Mette Rosenkilde

Mette Rosenkilde

Professor

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    ORCID: 0000-0001-9600-3254

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    1. Published

      Discovery of GPR183 Agonists Based on an Antagonist Scaffold

      Kjær, Viktoria Madeline Skovgaard, Ieremias, L., Daugvilaite, V., Lückmann, Michael, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette & Våbenø, J., 2021, In: ChemMedChem. 16, 17, p. 2623-2627

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism

      Kjeldsen, Sasha Alexandra Sampson, Hansen, L. H., Esser, N., Mongovin, S., Winther-Sørensen, Marie, Galsgaard, Katrine Douglas, Dal, Jenna Elizabeth Hunt, Kissow, Hannelouise, Ceutz, F. R., Terzic, D., Mark, P. D., Plomgaard, Peter Stendahl, Goetze, Jens P. , Goossens, G. H., Blaak, E. E., Deacon, Carolyn F., Rosenkilde, Mette, Zraika, S., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Endocrine Research. 5, 9, 15 p., bvab084.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Neprilysin inhibition increases plasma glucagon concentrations in humans with possible implications for hepatic amino acid metabolism

      Liver-Alpha-Cell Axis Grp, L. A. G., 2020, In: Diabetologia. 63, SUPPL 1, p. S72-S72 1 p., 144.

      Research output: Contribution to journal › Conference abstract in journal › Research

    4. E-pub ahead of print

      Using LanM Enzymes to Modify Glycagon-Like Peptides 1 and 2 in E.coli

      Kjeldgaard Larsen, C., Lindquist, Peter, Rosenkilde, Mette, Ravn Madsen, A., Haselmann, K., Glendorf, T., Olesen, K., Bank Kodal, A. L. & Tørring, T., 3 May 2024, (E-pub ahead of print) In: ChemBioChem. p. e202400201

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes

      Kizilkaya, Hüsün Sheyma, Sørensen, Kimmie Vestergaard, Kibsgaard, C. J., Gasbjerg, Lærke Smidt, Hauser, Alexander Sebastian, wbf943, wbf943, Grarup, Niels & Rosenkilde, Mette, 2021, In: Frontiers in Cell and Developmental Biology. 9, 12 p., 749607.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice

      Kissow, Hannelouise, Hartmann, Bolette, Holst, Jens Juul, Viby, N., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hare, K. J. & Poulsen, Steen Seier, 10 Nov 2012, In: Regulatory Peptides. 179, 1-3, p. 91-100 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)

      Karlshøj, S., Amarandi, R. M., Larsen, Olav, Daugvilaite, V., Steen, A., Brvar, M., Pui, A., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 23 Dec 2016, In: Journal of Biological Chemistry. 291, 52, p. 26860-26874

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Biased signaling of G protein-coupled receptors: rom a chemokine receptor CCR7 perspective

      Jørgensen, Astrid Sissel, Rosenkilde, Mette & Hjortø, Gertrud Malene, Mar 2018, In: General and Comparative Endocrinology. 258, SI, p. 4-14

      Research output: Contribution to journal › Review › Research › peer-review

    9. Published

      The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus

      Jørgensen, Astrid Sissel, Brandum, E. P., Mikkelsen, J. M., Orfin, K. A., Boilesen, D. R., Egerod, Kristoffer Lihme, Moussouras, N. A., Vilhardt, Frederik, Kalinski, P., Basse, P., Chen, Yen-Hsi, Yang, Zhang, Dwinell, M. B., Volkman, B. F., Veldkamp, C. T., Holst, Peter Johannes, Lahl, K., Goth, C. K., Rosenkilde, Mette & Hjortø, Gertrud Malene, 2021, In: Cellular and Molecular Life Sciences. 78, p. 6963-6978 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

      Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Frontiers in Immunology. 10, 14 p., 2156.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization

      Jørgensen, Astrid Sissel, Daugvilaite, V., De Filippo, K., Berg, Christian, Mavri, M., Benned-Jensen, T., Juzenaite, G., Hjortø, Gertrud Malene, Rankin, S., Vabeno, J. & Rosenkilde, Mette, 2021, In: Communications Biology . 4, 1, 12 p., 569.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

