Carolyn F., Carr, R. D., Krarup, T., Madsbad, Sten, Holst, Jens Juul, Vilsbøll, Tina, Ryskjaer, J., Deacon, C. F., Carr, R. D., Krarup, T., Madsbad, Sten, Holst, J. J. & Vilsbøll, T., 1 Sep 2006, In: European Journal of Endocrinology. 155, 3, p. 485-93 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Specific inhibition of bile acid transport alters plasma lipids and GLP-1
Rudling, M., Camilleri, M., Graffner, H., Holst, Jens Juul & Rikner, L., 2015, In: B M C Cardiovascular Disorders. 15, p. 1-8 8 p., 75.Research output: Contribution to journal › Journal article › Research › peer-review
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The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones
Rudenko, Olga, Shang, J., Munk, A., Ekberg, J. P., Petersen, N., Engelstoft, M. S., Egerod, Kristoffer Lihme, Hjorth, Siv Annegrethe, Wu, M., Feng, Y., Zhou, Y., Mokrosinski, J., Thams, P., Reimann, F., Gribble, F., Rehfeld, Jens Frederik, Holst, Jens Juul, Treebak, Jonas Thue, Howard, A. D. & Schwartz, Thue W., 2019, In: Molecular Metabolism. 19, p. 49-64 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Voices: Insulin and beyond
Roth, J., Ashcroft, F. M., Wollheim, C. B., Kieffer, T. J., Cherrington, A. D., Bergman, R. N., Taylor, R., Najjar, S. M., Pedersen, Oluf Borbye, Ellingsgaard, H., Holst, Jens Juul, Nauck, M. A., Kadowaki, T., Czech, M. P., Corvera, S., Saltiel, A. R., Corkey, B. E. & Atkinson, M. A., 2021, In: Cell Metabolism. 33, 4, p. 692-699 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance.
Rosenstock, J., Foley, J. E., Rendell, M., Landin-Olsson, M., Holst, Jens Juul, Deacon, Carolyn F., Rochotte, E. & Baron, M. A., 2008, In: Diabetes Care. 31, 1, p. 30-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inability to match energy intake with energy expenditure at sustained near-maximal rates of energy expenditure in older men during a 14-d cycling expedition
Rosenkilde Larsen, M., Morville, T., Riis Andersen, P., Kjær, K., Rasmusen, H., Holst, Jens Juul, Dela, Flemming, Westerterp, K., Sjödin, Anders Mikael & Helge, Jørn Wulff, 2015, In: American Journal of Clinical Nutrition. 102, 6, p. 1398-1405 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gastric myoelectrical activity and gut hormone secretion in myotonic dystrophy
Ronnblom, A., Hellstrom, P. M. & Holst, Jens Juul, 2001, In: Eur J Gastroen Hepat. 13, p. 825-831Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-1 acutely affects renal blood flow and urinary flow rate in spontaneously hypertensive rats despite significantly reduced renal expression of GLP-1 receptors
Ronn, J., Jensen, E. P., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul & Sorensen, Charlotte Mehlin, Dec 2017, In: Physiological Reports. 5, 23, 14 p., e13503.Research output: Contribution to journal › Journal article › Research › peer-review
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Impact of polymorphism in the β₂-receptor gene on metabolic responses to repeated hypoglycaemia in healthy humans
Rokamp, K. Z., Holst, Jens Juul, Olsen, N. V., Dela, Flemming, Secher, Niels H., Juul, Anders, Faber, Jens, Wiberg, S., Thorsteinsson, B. & Pedersen-Bjergaard, Ulrik, 2022, In: Journal of Clinical Endocrinology and Metabolism. 107, 8, p. e3194–e3205 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Impaired crosstalk between pulsatile insulin and glucagon secretion in prediabetic individuals
