Nils Billestrup
Professor
- 2024
- Published
Butyrate functions as a histone deacetylase inhibitor to protect pancreatic beta cells from IL-1β-induced dysfunction
Pedersen, Signe Schultz, Ingerslev, Lars Roed, Olsen, M., Prause, Michala Cecilie Burstein & Billestrup, Nils, 2024, In: FEBS Journal. 291, 3, p. 566-583Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Targeted Delivery of Butyrate Improves Glucose Homeostasis, Reduces Hepatic Lipid Accumulation and Inflammation in db/db Mice
Pedersen, Signe Schultz, Prause, Michala Cecilie Burstein, Sørensen, C., Størling, Joachim, Moritz, Thomas, Mariño, E. & Billestrup, Nils, 2023, In: International Journal of Molecular Sciences. 24, 5, 17 p., 4533.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding
Urizar, A. I., Prause, Michala Cecilie Burstein, Ingerslev, L. R., Wortham, M., Sui, Y., Sander, M., Williams, K., Barrès, Romain, Larsen, M. R., Christensen, G. L. & Billestrup, Nils, 2023, In: Cell Death and Disease. 14, 7, 16 p., 399.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Butyrate inhibits IL-1β-induced inflammatory gene expression by suppression of NF-κB activity in pancreatic beta cells
Pedersen, Signe Schultz, Prause, Michala Cecilie Burstein, Williams, K., Barrès, Romain & Billestrup, Nils, 2022, In: Journal of Biological Chemistry. 298, 9, 14 p., 102312.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Butyrate protects pancreatic beta cells from cytokine-induced dysfunction
Prause, Michala Cecilie Burstein, Pedersen, Signe Schultz, Tsonkova, V., Qiao, M. & Billestrup, Nils, 2021, In: International Journal of Molecular Sciences. 22, 19, 18 p., 10427.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1 beta is associated with changes in expression of beta-cell maturity genes and associated histone modifications
Urizar, A. I., Prause, Michala Cecilie Burstein, Wortham, M., Sui, Y., Thams, P., Sander, M., Christensen, G. L. & Billestrup, Nils, 2019, In: Molecular and Cellular Endocrinology. 496, 12 p., 110524 .Research output: Contribution to journal › Review › Research › peer-review
- 2018
- Published
Characterization of the Molecular Mechanisms Underlying Glucose Stimulated Insulin Secretion from Isolated Pancreatic β-cells Using Post-translational Modification Specific Proteomics (PTMomics)
Kang, T., Jensen, P., Huang, H., Lund Christensen, G., Billestrup, Nils & Larsen, M. R., Jan 2018, In: Molecular and Cellular Proteomics. 17, 1, p. 95-110 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Pannexin-2-deficiency sensitizes pancreatic beta-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo
Berchtold, L. A., Miani, M., Diep, T. A., Madsen, A. N., Cigliola, V., Colli, M., Miskovic Krivokapic, Jelena, Pociot, Flemming, Eizirik, D. L., Meda, P., Holst, Birgitte, Billestrup, Nils & Storling, J., 2017, In: Molecular and Cellular Endocrinology. 448, p. 108-121 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes
Skarbaliene, J., Rigbolt, K. T., Fosgerau, K. & Billestrup, Nils, 15 Nov 2017, In: European Journal of Pharmacology. 815, p. 181-189 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Regulation of Pancreatic Alpha Cell Function and Proliferation by Bone Morphogenetic Protein 4 (BMP4) in vitro.