      Jensen, P. C., Thiele, S., Ulven, Trond, Schwartz, Thue W. & Rosenkilde, Mette, 17 Jun 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-23128 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8

      Jensen, P. C., Nygaard, R., Thiele, S., Elder, A., Zhu, G., Kolbeck, R., Ghosh, S., Schwartz, Thue W. & Rosenkilde, Mette, 2007, In: Molecular Pharmacology. 72, 2, p. 327-40 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

      Jensen, P. C., Thiele, S., Ulven, T., Schwartz, Thue W. & Rosenkilde, Mette, 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Chapter 8. Activation mechanisms of chemokine receptors

      Jensen, P. C. & Rosenkilde, Mette, 2009, In: Methods in Enzymology. 461, p. 171-90 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2

      Jensen, P. C., Thiele, S., Steen, A., Elder, A., Kolbeck, R., Ghosh, S., Frimurer, Thomas Michael & Rosenkilde, Mette, May 2012, In: British Journal of Pharmacology. 166, 1, p. 258-75 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity

      Janssens, R., Boff, D., Ruytinx, P., Mortier, A., Vanheule, V., Larsen, Olav, Daugvilaite, V., Rosenkilde, Mette, Noppen, S., Liekens, S., Schols, D., De Meester, I., Opdenakker, G., Struyf, S., Teixeira, M. M., Amaral, F. A. & Proost, P., 2018, In: Frontiers in Immunology. 9, p. 1933

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo

      Janssens, R., Mortier, A., Boff, D., Vanheule, V., Gouwy, M., Franck, C., Larsen, Olav, Rosenkilde, Mette, Damme, J. V., Amaral, F. A., Teixeira, M. M., Struyf, S. & Proost, P., 2016, In: OncoTarget. 7, 38, p. 62439-62459 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes

      Janssens, R., Mortier, A., Boff, D., Ruytinx, P., Gouwy, M., Vantilt, B., Larsen, Olav, Daugvilaite, V., Rosenkilde, Mette, Parmentier, M., Noppen, S., Liekens, S., Van Damme, J., Struyf, S., Teixeira, M. M., Amaral, F. A. & Proost, P., 2017, In: Biochemical Pharmacology. 132, p. 92-101 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      The Glucagon Receptor Antagonist LY2409021 has No Effect on Postprandial Glucose in Type 2 Diabetes

      Hædersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Forman, Julie Lyng, van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: European Journal of Endocrinology. 186, 2, p. 207-221 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Microbiological exploitation of the chemokine system

      Holst, Peter Johannes & Rosenkilde, Mette, 2003, In: Microbes and Infection. Vol. 2, p. 179-87

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Virally encoded chemokines and chemokine receptors in the role of viral infections

      Holst, Peter Johannes, Lüttichau, H. R., Schwartz, Thue W. & Rosenkilde, Mette, 2003, In: Contributions to Microbiology. 10, p. 232-52 20 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Microbiological exploitation of the chemokine system

      Holst, Peter Johannes & Rosenkilde, Mette, 2003, In: Microbes and Infection. 5, 2, p. 179-87 8 p.

      Research output: Contribution to journal › Review › Research

    24. Published

      Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity

      Holst, Peter Johannes, Rosenkilde, Mette, Manfra, D., Chen, S. C., Wiekowski, M. T., Holst, Birgitte, Cifire, F., Lipp, M., Schwartz, Thue W. & Lira, S. A., 2001, In: Journal of Clinical Investigation. 108, 12, p. 1789-96 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Recent advances of GIP and future horizons

      Holst, Jens Juul & Rosenkilde, Mette, 2020, In: Peptides. 125, 6 p., 170230.

      Research output: Contribution to journal › Review › Research › peer-review

    26. Published

      The role of incretins on insulin function and glucose homeostasis

      Holst, Jens Juul, Gasbjerg, Lærke Smidt & Rosenkilde, Mette, 2021, In: Endocrinology. 162, 7, 10 p., bqab065.

