Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

  • Alon Barsheshet
  • Ilan Goldenberg
  • Jin O-Uchi
  • Arthur J Moss
  • Christian Jons
  • Wataru Shimizu
  • Arthur A Wilde
  • Scott McNitt
  • Derick R Peterson
  • Wojciech Zareba
  • Jennifer L Robinson
  • Michael J Ackerman
  • Michael Cypress
  • Daniel A Gray
  • Nynke Hofman
  • Elizabeth S Kaufman
  • Pyotr G Platonov
  • Ming Qi
  • Jeffrey A Towbin
  • G Michael Vincent
  • Coeli M Lopes
β-Adrenergic stimulation is the main trigger for cardiac events in type 1 long-QT syndrome (LQT1). We evaluated a possible association between ion channel response to β-adrenergic stimulation and clinical response to β-blocker therapy according to mutation location.
OriginalsprogEngelsk
TidsskriftCirculation
Vol/bind125
Udgave nummer16
Sider (fra-til)1988-96
Antal sider9
ISSN0009-7322
DOI
StatusUdgivet - 24 apr. 2012

ID: 48052006