Integrating Venom Peptide Libraries Into a Phylogenetic and Broader Biological Framework

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The venomous marine snails are conventionally divided into three groups, the cone snails (family Conidae), the auger snails (family Terebridae) and the turrids (formerly all assigned to a single family, Turridae). In this study, a library of venom peptides from species conventionally assigned to the genus Turris was correlated to a phylogenetic analysis. Nucleotide sequences of multiple genes from transcriptomes were used to assess the phylogenetic relationships across a diverse set of species. The resulting tree shows that as conventionally defined, the conoidean genus Turris, is polyphyletic. We describe a new genus, Purpuraturris gen. nov., that comprises the outlier species. In addition to morphological distinctions, molecular data reveal that this group is divergent from Turris sensu stricto. The correlation between phylogenetic information and a family of peptide sequences was used to highlight those peptides mostly likely to be unique and intimately associated with biological diversity. The plethora of peptide sequences available requires two prioritization decisions: which subset of peptides to initially characterize, and after these are characterized, which to comprehensively investigate for potential biomedical applications such as drug developments. Life Science Identifiers:; pub: 60D46561-28F0-4C39-BAC4-66DC8B4EAEA4

TidsskriftFrontiers in Molecular Biosciences
Antal sider16
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
This work was in part supported by National Institute of General Medical Science grants (P01GM048677 and R01GM122869 to BO) and by DoD W81XWH-17-1-0413 to BO. HS-H acknowledges fellowship support from the Villum Foundation (19063).

Publisher Copyright:
Copyright © 2022 Chase, Watkins, Safavi-Hemami and Olivera.

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