High tumor uptake of (64)Cu: implications for molecular imaging of tumor characteristics with copper-based PET tracers

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The use of copper-based positron emission tomography (PET) tracers in cancer studies is increasing. However, as copper has previously been found in high concentrations in human tumor tissue in vivo, instability of PET tracers could result in tumor accumulation of non-tracer-bound radioactive copper that may influence PET measurements. Here we determine the degree of (64)Cu uptake in five commonly used human cancer xenograft models in mice. Additionally, we compare copper accumulation in tumor tissue to gene expression of human copper transporter 1 (CTR1).
TidsskriftNuclear Medicine and Biology
Udgave nummer3
Sider (fra-til)345-50
Antal sider6
StatusUdgivet - apr. 2013

ID: 45845300