Thomas Mandrup-Poulsen
Professor
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(19)F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells
Malaisse, W. J., Zhang, Y., Louchami, K., Sharma, S., Dresselaers, T., Himmelreich, U., Novotny, G. W., Mandrup-Poulsen, Thomas, Waschke, D., Leshch, Y., Thimm, J., Thiem, J. & Sener, A., 2012, In: Archives of Biochemistry and Biophysics. 517, 2, p. 138-43 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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16 SKELETAL-MUSCLE LIPOPROTEIN EXPRESSION IS REGULATED BY TRAINING AND TYPE 2 DIABETES IN HUMANS AND IMPROVES INSULIN SENSITIVITY IN OBESE MICE
Bartels, E. M., Mandrup-Poulsen, Thomas & Nielsen, L. B., Jun 2011, In: Atherosclerosis. Supplement. 12, 1, p. 4 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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A Blunted GPR183/Oxysterol Axis during Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung during Mycobacterium tuberculosis Infection
Ngo, M. D., Bartlett, S., Bielefeldt-Ohmann, H., Foo, C. X., Sinha, R., Arachchige, B. J., Reed, S., Mandrup-Poulsen, Thomas, Rosenkilde, Mette & Ronacher, K., 2022, In: Journal of Infectious Diseases. 225, 12, p. 2219-2228Research output: Contribution to journal › Journal article › Research › peer-review
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A Placebo-Controlled Study on the Effects of the Glucagon-Like Peptide-1 Mimetic, Exenatide, on Insulin Secretion, Body Composition and Adipokines in Obese, Client-Owned Cats
Hoelmkjaer, K. M., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Cronin, A. M., Nielsen, Dorte Hald, Mandrup-Poulsen, Thomas & Bjørnvad, Charlotte Reinhard, 2 May 2016, In: P L o S One. 11, 5, 18 p., e0154727.Research output: Contribution to journal › Journal article › Research › peer-review
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A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells
Vestergaard, A. L., Blankestijn, M., Stahl, J. L., Pallesen, E. M. H., Bang-Berthelsen, C. H., Pociot, Flemming, Novotny, G. W., Lundh, M. & Mandrup-Poulsen, Thomas, 2016, In: International Journal of Molecular Sciences (Online). 17, 6, 8 p., 896.Research output: Contribution to journal › Comment/debate › Research › peer-review
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A guiding map for inflammation
Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., Heneka, M. T., Hoffman, H. M., Hotchkiss, R., Joosten, L. A. B., Kastner, D. L., Korte, M., Latz, E., Libby, P., Mandrup-Poulsen, T., Mantovani, A., Mills, K. H. G., Nowak, K. L. & 12 others, , 19 Jul 2017, In: Nature Immunology. 18, 8, p. 826-831 6 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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A randomised, double-blind, crossover study of the effect of the fluoroquinolone moxifloxacin on glucose levels and insulin sensitivity in young men and women
Juhl, C. R., Burgdorf, J., Knudsen, C., Lubberding, Anniek Frederike, Veedfald, Simon, Isaksen, Jonas L., Hartmann, Bolette, Frikke-Schmidt, Ruth, Mandrup-Poulsen, Thomas, Holst, Jens Juul, Kanters, Jørgen K. & Torekov, Signe Sørensen, 2023, In: Diabetes, Obesity and Metabolism. 25, 1, p. 98-109Research output: Contribution to journal › Journal article › Research › peer-review
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Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice
Christiansen, Charlotte Bayer, Jepsen, Sara Lind, Svendsen, B., Balk-Møller, E., Dahlby, T., Kuhre, Rune Ehrenreich, Hartmann, Bolette, Mandrup-Poulsen, Thomas, Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2018, In: Physiological Reports. 6, 13, p. 1-8 e13788.Research output: Contribution to journal › Journal article › Research › peer-review
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Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans
Mandrup-Poulsen, Thomas, Bendtzen, K., Nerup, J., Dinarello, C. A., Svenson, M. & Nielsen, Jens Høiriis, Jan 1986, In: Diabetologia. 29, 1, p. 63-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Age-dependent decline of beta-cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study
Barker, A., Lauria, A., Schloot, N., Hosszufalusi, N., Ludvigsson, J., Mathieu, C., Mauricio, D., Nordwall, M., Van der Schueren, B., Mandrup-Poulsen, Thomas, Scherbaum, W. A., Weets, I., Gorus, F. K., Wareham, N., Leslie, R. D. & Pozzilli, P., Mar 2014, In: Diabetes, Obesity and Metabolism. 16, 3, p. 262-267 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Age-dependent decline of β cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study
Barker, V. A., Lauria, A., Schloot, N., Hosszufalusi, N., Ludvigsson, J., Mathieu, C. J., Mauricio, D., Nordwall, M., Van der Schueren, B., Mandrup-Poulsen, Thomas, Scherbaum, W., Weets, I., Gorus, F., Wareham, N., Leslie, R. & Pozzilli, P., 1 Oct 2013, In: Diabetes, Obesity and Metabolism Online. 16, 3, p. 262-267 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V
