Michael J. Davies

Michael J. Davies

Professor


  1. Published

    M. jannaschii FtsZ, a key protein in bacterial cell division, is inactivated by peroxyl radical-mediated methionine oxidation

    Reyes, J. S., Fuentes Lemus, Eduardo, Aspée, A., Davies, Michael J., Monasterio, O. & López-Alarcón, C., 2021, In: Free Radical Biology and Medicine. 166, p. 53-66

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    MODULATION OF ENDOTHELIAL CELL FUNCTION BY THE MYELOPEROXIDASE-DERIVED OXIDANT HYPOCHLOROUS ACID (HOCl) AND ITS CONTRIBUTION TO ATHEROSCLEROSIS

    Rayner, B. S., Lloyd, M. M., Summers, F. A., Davies, Michael J. & Hawkins, Clare Louise, 2014, In: Hypertension.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Mammalian heme peroxidases: from molecular mechanisms to health implications

    Davies, Michael J., Hawkins, Clare Louise, Pattison, D. I. & Rees, M. D., Jul 2008, In: Antioxidants & Redox Signaling. 10, 7, p. 1199-234 36 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin and enhances rat gastric tumor cell invasion

    Indo, H. P., Matsui, H., Chen, J., Zhu, H., Hawkins, Clare Louise, Davies, Michael J., Yarana, C., Clair, D. K. S. & Majima, H. J., 1 Jul 2015, In: Journal of Clinical Biochemistry and Nutrition. 57, 1, p. 13-20 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Markers of protein oxidation: different oxidants give rise to variable yields of bound and released carbonyl products

    Headlam, H. A. & Davies, Michael J., 2004, In: Free Radical Biology & Medicine. 36, 9, p. 1175-84 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Mass-Spectrometry-Based Identification of Cross-Links in Proteins Exposed to Photo-Oxidation and Peroxyl Radicals Using 18O Labeling and Optimized Tandem Mass Spectrometry Fragmentation

    Mariotti, M., Leinisch, F., Leeming, D. J., Svensson, B., Davies, Michael J. & Hägglund, Per Mårten, 2018, In: Journal of Proteome Research. 17, 6, p. 2017-2027

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Mechanisms and consequences of oxidative damage to extracellular matrix

    Kennett, E. C., Chuang, Christine, Degendorfer, G., Whitelock, J. M. & Davies, Michael J., Oct 2011, In: Biochemical Society Transactions. 39, 5, p. 1279-87 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Mechanisms of degradation of the natural high-potency sweetener (2R,4R)-monatin in mock beverage solutions

    Storkey, C., Pattison, D. I., Gaspard, D. S., Hagestuen, E. D. & Davies, Michael J., 16 Apr 2014, In: Journal of Agricultural and Food Chemistry. 62, 15, p. 3476-87 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Mechanistic view of iodide in oxidative stress: [Meeting Abstract]

    Kciuk, M. I., Davies, Michael J. & Marciniak, B., 2018, In: Free Radical Biology and Medicine. 120, S1, p. S122-S122 P-254.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  10. Methylglyoxal-induced modification of arginine residues decreases the activity of NADPH-generating enzymes

    Morgan, P. E., Sheahan, P. J., Pattison, D. I. & Davies, Michael J., Aug 2013, In: Free Radical Biology & Medicine. 61, p. 229-42 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway

    Shu, N., Hägglund, Per Mårten, Cai, H., Hawkins, Clare Louise & Davies, Michael J., Jan 2020, In: Redox Biology. 29, UNSP 101400.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Modification of Cys residues in thioredoxin by p-benzoquinone causes inhibition of its catalytic activity and activation of ASK1/p38-MAPK signalling pathway: [Meeting Abstract]

    Shu, N., Hägglund, Per Mårten & Davies, Michael J., 1 Aug 2019, In: Free Radical Biology and Medicine. 139, S1, p. S9-S9 8.

    Research output: Contribution to journalConference abstract in journalResearch

  13. Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid

    Malle, E., Marsche, G., Arnhold, J. & Davies, Michael J., Apr 2006, In: B B A - Reviews on Cancer. 1761, 4, p. 392-415 24 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Modification of selenocysteine residues in thioredoxin reductase and glutathione peroxidase by p-benzoquinone affects protein structure and function: [Meeting Abstract]

    Shu, N. & Davies, Michael J., 1 Aug 2019, In: Free Radical Biology and Medicine. 139, S1, p. S49-S49 168.