Nielsen, S. S., Christensen, G. L., Holst, Jens Juul & Billestrup, Nils, Oct 2016, In: Endocrinology. 157, 10, p. 3809-3820 12 p., 27479530 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of Pancreatic α-Cell Function and Proliferation by Bone Morphogenetic Protein 4 (BMP4) In Vitro
Nielsen, S. S., Christensen, G. L., Holst, Jens Juul & Billestrup, Nils, Oct 2016, In: Endocrinology. 157, 10, p. 3809-3820 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aberrant accumulation of the diabetes autoantigen GAD65 in Golgi membranes in conditions of ER stress and autoimmunity
Phelps, E. A., Cianciaruso, C., Michael, I. P., Pasquier, M., Kanaani, J., Nano, R., Lavallard, V., Billestrup, Nils, Hubbell, J. A. & Baekkeskov, S., Sep 2016, In: Diabetes. 65, 9, p. 2686-2699Research output: Contribution to journal › Journal article › Research › peer-review
- Published
JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1 beta-Induced Apoptosis Associated with Abrogated Myc Expression
Prause, Michala Cecilie Burstein, Mayer, C. M., Brorsson, C., Frederiksen, K. S., Billestrup, Nils, Størling, Joachim & Mandrup-Poulsen, Thomas, 2016, In: Journal of Diabetes Research. 2016, 15 p., 1312705.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells
Prause, Michala Cecilie Burstein, Berchtold, L. A., Urizar, A. I., Trauelsen, Mette, Billestrup, Nils, Mandrup-Poulsen, Thomas & Størling, Joachim, 15 Jan 2016, In: Molecular and Cellular Endocrinology. 420, p. 24-36 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inflammatory Cytokines Stimulate Bone Morphogenetic Protein-2 Expression and Release from Pancreatic Beta Cells
Urizar, A. I., Friberg, J., Christensen, D. P., Christensen, G. L. & Billestrup, Nils, 1 Jan 2016, In: Journal of Interferon & Cytokine Research. 36, 1, p. 20-29Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents
Christensen, G. L., Jacobsen, M. L. B., Wendt, A., Mollet, I. G., Friberg, J., Frederiksen, K. S., Meyer, M., Bruun, C., Eliasson, L. & Billestrup, Nils, Jun 2015, In: Diabetologia. 58, 6, p. 1282-1290 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons
Kanaani, J., Cianciaruso, C., Phelps, E. A., Pasquier, M., Brioudes, E., Billestrup, Nils & Baekkeskov, S., 2015, In: PLOS ONE. 10, 2, p. 1-24 24 p., e0117130.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Surface-expressed insulin receptors as well as IGF-I receptors both contribute to the mitogenic effects of human insulin and its analogues
Lundby, A., Bolvig, P., Hegelund, A. C., Hansen, B. F., Worm, J., Lützen, A., Billestrup, Nils, Bonnesen, C. & Oleksiewicz, M. B., Jul 2015, In: Journal of Applied Toxicology. 35, 7, p. 842-850 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Anti-diabetic Effects of GLP-1-gastrin Dual Agonist ZP3022 in ZDF rats
Skarbaliene, J., Secher, T., Jelsing, J., Ansarullah, Neerup, T. S. R., Billestrup, Nils & Fosgerau, K., Jul 2015, In: Peptides. 69, p. 47-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
CRFR1 activation protects against cytokine-induced beta cell death
Blaabjerg, L., Christensen, G. L., Matsumoto, M., van der Meulen, T., Huising, M. O., Billestrup, Nils & Vale, W., 16 Oct 2014, In: Journal of Molecular Endocrinology. 53, p. 417-427 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of beta cell growth and function by bone morphogenetic proteins
Bruun, C., Christensen, G. L., Jacobsen, M. L. B., Kanstrup, M. B., Jensen, P. R., Fjordvang, H., Mandrup-Poulsen, Thomas & Billestrup, Nils, 27 Sep 2014, In: Diabetologia. 57, 12, p. 2546-54 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection
Christensen, D. P., Gysemans, C., Lundh, M., Dahllöf, M. S., Noesgaard, D., Schmidt, S. F., Mandrup, S., Birkbak, N., Workman, C., Piemonti, L., Blaabjerg, L., Monzani, V., Fossati, G., Mascagni, P., Paraskevas, S., Aikin, R. A., Billestrup, N., Grunnet, L. G., Dinarello, C. A., Mathieu, C. & 1 others, , 6 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. 1055-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The mitogenic effect of Gas6 on pancreatic beta cells is mediated via the receptor tyrosine kinase Axl