      Research output: Contribution to journal › Review › Research › peer-review

    27. Published

      Physiology of the Incretin Hormones, GIP and GLP-1-Regulation of Release and Posttranslational Modifications

      Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Rosenkilde, Mette & Deacon, Carolyn F., 2019, In: Comprehensive Physiology. 9, 4, p. 1339-1381

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines

      Hjortø, Gertrud Malene, Larsen, Olav, Steen, A., Daugvilaite, V., Berg, Christian, Fares, S., Hansen, M., Ali, S. & Rosenkilde, Mette, 9 Dec 2016, In: Frontiers in Immunology. 7, 568.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      The importance of endogenously secreted GLP-1 and GIP for postprandial glucose tolerance and β-cell function after Roux-en-Y gastric bypass and sleeve gastrectomy surgery

      Hindsø, M., Hedbäck, N., Svane, M. S., Møller, A., Martinussen, C., Jørgensen, N. B., Dirksen, C., Gasbjerg, Lærke Smidt, Kristiansen, V. B., Hartmann, Bolette, Rosenkilde, Mette, Holst, Jens Juul, Madsbad, Sten & Bojsen-Møller, K. N., 2023, In: Diabetes. 72, 3, p. 336–347

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Importance of endogenous GLP-1 and GIP for postprandial glucose tolerance after Roux-en-Y gastric bypass and sleeve gastrectomy surgery

      Hindso, M., Hedback, N., Moller, A., Svane, M. S., Martinussen, C., Jorgensen, N. B., Dirksen, C., Gasbjerg, Lærke Smidt, Kristiansen, V. B., Hartmann, Bolette, Rosenkilde, Mette, Holst, Jens Juul, Madsbad, Sten & Bojsen-Moller, K. N., 2021, In: Diabetologia. 64, SUPPL 1, p. 200-201 387.

      Research output: Contribution to journal › Conference abstract in journal › Research

    31. Published

      Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction

      Heydorn, A., Ward, R. J., Jorgensen, R., Rosenkilde, Mette, Frimurer, T. M., Milligan, G. & Kostenis, E., 2004, In: Molecular Pharmacology. Vol. 66, no. 2, p. 250-9

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      The role of endogenous GIP and GLP-1 in postprandial bone homeostasis

      Helsted, M. M., Gasbjerg, Lærke Smidt, Lanng, A. R., Bergmann, N. C., Stensen, S., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Bone. 140, 7 p., 115553.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor

      Hatse, S., Huskens, D., Princen, K., Vermeire, K., Bridger, G. J., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W. & Schols, D., 2007, In: Journal of Virology. 81, 7, p. 3632-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

      Hatse, S., Princen, K., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W., Hernandez-Abad, P. E., Skerlj, R. T., Bridger, G. J. & Schols, D., 2005, In: Biochemical Pharmacology. 70, 5, p. 752-61 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry

      Hatse, S., Princen, K., Vermeire, K., Gerlach, L., Rosenkilde, Mette, Schwartz, Thue W., Bridger, G., De Clercq, E. & Schols, D., 2003, In: FEBS Letters. 546, 2-3, p. 300-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119

      Hassing, H. A., Fares, S., Larsen, Olav, Pad, H., Pedersen, M. H., Jones, R. M., Schwartz, Thue W., Hansen, Harald S. & Rosenkilde, Mette, 26 Aug 2016, In: Biochemical Pharmacology. 119, 1, p. 66-75 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor

      Hassing, H. A., Engelstoft, M. S., Sichlau, R. M., Madsen, A. N., Rehfeld, Jens Frederik, Pedersen, Jens, Jones, R. M., Holst, Jens Juul, Schwartz, Thue W., Rosenkilde, Mette & Hansen, Harald S., 2016, In: BioFactors. 42, 6, p. 665-673

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells

      Hansen, M. S., Soe, K., Christensen, L. L., Fernandez-Guerra, P., Hansen, N. W., Wyatt, R. A., Martin, C., Hardy, R. S., Andersen, T. L., Olesen, J. B., Hartmann, Bolette, Rosenkilde, Mette, Kassem, M., Rauch, A., Gorvin, C. M. & Frost, M., 2023, In: European Journal of Endocrinology. 188, 1, 14 p., 004.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21

      Hansen, M., Met, Özcan, Larsen, N. B., Rosenkilde, Mette, Andersen, Mads Hald, Svane, Inge Marie & Hjortø, Gertrud Malene, Sep 2016, In: Cytotherapy. 18, 9, p. 1187-1196