    Research output: Contribution to journalConference abstract in journalResearch

  15. Published

    Modification of the extracellular matrix of the arterial wall by myeloperoxidase contributes to atherosclerosis: [Meeting Absract]

    Cai, H., Chuang, Christine & Davies, Michael J., 2018, In: International Journal of Experimental Pathology. 99, 6, p. A24-A24

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  16. Published

    Modulation of hypochlorous acid (HOCl) induced damage to vascular smooth muscle cells by thiocyanate and selenium analogues

    Flouda, K., Gammelgaard, Bente, Davies, Michael J. & Hawkins, Clare Louise, May 2021, In: Redox Biology. 41, 101873.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Modulation of the cellular expression of circulating advanced glycation end-product receptors in type 2 diabetic nephropathy

    Sourris, K. C., Harcourt, B. E., Penfold, S. A., Yap, F. Y. T., Morley, A. L., Morgan, P. E., Davies, Michael J., Baker, S. T., Jerums, G. & Forbes, J. M., 2010, In: Journal of Diabetes Research. 2010, p. 974681

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: The Microalbuminuria Education and Medication Optimisation (MEMO) study

    Crasto, W., Jarvis, J., Khunti, K., Skinner, Timothy, Gray, L. J., Brela, J., Troughton, J., Daly, H., Lawrence, I. G., McNally, P. G., Carey, M. E. & Davies, Michael J., 1 Sep 2011, In: Diabetes Research and Clinical Practice. 93, 3, p. 328-336 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases

    Davies, Michael J., 2021, In: Pharmacology and Therapeutics. 218, 23 p., 107685.

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published

    Myeloperoxidase Modulates Hydrogen Peroxide Mediated Cellular Damage in Murine Macrophages

    Guo, C., Sileikaite, Inga, Davies, Michael J. & Hawkins, Clare Louise, 2020, In: Antioxidants. 9, 12, 14 p., 1255.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Myeloperoxidase-Derived Oxidants Rapidly and Efficiently Oxidise Protein Zinc-Thiol Clusters

    Cook, N. L., Pattison, D. I. & Davies, Michael J., 2012, In: Free Radical Biology and Medicine. 53, Supl. 2, p. S146 1 p., 355.

    Research output: Contribution to journalConference abstract in journalResearch

  22. Published

    Myeloperoxidase-derived damage to human plasma fibronectin: Modulation by protein binding and thiocyanate ions (SCN)

    Vanichkitrungruang, S., Chuang, Christine, Hawkins, Clare Louise & Davies, Michael J., 2020, In: Redox Biology. 36, 13 p., 101641.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Myeloperoxidase-derived oxidants inhibit sarco/endoplasmic reticulum Ca2+-ATPase activity and perturb Ca2+ homeostasis in human coronary artery endothelial cells

    Cook, N. L., Viola, H. M., Sharov, V. S., Hool, L. C., Schöneich, C. & Davies, Michael J., 1 Mar 2012, In: Free Radical Biology & Medicine. 52, 5, p. 951-61 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)

    Hadfield, K. A., Pattison, D. I., Brown, B. E., Hou, L., Rye, K., Davies, Michael J. & Hawkins, Clare Louise, 15 Jan 2013, In: Biochemical Journal. 449, 2, p. 531-42 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Myeloperoxidase-derived oxidants rapidly oxidize and disrupt zinc-cysteine/histidine clusters in proteins

    Cook, N. L., Pattison, D. I. & Davies, Michael J., 1 Dec 2012, In: Free Radical Biology & Medicine. 53, 11, p. 2072-80 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan

    Rees, M. D., Whitelock, J. M., Malle, E., Chuang, Christine, Iozzo, R. V., Nilasaroya, A. & Davies, Michael J., Jan 2010, In: Matrix Biology. 29, 1, p. 63-73 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention

    Davies, Michael J., Jan 2011, In: Journal of Clinical Biochemistry and Nutrition. 48, 1, p. 8-19 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Myoglobin-induced oxidative damage: evidence for radical transfer from oxidized myoglobin to other proteins and antioxidants

    Irwin, J. A., Ostdal, H. & Davies, Michael J., 1 Feb 1999, In: Archives of Biochemistry and Biophysics. 362, 1, p. 94-104 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Neuroprotectant effects of iso-osmolar D-mannitol to prevent Pacific ciguatoxin-1 induced alterations in neuronal excitability: a comparison with other osmotic agents and free radical scavengers

    Birinyi-Strachan, L. C., Davies, Michael J., Lewis, R. J. & Nicholson, G. M., Oct 2005, In: Neuropharmacology. 49, 5, p. 669-86 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Nitration alters laminin polymerization: [Meeting Abstract]

    Lorentzen, Lasse Gøbel & Davies, Michael J., 2018, In: Free Radical Biology and Medicine. 120, S1, p. S127-S127 P-271.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  31. Nitric oxide and nitroxides can act as efficient scavengers of protein-derived free radicals

    Lam, M. A., Pattison, D. I., Bottle, S. E., Keddie, D. J. & Davies, Michael J., Nov 2008, In: Chemical Research in Toxicology. 21, 11, p. 2111-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Nonenzymatic glycation impairs the antiinflammatory properties of apolipoprotein A-I

    Nobécourt, E., Tabet, F., Lambert, G., Puranik, R., Bao, S., Yan, L., Davies, Michael J., Brown, B. E., Jenkins, A. J., Dusting, G. J., Bonnet, D. J., Curtiss, L. K., Barter, P. J. & Rye, K., Apr 2010, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 4, p. 766-72 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Novel monohydroxamate drugs attenuate myocardial reperfusion-induced arrhythmias

    Collis, C. S., Rice-Evans, C. & Davies, Michael J., Apr 1996, In: International Journal of Biochemistry & Cell Biology. 28, 4, p. 405-13 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. One-electron reduction of N-chlorinated and N-brominated species is a source of radicals and bromine atom formation