Haase, T. N., Gustafsson, A., Nalla, A., Ringholm, L., Damm, Peter, Mathiesen, Elisabeth, Dahlback, B., Billestrup, Nils & Nielsen, Jens Høiriis, Sep 2014, In: Diabetologia. 57, 1 Suppl, p. S173-S174 408.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Implications for the offspring of circulating factors involved in beta cell adaptation in pregnancy
Nalla, A., Ringholm, L., Søstrup, B., Højrup, P., Thim, L., Levery, S. B., Vakhrushev, Sergey, Billestrup, Nils, Mathiesen, Elisabeth, Damm, Peter & Nielsen, Jens Høiriis, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1181-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of fetal and neonatal environment on beta cell function and development of diabetes
Nielsen, Jens Høiriis, Haase, T. N., Jaksch, C., Nalla, A., Søstrup, B., Nalla, A. A., Larsen, L., Rasmussen, M., Dalgaard, L. T., Gaarn, L. W., Thams, P., Kofod, H. & Billestrup, Nils, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1109-22 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis
Prause, Michala Cecilie Burstein, Christensen, D. P., Billestrup, Nils & Mandrup-Poulsen, Thomas, 2014, In: PLOS ONE. 9, 1, p. 1-11 11 p., e87067.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Co-ordinated regulation of neurogenin-3 expression in the maternal and fetal pancreas during pregnancy
Søstrup, B., Gaarn, L. W., Nalla, A., Billestrup, Nils & Nielsen, Jens Høiriis, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1190-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell
Haase, T. N., Rasmussen, M., Jaksch, C. A. M., Gaarn, L. W., Petersen, C. K., Billestrup, Nils & Nielsen, Jens Høiriis, Apr 2013, In: Diabetologia. 56, 4, p. 763-773 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines
Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, , 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
ID'ing a novel inhibitor of β-cell function, Id1
Billestrup, Nils, Oct 2011, In: Diabetes. 60, 10, p. 2455-6 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ß-cell specific overexpression of suppressor of cytokine signalling-3 does not protect against multiple low dose streptozotocin induced type 1 diabetes in mice
Börjesson, A., Rønn, S. G., Karlsen, A. E., Billestrup, Nils & Sandler, S., 30 Apr 2011, In: Immunology Letters. 136, 1, p. 74-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus
Christensen, D. P., Dahllöf, M. S., Lundh, M., Rasmussen, D. N., Nielsen, M. D., Billestrup, Nils, Grunnet, L. G. & Mandrup-Poulsen, Thomas, 2011, In: Molecular Medicine. 17, 5-6, p. 378-90 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique
Kulahin, N., Grunnet, L. G., Lundh, M., Christensen, D. P., Jorgensen, R., Heding, A., Billestrup, Nils, Berezin, V., Bock, E. & Mandrup-Poulsen, Thomas, 3 Jan 2011, In: FEBS Letters. 585, 1, p. 58-64 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Endothelial Progenitor Cells in Long-Standing Asymptomatic Type 1 Diabetic Patients with or without Diabetic Nephropathy
Reinhard, H., Jacobsen, P. K., Lajer, M., Tarnow, L., Astrup, A. S., Kim, W. Y., Pedersen, N., Billestrup, Nils, Mandrup-Poulsen, Thomas, Parving, H. & Rossing, Peter, 2011, In: Nephron Clinical Practice. 118, 3, p. c309-c314 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells
Eriksen, K. W., Woetmann, Anders , Skov, Lone, Krejsgaard, T., Bovin, L. F., Hansen, M. L., Grønbæk, Kirsten, Billestrup, Nils, Nissen, Mogens Holst, Geisler, Carsten, Wasik, M. A. & Ødum, Niels, 2010, In: Journal of Investigative Dermatology. 130, 6, p. 1590-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dissociation between skeletal muscle inhibitor-{kappa}B kinase/nuclear factor-{kappa}B pathway activity and insulin sensitivity in nondiabetic twins
Friedrichsen, M., Ribel-Madsen, R., Wojtaszewski, Jørgen F P, Grunnet, Louise Groth, Richter, Erik A., Billestrup, Nils, Ploug, Thorkil, Vaag, A. & Poulsen, P., 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 1, p. 414-421 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Genetic deficiency of tissue inhibitor of metalloproteinase (TIMP) 1 does not affect apoptosis in cytokine-exposed mouse islets in vitro.
