Thomas Jespersen

Thomas Jespersen

Professor

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    ORCID: 0000-0001-6575-360X

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    1. Published

      3D-electroanatomical mapping of the left atrium and catheter-based pulmonary vein isolation in pigs: A practical guide

      Hertel, Julie Norup, Jerltorp, K., Hansen, M. E. H., Isaksen, Jonas L., Sattler, Stefan M, Linz, Benedikt Maximilian, Chaldoupi, S. M., Jespersen, Thomas, Saljic, Arnela, Gang, Uffe Jakob Ortved, Manninger, M. & Dr Linz, Dominik Karl, 2023, In: Frontiers in Cardiovascular Medicine. 10, 8 p., 1139364.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      5-HT1A receptors modulate small-conductance Ca2+-activated K+ channels.

      Grunnet, Morten, Jespersen, Thomas & Perrier, J., 2004, In: Journal of Neuroscience Research. 78, 6, p. 845-54 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      A Multiple Kernel Learning Framework to Investigate the Relationship Between Ventricular Fibrillation and First Myocardial Infarction

      Marciniak, M., Arevalo, H., Tfelt-Hansen, Jacob, Ahtarovski, K. A., Jespersen, Thomas, Jabbari, R., Glinge, C., Vejlstrup, N., Engstrøm, Thomas, Maleckar, M. M. & McLeod, K., 1 Jan 2017, Functional Imaging and Modelling of the Heart: 9th International Conference, FIMH 2017, Toronto, ON, Canada, June 11-13, 2017, Proceedings. Springer, p. 161-171 11 p. (Lecture Notes in Computer Science, Vol. 10263 LNCS).

      Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

    4. Published

      A Novel Nonsense Variant in Nav1.5 Cofactor MOG1 Eliminates Its Sodium Current Increasing Effect and May Increase the Risk of Arrhythmias

      Olesen, M. S., Jensen, N. F., Holst, A. G., Nielsen, J. B., Tfelt-Hansen, Jacob, Jespersen, Thomas, Sajadieh, Ahmad, Haunsø, Stig, Lund, J. T., Callø, Kirstine, Schmitt, Nicole & Svendsen, Jesper Hastrup, 26 May 2011, In: Canadian Journal of Cardiology. 27, 4, p. 523.e17-23

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      A Novel SCN5A Mutation in a Patient with Coexistence of Brugada Syndrome Traits and Ischaemic Heart Disease

      Holst, A. G., Callø, Kirstine, Jespersen, Thomas, Cedergreen, P., Winkel, B. G., Jensen, H. K., Leren, T. P., Haunso, S., Svendsen, Jesper Hastrup & Tfelt-Hansen, J., 2009, In: Case Reports in Medicine. 2009, p. 963645

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      A Novel SCN5A Variant Associated with Abnormal Repolarization, Atrial Fibrillation, and Reversible Cardiomyopathy

      Boddum, K., Saljic, Arnela, Jespersen, Thomas & Christensen, A. H., 2018, In: Cardiology. 140, 1, p. 8-13

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      A novel approach for obtaining 12-lead electrocardiograms in horses

      Hesselkilde, E. M., Isaksen, Jonas L., Petersen, B. V., Carstensen, Helena, Jespersen, Thomas, Pehrson, S., Kanters, Jørgen K. & Buhl, Rikke, 2021, In: Journal of Veterinary Internal Medicine. 35, 1, p. 521-531

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein

      Andersen, M. N., Krzystanek, K., Petersen, F., Bomholtz, Sofia Hammami, Olesen, Søren-Peter, Abriel, H., Jespersen, Thomas & Rasmussen, Hanne Borger, 8 Nov 2013, In: The Journal of Biological Chemistry. 288, 52, p. 36841-54 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      AMP-activated protein kinase downregulates Kv7.1 cell surface expression

      Andersen, M. N., Krzystanek, K., Jespersen, Thomas, Olesen, Søren-Peter & Rasmussen, Hanne Borger, 2012, In: Traffic. 13, 1, p. 143-56 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Activation of KCNQ5 channels stably expressed in HEK293 cells by BMS-204352.

