Michael J. Davies
Professor
Inflammation, Metabolism and Oxidation
Blegdamsvej 3
2200 København N.
- 2010
- Published
Screening for the metabolic syndrome using simple anthropometric measurements in south Asian and white Europeans: A population-based screening study. The Leicester Ethnic Atherosclerosis and Diabetes Risk (LEADER) Study
Khunti, K., Taub, N., Tringham, J., Jarvis, J., Farooqi, A., Skinner, Timothy & Davies, Michael J., 1 Apr 2010, In: Primary Care Diabetes. 4, 1, p. 25-32 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations
Koelsch, M., Mallak, R., Graham, G. G., Kajer, T., Milligan, M. K., Nguyen, L. Q., Newsham, D. W., Keh, J. S., Kettle, A. J., Scott, K. F., Ziegler, J. B., Pattison, D. I., Fu, S., Hawkins, Clare Louise, Rees, M. D. & Davies, Michael J., 15 Apr 2010, In: Biochemical Pharmacology. 79, 8, p. 1156-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cellular effects of peptide and protein hydroperoxides
Rahmanto, A. S., Morgan, P. E., Hawkins, Clare Louise & Davies, Michael J., 15 Apr 2010, In: Free Radical Biology & Medicine. 48, 8, p. 1071-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteasomal function: possible links between diabetes and atherosclerosis
Moheimani, F., Morgan, P. E., van Reyk, D. M. & Davies, Michael J., Jun 2010, In: B B A - Reviews on Cancer. 1802, 6, p. 561-71 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains
Kennett, E. C., Rees, M. D., Malle, E., Hammer, A., Whitelock, J. M. & Davies, Michael J., 15 Jul 2010, In: Free Radical Biology & Medicine. 49, 2, p. 282-93 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Depressive symptoms in the first year from diagnosis of Type 2 diabetes: Results from the DESMOND trial
Skinner, Timothy, Carey, M. E., Cradock, S., Dallosso, H. M., Daly, H., Davies, Michael J., Doherty, Y., Heller, S., Khunti, K. & Oliver, L., 1 Aug 2010, In: Diabetic Medicine. 27, 8, p. 965-967 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The prevalence of depressive symptoms in a white European and South Asian population with impaired glucose regulation and screen-detected Type 2 diabetes mellitus: A comparison of two screening tools
Aujla, N., Skinner, Timothy, Khunti, K. & Davies, Michael J., 1 Aug 2010, In: Diabetic Medicine. 27, 8, p. 896-905 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages
Lane, A. E., Tan, J. T. M., Hawkins, Clare Louise, Heather, A. K. & Davies, Michael J., 15 Aug 2010, In: Biochemical Journal. 430, 1, p. 161-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delivering the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: Cost effectiveness analysis
Gillett, M., Dallosso, H. M., Dixon, S., Brennan, A., Carey, M. E., Campbell, M. J., Heller, S., Khunti, K., Skinner, Timothy & Davies, Michael J., 26 Aug 2010, In: BMJ (Online). 341, 7770, c4093.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ethnic differences in the prevalence and recognition of depression in a primary care population with and without type 2 diabetes
Ali, S., Taub, N. A., Stone, M. A., Davies, Michael J., Skinner, Timothy & Khunti, K., 1 Sep 2010, Diabetologia.Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
Cellular effects of photogenerated oxidants and long-lived, reactive, hydroperoxide photoproducts
Rahmanto, A. S., Morgan, P. E., Hawkins, Clare Louise & Davies, Michael J., 30 Nov 2010, In: Free Radical Biology & Medicine. 49, 10, p. 1505-15 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3
Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Hampton, M. B., Davies, Michael J. & Winterbourn, C. C., 1 Dec 2010, In: Biochemical Journal. 432, 2, p. 313-21 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Screening for type 2 diabetes in a multiethnic setting using known risk factors to identify those at high risk: A cross-sectional study