Hansen, J. B., Tonnesen, M. F., Rømer, M. U. K., Billestrup, Nils, Brunner, N. & Mandrup-Poulsen, Thomas, 2010, (Accepted/In press).Research output: Contribution to conference › Conference abstract for conference › Research
- Published
Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines
Lundh, M., Christensen, D. P., Rasmussen, D. N., Mascagni, P., Dinarello, C. A., Billestrup, Nils, Grunnet, L. G. & Mandrup-Poulsen, Thomas, 1 Dec 2010, In: Diabetologia. 53, 12, p. 2569-78 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multifactorial treatment increases endothelial progenitor cells in patients with type 2 diabetes
Reinhard, H., Jacobsen, P. K., Lajer, M., Pedersen, N., Billestrup, Nils, Mandrup-Poulsen, Thomas, Parving, H. & Rossing, Peter, 1 Oct 2010, In: Diabetologica. 53, 10, p. 2129-33 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells
Bruun, C., Heding, P. E., Rønn, S. G., Frobøse, H., Rhodes, C. J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2009, In: Molecular and Cellular Endocrinology. 311, 1-2, p. 32-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
Collombat, P., Xu, X., Ravassard, P., Sosa-Pineda, B., Dussaud, S., Billestrup, Nils, Madsen, O. D., Serup, P., Heimberg, H. & Mansouri, A., 2009, In: Cell. 138, 3, p. 449-62 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells
Grunnet, L. G., Aikin, R., Tonnesen, M. F., Paraskevas, S., Blaabjerg, L., Størling, J., Rosenberg, L., Billestrup, Nils, Maysinger, D. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes. 58, 8, p. 1807-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner
Huising, M. O., van der Meulen, T., Vaughan, J. M., Matsumoto, M., Donaldson, C. J., Park, H., Billestrup, Nils & Vale, W. W., 2009, In: Proceedings of the National Academy of Science of the United States of America. 107, 2, p. 912-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IL-1 beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells
Jacobsen, M. L. B., Ronn, S. G., Bruun, C., Larsen, C. M., Eizirik, D. L., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2009, In: Diabetologia. 52, 2, p. 281-288 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of Nuclear Factor-kappa B or Bax Prevents Endoplasmic Reticulum Stress-But Not Nitric Oxide-Mediated Apoptosis in INS-1E Cells
Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, Nils, Eizirik, D. L., Storling, J. & Mandrup-Poulsen, Thomas, 2009, In: Endocrinology. 150, 9, p. 4094-4103 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells
Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, Nils, Eizirik, D. L., Størling, Joachim & Mandrup-Poulsen, Thomas, Sep 2009, In: Endocrinology. 150, 9, p. 4094-103 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Dedifferentiation for replication of human beta-cells: a division between mice and men?
Billestrup, Nils & Otonkoski, T., 2008, In: Diabetes. 57, 6, p. 1457-8 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells
Jacobsen, M. L. B., Rønn, S. G., Bruun, C., Larsen, C. M., Eizirik, D. L., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2008, In: Diabetologia. 52, 2, p. 281-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of fasting on growth hormone signaling and action in muscle and fat
Moller, L., Dalman, L., Norrelund, H., Billestrup, Nils, Frystyk, J., Moller, N. & Jorgensen, J. O. L., 2008, In: Journal of Clinical Endocrinology and Metabolism. 94, 3, p. 965-72 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proliferation of sorted human and rat beta cells
Parnaud, G., Bosco, D., Berney, T., Pattou, F., Kerr-Conte, J., Donath, M. Y., Bruun, C., Mandrup-Poulsen, Thomas, Billestrup, Nils & Halban, P. A., 2008, In: Diabetologia. 51, 1, p. 91-100 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 15311848
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JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1 beta-Induced Apoptosis Associated with Abrogated Myc Expression
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
39
downloads
Butyrate protects pancreatic beta cells from cytokine-induced dysfunction
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
33
downloads
Butyrate inhibits IL-1β-induced inflammatory gene expression by suppression of NF-κB activity in pancreatic beta cells
Research output: Contribution to journal › Journal article › Research › peer-review
Published