Lubberding, Anniek Frederike, Zhang, J., Lundh, M., Nielsen, Thomas Svava, Søndergaard, M. S., Villadsen, M., Skovhøj, E. Z., Boer, G. A., Hansen, J. B., Thomsen, Morten Bækgaard, Treebak, Jonas Thue, Holst, Jens Juul, Kanters, Jørgen K., Mandrup-Poulsen, Thomas, Jespersen, Thomas, Emanuelli, Brice & Torekov, Signe Sørensen, 2021, In: Scientific Reports. 11, 1, 14 p., 12253.Research output: Contribution to journal › Journal article › Research › peer-review
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Altering β-cell number through stable alteration of miR-21 and miR-34a expression
Backe, M. B., Novotny, G. W., Christensen, D. P., Grunnet, L. G. & Mandrup-Poulsen, Thomas, 26 Feb 2014, In: Islets. 6, 1, p. 1-8 8 p., e27754.Research output: Contribution to journal › Journal article › Research › peer-review
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An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection
Wagner, F. F., Lundh, M., Kaya, T., McCarren, P., Zhang, Y-L., Chattopadhyay, S., Gale, J. P., Galbo, T., Fisher, S. L., Meier, B. C., Vetere, A., Richardson, S., Morgan, N. G., Christensen, D. P., Gilbert, T. J., Hooker, J. M., Leroy, M., Walpita, D., Mandrup-Poulsen, T., Wagner, B. K. & 1 others, , 19 Feb 2016, In: ACS chemical biology. 11, 2, p. 363-374 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An immune origin of type 2 diabetes?
Kolb, H. & Mandrup-Poulsen, Thomas, 1 Jun 2005, In: Diabetologia. 48, 6, p. 1038-50 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Anti-cytokine therapies in T1D: Concepts and strategies
Nepom, G. T., Ehlers, M. & Mandrup-Poulsen, Thomas, Dec 2013, In: Clinical Immunology. 149, 3 Part A, p. 279-85 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Anti-inflammatory properties of a novel peptide interleukin 1 receptor antagonist
Klementiev, B., Li, S., Korshunova, Irina, Dmytriyeva, O., Pankratova, Stanislava, Walmod, P. S., Kjær, L. K., Dahllöf, M. S., Lundh, M., Christensen, D. P., Mandrup-Poulsen, Thomas, Bock, E. & Berezin, V., 2014, In: Journal of Neuroinflammation. 11, 1, p. 27Research output: Contribution to journal › Journal article › Research › peer-review
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Antitumorigenic effect of proteasome inhibitors on insulinoma cells.
Størling, J., Allaman-Pillet, N., Karlsen, A. E., Billestrup, N., Bonny, C. & Mandrup-Poulsen, Thomas, 2004, In: Endocrinology. 146, 4, p. 1718-26 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Apolipoprotein CIII Reduces Proinflammatory Cytokine-Induced Apoptosis in Rat Pancreatic Islets via the Akt Prosurvival Pathway
Størling, Joachim, Juntti-Berggren, L., Olivecrona, G., Prause, M. C., Berggren, P. & Mandrup-Poulsen, Thomas, 2011, In: Endocrinology. 152, 8, p. 3040-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Apolipoprotein CIII reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the Akt prosurvival pathway.
Størling, Joachim, Juntti-Berggren, L., Olivecrona, G., Prause, Michala Cecilie Burstein, Berggren, P. & Mandrup-Poulsen, Thomas, Aug 2011, In: Endocrinology.Research output: Contribution to journal › Journal article › Research › peer-review
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Association between age, IL-10, IFN¿, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes
Kaas, A., Pfleger, C. C., Kharagjitsingh, A. V., Schloot, N. C., Hansen, L., Buschard, K., Koeleman, B. P. C., Roep, B. O., Mortensen, H. B., Alizadeh, B. Z., Hvidoere Study Group On Childhood Diabetes, H. S. G. O. C. D. & Mandrup-Poulsen, Thomas, 2012, In: Diabetic Medicine Online. 29, 6, p. 734-741 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females
Kristiansen, O. P., Nolsøe, R. L., Larsen, L., Gjesing, A. M. P., Johannesen, J., Larsen, Z. M. E., Lykkesfeldt, A. E., Karlsen, A. E., Pociot, Flemming, Mandrup-Poulsen, Thomas & DIEGG, D., 15 May 2003, In: Human Molecular Genetics. 12, 10, p. 1101-10 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission
Schloot, N. C., Hanifi-Moghaddam, P., Aabenhus-Andersen, N., Alizadeh, B. Z., Saha, M. T., Knip, M., Devendra, D., Wilkin, T., Bonifacio, E., Roep, B. O., Kolb, H. & Mandrup-Poulsen, Thomas, 2007, In: Diabetic Medicine. 24, 5, p. 512-520 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes
Alizadeh, B. Z., Hanifi-Moghaddam, P., Eerligh, P., van der Slik, A. R., Kolb, H., Kharagjitsingh, A. V., Pereira Arias, A. M., Ronkainen, M., Knip, M., Bonfanti, R., Bonifacio, E., Prasad, D., Wilkin, T., Giphart, M. J., Koeleman, B. P. C., Nolsøe, R., Mandrup-Poulsen, Thomas, Schloot, N. C., Roep, B. O. & DIABMARKER Study Group, D. S. G., 1 Sep 2006, In: Clinical and Experimental Immunology. 145, 3, p. 480-4 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Behandling af diabetes mellitus med biologiske laegemidler.
