Nils Billestrup

Nils Billestrup

Professor

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    ORCID: 0000-0002-4968-8067

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    1. Published

      Aberrant accumulation of the diabetes autoantigen GAD65 in Golgi membranes in conditions of ER stress and autoimmunity

      Phelps, E. A., Cianciaruso, C., Michael, I. P., Pasquier, M., Kanaani, J., Nano, R., Lavallard, V., Billestrup, Nils, Hubbell, J. A. & Baekkeskov, S., Sep 2016, In: Diabetes. 65, 9, p. 2686-2699

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Adenohypophysial changes in mice transgenic for human growth hormone-releasing factor: a histological, immunocytochemical, and electron microscopic investigation

      Stefaneanu, L., Kovacs, K., Horvath, E., Asa, S. L., Losinski, N. E., Billestrup, Nils, Price, J. & Vale, W., Nov 1989, In: Endocrinology. 125, 5, p. 2710-8 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding

      Urizar, A. I., Prause, Michala Cecilie Burstein, Ingerslev, L. R., Wortham, M., Sui, Y., Sander, M., Williams, K., Barrès, Romain, Larsen, M. R., Christensen, G. L. & Billestrup, Nils, 2023, In: Cell Death and Disease. 14, 7, 16 p., 399.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Beta cell proliferation and growth factors

      Nielsen, Jens Høiriis, Svensson, C., Møldrup, A., Galsgaard, E. D. & Billestrup, Nils, Jan 1999, In: Journal of Molecular Medicine. 77, 1, p. 62-6 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1 beta is associated with changes in expression of beta-cell maturity genes and associated histone modifications

      Urizar, A. I., Prause, Michala Cecilie Burstein, Wortham, M., Sui, Y., Thams, P., Sander, M., Christensen, G. L. & Billestrup, Nils, 2019, In: Molecular and Cellular Endocrinology. 496, 12 p., 110524 .

      Research output: Contribution to journal › Review › Research › peer-review

    6. Published

      Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

      Greenhalgh, C. J., Metcalf, D., Thaus, A. L., Corbin, J. E., Uren, R., Morgan, P. O., Fabri, L. J., Zhang, J., Martin, H. M., Willson, T. A., Billestrup, Nils, Nicola, N. A., Baca, M., Alexander, W. S. & Hilton, D. J., 25 Oct 2002, In: The Journal of Biological Chemistry. 277, 43, p. 40181-4 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents

      Christensen, G. L., Jacobsen, M. L. B., Wendt, A., Mollet, I. G., Friberg, J., Frederiksen, K. S., Meyer, M., Bruun, C., Eliasson, L. & Billestrup, Nils, Jun 2015, In: Diabetologia. 58, 6, p. 1282-1290 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Butyrate functions as a histone deacetylase inhibitor to protect pancreatic beta cells from IL-1β-induced dysfunction

      Pedersen, Signe Schultz, Ingerslev, Lars Roed, Olsen, M., Prause, Michala Cecilie Burstein & Billestrup, Nils, 2024, In: FEBS Journal. 291, 3, p. 566-583

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Butyrate inhibits IL-1β-induced inflammatory gene expression by suppression of NF-κB activity in pancreatic beta cells

      Pedersen, Signe Schultz, Prause, Michala Cecilie Burstein, Williams, K., Barrès, Romain & Billestrup, Nils, 2022, In: Journal of Biological Chemistry. 298, 9, 14 p., 102312.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Butyrate protects pancreatic beta cells from cytokine-induced dysfunction

      Prause, Michala Cecilie Burstein, Pedersen, Signe Schultz, Tsonkova, V., Qiao, M. & Billestrup, Nils, 2021, In: International Journal of Molecular Sciences. 22, 19, 18 p., 10427.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      CRFR1 activation protects against cytokine-induced beta cell death

