Cardiac 99mTc sestamibi SPECT and 18F FDG PET as viability markers in takotsubo cardiomyopathy

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Cardiac 99mTc sestamibi SPECT and 18F FDG PET as viability markers in takotsubo cardiomyopathy. / Christensen, Thomas Emil; Bang, Lia Evi; Holmvang, Lene; Ghotbi, Adam Ali; Lassen, Martin Lyngby; Andersen, Flemming; Ihlemann, Nikolaj; Andersson, Hedvig; Grande, Peer; Kjaer, Andreas; Hasbak, Philip.

In: International Journal of Cardiovascular Imaging, Vol. 30, No. 7, 2014, p. 1407-1416.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Christensen, TE, Bang, LE, Holmvang, L, Ghotbi, AA, Lassen, ML, Andersen, F, Ihlemann, N, Andersson, H, Grande, P, Kjaer, A & Hasbak, P 2014, 'Cardiac 99mTc sestamibi SPECT and 18F FDG PET as viability markers in takotsubo cardiomyopathy', International Journal of Cardiovascular Imaging, vol. 30, no. 7, pp. 1407-1416. https://doi.org/10.1007/s10554-014-0453-5

APA

Christensen, T. E., Bang, L. E., Holmvang, L., Ghotbi, A. A., Lassen, M. L., Andersen, F., Ihlemann, N., Andersson, H., Grande, P., Kjaer, A., & Hasbak, P. (2014). Cardiac 99mTc sestamibi SPECT and 18F FDG PET as viability markers in takotsubo cardiomyopathy. International Journal of Cardiovascular Imaging, 30(7), 1407-1416. https://doi.org/10.1007/s10554-014-0453-5

Vancouver

Christensen TE, Bang LE, Holmvang L, Ghotbi AA, Lassen ML, Andersen F et al. Cardiac 99mTc sestamibi SPECT and 18F FDG PET as viability markers in takotsubo cardiomyopathy. International Journal of Cardiovascular Imaging. 2014;30(7):1407-1416. https://doi.org/10.1007/s10554-014-0453-5

Author

Christensen, Thomas Emil ; Bang, Lia Evi ; Holmvang, Lene ; Ghotbi, Adam Ali ; Lassen, Martin Lyngby ; Andersen, Flemming ; Ihlemann, Nikolaj ; Andersson, Hedvig ; Grande, Peer ; Kjaer, Andreas ; Hasbak, Philip. / Cardiac 99mTc sestamibi SPECT and 18F FDG PET as viability markers in takotsubo cardiomyopathy. In: International Journal of Cardiovascular Imaging. 2014 ; Vol. 30, No. 7. pp. 1407-1416.

Bibtex

@article{afcff43124884a298e569e82a17a1610,
title = "Cardiac 99mTc sestamibi SPECT and 18F FDG PET as viability markers in takotsubo cardiomyopathy",
abstract = "In patients with heart failure (HF) due to coronary disease, a combined evaluation of perfusion and glucose metabolism by cardiac single photon emission computed tomography (SPECT)/positron emission tomography (PET) can be used to distinguish viable from non-viable myocardium, and current guidelines recommend cardiac SPECT and fluorodeoxyglucose (FDG) PET for viability assessment. Takotsubo cardiomyopathy (TTC) is a disease characterized by acute but reversible HF leaving no scarring. To explore how robust the semi-quantitative viability criteria used in cardiac SPECT and FDG PET stands their ground in a population with TTC. From 1 September 2009 to 1 October 2012, 24 patients suspected of TTC were enrolled in a multimodality cardiac imaging research project. Echocardiography, (99m)Tc SPECT, and (18)F FDG PET were performed during the acute admission and at follow-up 4 months later. Nineteen patients had a final diagnosis of TTC consistent with Mayo Clinic Diagnostic Criteria. Three of these patients were excluded from further analysis, since wall motion abnormalities were not persistent at the time of nuclear imaging. The remaining sixteen patients exhibited a distinct pattern with HF, {"}apical ballooning{"} and a perfusion-metabolism defect in the midventricular/apical region. When viability criteria were applied, they identified significant scarring/limited hibernation in the akinetic part of the left ventricle. However, full recovery was found in all TTC patients on follow-up. Using the current guideline-endorsed viability criteria for semiquantitative cardiac SPECT and FDG PET, these modalities failed to demonstrate the presence of viability in the acute state of TTC.",
keywords = "Aged, Coronary Angiography, Denmark, Female, Fluorodeoxyglucose F18, Heart Ventricles, Humans, Male, Myocardial Contraction, Positron-Emission Tomography, Predictive Value of Tests, Prognosis, Radiopharmaceuticals, Recovery of Function, Takotsubo Cardiomyopathy, Technetium Tc 99m Sestamibi, Time Factors, Tissue Survival, Tomography, Emission-Computed, Single-Photon, Ventricular Function, Left",
author = "Christensen, {Thomas Emil} and Bang, {Lia Evi} and Lene Holmvang and Ghotbi, {Adam Ali} and Lassen, {Martin Lyngby} and Flemming Andersen and Nikolaj Ihlemann and Hedvig Andersson and Peer Grande and Andreas Kjaer and Philip Hasbak",
year = "2014",
doi = "10.1007/s10554-014-0453-5",
language = "English",
volume = "30",
pages = "1407--1416",
journal = "International Journal of Cardiovascular Imaging",
issn = "1569-5794",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Cardiac 99mTc sestamibi SPECT and 18F FDG PET as viability markers in takotsubo cardiomyopathy

