Mette Rosenkilde

Mette Rosenkilde

Professor

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    ORCID: 0000-0001-9600-3254

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    1. Published

      High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3

      Rosenkilde, Mette, Kledal, T. N. & Schwartz, Thue W., 2005, In: Molecular Pharmacology. 68, 1, p. 11-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      High content screening for G protein-coupled receptors using cell-based protein translocation assays

      Grånäs, C., Lundholt, B. K., Heydorn, A., Linde, V., Pedersen, H., Krog-Jensen, C., Rosenkilde, Mette & Pagliaro, L., 2005, In: Combinatorial Chemistry & High Throughput Screening. 8, 4, p. 301-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1

      Torekov, S. S., Ma, L., Grarup, N., Hartmann, B., Hainerová, I. A., Kielgast, U., Kissow, H., Rosenkilde, M., Lebl, J., Witte, D. R., Jørgensen, T., Sandbaek, A., Lauritzen, T., Madsen, O. D., Wang, J., Linneberg, A., Madsbad, S., Holst, J. J., Hansen, T., Pedersen, O. & 1 others, GIANT Consortium, G. C., 2011, In: Diabetologia. 54, 11, p. 2820-31 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      How receptor mutagenesis may confirm or confuse receptor classification

      Schwartz, Thue W., Perlman, S., Rosenkilde, Mette & Hjorth, S. A., 1997, In: Annals of the New York Academy of Sciences. 817, p. 71-84

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor

      Gessier, F., Preuss, I., Yin, H., Rosenkilde, Mette, Laurent, S., Endres, R., Chen, Y. A., Marsilje, T. H., Seuwen, K., Nguyen, D. G. & Sailer, A. W., 24 Apr 2014, In: Journal of Medicinal Chemistry. 57, 8, p. 3358-68 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Identification and functional comparison of seven-transmembrane G-protein-coupled BILF1 receptors in recently discovered nonhuman primate lymphocryptoviruses

      Spiess, Katja, Fares, S., wbf943, wbf943, Hilgenberg, E., Jarvis, M. A., Ehlers, B. & Rosenkilde, Mette, Feb 2015, In: Journal of Virology. 89, 4, p. 2253-67 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Identification of a Salt Bridge That Is Functionally Important for Chemokine Receptor CXCR1 but not CXCR2

      Våbenø, J., Oliva-Santiago, M., Jørgensen, Astrid Sissel, Karlshøj, S. & Rosenkilde, Mette, 2023, In: ACS Pharmacology and Translational Science. 6, 8, p. 1120-1128 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Identification of a conserved chemokine receptor motif that enables ligand discrimination

      Larsen, Olav, van der Velden, W. J. C., Mavri, M., Schuermans, S., Rummel, P. C., Karlshøj, S., Gustavsson, Martin, Proost, P., Våbenø, J. & Rosenkilde, Mette, 2022, In: Science Signaling. 15, 724, eabg7042.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction

      Heydorn, A., Ward, R. J., Jorgensen, R., Rosenkilde, Mette, Frimurer, T. M., Milligan, G. & Kostenis, E., 2004, In: Molecular Pharmacology. Vol. 66, no. 2, p. 250-9

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model

      Farrell, H. E., Abraham, A. M., Cardin, R. D., Mølleskov-Jensen, A., Rosenkilde, Mette & Davis-Poynter, N., Apr 2013, In: Journal of Virology. 87, 7, p. 4112-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Importance of endogenous GLP-1 and GIP for postprandial glucose tolerance after Roux-en-Y gastric bypass and sleeve gastrectomy surgery

      Hindso, M., Hedback, N., Moller, A., Svane, M. S., Martinussen, C., Jorgensen, N. B., Dirksen, C., Gasbjerg, Lærke Smidt, Kristiansen, V. B., Hartmann, Bolette, Rosenkilde, Mette, Holst, Jens Juul, Madsbad, Sten & Bojsen-Moller, K. N., 2021, In: Diabetologia. 64, SUPPL 1, p. 200-201 387.