      Blaabjerg, L., Christensen, G. L., Matsumoto, M., van der Meulen, T., Huising, M. O., Billestrup, Nils & Vale, W., 16 Oct 2014, In: Journal of Molecular Endocrinology. 53, p. 417-427 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner

      Huising, M. O., van der Meulen, T., Vaughan, J. M., Matsumoto, M., Donaldson, C. J., Park, H., Billestrup, Nils & Vale, W. W., 2009, In: Proceedings of the National Academy of Science of the United States of America. 107, 2, p. 912-7 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Cell transfection as a tool to study growth hormone action

      Norstedt, G., Enberg, B., Francis, S., Hansson, A., Hulthén, A., Lobie, P. E., Sliva, D., Wood, T. J. & Billestrup, Nils, Jul 1994, In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 206, 3, p. 181-4 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Characterization of the Molecular Mechanisms Underlying Glucose Stimulated Insulin Secretion from Isolated Pancreatic β-cells Using Post-translational Modification Specific Proteomics (PTMomics)

      Kang, T., Jensen, P., Huang, H., Lund Christensen, G., Billestrup, Nils & Larsen, M. R., Jan 2018, In: Molecular and Cellular Proteomics. 17, 1, p. 95-110 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Characterization of the inhibitory effect of growth hormone on primary preadipocyte differentiation

      Hansen, L. H., Madsen, B., Teisner, B., Nielsen, Jens Høiriis & Billestrup, Nils, Aug 1998, In: Molecular endocrinology (Baltimore, Md.). 12, 8, p. 1140-9 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Co-ordinated regulation of neurogenin-3 expression in the maternal and fetal pancreas during pregnancy

      Søstrup, B., Gaarn, L. W., Nalla, A., Billestrup, Nils & Nielsen, Jens Høiriis, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1190-7 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons

      Kanaani, J., Cianciaruso, C., Phelps, E. A., Pasquier, M., Brioudes, E., Billestrup, Nils & Baekkeskov, S., 2015, In: PLOS ONE. 10, 2, p. 1-24 24 p., e0117130.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Dedifferentiation for replication of human beta-cells: a division between mice and men?

      Billestrup, Nils & Otonkoski, T., 2008, In: Diabetes. 57, 6, p. 1457-8 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells

      Eriksen, K. W., Woetmann, Anders , Skov, Lone, Krejsgaard, T., Bovin, L. F., Hansen, M. L., Grønbæk, Kirsten, Billestrup, Nils, Nissen, Mogens Holst, Geisler, Carsten, Wasik, M. A. & Ødum, Niels, 2010, In: Journal of Investigative Dermatology. 130, 6, p. 1590-7 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Developmental expression of proprotein convertase 1/3 in the rat

      Lee, Y. C., Damholt, A. B., Billestrup, Nils, Kisbye, T., Galante, P., Michelsen, B., Kofod, H. & Nielsen, Jens Høiriis, 10 Sep 1999, In: Molecular and Cellular Endocrinology. 155, 1-2, p. 27-35 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique

      Kulahin, N., Grunnet, L. G., Lundh, M., Christensen, D. P., Jorgensen, R., Heding, A., Billestrup, Nils, Berezin, V., Bock, E. & Mandrup-Poulsen, Thomas, 3 Jan 2011, In: FEBS Letters. 585, 1, p. 58-64 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Dissociation between skeletal muscle inhibitor-{kappa}B kinase/nuclear factor-{kappa}B pathway activity and insulin sensitivity in nondiabetic twins

      Friedrichsen, M., Ribel-Madsen, R., Wojtaszewski, Jørgen F P, Grunnet, Louise Groth, Richter, Erik A., Billestrup, Nils, Ploug, Thorkil, Vaag, A. & Poulsen, P., 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 1, p. 414-421 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Distinct cytoplasmic domains of the growth hormone receptor are required for glucocorticoid- and phorbol ester-induced decreases in growth hormone (GH) binding. These domains are different from that reported for GH-induced receptor internalization