Gray, L. J., Tringham, J. R., Davies, Michael J., Webb, D. R., Jarvis, J., Skinner, Timothy, Farooqi, A. M. & Khunti, K., 1 Dec 2010, In: Vascular Health and Risk Management. 6, 1, p. 837-842 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
Effect of exposure of human monocyte-derived macrophages to high, versus normal, glucose on subsequent lipid accumulation from glycated and acetylated low-density lipoproteins
Moheimani, F., Tan, J. T. M., Brown, B. E., Heather, A. K., van Reyk, D. M. & Davies, Michael J., 2011, In: Journal of Diabetes Research. 2011, p. 851280Research output: Contribution to journal › Journal article › Research › peer-review
Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention
Davies, Michael J., Jan 2011, In: Journal of Clinical Biochemistry and Nutrition. 48, 1, p. 8-19 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome
Gracanin, M., Lam, M. A., Morgan, P. E., Rodgers, K. J., Hawkins, Clare Louise & Davies, Michael J., 15 Jan 2011, In: Free Radical Biology & Medicine. 50, 2, p. 389-99 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparison of illness representations dimensions and illness representation clusters in predicting outcomes in the first year following diagnosis of type 2 diabetes: Results from the DESMOND trial
Skinner, Timothy, Carey, M. E., Cradock, S., Dallosso, H. M., Dalyb, H., Davies, Michael J., Doherty, Y., Heller, S., Khunti, K. & Olivere, L., 1 Mar 2011, In: Psychology and Health. 26, 3, p. 321-335 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
One-electron reduction of N-chlorinated and N-brominated species is a source of radicals and bromine atom formation
Pattison, D. I., O'Reilly, R. J., Skaff, O., Radom, L., Anderson, R. F. & Davies, Michael J., 21 Mar 2011, In: Chemical Research in Toxicology. 24, 3, p. 371-82 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The association between anxiety and measures of glycaemia in a population-based diabetes screening programme
Aujla, N., Davies, Michael J., Skinner, Timothy, Gray, L. J., Webb, D. R., Srinivasan, B. & Khunti, K., 1 Jul 2011, In: Diabetic Medicine. 28, 7, p. 785-788 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dityrosine, 3,4-dihydroxyphenylalanine (DOPA), and radical formation from tyrosine residues on milk proteins with globular and flexible structures as a result of riboflavin-mediated photo-oxidation
Dalsgaard, T. K., Nielsen, J. H., Brown, B. E., Stadler, N. & Davies, Michael J., 27 Jul 2011, In: Journal of Agricultural and Food Chemistry. 59, 14, p. 7939-47 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Peroxidase catalysed cross-linking of an intrinsically unstructured protein via dityrosine bonds in the oocyst wall of the apicomplexan parasite, Eimeria maxima
Mai, K., Smith, N. C., Feng, Z., Katrib, M., Slapeta, J., Slapetova, I., Wallach, M. G., Luxford, C., Davies, Michael J., Zhang, X., Norton, R. S. & Belli, S. I., Sep 2011, In: International Journal for Parasitology (Online). 41, 11, p. 1157-64 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: The Microalbuminuria Education and Medication Optimisation (MEMO) study
Crasto, W., Jarvis, J., Khunti, K., Skinner, Timothy, Gray, L. J., Brela, J., Troughton, J., Daly, H., Lawrence, I. G., McNally, P. G., Carey, M. E. & Davies, Michael J., 1 Sep 2011, In: Diabetes Research and Clinical Practice. 93, 3, p. 328-336 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Synthesis and antioxidant capacity of 5-selenopyranose derivatives
Storkey, C., Davies, Michael J., White, J. M. & Schiesser, C. H., 14 Sep 2011, In: Chemical communications (Cambridge, England). 47, 34, p. 9693-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mechanisms and consequences of oxidative damage to extracellular matrix
Kennett, E. C., Chuang, Christine, Degendorfer, G., Whitelock, J. M. & Davies, Michael J., Oct 2011, In: Biochemical Society Transactions. 39, 5, p. 1279-87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase
Morgan, P. E., Pattison, D. I., Talib, J., Summers, F. A., Harmer, J. A., Celermajer, D. S., Hawkins, Clare Louise & Davies, Michael J., 1 Nov 2011, In: Free Radical Biology & Medicine. 51, 9, p. 1815-22 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Catalytic activity of selenomethionine in removing amino acid, peptide, and protein hydroperoxides
Suryo Rahmanto, A. & Davies, Michael J., 15 Dec 2011, In: Free Radical Biology & Medicine. 51, 12, p. 2288-99 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
Myeloperoxidase-Derived Oxidants Rapidly and Efficiently Oxidise Protein Zinc-Thiol Clusters
Cook, N. L., Pattison, David & Davies, Michael J., 2012, In: Free Radical Biology and Medicine. 53, Supl. 2, p. S146 1 p., 355.Research output: Contribution to journal › Conference abstract in journal › Research
Free Radical Research origins
Davies, Michael J., Jan 2012, In: Free Radical Research. 46, 1, p. 1Research output: Contribution to journal › Journal article › Research
Photo-oxidation of proteins
Pattison, D. I., Rahmanto, A. S. & Davies, Michael J., Jan 2012, In: Photochemical & Photobiological Sciences. 11, 1, p. 38-53 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage
Skaff, O., Pattison, D. I., Morgan, P. E., Bachana, R., Jain, V. K., Priyadarsini, K. I. & Davies, Michael J., 1 Jan 2012, In: Biochemical Journal. 441, 1, p. 305-16 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quantification of hydroxyl radical-derived oxidation products in peptides containing glycine, alanine, valine, and proline
Morgan, P. E., Pattison, D. I. & Davies, Michael J., 15 Jan 2012, In: Free Radical Biology & Medicine. 52, 2, p. 328-39 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Myeloperoxidase-derived oxidants inhibit sarco/endoplasmic reticulum Ca2+-ATPase activity and perturb Ca2+ homeostasis in human coronary artery endothelial cells
Cook, N. L., Viola, H. M., Sharov, V. S., Hool, L. C., Schöneich, C. & Davies, Michael J., 1 Mar 2012, In: Free Radical Biology & Medicine. 52, 5, p. 951-61 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates
Barrett, T. J., Pattison, D. I., Leonard, S. E., Carroll, K. S., Davies, Michael J. & Hawkins, Clare Louise, 15 Mar 2012, In: Free Radical Biology & Medicine. 52, 6, p. 1075-85 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine?
Truscott, R. J. W., Mizdrak, J., Friedrich, M. G., Hooi, M. Y., Lyons, B., Jamie, J. F., Davies, Michael J., Wilmarth, P. A. & David, L. L., Jun 2012, In: Experimental Eye Research. 99, p. 48-54 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Reduced metal ion concentrations in atherosclerotic plaques from subjects with type 2 diabetes mellitus
Stadler, N., Heeneman, S., Vöö, S., Stanley, N., Giles, G. I., Gang, B. P., Croft, K. D., Mori, T. A., Vacata, V., Daemen, M. J. A. P., Waltenberger, J. & Davies, Michael J., Jun 2012, In: Atherosclerosis. 222, 2, p. 512-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: Three year follow-up of a cluster randomised controlled trial in primary care
Khunti, K., Gray, L. J., Skinner, Timothy, Carey, M. E., Realf, K., Dallosso, H., Fisher, H., Campbell, M., Heller, S. & Davies, Michael J., 9 Jun 2012, In: BMJ (Online). 344, 7860, e2333.Research output: Contribution to journal › Journal article › Research › peer-review
Inhibition of lysosomal function in macrophages incubated with elevated glucose concentrations: a potential contributory factor in diabetes-associated atherosclerosis
Moheimani, F., Kim, C. H. J., Rahmanto, A. S., van Reyk, D. M. & Davies, Michael J., Jul 2012, In: Atherosclerosis. 223, 1, p. 144-51 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
High plasma thiocyanate levels modulate protein damage induced by myeloperoxidase and perturb measurement of 3-chlorotyrosine