    Pattison, D. I., O'Reilly, R. J., Skaff, O., Radom, L., Anderson, R. F. & Davies, Michael J., 21 Mar 2011, In: Chemical Research in Toxicology. 24, 3, p. 371-82 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Oral pre-treatment with thiocyanate (SCN-) protects against myocardial ischaemia-reperfusion injury in rats

    Hall, L., Guo, C., Tandy, S., Broadhouse, K., Dona, A. C., Malle, E., Bartels, Emil Daniel, Christoffersen, Christina, Grieve, S. M., Figtree, G., Hawkins, Clare Louise & Davies, Michael J., 2021, In: Scientific Reports. 11, 1, 18 p., 12712.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Oxidant-induced glutathionylation at protein disulfide bonds

    Carroll, L., Jiang, S., Irnstorfer, J., Beneyto, S., Ignasiak, M. T., Rasmussen, L. M., Rogowska-Wrzesinska, A. & Davies, Michael J., 20 Nov 2020, In: Free Radical Biology and Medicine. 160, p. 513-525 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Oxidant-mediated modification and cross-linking of beta-2-microglobulin

    Jiang, S., Fuentes Lemus, Eduardo & Davies, Michael J., 2022, In: Free Radical Biology and Medicine. 187, p. 59-71

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite

    Thomas, S. R., Davies, Michael J. & Stocker, R., 1998, In: Chemical Research in Toxicology. 11, 5, p. 484-94 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Oxidation and inactivation of SERCA by selective reaction of cysteine residues with amino acid peroxides

    Dremina, E. S., Sharov, V. S., Davies, Michael J. & Schöneich, C., Oct 2007, In: Chemical Research in Toxicology. 20, 10, p. 1462-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Oxidation and modification of extracellular matrix and its role in disease

    Chuang, Christine, Degendorfer, G. & Davies, Michael J., Sep 2014, In: Free Radical Research. 48, 9, p. 970-89 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells

    Chuang, Christine, Degendorfer, G., Hammer, A., Whitelock, J. M., Malle, E. & Davies, Michael J., 15 Apr 2014, In: Biochemical Journal. 459, 2, p. 313-22 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Oxidation of DNA, proteins and lipids by DOPA, protein-bound DOPA, and related catechol(amine)s

    Pattison, D. I., Dean, R. T. & Davies, Michael J., 1 Aug 2002, In: Toxicology. 177, 1, p. 23-37 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Oxidation of free, peptide and protein tryptophan residues mediated by AAPH-derived free radicals: role of alkoxyl and peroxyl radicals

    Fuentes-Lemus, E., Dorta, E., Escobar, E., Aspee, A., Pino, E., Abasq, M. L., Speisky, H., Silva, E., Lissi, E., Davies, Michael J. & Lopez-Alarcon, C., 2016, In: RSC Advances. 6, 63, p. 57948-57955 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Oxidation of heparan sulphate by hypochlorite: role of N-chloro derivatives and dichloramine-dependent fragmentation

    Rees, M. D., Pattison, D. I. & Davies, Michael J., 1 Oct 2005, In: Biochemical Journal. 391, Pt 1, p. 125-34 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function

    Vanichkitrungruang, S., Chuang, Christine, Hawkins, Clare Louise, Hammer, A., Hoefler, G., Malle, E. & Davies, Michael J., 2019, In: Free Radical Biology and Medicine. 136, p. 118-134

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Oxidation of lysozyme induced by peroxyl radicals involves amino acid modifications, loss of activity, and formation of specific crosslinks

    Fuentes Lemus, Eduardo, Mariotti, M., Hägglund, Per Mårten, Leinisch, F., Fierro, A., Silva, E., Davies, Michael J. & Lopez-Alarcon, C., 2021, In: Free Radical Biology and Medicine. 167, p. 258-270

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Oxidation of myosin by haem proteins generates myosin radicals and protein cross-links

    Lund, Marianne N., Luxford, C., Skibsted, Leif Horsfelt & Davies, Michael J., 2008, In: Biochemical Journal. 410, 3, p. 565-574 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Oxidation of protein disulfide bonds by singlet oxygen gives rise to glutathionylated proteins

    Jiang, S., Carroll, L., Rasmussen, L. M. & Davies, Michael J., 2021, In: Redox Biology. 38, 16 p., 101822.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Oxidative Crosslinking of Peptides and Proteins: Mechanisms of Formation, Detection, Characterization and Quantification

    Fuentes Lemus, Eduardo, Hägglund, Per Mårten, López-Alarcón, C. & Davies, Michael J., 1 Jan 2022, In: Molecules. 27, 1, p. 1-31 15.

    Research output: Contribution to journalReviewResearchpeer-review

  50. Published

    Oxidative damage on proteins is enhanced in crowded environments

    Fuentes Lemus, Eduardo, Gamon, Luke Francis, Lopez-Alarcon, C. & Davies, Michael J., 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1, p. S31-S32

    Research output: Contribution to journalConference abstract in journalResearch

ID: 38036205