Larsen, C. M. & Mandrup-Poulsen, Thomas, 2008, In: Ugeskrift for læger. 170, 24, p. 2134-7 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Beta-Cell Specific DMT1 KO Protects Islets from Cytokine Induced ROS and Apoptosis
Hansen, J. B., Heller, S., Madsen, A. N., Holst, Birgitte, Tonnesen, M. F. & Mandrup-Poulsen, Thomas, 2012.Research output: Contribution to conference › Poster › Research › peer-review
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Blockade of Interleukin 1 in Type 1 diabetes mellitus
Mandrup-Poulsen, Thomas, Pickersgill, L. M. S. & Donath, M. Y., 2010, In: Nature Reviews Endocrinology. 6, p. 158-166 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.
Størling, J., Zaitsev, S. V., Kapelioukh, I. L., Karlsen, A. E., Billestrup, N., Berggren, P. & Mandrup-Poulsen, Thomas, 2005, In: Endocrinology. 146, 7, p. 3026-36 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cardiovascular and All-Cause Mortality Risk Associated With Urinary Excretion of 8-oxoGuo, a Biomarker for RNA Oxidation, in Patients With Type 2 Diabetes: A Prospective Cohort Study
Kjær, L. K., Cejvanovic, V., Henriksen, T., Petersen, K. M., Hansen, Torben, Pedersen, Oluf Borbye, Christensen, C. K., Torp-Pedersen, C., Gerds, Thomas Alexander, Brandslund, I., Mandrup-Poulsen, Thomas & Poulsen, Henrik Enghusen, Dec 2017, In: Diabetes Care. 40, 12, p. 1771-1778 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Celebrities in the heart, strangers in the pancreatic beta cell: Voltage-gated potassium channels Kv7.1 and Kv11.1 bridge long QT syndrome with hyperinsulinaemia as well as type 2 diabetes
Lubberding, Anniek Frederike, Juhl, C. R., Skovhøj, Emil Zeng, Kanters, Jørgen K., Mandrup-Poulsen, Thomas & Torekov, Signe Sørensen, 2022, In: Acta Physiologica. 234, 3, 18 p., 13781.Research output: Contribution to journal › Review › Research › peer-review
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Circulating endothelial progenitor cell number in long-standing type 1 diabetic patients
Reinhard, H., Jacobsen, P. K., Tarnov, L., Astrup, A. S., Lajer, M., Pedersen, N., Billestrup, N., Mandrup-Poulsen, Thomas, Kastrup, J., Parving, H. H. & Rossing, P., 2008, In: Diabetologia. 51, Suppl. 1, p. S531-S531Research output: Contribution to journal › Journal article › Research › peer-review
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Combination of ferric ammonium citrate with cytokines involved in apoptosis and insulin secretion of human pancreatic beta cells related to diabetes in thalassemia
Rattanaporn, P., Tongsima, S., Mandrup-Poulsen, Thomas, Svasti, S. & Tanyong, D., 2020, In: PeerJ. 8, e9298.Research output: Contribution to journal › Journal article › Research › peer-review
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Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.
