Thomas Mandrup-Poulsen

Thomas Mandrup-Poulsen

Professor


  1. Published

    The Fas pathway is involved in pancreatic beta cell secretory function.

    Schumann, D. M., Maedler, K., Franklin, I., Konrad, D., Størling, J., Böni-Schnetzler, M., Gjinovci, A., Kurrer, M. O., Gauthier, B. R., Bosco, D., Andres, A., Berney, T., Greter, M., Becher, B., Chervonsky, A. V., Halban, P. A., Mandrup-Poulsen, Thomas, Wollheim, C. B. & Donath, M. Y., 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 8, p. 2861-6 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis

    Backe, M. B., Jin, C., Andreone, L., Sankar, A., Agger, K., Helin, K., Madsen, A. N., Poulsen, Steen Seier, Bysani, M., Bacos, K., Ling, C., Javier Perone, M., Holst, Birgitte & Mandrup-Poulsen, Thomas, 2019, In: Journal of Diabetes Research. 2019, 15 p., 5451038.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    The No-Go and Nonsense-Mediated RNA Decay Pathways Are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival

    Ghiasi, S. M., Krogh, Nicolai, Tyrberg, B. & Mandrup-Poulsen, Thomas, 2018, In: Diabetes. 67, 10, p. 2019-2037 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up

    Akerblom, H. K., Krischer, J., Virtanen, V. S., Berseth, C., Becker, D., Dupré, J., Ilonen, J., Trucco, M., Savilahti, E., Koski, K., Pajakkala, E., Fransiscus, M., Lough, G., Bradley, B., Koski, M., Knip, M., TRIGR Study Group, T. S. G. & Mandrup-Poulsen, Thomas, 1 Mar 2011, In: Diabetologica. 54, 3, p. 627-633 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The anti-interleukin-1 in type 1 diabetes action trial - Background and rationale

    Pickersgill, L. M. S. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 25, 4, p. 321-324 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The bimodal effect of interleukin 1 on rat pancreatic beta-cells--stimulation followed by inhibition--depends upon dose, duration of exposure, and ambient glucose concentration

    Spinas, G. A., Palmer, J. P., Mandrup-Poulsen, Thomas, Andersen, Heine, Nerup, J. & Nielsen, Jens Høiriis, Oct 1988, In: Acta Endocrinologica. 119, 2, p. 307-11 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation

    Kolb, H. & Mandrup-Poulsen, Thomas, 2009, In: Diabetologia. 53, 1, p. 10-20 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The imidazoline RX871024 induces death of proliferating insulin-secreting cells by activation of c-jun N-terminal kinase

    Zaitseva, I. I., Storling, J., Mandrup-Poulsen, Thomas, Berggren, P. O. & Zaitsev, S. V., 2008, In: Cellular and Molecular Life Sciences. 65, 7-8, p. 1248-1255 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The immunoproteasome is induced by cytokines and regulates apoptosis in human islets

    Lundh, M., Bugliani, M., Dahlby, T., Chou, D. H., Wagner , B., Ghiasi, S. M., De Tata, V., Chen, Z., Lund, Marianne N., Davies, Michael J., Marchetti, P. & Mandrup-Poulsen, Thomas, 2017, In: Journal of Endocrinology. 233, 3, p. 369-379 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The inducible beta 5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient beta-cells and is overexpressed in type 2 diabetes pancreatic islets

    Khilji, Muhammad Saad, Bresson, S. E., Verstappen, D., Pihl, Celina, Andersen, Phillip Alexander Keller, Agergaard, Jette Bach, Dahlby, T., Holgersen Bryde, Tenna, Klindt, K., Nielsen, C. K., Walentinsson, A., Zivkovic, D., Bousquet, M., Tyrberg, B., Richardson, S. J., Morgan, N. G., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, 2020, In: American Journal of Physiology: Endocrinology and Metabolism. 318, 6, p. E892-E900

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β

    Khilji, Muhammad Saad, Verstappen, D., Dahlby, T., Prause, Michala Cecilie Burstein, Pihl, Celina, Bresson, S. E., Holgersen Bryde, Tenna, Andersen, Phillip Alexander Keller, Klindt, K., Zivkovic, D., Bousquet-Dubouch, M. P., Tyrberg, B., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, 2020, In: PLoS ONE. 15, 2, 21 p., e0222432.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The lysine deacetylase inhibitor givinostat inhibits ß-cell IL-1ß induced IL-1ß transcription and processing

