Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus
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Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus. / Rauch, Thomas; Graefe-Mody, Ulrike; Deacon, Carolyn F; Ring, Arne; Holst, Jens Juul; Woerle, Hans-Juergen; Dugi, Klaus A; Heise, Tim.
In: Diabetes Therapy, Vol. 3, No. 1, 11.2012, p. 10.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus
AU - Rauch, Thomas
AU - Graefe-Mody, Ulrike
AU - Deacon, Carolyn F
AU - Ring, Arne
AU - Holst, Jens Juul
AU - Woerle, Hans-Juergen
AU - Dugi, Klaus A
AU - Heise, Tim
PY - 2012/11
Y1 - 2012/11
N2 - Linagliptin is a xanthine-based dipeptidyl peptidase (DPP)-4 inhibitor that is now available in numerous countries worldwide for the treatment of type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate further the mechanisms underlying the improvements in glycemic control observed with linagliptin. The effects of linagliptin on DPP-4, pharmacodynamic parameters, and glycemic control versus placebo were assessed in patients with inadequately controlled T2DM.
AB - Linagliptin is a xanthine-based dipeptidyl peptidase (DPP)-4 inhibitor that is now available in numerous countries worldwide for the treatment of type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate further the mechanisms underlying the improvements in glycemic control observed with linagliptin. The effects of linagliptin on DPP-4, pharmacodynamic parameters, and glycemic control versus placebo were assessed in patients with inadequately controlled T2DM.
U2 - 10.1007/s13300-012-0010-y
DO - 10.1007/s13300-012-0010-y
M3 - Journal article
C2 - 22986920
VL - 3
SP - 10
JO - Diabetes Therapy
JF - Diabetes Therapy
SN - 1869-6953
IS - 1
ER -
ID: 45841462