      King, A. P., Tseng, M. J., Logsdon, C. D., Billestrup, Nils & Carter-Su, C., 26 Jul 1996, In: The Journal of Biological Chemistry. 271, 30, p. 18088-94 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines

      Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, Mandrup-Poulsen, Thomas, 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase

      VanderKuur, J. A., Wang, X., Zhang, L., Campbell, G. S., Allevato, G., Billestrup, Nils, Norstedt, G. & Carter-Su, C., 26 Aug 1994, In: The Journal of Biological Chemistry. 269, 34, p. 21709-17 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Effect of growth hormone and serum on the expression of the proto-oncogenes c-jun and c-fos in insulin producing cells

      Petersen, E. D., Billestrup, Nils & Nielsen, Jens Høiriis, 1990, In: Biomedica Biochimica Acta. 49, 12, p. 1171-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Effects of growth hormone on glucose and fat metabolism in human subjects

      Jørgensen, J. O. L., Møller, L., Krag, M. B., Billestrup, Nils & Christiansen, J. K. S., 1 Mar 2007, In: Endocrinology & Metabolism Clinics of North America. 36, 1, p. 75-87 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Endothelial Progenitor Cells in Long-Standing Asymptomatic Type 1 Diabetic Patients with or without Diabetic Nephropathy

      Reinhard, H., Jacobsen, P. K., Lajer, M., Tarnow, L., Astrup, A. S., Kim, W. Y., Pedersen, N., Billestrup, Nils, Mandrup-Poulsen, Thomas, Parving, H. & Rossing, Peter, 2011, In: Nephron Clinical Practice. 118, 3, p. c309-c314 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Evidence for association of the cloned liver growth hormone receptor with a tyrosine kinase

      Wang, X., Uhler, M. D., Billestrup, Nils, Norstedt, G., Talamantes, F., Nielsen, Jens Høiriis & Carter-Su, C., 25 Aug 1992, In: The Journal of Biological Chemistry. 267, 24, p. 17390-6 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Expression of the growth hormone receptor gene in insulin producing cells

      Møldrup, A., Billestrup, Nils & Nielsen, Jens Høiriis, 1990, In: Biomedica Biochimica Acta. 49, 12, p. 1151-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells

      Larsen, L., Størling, Joachim, Darville, M., Eizirik, D. L., Bonny, C., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 Dec 2005, In: Diabetologia. 48, 12, p. 2582-90 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      GH receptor signaling in skeletal muscle and adipose tissue in human subjects following exposure to an intravenous GH bolus

      Jørgensen, J. O. L., Jessen, N., Pedersen, S. B., Vestergaard, E. T., Gormsen, L. C., Lund, S. & Billestrup, Nils, 1 Nov 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 5, p. E899-905

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Accepted/In press

      Genetic deficiency of tissue inhibitor of metalloproteinase (TIMP) 1 does not affect apoptosis in cytokine-exposed mouse islets in vitro.

      Hansen, J. B., Tonnesen, M. F., Rømer, M. U. K., Billestrup, Nils, Brunner, N. & Mandrup-Poulsen, Thomas, 2010, (Accepted/In press).

      Research output: Contribution to conference › Conference abstract for conference › Research

    34. Published

      Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell

      Haase, T. N., Rasmussen, M., Jaksch, C. A. M., Gaarn, L. W., Petersen, C. K., Billestrup, Nils & Nielsen, Jens Høiriis, Apr 2013, In: Diabetologia. 56, 4, p. 763-773 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells

      Larsen, C. M., Døssing, M. G., Papa, S., Franzoso, G., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 May 2006, In: Diabetologia. 49, 5, p. 980-9 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation

      Behncken, S. N., Billestrup, Nils, Brown, R., Amstrup, J., Conway-Campbell, B. & Waters, M. J., 2 Jun 2000, In: The Journal of Biological Chemistry. 275, 22, p. 17000-7 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Growth hormone action in rat insulinoma cells expressing truncated growth hormone receptors

