Nils Billestrup

Nils Billestrup

Professor

Member of:

    ORCID: 0000-0002-4968-8067

    Publication year:
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    51 - 100 out of 118Page size: 50
    1. 2002
    2. Published

      The effect of suppressor of cytokine signaling 3 on GH signaling in beta-cells

      Rønn, S. G., Hansen, J. A., Lindberg, K., Karlsen, A. E. & Billestrup, Nils, Sep 2002, In: Molecular endocrinology (Baltimore, Md.). 16, 9, p. 2124-34 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. 2003
    4. Published

      Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells

      Friedrichsen, B. N., Richter, H. E., Hansen, J. A., Rhodes, C. J., Nielsen, Jens Høiriis, Billestrup, Nils & Møldrup, A., May 2003, In: Molecular endocrinology (Baltimore, Md.). 17, 5, p. 945-58 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Nuclear translocation and retention of growth hormone

      Mertani, H. C., Raccurt, M., Abbate, A., Kindblom, J., Törnell, J., Billestrup, Nils, Usson, Y., Morel, G. & Lobie, P. E., Jul 2003, In: Endocrinology. 144, 7, p. 3182-95 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      The role of signal transducer and activator of transcription 5 in the inhibitory effects of GH on adipocyte differentiation

      Richter, H. E., Albrektsen, T. & Billestrup, Nils, Apr 2003, In: Journal of Molecular Endocrinology. 30, 2, p. 139-50 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      SOCS-3 is involved in the downregulation of the acute insulin-like effects of growth hormone in rat adipocytes by inhibition of Jak2/IRS-1 signaling

      Ridderstråle, M., Amstrup, J., Hilton, D. J., Billestrup, Nils & Tornqvist, H., Mar 2003, In: Hormone and Metabolic Research. Supplement. 35, 3, p. 169-77 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. 2004
    9. Published

      Growth hormone receptor expression and function in pituitary adenomas

      Clausen, L. R., Kristiansen, M. T., Rasmussen, L. M., Billestrup, Nils, Blaabjerg, O., Ledet, T. & Jørgensen, J. O. L., May 2004, In: Clinical Endocrinology. 60, 5, p. 576-83 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

      Gylvin, T., Nolsøe, R., Hansen, Torben, Nielsen, E. M. D., Bergholdt, R., Karlsen, A. E., Billestrup, Nils, Borch-Johnsen, K., Pedersen, O., Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 1 Jul 2004, In: Diabetologia. 47, 7, p. 1273-7 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

      Karlsen, A. E., Heding, P. E., Frobøse, H., Rønn, S. G., Kruhøffer, M., Orntoft, T. F., Darville, M., Eizirik, D. L., Pociot, Flemming, Nerup, J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 1 Nov 2004, In: Diabetologia. 47, 11, p. 1998-2011 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. 2005
    13. Published

      Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells

      Larsen, L., Størling, Joachim, Darville, M., Eizirik, D. L., Bonny, C., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 Dec 2005, In: Diabetologia. 48, 12, p. 2582-90 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Regulation of pancreatic beta-cell mass and proliferation by SOCS-3

      Lindberg, K., Rønn, S. G., Tornehave, D., Richter, H., Hansen, J. A., Rømer, J., Jackerott, M. & Billestrup, Nils, Oct 2005, In: Journal of Molecular Endocrinology. 35, 2, p. 231-43 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling

      Lund, I. K., Hansen, J. A., Andersen, H. S., Møller, N. P. H. & Billestrup, Nils, 1 Apr 2005, In: Journal of Molecular Endocrinology. 34, 2, p. 339-51 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt

      Størling, Joachim, Binzer, J., Andersson, A., Züllig, R. A., Tonnesen, M., Knudsen, R. L. P., Spinas, G. A., Sandler, S., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 Oct 2005, In: Diabetologia. 48, 10, p. 2039-50 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. 2006
    18. Published

      GH receptor signaling in skeletal muscle and adipose tissue in human subjects following exposure to an intravenous GH bolus