      Dupuis, D. S., Schrøder, R. L., Jespersen, Thomas, Christensen, J. K., Christophersen, P., Jensen, B. S. & Olesen, Søren-Peter, 2002, In: European Journal of Pharmacology. 437, 3, p. 129-37 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury

      Bentzen, Bo Hjorth, Osadchii, O., Jespersen, Thomas, Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2009, In: Pflügers Archiv: European Journal of Physiology. 457, 5, p. 979-88 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance

      Gawalko, M., Saljic, Arnela, Li, N., Abu-Taha, I., Jespersen, Thomas, Dr Linz, Dominik Karl, Nattel, S., Heijman, J., Fender, A. & Dobrev, D., 2023, In: Cardiovascular Research. 119, 3, p. 614–630 17 p.

      Research output: Contribution to journal › Review › Research › peer-review

    13. Published

      Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V

      Lubberding, Anniek Frederike, Zhang, J., Lundh, M., Nielsen, Thomas Svava, Søndergaard, M. S., Villadsen, M., Skovhøj, E. Z., Boer, G. A., Hansen, J. B., Thomsen, Morten Bækgaard, Treebak, Jonas Thue, Holst, Jens Juul, Kanters, Jørgen K., Mandrup-Poulsen, Thomas, Jespersen, Thomas, Emanuelli, Brice & Torekov, Signe Sørensen, 2021, In: Scientific Reports. 11, 1, 14 p., 12253.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model

      Sattler, Stefan M, Lubberding, Anniek Frederike, Skibsbye, L., Jabbari, R., Wakili, R., Jespersen, Thomas & Tfelt-Hansen, Jacob, 2019, In: Journal of Cardiovascular Translational Research. 12, 4, p. 321-330

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      An ERG channel inhibitor from the scorpion Buthus eupeus

      Korolkova, Y. V., Kozlov, S. A., Lipkin, A. V., Pluzhnikov, K. A., Hadley, J. K., Filippov, A. K., Brown, D. A., Pedersen, K. A., Strøbaek, D., Jespersen, Thomas, Olesen, Søren-Peter, Jensen Skanning, B. & Grishin, E. V., 30 Mar 2001, In: Journal of Biological Chemistry. 276, 13, p. 9868-76 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      An RNA secondary structure bias for non-homologous reverse transcriptase-mediated deletions in vivo

      Duch, M. R., Carrasco, M. L., Jespersen, T., Aagaard, L., Pedersen, F. S. & Jespersen, Thomas, 1 Jan 2004, In: Nucleic Acids Symposium Series. 32, 6, p. 2039-48 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Analyses of a novel SCN5A mutation (C1850S): conduction vs. repolarization disorder hypotheses in the Brugada syndrome.

      Petitprez, S., Jespersen, Thomas, Pruvot, E., Keller, D. I., Corbaz, C., Schläpfer, J., Abriel, H. & Kucera, J. P., 2008, In: Cardiovascular Research. 78, 3, p. 494-504 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Analysis and exploitation of murine leukemia virus cis- and trans-elements using novel transduction systems

      Jespersen, Thomas, 3 Mar 1999

      Research output: Book/Report › Ph.D. thesis › Research

    19. Published

      Anti-arrhythmic investigations in large animal models of atrial fibrillation

      Saljic, Arnela, Jespersen, Thomas & Buhl, Rikke, 2022, In: British Journal of Pharmacology. 179, 5, p. 838-858

      Research output: Contribution to journal › Review › Research › peer-review

    20. Published

      Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses

      Carstensen, Helena, Kjær, L., Haugaard, M. M., Flethøj, M., Hesselkilde, E. Z., Kanters, Jørgen K., Pehrson, S., Buhl, Rikke & Jespersen, Thomas, Jan 2018, In: Journal of Cardiovascular Pharmacology. 71, 1, p. 26-35 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium

      Skibsbye, L., Wang, X., Axelsen, L. N., Bomholtz, Sofia Hammami, Nielsen, Morten Schak, Grunnet, Morten, Bentzen, Bo Hjorth & Jespersen, Thomas, Aug 2015, In: Journal of Cardiovascular Pharmacology. 66, 2, p. 165-176 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Antiarrhythmic and electrophysiologic effects of flecainide on acutely induced atrial fibrillation in healthy horses

      Haugaard, M. M., Pehrson, S., Carstensen, Helena, Madsen, M. F., Hesselkilde, E. Z., Præstegaard, K. F., Diness, J. G., Grunnet, M., Jespersen, Thomas & Buhl, Rikke, 2015, In: Journal of Veterinary Internal Medicine. 29, 1, p. 339-347 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Antiarrhythmic effect of IKr activation in a cellular model of LQT3

      Diness, Jonas Goldin, Hansen, R. S., Nissen, J. D., Jespersen, Thomas & Grunnet, Morten, 2008, In: Heart Rhythm. 6, 1, p. 100-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Antiarrhythmic effect of either negative modulation or blockade of small conductance Ca2+ activated K+ channels on ventricular fibrillation in guinea pig Langendorff perfused heart

      Diness, J. G., Kirchhoff, J. E., Sheykhzade, Majid, Jespersen, Thomas & Grunnet, M., 8 May 2015, In: Journal of Cardiovascular Pharmacology. 66, 3, p. 294–299 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation

      Kirchhoff, J. E., Diness, Jonas Goldin, Abildgaard, L., Sheykhzade, Majid, Grunnet, Morten & Jespersen, Thomas, 8 Oct 2016, In: Pfluegers Archiv. 468, 11, p. 1853–1863 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Arrhythmia development during inhibition of small-conductance calcium-activated potassium channels in acute myocardial infarction in a porcine model

      Lubberding, Anniek Frederike, Sattler, Stefan M, Grunnet, Morten, Sørensen, U. S., Tfelt-Hansen, Jacob & Jespersen, Thomas, Oct 2019, In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 21, 10, p. 1584–1593

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Arrhythmogenic mechanisms of acute obstructive respiratory events in a porcine model of drug-induced Long-QT

      Linz, Benedikt Maximilian, Sattler, Stefan M, Flethoj, M., Høtbjerg Hansen, M. E., Hesselkilde, E. M., Saljic, Arnela, Wirth, K., Dr Linz, Dominik Karl, Tfelt-Hansen, Jacob & Jespersen, Thomas, 2021, In: Heart Rhythm. 18, 8, p. 1384-1391

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Arvelige hjertesygdomme forårsaget af natriumkanalmutationer

      Tfelt-Hansen, J., Olesen, Søren-Peter, Svendsen, Jesper Hastrup & Jespersen, Thomas, 2009, In: Ugeskrift for læger. 171, 15, p. 1261-5 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Associations between thyroid-stimulating hormone, blood pressure and adiponectin are attenuated in children and adolescents with overweight or obesity

      Drivsholm, A., Lund, Morten Asp Vonsild, Hedley, P. L., Jespersen, Thomas, Christiansen, M., Hansen, Torben & Holm, Jens-Christian, 2019, In: Journal of Pediatric Endocrinology and Metabolism. 32, 12, p. 1351-1358

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Atrieflimmer og elektrofysiologi hos heste

      Haugaard, M. M., Buhl, Rikke & Jespersen, Thomas, 2011, In: Dansk Veterinaertidsskrift. 12, p. 28-31 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Attenuated ventricular β-adrenergic response and reduced repolarization reserve in a rabbit model of chronic heart failure

      Nissen, J. D., Thomsen, Morten Bækgaard, Bentzen, Bo Hjorth, Diness, Jonas Goldin, Diness, T. G., Jespersen, Thomas & Grunnet, Morten, 2012, In: Journal of Cardiovascular Pharmacology. 59, 2, p. 142-150 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Basolateral localisation of KCNQ1 potassium channels in MDCK cells: molecular identification of an N-terminal targeting motif.

