Iron Status and Gestational Diabetes: A Meta-Analysis
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Iron Status and Gestational Diabetes : A Meta-Analysis. / Kataria, Yachana; Wu, Yanxin; Horskjaer, Peter de Hemmer; Mandrup-Poulsen, Thomas; Ellervik, Christina.
In: Nutrients, Vol. 10, No. 5, 621 , 2018.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Iron Status and Gestational Diabetes
T2 - A Meta-Analysis
AU - Kataria, Yachana
AU - Wu, Yanxin
AU - Horskjaer, Peter de Hemmer
AU - Mandrup-Poulsen, Thomas
AU - Ellervik, Christina
PY - 2018
Y1 - 2018
N2 - A meta-analysis of the association of iron overload with gestational diabetes mellitus (GDM) may inform the health debate. We performed a meta-analysis investigating the association of iron biomarkers and dietary iron exposure with GDM. We identified 33 eligible studies (N = 44,110) published in 2001-2017. The standardized mean differences (SMD) in women who had GDM compared to pregnant women without were 0.25 mu g/dL (95% CI: 0.001-0.50) for iron, 1.54 ng/mL (0.56-2.53) for ferritin, 1.05% (0.02 to 2.08) for transferrin saturation, and 0.81 g/dL (0.40-1.22) for hemoglobin. Adjusted odds ratio for GDM were 1.58 (95% CI: 1.20-2.08) for ferritin, 1.30 (1.01-1.67) for hemoglobin, and 1.48 (1.29-1.69) for dietary heme intake. We did not find any differences in TIBC or transferrin concentration in women with and without GDM. We also did not find any association of increased transferrin receptor or increased intake of total dietary iron, non-heme iron or supplemental iron, with increased odds ratios for GDM. Considerable heterogeneity was present among the studies (0-99%), but no evidence of publication bias. Accumulating evidence suggests that circulating and dietary iron biomarkers among pregnant women are associated with GDM, but the results should be interpreted with caution due to the high heterogeneity of analyses. Randomized trials investigating the benefits of iron reduction in women at high risk for GDM are warranted.
AB - A meta-analysis of the association of iron overload with gestational diabetes mellitus (GDM) may inform the health debate. We performed a meta-analysis investigating the association of iron biomarkers and dietary iron exposure with GDM. We identified 33 eligible studies (N = 44,110) published in 2001-2017. The standardized mean differences (SMD) in women who had GDM compared to pregnant women without were 0.25 mu g/dL (95% CI: 0.001-0.50) for iron, 1.54 ng/mL (0.56-2.53) for ferritin, 1.05% (0.02 to 2.08) for transferrin saturation, and 0.81 g/dL (0.40-1.22) for hemoglobin. Adjusted odds ratio for GDM were 1.58 (95% CI: 1.20-2.08) for ferritin, 1.30 (1.01-1.67) for hemoglobin, and 1.48 (1.29-1.69) for dietary heme intake. We did not find any differences in TIBC or transferrin concentration in women with and without GDM. We also did not find any association of increased transferrin receptor or increased intake of total dietary iron, non-heme iron or supplemental iron, with increased odds ratios for GDM. Considerable heterogeneity was present among the studies (0-99%), but no evidence of publication bias. Accumulating evidence suggests that circulating and dietary iron biomarkers among pregnant women are associated with GDM, but the results should be interpreted with caution due to the high heterogeneity of analyses. Randomized trials investigating the benefits of iron reduction in women at high risk for GDM are warranted.
KW - iron
KW - ferritin
KW - transferrin
KW - gestational diabetes
KW - pregnancy
U2 - 10.3390/nu10050621
DO - 10.3390/nu10050621
M3 - Review
C2 - 29762515
VL - 10
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 5
M1 - 621
ER -
ID: 213285296