Ortis, F., Cardozo, A. K., Crispim, D., Störling, J., Mandrup-Poulsen, Thomas & Eizirik, D. L., 2006, In: Molecular Endocrinology. 20, 8, p. 1867-79 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cytokines and Pancreatic β-Cell Apoptosis
Berchtold, L. A., Prause, Michala Cecilie Burstein, Størling, Joachim & Mandrup-Poulsen, Thomas, 28 Jun 2016, Advances in Clinical Chemistry. Academic Press, Vol. 75. p. 99-158 60 p. (Advances in Clinical Chemistry, Vol. 75).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Cytokines and beta-cell biology: from concept to clinical translation
Donath, M. Y., Storling, J., Berchtold, L. A., Billestrup, N. & Mandrup-Poulsen, Thomas, 2007, In: Endocrine Reviews. 29, 3, p. 334-50 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cytokines and type 1 diabetes: a numbers game
Grunnet, L. G. & Mandrup-Poulsen, Thomas, 2011, In: Diabetes. 60, 3, p. 697-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cytokines cause functional and structural damage to isolated islets of Langerhans
Mandrup-Poulsen, Thomas, Bendtzen, K., Bendixen, G., Nerup, J. & Nielsen, Jens Høiriis, Aug 1985, In: Allergy. 40, 6, p. 424-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
Cardozo, A. K., Ortis, F., Storling, J., Feng, Y., Rasschaert, J., Tonnesen, M., Van Eylen, F., Mandrup-Poulsen, Thomas, Herchuelz, A. & Eizirik, D. L., 2005, In: Diabetes. 54, 2, p. 452-61 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans
Bendtzen, K., Mandrup-Poulsen, Thomas, Nerup, J., Dinarello, C. A., Svenson, M. & Nielsen, Jens Høiriis, 20 Jun 1986, In: Science (New York, N.Y.). 232, 4757, p. 1545-7 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DIAMAP team group. Europe draws up a map to a better future: Diabetes Breakthrough
Mandrup-Poulsen, Thomas, 2009Research output: Other contribution › Communication
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DIFFERENTIAL TRANSCRIPTIONAL REGULATION OF EXTRA CELLULAR MATRIX MODULATING GENES BY PROINFLAMMATORY CYTOKINES IN INS-1 CELLS
Hansen, J. B., Tonnesen, M. F., Friberg, J., Brunner, N. & Mandrup-Poulsen, Thomas, 2010.Research output: Contribution to conference › Conference abstract for conference › Research
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Defective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in β-Cells
Khilji, Muhammad Saad, Faridi, P., Pinheiro-Machado, E., Hoefner, C., Dahlby, T., Aranha, R., Buus, Søren, Nielsen, M., Klusek, J., Mandrup-Poulsen, Thomas, Pandey, K., Purcell, A. W. & Marzec, Michal Tomasz, 2022, In: Biomedicines. 10, 4, 814.Research output: Contribution to journal › Journal article › Research › peer-review
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Detrimental Actions of Chlorinated Nucleosides on the Function and Viability of Insulin-Producing Cells
Sileikaite-Morvaközi, I., Hansen, W. H., Davies, Michael J., Mandrup-Poulsen, Thomas & Hawkins, Clare Louise, 2023, In: International Journal of Molecular Sciences. 24, 19, 13 p., 14585.Research output: Contribution to journal › Journal article › Research › peer-review
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Diabetes and suppressors of cytokine signaling proteins.
Rønn, S. G., Billestrup, N. & Mandrup-Poulsen, Thomas, 2007, In: Diabetes. 56, 2, p. 541-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential transcriptional regulation of extra cellular matrix modulating genes by proinflammatory cytokines in ins-1 cells
Hansen, J. B., Tonnesen, M., Friberg, J., Brünner, N. & Mandrup-Poulsen, Thomas, 2009. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research
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Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique
Kulahin, N., Grunnet, L. G., Lundh, M., Christensen, D. P., Jorgensen, R., Heding, A., Billestrup, Nils, Berezin, V., Bock, E. & Mandrup-Poulsen, Thomas, 3 Jan 2011, In: FEBS Letters. 585, 1, p. 58-64 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Direct effects of cyclosporin A on human pancreatic beta-cells
Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, Sep 1986, In: Diabetes. 35, 9, p. 1049-52 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Divalent metal transporter 1 knock-down modulates il-1β mediated pancreatic beta-cell pro-apoptotic signaling pathways through the autophagic machinery
Kang, T., Huang, H., Mandrup-Poulsen, Thomas & Larsen, M. R., 2021, In: International Journal of Molecular Sciences. 22, 15, 25 p., 8013.Research output: Contribution to journal › Journal article › Research › peer-review
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Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines
Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, , 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 923693
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Tissue inhibitor of matrix metalloproteinase-1 is required for high-fat diet-induced glucose intolerance and hepatic steatosis in mice
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
210
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JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1 beta-Induced Apoptosis Associated with Abrogated Myc Expression
Research output: Contribution to journal › Journal article › Research › peer-review
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198
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A Placebo-Controlled Study on the Effects of the Glucagon-Like Peptide-1 Mimetic, Exenatide, on Insulin Secretion, Body Composition and Adipokines in Obese, Client-Owned Cats
Research output: Contribution to journal › Journal article › Research › peer-review
Published