      Research output: Contribution to journal › Conference abstract in journal › Research

    12. Published

      In vivo and in vitro degradation of peptide YY3-36 to inactive peptide YY3-34 in humans

      Toräng, S., Bojsen-Møller, K. N., Svane, M. S., Hartmann, Bolette, Rosenkilde, Mette, Madsbad, Sten & Holst, Jens Juul, 27 Jan 2016, In: A J P: Regulatory, Integrative and Comparative Physiology (Online). 310, 1, p. R866-R874 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats

      Baidassano, S., Gasbjerg, Lærke Smidt, Kizilkaya, Hüsün Sheyma, Rosenkilde, Mette, Holst, Jens Juul & Hartmann, Bolette, 2019, In: Frontiers in Endocrinology. 10, 11 p., 492.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor

      Rode, A. K. O., Buus, Terkild Brink, Mraz, Veronika, Al-Jaberi, F. A. H., Lopez, D. V., Ford, Shayne Lavondua, Hennen, S., Eliasen, I. P., Klewe, I. V., Gharehdaghi, L., Dragan, A., Rosenkilde, Mette, Woetmann, Anders , Skov, Lone, Ødum, Niels, Bonefeld, Charlotte Menne, Kongsbak-Wismann, Martin & Geisler, Carsten, 2022, In: Cells. 11, 16, 2587.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Influence of chain length on the activity of tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)

      Baumann, M., Hussain, M. M., Henne, N., Garrote, D. M., Karlshoj, S., Fossen, T., Rosenkilde, Mette, Vabeno, J. & Haug, B. E., 15 Jan 2017, In: Bioorganic & Medicinal Chemistry. 25, 2, p. 646-657

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Inhibition of HIV Fusion by Small Molecule Agonists through Efficacy-Engineering of CXCR4

      Berg, Christian, Daugvilaite, V., Steen, A., Jørgensen, Astrid Sissel, Våbenø, J. & Rosenkilde, Mette, 20 Apr 2018, In: ACS chemical biology. 13, 4, p. 881-886 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist

      Princen, K., Hatse, S., Vermeire, K., Aquaro, S., De Clercq, E., Gerlach, L., Rosenkilde, Mette, Schwartz, Thue W., Skerlj, R., Bridger, G. & Schols, D., 2004, In: Journal of Virology. 78, 23, p. 12996-3006 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor

      Yuliantie, E., van der Velden, W. J. C., Labroska, V., Dai, A., Zhao, F., Darbalaei, S., Deganutti, G., Xu, T., Zhou, Q., Yang, D., Rosenkilde, Mette, Sexton, P. M., Wang, M. W. & Wootten, D., 2021, In: Biochemical Pharmacology. 192, 16 p., 114715.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Interaction of chemokines with their receptors--from initial chemokine binding to receptor activating steps

      Thiele, S. & Rosenkilde, Mette, 2014, In: Current Medicinal Chemistry. 21, 31, p. 3594-614 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor

      Smit, F. X., van der Velden, W. J. C., Kizilkaya, Hüsün Sheyma, Nørskov, A., Lückmann, Michael, Hansen, T. N., wbf943, wbf943, Qvotrup, K., Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: Structure. 29, 7, p. 679-693.e6 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3

      Lüttichau, H. R., Johnsen, A. H., Jurlander, J., Rosenkilde, Mette & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 24, p. 17794-805 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion

      Kuhre, Rune Ehrenreich, Modvig, Ida Marie, Jepsen, Sara Lind, Kizilkaya, Hüsün Sheyma, Bæch-Laursen, C., Smith, C. A., Reimann, F., Gribble, F. M., Rosenkilde, Mette & Holst, Jens Juul, 2021, In: Frontiers in Endocrinology. 12, 12 p., 690387.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Ligand Modulation of the Epstein-Barr Virus-induced Seven-transmembrane Receptor EBI2: IDENTIFICATION OF A POTENT AND EFFICACIOUS INVERSE AGONIST

      Benned-Jensen, T., Smethurst, C., Holst, Peter Johannes, Page, K. R., Sauls, H., Sivertsen, B. B., Schwartz, Thue W., Blanchard, A., Jepras, R. & Rosenkilde, Mette, 19 Aug 2011, In: Journal of Biological Chemistry. 286, p. 29292-29302 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Ligand binding and micro-switches in 7TM receptor structures