AU - Christensen, Thomas Emil

AU - Bang, Lia Evi

AU - Holmvang, Lene

AU - Ghotbi, Adam Ali

AU - Lassen, Martin Lyngby

AU - Andersen, Flemming

AU - Ihlemann, Nikolaj

AU - Andersson, Hedvig

AU - Grande, Peer

AU - Kjaer, Andreas

AU - Hasbak, Philip

PY - 2014

Y1 - 2014

N2 - In patients with heart failure (HF) due to coronary disease, a combined evaluation of perfusion and glucose metabolism by cardiac single photon emission computed tomography (SPECT)/positron emission tomography (PET) can be used to distinguish viable from non-viable myocardium, and current guidelines recommend cardiac SPECT and fluorodeoxyglucose (FDG) PET for viability assessment. Takotsubo cardiomyopathy (TTC) is a disease characterized by acute but reversible HF leaving no scarring. To explore how robust the semi-quantitative viability criteria used in cardiac SPECT and FDG PET stands their ground in a population with TTC. From 1 September 2009 to 1 October 2012, 24 patients suspected of TTC were enrolled in a multimodality cardiac imaging research project. Echocardiography, (99m)Tc SPECT, and (18)F FDG PET were performed during the acute admission and at follow-up 4 months later. Nineteen patients had a final diagnosis of TTC consistent with Mayo Clinic Diagnostic Criteria. Three of these patients were excluded from further analysis, since wall motion abnormalities were not persistent at the time of nuclear imaging. The remaining sixteen patients exhibited a distinct pattern with HF, "apical ballooning" and a perfusion-metabolism defect in the midventricular/apical region. When viability criteria were applied, they identified significant scarring/limited hibernation in the akinetic part of the left ventricle. However, full recovery was found in all TTC patients on follow-up. Using the current guideline-endorsed viability criteria for semiquantitative cardiac SPECT and FDG PET, these modalities failed to demonstrate the presence of viability in the acute state of TTC.

AB - In patients with heart failure (HF) due to coronary disease, a combined evaluation of perfusion and glucose metabolism by cardiac single photon emission computed tomography (SPECT)/positron emission tomography (PET) can be used to distinguish viable from non-viable myocardium, and current guidelines recommend cardiac SPECT and fluorodeoxyglucose (FDG) PET for viability assessment. Takotsubo cardiomyopathy (TTC) is a disease characterized by acute but reversible HF leaving no scarring. To explore how robust the semi-quantitative viability criteria used in cardiac SPECT and FDG PET stands their ground in a population with TTC. From 1 September 2009 to 1 October 2012, 24 patients suspected of TTC were enrolled in a multimodality cardiac imaging research project. Echocardiography, (99m)Tc SPECT, and (18)F FDG PET were performed during the acute admission and at follow-up 4 months later. Nineteen patients had a final diagnosis of TTC consistent with Mayo Clinic Diagnostic Criteria. Three of these patients were excluded from further analysis, since wall motion abnormalities were not persistent at the time of nuclear imaging. The remaining sixteen patients exhibited a distinct pattern with HF, "apical ballooning" and a perfusion-metabolism defect in the midventricular/apical region. When viability criteria were applied, they identified significant scarring/limited hibernation in the akinetic part of the left ventricle. However, full recovery was found in all TTC patients on follow-up. Using the current guideline-endorsed viability criteria for semiquantitative cardiac SPECT and FDG PET, these modalities failed to demonstrate the presence of viability in the acute state of TTC.

KW - Aged

KW - Coronary Angiography

KW - Denmark

KW - Female

KW - Fluorodeoxyglucose F18

KW - Heart Ventricles

KW - Humans

KW - Male

KW - Myocardial Contraction

KW - Positron-Emission Tomography

KW - Predictive Value of Tests

KW - Prognosis

KW - Radiopharmaceuticals

KW - Recovery of Function

KW - Takotsubo Cardiomyopathy

KW - Technetium Tc 99m Sestamibi

KW - Time Factors

KW - Tissue Survival

KW - Tomography, Emission-Computed, Single-Photon

KW - Ventricular Function, Left

U2 - 10.1007/s10554-014-0453-5

DO - 10.1007/s10554-014-0453-5

M3 - Journal article

C2 - 24852336

VL - 30

SP - 1407

EP - 1416

JO - International Journal of Cardiovascular Imaging

JF - International Journal of Cardiovascular Imaging

SN - 1569-5794

IS - 7

ER -

ID: 138379193