Rohrer, S., Menge, B. A., Grüber, L., Deacon, Carolyn F., Schmidt, W. E., Veldhuis, J. D., Holst, Jens Juul & Meier, J. J., 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 5, p. E791-E795Research output: Contribution to journal › Journal article › Research › peer-review
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Cholecystokinin-Induced Gallbladder Emptying and Single-Dose Metformin Elicit Additive Glucagon-Like Peptide-1 Responses
Rohde, U., Sonne, D. P., Christensen, M., Hansen, M., Brønden, A., Toräng, S., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 May 2016, In: The Journal of clinical endocrinology and metabolism. 101, 5, p. 2076-2083Research output: Contribution to journal › Journal article › Research › peer-review
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The impact of EndoBarrier gastrointestinal liner in obese patients with normal glucose tolerance and in patients with type 2 diabetes
Rohde, U., Federspiel, C. A., Vilmann, Peter, Langholz, Ebbe, Friis, S. U., Krakauer, M., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Feb 2017, In: Diabetes, Obesity and Metabolism. 19, 2, p. 189-199 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study
Robertson, M. A., Sigalet, D. L., Holst, Jens Juul, Meddings, J. B., Wood, J. & Sharkey, K. A., Jul 2008, In: Journal of Autism and Developmental Disorders. 38, 6, p. 1066-71 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study
Robertson, M. A., Sigalet, D. L., Holst, Jens Juul, Meddings, J. B., Wood, J. & Sharkey, K. A., 2008, In: Journal of Autism and Developmental Disorders. 38, 6, p. 1066-1071 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
Roager, H. M., Vogt, J. K., Kristensen, M. B., Hansen, L. B. S., Ibrügger, S., Mærkedahl, R. B., Bahl, M. I., Lind, M. V., Nielsen, R. L., Frøkiær, H., Gøbel, R. J., Landberg, R., Ross, A. B., Brix, S., Holck, J., Meyer, A. S., Sparholt, M. H., Christensen, A. F., Carvalho, V., Hartmann, B. & 18 others, , Jan 2019, In: Gut. 68, 1, p. 83-93 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased hepatic glucagon sensitivity in totally pancreatectomised patients
Rix, I., Lund, Asger Bach, Garvey, L. F., Hansen, C. P., Chabanova, E., Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina, van Hall, Gerrit & Knop, Filip Krag, 2024, In: European Journal of Endocrinology. 190, 6, p. 446-457 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hyperglucagonaemia and amino acid alterations in individuals with type 2 diabetes and non-alcoholic fatty liver disease
Rix, I., Johansen, M. L., Lund, A., Suppli, M. P., Chabanova, E., van Hall, Gerrit, Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Kistorp, Caroline Michaela Nervil & Knop, Filip Krag, 2023, In: Endocrine Connections. 13, 1, 11 p., e230161.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased glucagon sensitivity in totally pancreatectomised patients
Rix, I., Lund, A., Garvey, Lene Heise, Owen, K., Hansen, C., van Hall, Gerrit, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 118-119 226.Research output: Contribution to journal › Conference abstract in journal › Research
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Einfluss von subkutanem GLP-1 auf die frühe und langsame Phase der Insulin-sekretion nach intravenöser Glukosebelastung bei gesunden Probanden.