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Combined N-terminal and C-terminal truncations of Glucose dependent Insulinotropic Polypeptide (GIP) are potent and efficient GIP receptor antagonists

      Hansen, L. S., wbf943, wbf943, Svendsen, B., Christensen, M., Hartmann, Bolette, Knop, Filip Krag, Holst, Jens Juul & Rosenkilde, Mette, Sep 2015, In: Diabetologia. 58, 1 supplement, p. S276-S277 2 p., 569.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    41. Published

      N- and C-terminally truncated forms of glucose-dependent insulinotropic polypeptide are high-affinity competitive antagonists of the human GIP receptor

      Hansen, L. S., wbf943, wbf943, Christensen, M., Knop, Filip Krag, Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 826-838 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

      Hansen, K. B., Rosenkilde, Mette, Knop, Filip Krag, Wellner, N., Diep, T. A., Rehfeld, Jens Frederik, Andersen, U. B., Holst, Jens Juul & Hansen, Harald S., 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 9, p. E1409-17

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Treatment of insulin resistance and obesity by stimulating GLP-1 release

      Hansen, Harald S., Diep, T. A., Holst, Jens Juul, Rosenkilde, Mette & Andersen, N. W., 29 Dec 2010, IPC No. A61K 31/23, Patent No. PCT/DK2010/050161, 24 Jun 2010

      Research output: Patent

    44. Published

      GPR119 as a fat sensor

      Hansen, Harald S., Rosenkilde, Mette, Holst, Jens Juul & Schwartz, Thue W., Jul 2012, In: Trends in Pharmacological Sciences. 33, 7, p. 374-81 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      High content screening for G protein-coupled receptors using cell-based protein translocation assays

      Grånäs, C., Lundholt, B. K., Heydorn, A., Linde, V., Pedersen, H., Krog-Jensen, C., Rosenkilde, Mette & Pagliaro, L., 2005, In: Combinatorial Chemistry & High Throughput Screening. 8, 4, p. 301-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats

      Grunddal, Kaare Villum, Trammell, Sam, Bæch-Laursen, C., Andersen, Daniel Bjørklund, Xu, S. F. S., Andersen, H., Gillum, M. P., Ghiasi, S. M., Novak, Ivana, Tyrberg, B., Li, C., Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul & Kuhre, Rune Ehrenreich, 2022, In: Diabetologia. 65, p. 1018–1031

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation

      Goth, C. K., Mehta, A. Y., McQuillan, A. M., Baker, K. J., Hanes, M. S., Park, S. S., Stavenhagen, K., Hjortø, Gertrud Malene, Heimburg-Molinaro, J., Chaikof, E. L., Rosenkilde, Mette & Cummings, R. D., 2023, In: Cell Chemical Biology. 30, 8, p. 893-905.e7

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      G Protein-Coupled Receptors in the Sweet Spot: Glycosylation and other Post-translational Modifications

      Goth, C. K., Petaja-Repo, U. E. & Rosenkilde, Mette, 2020, In: ACS Pharmacology & Translational Science. 3, 2, p. 237-245

      Research output: Contribution to journal › Review › Research › peer-review

    49. Published

      Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration

      González-Motos, V., Jürgens, C., Ritter, B., Kropp, K. A., Durán, V., Larsen, Olav, Binz, A., Ouwendijk, W. J. D., Lenac Rovis, T., Jonjic, S., Verjans, G. M. G. M., Sodeik, B., Krey, T., Bauerfeind, R., Schulz, T. F., Kaufer, B. B., Kalinke, U., Proudfoot, A. E. I., Rosenkilde, Mette & Viejo-Borbolla, A., May 2017, In: PLOS Pathogens. 13, 5, 28 p., e1006346.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice

      Gobron, B., Bouvard, B., Vyavahare, S., Blom, L. V. V., Pedersen, K. K., Windeløv, Johanne Agerlin, Boer, G. A., Harada, N., Zhang, S., Shimazu-Kuwahara, S., Wice, B., Inagaki, N., Legrand, E., Flatt, P. R., Chappard, D., Hartmann, Bolette, Holst, Jens Juul, Rosenkilde, Mette, Irwin, N. & Mabilleau, G., 2020, In: Journal of Bone and Mineral Research. 35, 7, p. 1363-1374 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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