      Jespersen, Thomas, Rasmussen, Hanne Borger, Grunnet, Morten, Jensen, H. S., Angelo, K., Dupuis, D. S., Vogel, L. K., Jorgensen, N. K., Klærke, Dan Arne & Olesen, Søren-Peter, 2004, In: Journal of Cell Science. 117, Pt 19, p. 4517-26 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Biophysical characterization of KV3.1 potassium channel activating compounds

      Taskin, B., von Schoubye, N. L., Sheykhzade, Majid, Bastlund, J. F., Grunnet, M. & Jespersen, Thomas, 5 Jul 2015, In: European Journal of Pharmacology. 758, p. 164-170 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Biophysical characterization of inwardly rectifying potassium currents (I(K1) I(K,ACh), I(K,Ca)) using sinus rhythm or atrial fibrillation action potential waveforms

      Tang, C., Skibsbye, L., Yuan, L., Bentzen, Bo Hjorth & Jespersen, Thomas, Oct 2015, In: General Physiology and Biophysics. 34, 4, p. 383-92 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Brugada syndrome unmasked by accidental inhalation of gasoline vapors.

      Kranjcec, D., Bergovec, M., Rougier, J., Raguz, M., Pavlovic, S., Jespersen, Thomas, Castella, V., Keller, D. I. & Abriel, H., 2007, In: Pacing and Clinical Electrophysiology. 30, 10, p. 1294-8 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Cardiac Arrhythmia - new considerations: The Cardiac Ion Channels

      Jespersen, Thomas, 29 Feb 2012, Cardiac Arrhythmias - new considerations. Breijo-Marquez, F. R. (ed.). Croatia: InTech, p. 45-72 29 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    37. Published

      Cardiac channelopathies and sudden infant death syndrome

      Tfelt-Hansen, J., Winkel, B. G., Grunnet, Morten & Jespersen, Thomas, 2011, In: The Cardiology. 119, 1, p. 21-33 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1.

      Jespersen, Thomas, Gavillet, B., van Bemmelen, M. X., Cordonier, S., Thomas, M. A., Staub, O. & Abriel, H., 2006, In: Biochemical and Biophysical Research Communications. 348, 4, p. 1455-62 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Cartilaginous Intrusion of the Atrioventricular Node in a Quarter Horse with a High Burden of Second-Degree AV Block and Collapse: A Case Report

      Nissen, Sarah Dalgas, Saljic, Arnela, Kjeldsen, Sofie Troest, Jespersen, Thomas, Hopster-Iversen, Charlotte & Buhl, Rikke, 2022, In: Animals. 12, 21, 2915.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Cause-specific mortality in children and young adults with diabetes mellitus: A Danish nationwide cohort study

      Svane, Jesper, Lynge, T. H., Pedersen-Bjergaard, Ulrik, Jespersen, Thomas, Gislason, Gunnar Hilmar, Risgaard, B., Winkel, B. G. & Tfelt-Hansen, Jacob, 2021, In: European Journal of Preventive Cardiology. 28, 2, p. 159-165

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Change in global longitudinal strain following acute coronary syndrome and subsequent risk of heart failure

      Ravnkilde, K., Skaarup, K. G., Grove, G. L., Modin, D., Nielsen, A. B., Falsing, M. M., Iversen, A. Z., Pedersen, S., Fritz-Hansen, T., Galatius, S., Jespersen, Thomas, Shah, A., Gislason, Gunnar Hilmar & Biering-Sørensen, Tor, 2021, In: International Journal of Cardiovascular Imaging. 37, p. 3193–3202

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Characterization of cardiac repolarization in the Göttingen minipig

      Laursen, M., Olesen, Søren-Peter, Grunnet, Morten, Mow, T., Jespersen, T. & Jespersen, Thomas, 2011, In: Journal of Pharmacological and Toxicological Methods. 63, 2, p. 186-95 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current.