      Møldrup, A., Allevato, G., Dyrberg, T., Billestrup, Nils & Nielsen, Jens Høiriis, 15 Sep 1991, In: The Journal of Biological Chemistry. 266, 26, p. 17441-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas

      Carlsson, C., Tornehave, D., Lindberg, K., Galante, P., Billestrup, Nils, Michelsen, B., Larsson, L. I. & Nielsen, Jens Høiriis, Sep 1997, In: Endocrinology. 138, 9, p. 3940-8 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Growth hormone binding to specific receptors stimulates growth and function of cloned insulin-producing rat insulinoma RIN-5AH cells

      Billestrup, Nils & Martin, J. M., Mar 1985, In: Endocrinology. 116, 3, p. 1175-81 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Growth hormone is a growth factor for the differentiated pancreatic beta-cell

      Linde, S., Welinder, B. S., Billestrup, Nils, Madsen, O. D. & Nielsen, Jens Høiriis, Jan 1989, In: Molecular endocrinology (Baltimore, Md.). 3, 1, p. 165-73 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

      Adams, T. E., Hansen, J. A., Starr, R., Nicola, N. A., Hilton, D. J. & Billestrup, Nils, 16 Jan 1998, In: The Journal of Biological Chemistry. 273, 3, p. 1285-7 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Growth hormone receptor C-terminal domains required for growth hormone-induced intracellular free Ca2+ oscillations and gene transcription

      Billestrup, Nils, Bouchelouche, P., Allevato, G., Ilondo, M. & Nielsen, Jens Høiriis, 28 Mar 1995, In: Proceedings of the National Academy of Sciences of the United States of America. 92, 7, p. 2725-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Growth hormone receptor expression and function in pituitary adenomas

      Clausen, L. R., Kristiansen, M. T., Rasmussen, L. M., Billestrup, Nils, Blaabjerg, O., Ledet, T. & Jørgensen, J. O. L., May 2004, In: Clinical Endocrinology. 60, 5, p. 576-83 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

      Argetsinger, L. S., Hsu, G. W., Myers, M. G., Billestrup, Nils, White, M. F. & Carter-Su, C., 16 Jun 1995, In: The Journal of Biological Chemistry. 270, 24, p. 14685-92 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling

      Argetsinger, L. S., Norstedt, G., Billestrup, Nils, White, M. F. & Carter-Su, C., 15 Nov 1996, In: The Journal of Biological Chemistry. 271, 46, p. 29415-21 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Growth hormone-dependent phosphorylation of tyrosine 333 and/or 338 of the growth hormone receptor

      VanderKuur, J. A., Wang, X., Zhang, L., Allevato, G., Billestrup, Nils & Carter-Su, C., 15 Sep 1995, In: The Journal of Biological Chemistry. 270, 37, p. 21738-44 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2

      VanderKuur, J., Allevato, G., Billestrup, Nils, Norstedt, G. & Carter-Su, C., 31 Mar 1995, In: The Journal of Biological Chemistry. 270, 13, p. 7587-93 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Growth hormone-releasing factor induces c-fos expression in cultured primary pituitary cells

      Billestrup, Nils, Mitchell, R. L., Vale, W. & Verma, I. M., Apr 1987, In: Molecular endocrinology (Baltimore, Md.). 1, 4, p. 300-5 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro

      Billestrup, Nils, Swanson, L. W. & Vale, W., Sep 1986, In: Proceedings of the National Academy of Sciences of the United States of America. 83, 18, p. 6854-7 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Growth of the endocrine pancreas: the role of somatolactogenic hormones and receptors

      Billestrup, Nils, Møldrup, A., Allevato, G., Petersen, Erik Brinch, Pedersen, Johan, Hansen, J. A. & Nielsen, Jens Høiriis, Feb 1993, In: Biochemical Society Transactions. 21, 1, p. 146-9 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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