Ritzelt, R., Ørskov, C., Holst, Jens Juul, Schmiegel, W. & Nauck, M. A., 1997, In: Diabetes und Stoffwechsel. 6, p. 64-69.Research output: Contribution to journal › Journal article › Research › peer-review
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Preserved GLP-1 effects in a diabetic patient with Cushing's disease
Ritzel, R. A., Kleine, N., Holst, Jens Juul, Willms, B., Schmiegel, W. & Nauck, M. A., 2007, In: Experimental and Clinical Endocrinology and Diabetes. 115, 2, p. 146-150 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacokinetic, insulinotropic and glucagonostatic properties of GLP-1 (7-36 amide) after subcutaneous injection in healthy volunteers. Dose-response-relationships
Ritzel, R., Ørskov, Cathrine, Holst, Jens Juul & Nauck, M. A., 1995, In: Diabetologia. 38, p. 720-725Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide 1 increases secretory burst mass of pulsatile insulin secretion in patients with type 2 diabetes and impaired glucose tolerance
Ritzel, R., Schulte, M., Porksen, N. & Holst, Jens Juul, 2001, In: Diabetes. 50, p. 776-784Research output: Contribution to journal › Journal article › Research › peer-review
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Preserved GLP-1 effects in a diabetic patient with Cushing's disease
Ritzel, R. A., Kleine, N., Holst, Jens Juul, Willms, B., Schmiegel, W. & Nauck, M. A., Feb 2007, In: Experimental and Clinical Endocrinology and Diabetes. 115, 2, p. 146-50 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Metformin stimulates intestinal glycolysis and lactate release: A single-dose study of metformin in patients with intrahepatic portosystemic stent
Rittig, N., Aagaard, N. K., Sundelin, E., Villadsen, G. E., Sandahl, T. D., Holst, Jens Juul, Hartmann, Bolette, Brøsen, K., Grønbaek, H. & Jessen, N., 2021, In: Clinical Pharmacology and Therapeutics. 110, 5, p. 1329-1336Research output: Contribution to journal › Journal article › Research › peer-review
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Oral D/L-3-Hydroxybutyrate Stimulates Cholecystokinin and Insulin Secretion and Slows Gastric Emptying in Healthy Males
Rittig, N., Svart, M., Thomsen, H. H., Vestergaard, E. T., Rehfeld, Jens Frederik, Hartmann, Bolette, Holst, Jens Juul, Johannsen, M., Møller, N. & Jessen, N., 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 10, 9 p., dgaa483.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of meal size and composition on incretin, alpha-cell, and beta-cell responses
Rijkelijkhuizen, J. M., McQuarrie, K., Girman, C. J., Stein, P. P., Mari, A., Holst, Jens Juul, Nijpels, G. & Dekker, J. M., 2009, In: Metabolism - Clinical and Experimental.Research output: Contribution to journal › Journal article › Research › peer-review
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The Liver-Alpha Cell Axis in Health and in Disease
Richter, Michael Martin, Galsgaard, Katrine Douglas, Elmelund, E., Knop, Filip Krag, Suppli, M. P., Holst, Jens Juul, Winther-Sørensen, Marie, Kjeldsen, Sasha Alexandra Sampson & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Diabetes. 71, +, p. 1852–1861Research output: Contribution to journal › Review › Research › peer-review
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Glucagon augments the secretion of FGF21 and GDF15 in MASLD by indirect mechanisms
Richter, Michael Martin, Kemp, I. M., Heebøll, S., Winther-Sørensen, Marie, Kjeldsen, Sasha Alexandra Sampson, Jensen, N. J., Nybing, J. D., Linden, F. H., Høgh-Schmidt, E., Boesen, Mikael Ploug, Madsbad, Sten, Schiødt, Frank Vinholt, Nørgaard, Kirsten, Schmidt, S., Gluud, Lise Lotte, Haugaard, Steen Bendix, Holst, Jens Juul, Nielsen, S., Rungby, Jørgen & Albrechtsen, Nicolai Jacob Wewer, 2024, In: Metabolism: Clinical and Experimental. 156, 13 p., 155915.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of a 6-Week Carbohydrate-Reduced High-Protein Diet on Levels of FGF21 and GDF15 in People With Type 2 Diabetes
Richter, Michael Martin, Thomsen, M. N., Skytte, M. J., Kjeldsen, Sasha Alexandra Sampson, Samkani, A., Frystyk, J., Magkos, Faidon, Holst, Jens Juul, Madsbad, Sten, Krarup, T., Haugaard, Steen Bendix & Albrechtsen, Nicolai Jacob Wewer, 2024, In: Journal of the Endocrine Society. 8, 4, 11 p., bvae008.Research output: Contribution to journal › Journal article › Research › peer-review