      Nygaard, R., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Schwartz, Thue W., 2009, In: TIPS - Trends in Pharmacological Sciences. 30, 5, p. 249-59 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Ligand entry pathways control the chemical space recognized by GPR183

      Kjær, Viktoria Madeline Skovgaard, Stępniewski, T. M., Medel-Lacruz, B., Reinmuth, L., Ciba, Marija, Ulven, Elisabeth Rexen, Bonomi, M., Selent, J. & Rosenkilde, Mette, 2023, In: Chemical Science. 14, 39, p. 10671-10683

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Ligand-selective small molecule modulators of the constitutively active vGPCR US28

      Amarandi, R., Lückmann, Michael, Melynis, M., Jakobsen, M. H., Fallah, Z., Spiess, Katja, Hjortø, Gertrud Malene, Pui, A., Frimurer, Thomas Michael & Rosenkilde, Mette, 2018, In: European Journal of Medicinal Chemistry. 155, p. 244-254

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Long-acting agonists of human and rodent GLP-2 receptors for studies of the physiology and pharmacological potential of the GLP-2 system

      Gadgaard, S., Windeløv, Johanne Agerlin, Schiellerup, S. P., Holst, Jens Juul, Hartmann, Bolette & Rosenkilde, Mette, 2023, In: Biomedicine and Pharmacotherapy. 160, 13 p., 114383.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice

      Nybo, Maja Lind, Kvam, J. M., Nielsen, J. E., Frederiksen, H., Spiess, Katja, Jensen, Kristian HR, Gadgaard, S., Walser, Anna Louise Silvia, Thomsen, J. S., Cowin, P., Juul, Anders, Jensen, M. B. & Rosenkilde, Mette, 2023, In: FASEB Journal. 37, 2, 13 p., 22781.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes

      Kizilkaya, Hüsün Sheyma, Sørensen, Kimmie Vestergaard, Kibsgaard, C. J., Gasbjerg, Lærke Smidt, Hauser, Alexander Sebastian, wbf943, wbf943, Grarup, Niels & Rosenkilde, Mette, 2021, In: Frontiers in Cell and Developmental Biology. 9, 12 p., 749607.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Maintenance of cardiorespiratory fitness, body composition, and a physically active lifestyle after structured exercise interventions in individuals with overweight and obesity: A mixed-method follow-up study

      Quist, Jonas Salling, Winther, J., Friis, A. L., Gram, A. S., Blond, Martin Bæk, Rosenkilde, Mette, Jespersen, Astrid Pernille & Stallknecht, Bente Merete, 2022, In: Public Health in Practice. 4, 10 p., 100293.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Maintenance of improvements in fitness and fatness 1 year after a 3-month lifestyle intervention in overweight men

      Rosenkilde, Mette, Nordby, P. & Stallknecht, Bente Merete, Oct 2016, In: European Journal of Clinical Nutrition. 70, 10, p. 1212-1214 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor

      Gerlach, L. O., Jakobsen, J. S., Jensen, K. P., Rosenkilde, Mette, Skerlj, R. T., Ryde, U., Bridger, G. J. & Schwartz, Thue W., 2003, In: Biochemistry. 42, 3, p. 710-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Methods for Studying Endocytotic Pathways of Herpesvirus Encoded G Protein-Coupled Receptors

      Mavri, M., Spiess, Katja, Rosenkilde, Mette, Rutland, C. S., Vrecl, M. & Kubale, V., 2020, In: Molecules. 25, 23, 23 p., 5710.

      Research output: Contribution to journal › Review › Research › peer-review

    34. Published

      Microbiological exploitation of the chemokine system

      Holst, Peter Johannes & Rosenkilde, Mette, 2003, In: Microbes and Infection. 5, 2, p. 179-87 8 p.

