Effectiveness of omalizumab in chronic spontaneous urticaria assessed with patient-reported outcomes: a prospective study

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Aim: To examine the effectiveness of omalizumab (anti-IgE) on symptoms and disease-related quality of life in chronic spontaneous urticaria (CSU) and to identify possible patient-specific factors associated with response to omalizumab in patients with antihistamine refractory CSU. Methods: Six months prospective trial of omalizumab 300 mg every 4 weeks among patients with CSU from a dermatological university department. The primary outcome was the urticaria activity score in the past week (UAS7) at 3 months. Results: A total of 117 patients (39 men and 78 women) with a mean age of 42 years were included. The mean baseline UAS7 score was 29.3 points (SD = 10.8), which improved to 11.9 points (SD = 12.9) at 3 months follow-up, difference = 17.4 points (95% CI: 14.8–19.9), P < 0.0001. (cindu), (pros) 3 months 3 months, 6 months absolute age age, also and angio-oedema, associated at between chronic comorbidities, count crp, csu, duration, during ethnicity, factors: follow-up. following further hr ige improved improvement inducible leucocytes, level, montelukast neutrophil no none of omalizumab onset or other outcomes p  patient-reported patient-specific positive prednisolone presence previous response seen serum sex, significant significantly smoking, symptom test, the three to total treatment treatment. urticaria was were with> 0.05 for all comparisons. Previous treatment with traditional immunosuppressant drugs (azathioprine, cyclosporine or methotrexate) was associated with poorer treatment response to omalizumab at 3 months, P < 0.001. A strong correlation was seen between different patient-reported outcomes (PROs) at baseline and 3 months follow-up. Fifteen patients (12.8%) reported side-effects of the treatment. Conclusion: Omalizumab is a highly effective therapy for antihistamine refractory CSU with treatment effects similar to those observed in randomized controlled trials. Validated PROs to assess disease activity, disease control and impairment of quality of life are valuable tools in the clinical management of CSU. Identification of patient-specific predictors of effect and safety of omalizumab in CSU is still warranted.

BogserieJournal of the European Academy of Dermatology and Venereology. Supplement
Udgave nummer10
Sider (fra-til)1761-1767
StatusUdgivet - okt. 2018

ID: 210014218