Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus

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Linagliptin is a xanthine-based dipeptidyl peptidase (DPP)-4 inhibitor that is now available in numerous countries worldwide for the treatment of type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate further the mechanisms underlying the improvements in glycemic control observed with linagliptin. The effects of linagliptin on DPP-4, pharmacodynamic parameters, and glycemic control versus placebo were assessed in patients with inadequately controlled T2DM.
Original languageEnglish
JournalDiabetes Therapy
Issue number1
Pages (from-to)10
Publication statusPublished - Nov 2012

ID: 45841462