Expression of SMAD signal transduction molecules in the pancreas

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Michael Brorson, D. Hougaard, Jens Høiriis Nielsen, D. Tornehave, Lars-Inge Larsson

Members of the TGF-beta superfamily of cytokines have been implicated in pancreatic cancer, pancreatitis and in regulation and differentiation of pancreatic endocrine and exocrine cells. Different TGF-beta members signal through phosphorylation of different signal transduction proteins, which eventually form oligomers with SMAD 4 and translocate to the nucleus. Reverse transcriptase-polymerase chain reaction showed that SMADs 1, 2 and 4 are expressed in pancreatic islets. Immunostaining revealed that SMAD 1 and 4 predominantly were expressed by islet insulin and glucagon cells. Since SMAD 1 is known to transduce signals from receptors binding bone morphogenetic protein (BMP) these results indicate a previously unknown role of BMP-like ligands in islet function.
OriginalsprogEngelsk
TidsskriftHistochemistry and Cell Biology
Vol/bind116
Udgave nummer3
Sider (fra-til)263-7
Antal sider5
ISSN0948-6143
DOI
StatusUdgivet - 2001

ID: 47972420