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Postprandial secretion of follistatin after gastric bypass surgery and sleeve gastrectomy
Richter, Michael Martin, Svane, M. S., Kristiansen, V. B., Holst, Jens Juul, Madsbad, Sten & Bojsen-Møller, K. N., 2023, In: Peptides. 163, 8 p., 170978.Research output: Contribution to journal › Journal article › Research › peer-review
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The impact of dipeptidyl peptidase 4 inhibition on incretin effect, glucose tolerance, and gastrointestinal-mediated glucose disposal in healthy subjects
Rhee, N. A., Østoft, S. H., Holst, Jens Juul, Deacon, Carolyn F., Vilsbøll, T. & Knop, Filip Krag, 16 Jun 2014, In: European Journal of Endocrinology. 171, 3, p. 353-362 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The use of double-balloon enteroscopy in retrieving mucosal biopsies from the entire human gastrointestinal tract
Rhee, N. A., Vilmann, Peter, Hassan, H., Hendel, J. W., Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, Sep 2014, In: Scandinavian Journal of Gastroenterology. 49, 9, p. 1143-1149 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes
Rhee, N. A., Wahlgren, C. D., Pedersen, J., Mortensen, B., Langholz, E., Wandall, E. P., Friis, S. U., Vilmann, Peter, Paulsen, S. J., Kristiansen, V. B., Jelsing, J., Dalbøge, L. S., Poulsen, Steen Seier, Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, 2015, In: Diabetologia. 58, 10, p. 2254-2258 5 p.Research output: Contribution to journal › Letter › Research › peer-review
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Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice
Reimer, M. K., Holst, Jens Juul & Ahrén, B., 2002, In: European Journal of Endocrinology. 146, p. 717-727Research output: Contribution to journal › Journal article › Research › peer-review
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Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice
Reimer, M. K., Holst, Jens Juul & Ahrén, B., May 2002, In: European Journal of Endocrinology. Supplement. 146, 5, p. 717-27 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial
Reijnders, D., Goossens, G. H., Hermes, G. D. A., Neis, E. P. J. G., van der Beek, C. M., Most, J., Holst, Jens Juul, Lenaerts, K., Kootte, R. S., Nieuwdorp, M., Groen, A. K., Olde Damink, S. W. M., Boekschoten, M. V., Smidt, H., Zoetendal, E. G., Dejong, C. H. C. & Blaak, E. E., 12 Jul 2016, In: Cell Metabolism. 24, 1, p. 63-74 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dual-hormone treatment with insulin and glucagon in patients with type 1 diabetes
Reiband, H. K., Schmidt, S., Ranjan, A., Holst, Jens Juul, Madsbad, Sten & Nørgaard, Kirsten, 2015, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 31, 7, p. 672-9 8 p.Research output: Contribution to journal › Review › Research › peer-review
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Cholecystokinin secretion is suppressed by glucagon-like peptide-1: clue to the mechanism of the adverse gallbladder events of GLP-1-derived drugs
Rehfeld, Jens Frederik, Knop, Filip Krag, Asmar, A., Madsbad, Sten, Holst, Jens Juul & Asmar, M., 2018, In: Scandinavian Journal of Gastroenterology. 53, 12, p. 1429-1432Research output: Contribution to journal › Journal article › Research › peer-review
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Jan Fahrenkrug (6/6 1947 – 10/11 2021)
Rehfeld, Jens Frederik, Hannibal, Jens, Holst, Jens Juul, Hökfelt, T., de Muckadell, O. B. S. & Schwartz, Thue W., 2022, In: Peptides. 150, 170771.Research output: Contribution to journal › Editorial › Research
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The effect of glucagon-like Peptide-2 receptor agonists on colonic anastomotic wound healing
Redstone, H. A., Buie, W. D., Hart, D. A., Wallace, L., Hornby, P. J., Sague, S., Holst, Jens Juul & Sigalet, D. L., 1 Jan 2010, In: Gastroenterology Research and Practice. 2010, p. Article ID 672453 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus
Rauch, T., Graefe-Mody, U., Deacon, Carolyn F., Ring, A., Holst, Jens Juul, Woerle, H., Dugi, K. A. & Heise, T., Nov 2012, In: Diabetes Therapy. 3, 1, p. 10Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4207
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol
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691
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
Research output: Contribution to journal › Journal article › Research › peer-review
Published