      Jørgensen, J. O. L., Jessen, N., Pedersen, S. B., Vestergaard, E. T., Gormsen, L. C., Lund, S. & Billestrup, Nils, 1 Nov 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 5, p. E899-905

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells

      Larsen, C. M., Døssing, M. G., Papa, S., Franzoso, G., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 May 2006, In: Diabetologia. 49, 5, p. 980-9 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line

      Petersen, L. G., Størling, Joachim, Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, Nils, Bock, E. & Mandrup-Poulsen, Thomas, 2006, In: Diabetologia. 49, 8, p. 1864-75 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. 2007
    22. Published

      Effects of growth hormone on glucose and fat metabolism in human subjects

      Jørgensen, J. O. L., Møller, L., Krag, M. B., Billestrup, Nils & Christiansen, J. K. S., 1 Mar 2007, In: Endocrinology & Metabolism Clinics of North America. 36, 1, p. 75-87 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells

      Larsen, L., Tonnesen, M., Ronn, S. G., Størling, Joachim, Jørgensen, S., Mascagni, P., Dinarello, C. A., Billestrup, Nils & Mandrup-Poulsen, Thomas, Apr 2007, In: Diabetologia. 50, 4, p. 779-89 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. 2008
    25. Published

      Dedifferentiation for replication of human beta-cells: a division between mice and men?

      Billestrup, Nils & Otonkoski, T., 2008, In: Diabetes. 57, 6, p. 1457-8 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells

      Jacobsen, M. L. B., Rønn, S. G., Bruun, C., Larsen, C. M., Eizirik, D. L., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2008, In: Diabetologia. 52, 2, p. 281-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Impact of fasting on growth hormone signaling and action in muscle and fat

      Moller, L., Dalman, L., Norrelund, H., Billestrup, Nils, Frystyk, J., Moller, N. & Jorgensen, J. O. L., 2008, In: Journal of Clinical Endocrinology and Metabolism. 94, 3, p. 965-72 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Proliferation of sorted human and rat beta cells

      Parnaud, G., Bosco, D., Berney, T., Pattou, F., Kerr-Conte, J., Donath, M. Y., Bruun, C., Mandrup-Poulsen, Thomas, Billestrup, Nils & Halban, P. A., 2008, In: Diabetologia. 51, 1, p. 91-100 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

      Rønn, S. G., Börjesson, A., Bruun, C., Heding, P. E., Frobøse, H., Mandrup-Poulsen, Thomas, Karlsen, A. E., Rasschaert, J., Sandler, S. & Billestrup, Nils, 2008, In: Diabetologia. 51, 10, p. 1873-1882 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. 2009
    31. Published

      Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells

      Bruun, C., Heding, P. E., Rønn, S. G., Frobøse, H., Rhodes, C. J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2009, In: Molecular and Cellular Endocrinology. 311, 1-2, p. 32-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

      Collombat, P., Xu, X., Ravassard, P., Sosa-Pineda, B., Dussaud, S., Billestrup, Nils, Madsen, O. D., Serup, P., Heimberg, H. & Mansouri, A., 2009, In: Cell. 138, 3, p. 449-62 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells

      Grunnet, L. G., Aikin, R., Tonnesen, M. F., Paraskevas, S., Blaabjerg, L., Størling, J., Rosenberg, L., Billestrup, Nils, Maysinger, D. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes. 58, 8, p. 1807-15 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner

      Huising, M. O., van der Meulen, T., Vaughan, J. M., Matsumoto, M., Donaldson, C. J., Park, H., Billestrup, Nils & Vale, W. W., 2009, In: Proceedings of the National Academy of Science of the United States of America. 107, 2, p. 912-7 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      IL-1 beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells

      Jacobsen, M. L. B., Ronn, S. G., Bruun, C., Larsen, C. M., Eizirik, D. L., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2009, In: Diabetologia. 52, 2, p. 281-288 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Inhibition of Nuclear Factor-kappa B or Bax Prevents Endoplasmic Reticulum Stress-But Not Nitric Oxide-Mediated Apoptosis in INS-1E Cells

      Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, Nils, Eizirik, D. L., Storling, J. & Mandrup-Poulsen, Thomas, 2009, In: Endocrinology. 150, 9, p. 4094-4103 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells

      Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, Nils, Eizirik, D. L., Størling, Joachim & Mandrup-Poulsen, Thomas, Sep 2009, In: Endocrinology. 150, 9, p. 4094-103 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. 2010
    39. Published

      Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells

      Eriksen, K. W., Woetmann, Anders , Skov, Lone, Krejsgaard, T., Bovin, L. F., Hansen, M. L., Grønbæk, Kirsten, Billestrup, Nils, Nissen, Mogens Holst, Geisler, Carsten, Wasik, M. A. & Ødum, Niels, 2010, In: Journal of Investigative Dermatology. 130, 6, p. 1590-7 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Dissociation between skeletal muscle inhibitor-{kappa}B kinase/nuclear factor-{kappa}B pathway activity and insulin sensitivity in nondiabetic twins

      Friedrichsen, M., Ribel-Madsen, R., Wojtaszewski, Jørgen F P, Grunnet, Louise Groth, Richter, Erik A., Billestrup, Nils, Ploug, Thorkil, Vaag, A. & Poulsen, P., 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 1, p. 414-421 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Accepted/In press

      Genetic deficiency of tissue inhibitor of metalloproteinase (TIMP) 1 does not affect apoptosis in cytokine-exposed mouse islets in vitro.

      Hansen, J. B., Tonnesen, M. F., Rømer, M. U. K., Billestrup, Nils, Brunner, N. & Mandrup-Poulsen, Thomas, 2010, (Accepted/In press).

      Research output: Contribution to conference › Conference abstract for conference › Research

    42. Published

      Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

      Lundh, M., Christensen, D. P., Rasmussen, D. N., Mascagni, P., Dinarello, C. A., Billestrup, Nils, Grunnet, L. G. & Mandrup-Poulsen, Thomas, 1 Dec 2010, In: Diabetologia. 53, 12, p. 2569-78 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Multifactorial treatment increases endothelial progenitor cells in patients with type 2 diabetes

      Reinhard, H., Jacobsen, P. K., Lajer, M., Pedersen, N., Billestrup, Nils, Mandrup-Poulsen, Thomas, Parving, H. & Rossing, Peter, 1 Oct 2010, In: Diabetologica. 53, 10, p. 2129-33 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. 2011
    45. Published

      ID'ing a novel inhibitor of β-cell function, Id1

      Billestrup, Nils, Oct 2011, In: Diabetes. 60, 10, p. 2455-6 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      ß-cell specific overexpression of suppressor of cytokine signalling-3 does not protect against multiple low dose streptozotocin induced type 1 diabetes in mice

      Börjesson, A., Rønn, S. G., Karlsen, A. E., Billestrup, Nils & Sandler, S., 30 Apr 2011, In: Immunology Letters. 136, 1, p. 74-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus

      Christensen, D. P., Dahllöf, M. S., Lundh, M., Rasmussen, D. N., Nielsen, M. D., Billestrup, Nils, Grunnet, L. G. & Mandrup-Poulsen, Thomas, 2011, In: Molecular Medicine. 17, 5-6, p. 378-90 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique

      Kulahin, N., Grunnet, L. G., Lundh, M., Christensen, D. P., Jorgensen, R., Heding, A., Billestrup, Nils, Berezin, V., Bock, E. & Mandrup-Poulsen, Thomas, 3 Jan 2011, In: FEBS Letters. 585, 1, p. 58-64 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Endothelial Progenitor Cells in Long-Standing Asymptomatic Type 1 Diabetic Patients with or without Diabetic Nephropathy

