Expression of SMAD signal transduction molecules in the pancreas
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Expression of SMAD signal transduction molecules in the pancreas. / Brorson, Michael; Hougaard, D.; Nielsen, Jens Høiriis; Tornehave, D.; Larsson, Lars-Inge.
I: Histochemistry and Cell Biology, Bind 116, Nr. 3, 2001, s. 263-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Expression of SMAD signal transduction molecules in the pancreas
AU - Brorson, Michael
AU - Hougaard, D.
AU - Nielsen, Jens Høiriis
AU - Tornehave, D.
AU - Larsson, Lars-Inge
PY - 2001
Y1 - 2001
N2 - Members of the TGF-beta superfamily of cytokines have been implicated in pancreatic cancer, pancreatitis and in regulation and differentiation of pancreatic endocrine and exocrine cells. Different TGF-beta members signal through phosphorylation of different signal transduction proteins, which eventually form oligomers with SMAD 4 and translocate to the nucleus. Reverse transcriptase-polymerase chain reaction showed that SMADs 1, 2 and 4 are expressed in pancreatic islets. Immunostaining revealed that SMAD 1 and 4 predominantly were expressed by islet insulin and glucagon cells. Since SMAD 1 is known to transduce signals from receptors binding bone morphogenetic protein (BMP) these results indicate a previously unknown role of BMP-like ligands in islet function.
AB - Members of the TGF-beta superfamily of cytokines have been implicated in pancreatic cancer, pancreatitis and in regulation and differentiation of pancreatic endocrine and exocrine cells. Different TGF-beta members signal through phosphorylation of different signal transduction proteins, which eventually form oligomers with SMAD 4 and translocate to the nucleus. Reverse transcriptase-polymerase chain reaction showed that SMADs 1, 2 and 4 are expressed in pancreatic islets. Immunostaining revealed that SMAD 1 and 4 predominantly were expressed by islet insulin and glucagon cells. Since SMAD 1 is known to transduce signals from receptors binding bone morphogenetic protein (BMP) these results indicate a previously unknown role of BMP-like ligands in islet function.
KW - Animals
KW - Animals, Newborn
KW - DNA-Binding Proteins
KW - Fluorescein-5-isothiocyanate
KW - Fluorescent Antibody Technique
KW - Gene Expression
KW - Immunohistochemistry
KW - Pancreas
KW - RNA, Messenger
KW - Rats
KW - Rats, Wistar
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Signal Transduction
KW - Smad Proteins
KW - Smad1 Protein
KW - Smad2 Protein
KW - Smad4 Protein
KW - Trans-Activators
U2 - 10.1007/s004180100316
DO - 10.1007/s004180100316
M3 - Journal article
C2 - 11685556
VL - 116
SP - 263
EP - 267
JO - Histochemistry and Cell Biology
JF - Histochemistry and Cell Biology
SN - 0948-6143
IS - 3
ER -
ID: 47972420