    Dahllöf, M. S., Christensen, D. P., Lundh, M., Dinarello, C. A., Mascagni, P., Grunnet, L. G. & Mandrup-Poulsen, Thomas, 1 Nov 2012, In: Islets. 4, 6, p. 417-22 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet ß cells in vivo and in vitro

    Lewis, E. C., Blaabjerg, L., Størling, Joachim, Ronn, S. G., Mascagni, P., Dinarello, C. A. & Mandrup-Poulsen, Thomas, May 2011, In: Molecular Medicine. 17, 5-6, p. 369-377 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The role of NCAM signaling in the pancreatic beta-cell

    Grunnet, L. G., Storling, J., Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, N., Bock, E. & Mandrup-Poulsen, Thomas, 2008, In: FEBS Journal. 275, Suppl. 1

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    The role of RNA oxidation in islet dysfunction in Type 2 diabetes

    Sileikaite, I., Davies, Michael J., Mandrup-Poulsen, Thomas & Hawkins, Clare Louise, 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1 , p. S37-S38

    Research output: Contribution to journalConference abstract in journalResearch

  16. Published

    The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus.

    Donath, M. Y. & Mandrup-Poulsen, Thomas, 2008, In: Nature Clinical Practice Endocrinology & Metabolism. 4, 5, p. 240-1 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    TiSH--a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC

    Engholm-Keller, K., Birck, P., Størling, Joachim, Pociot, Flemming, Mandrup-Poulsen, Thomas & Larsen, M. R., 22 Oct 2012, In: International Journal of Proteomics. 75, 18, p. 5749-61 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Tissue inhibitor of matrix metalloproteinase-1 is required for high-fat diet-induced glucose intolerance and hepatic steatosis in mice

    Fjære, E., Andersen, C., Myrmel, L. S., Petersen, R. K., Hansen, J. B., Tastesen, H. S., Mandrup-Poulsen, Thomas, Brünner, N., Kristiansen, Karsten, Madsen, L. & Rømer, M. U. K., 2015, In: PloS one. 10, 7, 19 p., e0132910.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published
  20. Published

    Total mortality by elevated transferrin saturation in patients with diabetes

    Ellervik, Christina, Andersen, H. U., Tybjærg-Hansen, Anne, Frandsen, M. M., Birgens, H., Nordestgaard, Børge & Mandrup-Poulsen, Thomas, Sep 2013, In: Diabetes Care. 36, 9, p. 2646-54 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Transcriptional and translational regulation of cytokine signaling in inflammatory ß-cell dysfunction and apoptosis

    Novotny, G. W., Lundh, M., Backe, M. B., Christensen, D. P., Hansen, J. B., Dahllöf, M. S., Pallesen, E. & Mandrup-Poulsen, Thomas, 2012, In: Archives of Biochemistry and Biophysics. 528, 2, p. 171-84

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    Transplantation mellem enaeggede tvillinger

    Mandrup-Poulsen, Thomas, 26 Jan 2004, In: Ugeskrift for Laeger. 166, 5, p. 398-9; author reply 399

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Treatment of type 2 diabetes by targeting interleukin-1: a meta-analysis of 2921 patients

    Kataria, Y., Ellervik, Christina & Mandrup-Poulsen, Thomas, 2019, In: Seminars in Immunopathology. 41, 4, p. 413-425

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    Type 1 database mellitus: an inflammatory disease of the islet.

    Bergholdt, R., Heding, P., Nielsen, K., Nolsøe, R., Sparre, T., Størling, J., Nerup, J., Pociot, Flemming & Mandrup-Poulsen, Thomas, 2004, In: Advances in Experimental Medicine and Biology. 552, p. 129-53 24 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Type 1 diabetes - the copenhagen model

    Mandrup-Poulsen, Thomas, Binder, C., Deckert, T. & Nerup, J., 2007, Diabetes og Danmark. 1 ed. Gad, p. 184-195 11 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

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