      Reinhard, H., Jacobsen, P. K., Lajer, M., Tarnow, L., Astrup, A. S., Kim, W. Y., Pedersen, N., Billestrup, Nils, Mandrup-Poulsen, Thomas, Parving, H. & Rossing, Peter, 2011, In: Nephron Clinical Practice. 118, 3, p. c309-c314 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. 2012
    51. Published

      Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines

      Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, Mandrup-Poulsen, Thomas, 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. 2013
    53. Published

      Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell

      Haase, T. N., Rasmussen, M., Jaksch, C. A. M., Gaarn, L. W., Petersen, C. K., Billestrup, Nils & Nielsen, Jens Høiriis, Apr 2013, In: Diabetologia. 56, 4, p. 763-773 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. 2014
    55. Published

      CRFR1 activation protects against cytokine-induced beta cell death

      Blaabjerg, L., Christensen, G. L., Matsumoto, M., van der Meulen, T., Huising, M. O., Billestrup, Nils & Vale, W., 16 Oct 2014, In: Journal of Molecular Endocrinology. 53, p. 417-427 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      Inhibition of beta cell growth and function by bone morphogenetic proteins

      Bruun, C., Christensen, G. L., Jacobsen, M. L. B., Kanstrup, M. B., Jensen, P. R., Fjordvang, H., Mandrup-Poulsen, Thomas & Billestrup, Nils, 27 Sep 2014, In: Diabetologia. 57, 12, p. 2546-54 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Published

      Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

      Christensen, D. P., Gysemans, C., Lundh, M., Dahllöf, M. S., Noesgaard, D., Schmidt, S. F., Mandrup, S., Birkbak, N., Workman, C., Piemonti, L., Blaabjerg, L., Monzani, V., Fossati, G., Mascagni, P., Paraskevas, S., Aikin, R. A., Billestrup, N., Grunnet, L. G., Dinarello, C. A., Mathieu, C. & 1 others, Mandrup-Poulsen, Thomas, 6 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. 1055-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Published

      The mitogenic effect of Gas6 on pancreatic beta cells is mediated via the receptor tyrosine kinase Axl

      Haase, T. N., Gustafsson, A., Nalla, A., Ringholm, L., Damm, Peter, Mathiesen, Elisabeth, Dahlback, B., Billestrup, Nils & Nielsen, Jens Høiriis, Sep 2014, In: Diabetologia. 57, 1 Suppl, p. S173-S174 408.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    59. Published

      Implications for the offspring of circulating factors involved in beta cell adaptation in pregnancy

      Nalla, A., Ringholm, L., Søstrup, B., Højrup, P., Thim, L., Levery, S. B., Vakhrushev, Sergey, Billestrup, Nils, Mathiesen, Elisabeth, Damm, Peter & Nielsen, Jens Høiriis, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1181-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Impact of fetal and neonatal environment on beta cell function and development of diabetes

      Nielsen, Jens Høiriis, Haase, T. N., Jaksch, C., Nalla, A., Søstrup, B., Nalla, A. A., Larsen, L., Rasmussen, M., Dalgaard, L. T., Gaarn, L. W., Thams, P., Kofod, H. & Billestrup, Nils, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1109-22 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis

      Prause, Michala Cecilie Burstein, Christensen, D. P., Billestrup, Nils & Mandrup-Poulsen, Thomas, 2014, In: PLOS ONE. 9, 1, p. 1-11 11 p., e87067.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      Co-ordinated regulation of neurogenin-3 expression in the maternal and fetal pancreas during pregnancy

      Søstrup, B., Gaarn, L. W., Nalla, A., Billestrup, Nils & Nielsen, Jens Høiriis, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1190-7 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. 2015
    64. Published

      Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents

      Christensen, G. L., Jacobsen, M. L. B., Wendt, A., Mollet, I. G., Friberg, J., Frederiksen, K. S., Meyer, M., Bruun, C., Eliasson, L. & Billestrup, Nils, Jun 2015, In: Diabetologia. 58, 6, p. 1282-1290 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 15311848