Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study

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Martin Hinterseer, Morten Bækgaard Thomsen, Britt-Maria Beckmann, Arne Pfeufer, Rainer Schimpf, H-Erich Wichmann, Gerhard Steinbeck, Marc A Vos, Stefan Kaab

Torsades de pointes arrhythmias (TdP) occur by definition in the setting of prolonged QT intervals. Animal models of drug induced Long-QT syndrome (dLQTS) have shown higher predictive value for proarrhythmia with beat-to-beat variability of repolarization duration (BVR) when compared with QT intervals. Here, we evaluate variability of QT intervals in patients with a history of drug-induced long QT syndrome (dLQTS) and TdP in absence of a mutation in any of the major LQTS genes.
OriginalsprogEngelsk
TidsskriftEuropean Heart Journal
Vol/bind29
Udgave nummer2
Sider (fra-til)185-90
Antal sider6
ISSN0195-668X
DOI
StatusUdgivet - jan. 2008

ID: 45965394