Expression of SMAD signal transduction molecules in the pancreas

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Expression of SMAD signal transduction molecules in the pancreas. / Brorson, Michael; Hougaard, D.; Nielsen, Jens Høiriis; Tornehave, D.; Larsson, Lars-Inge.

I: Histochemistry and Cell Biology, Bind 116, Nr. 3, 2001, s. 263-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Brorson, M, Hougaard, D, Nielsen, JH, Tornehave, D & Larsson, L-I 2001, 'Expression of SMAD signal transduction molecules in the pancreas', Histochemistry and Cell Biology, bind 116, nr. 3, s. 263-7. https://doi.org/10.1007/s004180100316

APA

Brorson, M., Hougaard, D., Nielsen, J. H., Tornehave, D., & Larsson, L-I. (2001). Expression of SMAD signal transduction molecules in the pancreas. Histochemistry and Cell Biology, 116(3), 263-7. https://doi.org/10.1007/s004180100316

Vancouver

Brorson M, Hougaard D, Nielsen JH, Tornehave D, Larsson L-I. Expression of SMAD signal transduction molecules in the pancreas. Histochemistry and Cell Biology. 2001;116(3):263-7. https://doi.org/10.1007/s004180100316

Author

Brorson, Michael ; Hougaard, D. ; Nielsen, Jens Høiriis ; Tornehave, D. ; Larsson, Lars-Inge. / Expression of SMAD signal transduction molecules in the pancreas. I: Histochemistry and Cell Biology. 2001 ; Bind 116, Nr. 3. s. 263-7.

Bibtex

@article{c98728e33ff342869eff856eba6d616e,
title = "Expression of SMAD signal transduction molecules in the pancreas",
abstract = "Members of the TGF-beta superfamily of cytokines have been implicated in pancreatic cancer, pancreatitis and in regulation and differentiation of pancreatic endocrine and exocrine cells. Different TGF-beta members signal through phosphorylation of different signal transduction proteins, which eventually form oligomers with SMAD 4 and translocate to the nucleus. Reverse transcriptase-polymerase chain reaction showed that SMADs 1, 2 and 4 are expressed in pancreatic islets. Immunostaining revealed that SMAD 1 and 4 predominantly were expressed by islet insulin and glucagon cells. Since SMAD 1 is known to transduce signals from receptors binding bone morphogenetic protein (BMP) these results indicate a previously unknown role of BMP-like ligands in islet function.",
keywords = "Animals, Animals, Newborn, DNA-Binding Proteins, Fluorescein-5-isothiocyanate, Fluorescent Antibody Technique, Gene Expression, Immunohistochemistry, Pancreas, RNA, Messenger, Rats, Rats, Wistar, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Smad Proteins, Smad1 Protein, Smad2 Protein, Smad4 Protein, Trans-Activators",
author = "Michael Brorson and D. Hougaard and Nielsen, {Jens H{\o}iriis} and D. Tornehave and Lars-Inge Larsson",
year = "2001",
doi = "10.1007/s004180100316",
language = "English",
volume = "116",
pages = "263--7",
journal = "Histochemistry and Cell Biology",
issn = "0948-6143",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Expression of SMAD signal transduction molecules in the pancreas

AU - Brorson, Michael

AU - Hougaard, D.

AU - Nielsen, Jens Høiriis

AU - Tornehave, D.

AU - Larsson, Lars-Inge

PY - 2001

Y1 - 2001

N2 - Members of the TGF-beta superfamily of cytokines have been implicated in pancreatic cancer, pancreatitis and in regulation and differentiation of pancreatic endocrine and exocrine cells. Different TGF-beta members signal through phosphorylation of different signal transduction proteins, which eventually form oligomers with SMAD 4 and translocate to the nucleus. Reverse transcriptase-polymerase chain reaction showed that SMADs 1, 2 and 4 are expressed in pancreatic islets. Immunostaining revealed that SMAD 1 and 4 predominantly were expressed by islet insulin and glucagon cells. Since SMAD 1 is known to transduce signals from receptors binding bone morphogenetic protein (BMP) these results indicate a previously unknown role of BMP-like ligands in islet function.

AB - Members of the TGF-beta superfamily of cytokines have been implicated in pancreatic cancer, pancreatitis and in regulation and differentiation of pancreatic endocrine and exocrine cells. Different TGF-beta members signal through phosphorylation of different signal transduction proteins, which eventually form oligomers with SMAD 4 and translocate to the nucleus. Reverse transcriptase-polymerase chain reaction showed that SMADs 1, 2 and 4 are expressed in pancreatic islets. Immunostaining revealed that SMAD 1 and 4 predominantly were expressed by islet insulin and glucagon cells. Since SMAD 1 is known to transduce signals from receptors binding bone morphogenetic protein (BMP) these results indicate a previously unknown role of BMP-like ligands in islet function.

KW - Animals

KW - Animals, Newborn

KW - DNA-Binding Proteins

KW - Fluorescein-5-isothiocyanate

KW - Fluorescent Antibody Technique

KW - Gene Expression

KW - Immunohistochemistry

KW - Pancreas

KW - RNA, Messenger

KW - Rats

KW - Rats, Wistar

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Signal Transduction

KW - Smad Proteins

KW - Smad1 Protein

KW - Smad2 Protein

KW - Smad4 Protein

KW - Trans-Activators

U2 - 10.1007/s004180100316

DO - 10.1007/s004180100316

M3 - Journal article

VL - 116

SP - 263

EP - 267

JO - Histochemistry and Cell Biology

JF - Histochemistry and Cell Biology

SN - 0948-6143

IS - 3

ER -

ID: 47972420