Anthropometry, DXA and leptin reflect subcutaneous but not visceral abdominal adipose tissue by MRI in 197 healthy adolescents

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Jeanette Tinggaard, Casper P Hagen, Anders N Christensen, Annette Mouritsen, Mikkel G Mieritz, Christine Wohlfahrt-Veje, Jørn W Helge, Thomas N Beck, Eva Fallentin, Rasmus Larsen, Rikke B Jensen, Anders Juul, Katharina M Main

BACKGROUND: Abdominal fat distribution is associated with development of cardio-metabolic disease, independently of BMI. We assessed anthropometry, serum adipokines and DXA as markers of abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) by MRIMETHODS:We performed a cross-sectional study including 197 healthy adolescents (114 boys) aged 10-15 years nested within a longitudinal population-based cohort. Clinical examination, blood sampling, DXA and abdominal MRI was performed. SAT% and VAT% was adjusted to total abdominal volume.

RESULTS: Girls had a higher SAT% than boys in early and late puberty (16 vs. 13%, P<0.01 and 20 vs. 15%, P=0.001, respectively), whereas VAT% was comparable (7% in both genders, independent of puberty). DXA android fat% (Standard Deviation Score [SDS]), suprailliac skinfold thickness (SDS), leptin, BMI (SDS), waist-to-height ratio (WHtR) and waist circumference (SDS) correlated strongly with SAT% (descending order: r=0.90 to r=0.55, all P<0.001), but weaker to VAT% (r=0.49 to r=0.06). Suprailiac skinfold was the best anthropometric marker of SAT% (girls: R(2)=48.6%, boys: R(2)=65.0%, P<0.001) and VAT% in boys (R(2)=16.4%, P<0.001). WHtR was the best marker of VAT% in girls (R(2)=7.6%, P=0.007).

CONCLUSIONS: Healthy girls have a higher SAT% than boys, whereas VAT% is comparable, independent of puberty. Anthropometry and circulating leptin are valid markers of SAT%, but not VAT%.Pediatric Research accepted article preview online, 12 June 2017. doi:10.1038/pr.2017.138.

OriginalsprogEngelsk
TidsskriftPediatric Research
Vol/bind82
Sider (fra-til)620-628
ISSN0031-3998
DOI
StatusUdgivet - 2017

ID: 179406200