      Research output: Contribution to journal › Review › Research

    35. Published

      Microbiological exploitation of the chemokine system

      Holst, Peter Johannes & Rosenkilde, Mette, 2003, In: Microbes and Infection. Vol. 2, p. 179-87

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization

      Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Stepniewski, T. M., Madsen, C. M., Jørgensen, Astrid Sissel, Bhuskute, K. R., Inoue, A., Ulven, Trond, Benned-Jensen, T., Hjorth, Siv Annegrethe, Hjortø, Gertrud Malene, Moo, Ee Von, Selent, J. & Rosenkilde, Mette, 2023, In: Science Signaling. 16, 779, 13 p., eabl4283.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor

      Hatse, S., Huskens, D., Princen, K., Vermeire, K., Bridger, G. J., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W. & Schols, D., 2007, In: Journal of Virology. 81, 7, p. 3632-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors

      Thiele, S., Malmgaard-Clausen, M., Engel-Andreasen, J., Steen, A., Rummel, P. C., Nielsen, M. C., Gloriam, David E., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 27 Sep 2012, In: Journal of Medicinal Chemistry. 55, 18, p. 8164-77 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)

      Karlshøj, S., Amarandi, R. M., Larsen, Olav, Daugvilaite, V., Steen, A., Brvar, M., Pui, A., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 23 Dec 2016, In: Journal of Biological Chemistry. 291, 52, p. 26860-26874

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183)

      Benned-Jensen, T., Norn, C., Laurent, S., Madsen, C. M., Larsen, H. M., Arfelt, K. N., Wolf, R. M., Frimurer, Thomas Michael, Sailer, A. W. & Rosenkilde, Mette, 12 Oct 2012, In: The Journal of Biological Chemistry. 287, 42, p. 35470-83 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8

      Jensen, P. C., Nygaard, R., Thiele, S., Elder, A., Zhu, G., Kolbeck, R., Ghosh, S., Schwartz, Thue W. & Rosenkilde, Mette, 2007, In: Molecular Pharmacology. 72, 2, p. 327-40 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Molecular interactions of full-length and truncated GIP peptides with the GIP receptor - A comprehensive review

      Gabe, M. B. N., van der Velden, W. J. C., Smit, F. X., Gasbjerg, Lærke Smidt & Rosenkilde, Mette, 2020, In: Peptides. 125, 8 p., 170224.

      Research output: Contribution to journal › Review › Research › peer-review

    43. Published

      Molecular mechanism of 7TM receptor activation--a global toggle switch model

      Schwartz, Thue W., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Elling, C. E., 2006, In: Annual Review of Pharmacology and Toxicology. 46, p. 481-519 38 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor

      Rosenkilde, Mette, Gerlach, L., Jakobsen, J. S., Skerlj, R. T., Bridger, G. J. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 4, p. 3033-41 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor

      Rosenkilde, Mette, Gerlach, L., Jakobsen, J. S., Skerlj, R. T., Bridger, G. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. VOl. 279, no. 4, p. 3033-41

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor

      Rosenkilde, Mette, Gerlach, L., Hatse, S., Skerlj, R. T., Schols, D., Bridger, G. J. & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 37, p. 27354-65 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity

      Rosenkilde, Mette, Benned-Jensen, T., Holst, Peter Johannes, Kledal, T. N., Lüttichau, H. R., Larsen, J. K., Christensen, Jan Pravsgaard, Schwartz, Thue W. & Andersen, H., 2006, In: Journal of Biological Chemistry. 281, 19, p. 13199-208 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Molecular properties and therapeutic targeting of the ebv-encoded receptor bilf1

      Knerr, J. M., Kledal, T. N. & Rosenkilde, Mette, 2021, In: Cancers. 13, 16, 26 p., 4079.

      Research output: Contribution to journal › Review › Research › peer-review

    49. Published

      Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions

      Rummel, P. C., Arfelt, K. N., Baumann, L., Jenkins, T. J., Thiele, S., Lüttichau, H. R., Johnsen, A., Pease, J., Ghosh, S., Kolbeck, R. & Rosenkilde, Mette, Nov 2012, In: British Journal of Pharmacology. 167, 6, p. 1206-17 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Multiple Targets for Oxysterols in Their Regulation of the Immune System

      Reinmuth, L., Hsiao, C. C., Hamann, J., Rosenkilde, Mette & Mackrill, J., 2021, In: Cells. 10, 8, 27 p., 2078.

      Research output: Contribution to journal › Review › Research › peer-review

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