Talib, J., Pattison, D. I., Harmer, J. A., Celermajer, D. S. & Davies, Michael J., 1 Jul 2012, In: Free Radical Biology & Medicine. 53, 1, p. 20-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids
Pattison, D. I., Davies, Michael J. & Hawkins, Clare Louise, Aug 2012, In: Free Radical Research. 46, 8, p. 975-95 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
Photo-oxidation-induced inactivation of the selenium-containing protective enzymes thioredoxin reductase and glutathione peroxidase
Suryo Rahmanto, A., Pattison, D. I. & Davies, Michael J., 15 Sep 2012, In: Free Radical Biology & Medicine. 53, 6, p. 1308-16 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Selenium-containing amino acids as direct and indirect antioxidants
Rahmanto, A. S. & Davies, Michael J., Nov 2012, In: I U B M B Life. 64, 11, p. 863-71 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
The nitroxide TEMPO is an efficient scavenger of protein radicals: cellular and kinetic studies
Pattison, D. I., Lam, M., Shinde, S. S., Anderson, R. F. & Davies, Michael J., 1 Nov 2012, In: Free Radical Biology & Medicine. 53, 9, p. 1664-74 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Preventing protein oxidation with sugars: scavenging of hypohalous acids by 5-selenopyranose and 4-selenofuranose derivatives
Storkey, C., Pattison, D. I., White, J. M., Schiesser, C. H. & Davies, Michael J., 19 Nov 2012, In: Chemical Research in Toxicology. 25, 11, p. 2589-99 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Computational design of effective, bioinspired HOCl antioxidants: the role of intramolecular Cl+ and H+ shifts
Karton, A., O'Reilly, R. J., Pattison, D. I., Davies, Michael J. & Radom, L., 21 Nov 2012, In: Journal of the American Chemical Society. 134, 46, p. 19240-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Myeloperoxidase-derived oxidants rapidly oxidize and disrupt zinc-cysteine/histidine clusters in proteins
Cook, N. L., Pattison, D. I. & Davies, Michael J., 1 Dec 2012, In: Free Radical Biology & Medicine. 53, 11, p. 2072-80 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
Apolipoprotein A-I glycation by glucose and reactive aldehydes alters phospholipid affinity but not cholesterol export from lipid-laden macrophages
Brown, B. E., Nobecourt, E., Zeng, J., Jenkins, A. J., Rye, K. & Davies, Michael J., 2013, In: PLOS ONE. 8, 5, p. e65430Research output: Contribution to journal › Journal article › Research › peer-review
Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content
Thallas-Bonke, V., Coughlan, M. T., Tan, A. L., Harcourt, B. E., Morgan, P. E., Davies, Michael J., Bach, L. A., Cooper, M. E. & Forbes, J. M., Jan 2013, In: Nephrology. 18, 1, p. 47-56 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)
Hadfield, K. A., Pattison, D. I., Brown, B. E., Hou, L., Rye, K., Davies, Michael J. & Hawkins, Clare Louise, 15 Jan 2013, In: Biochemical Journal. 449, 2, p. 531-42 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Chemical modification of lysozyme, glucose 6-phosphate dehydrogenase, and bovine eye lens proteins induced by peroxyl radicals: role of oxidizable amino acid residues
Arenas, A., López-Alarcón, C., Kogan, M., Lissi, E., Davies, Michael J. & Silva, E., 18 Jan 2013, In: Chemical Research in Toxicology. 26, 1, p. 67-77 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings
Graham, G. G., Davies, Michael J., Day, R. O., Mohamudally, A. & Scott, K. F., Jun 2013, In: Inflammopharmacology. 21, 3, p. 201-32 32 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 38036205
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Protein oxidation and peroxidation
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Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes
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Cardiac spheroids as promising in vitro models to study the human heart microenvironment
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