Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
The compound NS5806 increases the transient outward current (I(to)) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, I(to) is thought to be mediated by K(V)4.3 and various ancillary proteins, yet, the exact subunit composition of I(to) channels is still debated. Here we characterize the effect of NS5806 on heterologously expressed putative I(to) channel subunits and other potassium channels.
Originalsprog | Engelsk |
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Tidsskrift | British Journal of Pharmacology |
Vol/bind | 160 |
Udgave nummer | 8 |
Sider (fra-til) | 2028-44 |
Antal sider | 17 |
ISSN | 0007-1188 |
DOI | |
Status | Udgivet - aug. 2010 |
ID: 32434189