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Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events : implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome. / Barsheshet, Alon; Goldenberg, Ilan; O-Uchi, Jin; Moss, Arthur J; Jons, Christian; Shimizu, Wataru; Wilde, Arthur A; McNitt, Scott; Peterson, Derick R; Zareba, Wojciech; Robinson, Jennifer L; Ackerman, Michael J; Cypress, Michael; Gray, Daniel A; Hofman, Nynke; Kanters, Jørgen K.; Kaufman, Elizabeth S; Platonov, Pyotr G; Qi, Ming; Towbin, Jeffrey A; Vincent, G Michael; Lopes, Coeli M.
I:
Circulation, Bind 125, Nr. 16, 24.04.2012, s. 1988-96.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Barsheshet, A, Goldenberg, I, O-Uchi, J, Moss, AJ, Jons, C, Shimizu, W, Wilde, AA, McNitt, S, Peterson, DR, Zareba, W, Robinson, JL, Ackerman, MJ, Cypress, M, Gray, DA, Hofman, N
, Kanters, JK, Kaufman, ES, Platonov, PG, Qi, M, Towbin, JA, Vincent, GM & Lopes, CM 2012, '
Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome',
Circulation, bind 125, nr. 16, s. 1988-96.
https://doi.org/10.1161/CIRCULATIONAHA.111.048041APA
Barsheshet, A., Goldenberg, I., O-Uchi, J., Moss, A. J., Jons, C., Shimizu, W., Wilde, A. A., McNitt, S., Peterson, D. R., Zareba, W., Robinson, J. L., Ackerman, M. J., Cypress, M., Gray, D. A., Hofman, N.
, Kanters, J. K., Kaufman, E. S., Platonov, P. G., Qi, M., ... Lopes, C. M. (2012).
Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome.
Circulation,
125(16), 1988-96.
https://doi.org/10.1161/CIRCULATIONAHA.111.048041Vancouver
Barsheshet A, Goldenberg I, O-Uchi J, Moss AJ, Jons C, Shimizu W o.a.
Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome.
Circulation. 2012 apr. 24;125(16):1988-96.
https://doi.org/10.1161/CIRCULATIONAHA.111.048041Author
Barsheshet, Alon ; Goldenberg, Ilan ; O-Uchi, Jin ; Moss, Arthur J ; Jons, Christian ; Shimizu, Wataru ; Wilde, Arthur A ; McNitt, Scott ; Peterson, Derick R ; Zareba, Wojciech ; Robinson, Jennifer L ; Ackerman, Michael J ; Cypress, Michael ; Gray, Daniel A ; Hofman, Nynke ; Kanters, Jørgen K. ; Kaufman, Elizabeth S ; Platonov, Pyotr G ; Qi, Ming ; Towbin, Jeffrey A ; Vincent, G Michael ; Lopes, Coeli M. / Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events : implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome. I: Circulation. 2012 ; Bind 125, Nr. 16. s. 1988-96.
Bibtex
@article{3c66a1d7a28c4edb946e46cc1cad49c3,
title = "Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome",
abstract = "β-Adrenergic stimulation is the main trigger for cardiac events in type 1 long-QT syndrome (LQT1). We evaluated a possible association between ion channel response to β-adrenergic stimulation and clinical response to β-blocker therapy according to mutation location.",
keywords = "Adolescent, Adrenergic beta-Antagonists, Adult, Child, Female, Genetic Predisposition to Disease, Heart Arrest, Humans, KCNQ1 Potassium Channel, Male, Mutation, Risk, Romano-Ward Syndrome, Treatment Outcome, Young Adult",
author = "Alon Barsheshet and Ilan Goldenberg and Jin O-Uchi and Moss, {Arthur J} and Christian Jons and Wataru Shimizu and Wilde, {Arthur A} and Scott McNitt and Peterson, {Derick R} and Wojciech Zareba and Robinson, {Jennifer L} and Ackerman, {Michael J} and Michael Cypress and Gray, {Daniel A} and Nynke Hofman and Kanters, {J{\o}rgen K.} and Kaufman, {Elizabeth S} and Platonov, {Pyotr G} and Ming Qi and Towbin, {Jeffrey A} and Vincent, {G Michael} and Lopes, {Coeli M}",
year = "2012",
month = apr,
day = "24",
doi = "10.1161/CIRCULATIONAHA.111.048041",
language = "English",
volume = "125",
pages = "1988--96",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams & Wilkins",
number = "16",
}
RIS
TY - JOUR
T1 - Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events
T2 - implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome
AU - Barsheshet, Alon
AU - Goldenberg, Ilan
AU - O-Uchi, Jin
AU - Moss, Arthur J
AU - Jons, Christian
AU - Shimizu, Wataru
AU - Wilde, Arthur A
AU - McNitt, Scott
AU - Peterson, Derick R
AU - Zareba, Wojciech
AU - Robinson, Jennifer L
AU - Ackerman, Michael J
AU - Cypress, Michael
AU - Gray, Daniel A
AU - Hofman, Nynke
AU - Kanters, Jørgen K.
AU - Kaufman, Elizabeth S
AU - Platonov, Pyotr G
AU - Qi, Ming
AU - Towbin, Jeffrey A
AU - Vincent, G Michael
AU - Lopes, Coeli M
PY - 2012/4/24
Y1 - 2012/4/24
N2 - β-Adrenergic stimulation is the main trigger for cardiac events in type 1 long-QT syndrome (LQT1). We evaluated a possible association between ion channel response to β-adrenergic stimulation and clinical response to β-blocker therapy according to mutation location.
AB - β-Adrenergic stimulation is the main trigger for cardiac events in type 1 long-QT syndrome (LQT1). We evaluated a possible association between ion channel response to β-adrenergic stimulation and clinical response to β-blocker therapy according to mutation location.
KW - Adolescent
KW - Adrenergic beta-Antagonists
KW - Adult
KW - Child
KW - Female
KW - Genetic Predisposition to Disease
KW - Heart Arrest
KW - Humans
KW - KCNQ1 Potassium Channel
KW - Male
KW - Mutation
KW - Risk
KW - Romano-Ward Syndrome
KW - Treatment Outcome
KW - Young Adult
U2 - 10.1161/CIRCULATIONAHA.111.048041
DO - 10.1161/CIRCULATIONAHA.111.048041
M3 - Journal article
C2 - 22456477
VL - 125
SP - 1988
EP - 1996
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 16
ER -