      Larsen, A. P., Olesen, Søren-Peter, Grunnet, Morten & Jespersen, Thomas, 2008, In: Pflügers Archiv: European Journal of Physiology. 456, 6, p. 1137-48 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Characterization of two new dominant ClC-1 channel mutations associated with myotonia.

      Grunnet, Morten, Jespersen, Thomas, Colding-Jørgensen, E., Schwartz, M., Klærke, Dan Arne, Vissing, John, Olesen, Søren-Peter & Dunø, M., 2003, In: Muscle & Nerve. 28, 6, p. 722-32 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Clinical Implications of SCN10A Loss-of-Function Variants in 169 610 Exomes Representing the General Population.

      Paludan-Müller, Christian, Larsen, S., Ahlberg, G., Monfort, L. M., Andreasen, L., Svendsen, Jesper Hastrup, Jespersen, Thomas, Bundgård, Henning, Kanters, Jørgen K. & Olesen, Morten Steen Salling, 2022, In: Circulation. Genomic and precision medicine. 15, 1, p. 83-85 3 p., e003574.

      Research output: Contribution to journal › Letter › Research › peer-review

    46. Published

      Combined In-silico and Machine Learning Approaches Toward Predicting Arrhythmic Risk in Post-infarction Patients

      Maleckar, M. M., Myklebust, L., Uv, J., Florvaag, P. M., Strøm, V., Glinge, C., Jabbari, R., Vejlstrup, N., Engstrøm, Thomas, Ahtarovski, K., Jespersen, Thomas, Tfelt-Hansen, Jacob, Naumova, V. & Arevalo, H., 2021, In: Frontiers in Physiology. 12, 745349.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Combined gating and trafficking defect in Kv11.1 manifests as a malignant long QT syndrome phenotype in a large Danish p.F29L founder family

      Kanters, Jørgen K., Skibsbye, L., Hedley, P. L., Dembic, M., Liang, B., Hagen, C. M., Eschen, O., Grunnet, Morten, Christiansen, M. & Jespersen, Thomas, 2015, In: Scandinavian Journal of Clinical & Laboratory Investigation. 75, 8, p. 699-709 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Common and rare variants in SCN10A modulate the risk of atrial fibrillation.

      Jabbari, J., Olesen, Morten Steen Salling, Yuan, L., Nielsen, J. B., Liang, B., Macri, V., Christophersen, I. E., Nielsen, N., Sajadieh, Ahmad, Ellinor, P. T., Grunnet, Morten, Haunsø, Stig, Holst, A. G., Svendsen, Jesper Hastrup & Jespersen, Thomas, 2015, In: Circulation: Cardiovascular Genetics. 8, 1, p. 64-73 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Comparison of hemodynamics, cardiac electrophysiology and ventricular arrhythmia in an open and a closed chest porcine model of acute myocardial infarction

      Lubberding, Anniek Frederike, Sattler, Stefan M, Flethøj, M., Tfelt-Hansen, Jacob & Jespersen, Thomas, 2020, In: American Journal of Physiology: Heart and Circulatory Physiology. 318, 2, p. H391-H400

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Comparison of the Effects of a Transient Outward Potassium Channel Activator on Currents Recorded from Atrial and Ventricular Cardiomyocytes.

      Callø, Kirstine, Nof, E., Jespersen, Thomas, Di Diego, J. M., Chlus, N., Olesen, Søren-Peter, Antzelevitch, C. & Cordeiro, J. M., 2011, In: Journal of Cardiovascular Electrophysiology. 22, 9, p. 1057-1066 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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