Jens Juul Holst

Jens Juul Holst

Professor


  1. 2017
  2. Published

    On the relationship between glucose absorption and glucose‐stimulated secretion of GLP‐1, neurotensin, and PYY from different intestinal segments in the rat

    Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Saltiel, M. Y., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 3 Dec 2017, In: Physiological Reports. 5, 23, 13 p., e13507.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Discovery, characterization, and clinical development of the glucagon-like peptides

    Drucker, D. J., Habener, J. F. & Holst, Jens Juul, 1 Dec 2017, In: The Journal of Clinical Investigation. 127, 12, p. 4217-4227 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  4. Published

    Roles of increased glycemic variability, GLP-1 and glucagon in hypoglycaemia after Roux-en-Y gastric bypass

    Tharakan, G., Behary, P., Albrechtsen, Nicolai Jacob Wewer, Chahal, H., Kenkre, J., Miras, A. D., Ahmed, A. R., Holst, Jens Juul, Bloom, S. R. & Tan, T. M. M., 1 Dec 2017, In: European Journal of Endocrinology. 177, p. 455-464 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Glucagon-like peptide-1 acutely affects renal blood flow and urinary flow rate in spontaneously hypertensive rats despite significantly reduced renal expression of GLP-1 receptors

    Ronn, J., Jensen, E. P., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul & Sorensen, Charlotte Mehlin, Dec 2017, In: Physiological Reports. 5, 23, 14 p., e13503.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Impaired beta cell sensitivity to incretins in type 2 diabetes is insufficiently compensated by higher incretin response

    Tura, A., Bagger, J. I., Ferrannini, E., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina & Mari, A., Dec 2017, In: Nutrition, Metabolism and Cardiovascular Diseases. 27, 12, p. 1123-1129 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Nutrient re-routing and altered gut-islet cell crosstalk may explain early relief of severe postprandial hypoglycaemia after reversal of Roux-en-Y gastric bypass

    Svane, M. S., Toft-Nielsen, M. B., Kristiansen, V. B., Hartmann, Bolette, Holst, Jens Juul, Madsbad, Sten & Bojsen-Møller, K. N., Dec 2017, In: Diabetic Medicine Online. 34, 12, p. 1783-1787

    Research output: Contribution to journalLetterResearchpeer-review

  8. Published

    Semaglutide seems to be more effective the other GLP-1Ras

    Holst, Jens Juul & Madsbad, Sten, Dec 2017, In: Annals of Translational Medicine. 5, 24, 5 p., 505.

    Research output: Contribution to journalComment/debateResearch

  9. Published

    Genetic determinants of circulating GIP and GLP-1 concentrations

    Almgren, P., Lindqvist, A., Krus, U., Hakaste, L., Ottosson-Laakso, E., Asplund, O., Sonestedt, E., Prasad, R. B., Laurila, E., Orho-Melander, M., Melander, O., Tuomi, T., Holst, Jens Juul, Nilsson, P. M., Wierup, N., Groop, L. & Ahlqvist, E., 2 Nov 2017, In: JCI insight. 2, 21, 13 p., e93306.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Cross-Validation of a Glucose-Insulin-Glucagon Pharmacodynamics Model for Simulation Using Data From Patients With Type 1 Diabetes

    Wendt, S. L., Ranjan, A., Møller, J. K., Schmidt, S., Knudsen, C. B., Holst, Jens Juul, Madsbad, Sten, Madsen, H., Nørgaard, Kirsten & Jørgensen, J. B., 1 Nov 2017, In: Journal of Diabetes Science and Technology. 11, 6, p. 1101-1111 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Role of Glucagon in Catabolism and Muscle Wasting of Critical Illness and Modulation by Nutrition

    Thiessen, S. E., Derde, S., Derese, I., Dufour, T., Vega, C. A., Langouche, L., Goossens, C., Peersman, N., Vermeersch, P., Vander Perre, S., Holst, Jens Juul, Wouters, P. J., Vanhorebeek, I. & Van den Berghe, G., 1 Nov 2017, In: American Journal of Respiratory and Critical Care Medicine. 196, 9, p. 1131-1143 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

    Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N. & 9 others, Idorn, T., Deacon, Carolyn F., Knop, Filip Krag, Rosenkilde, Mette, Hartmann, Bolette, Feldt-Rasmussen, Bo, Mann, Matthias, Madsbad, Sten & Holst, Jens Juul, Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues

    Ten Kulve, J. S., Veltman, D. J., Gerdes, V. E. A., van Bloemendaal, L., Barkhof, F., Deacon, Carolyn F., Holst, Jens Juul, Drent, M. L., Diamant, M. & IJzerman, R. G., Nov 2017, In: Diabetes Care. 40, 11, p. 1522-1529 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Single-Dose Metformin Enhances Bile Acid-Induced Glucagon-Like Peptide-1 Secretion in Patients With Type 2 Diabetes

    Brønden, A., Albér, A., Rohde, U., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Nov 2017, In: The Journal of clinical endocrinology and metabolism. 102, 11, p. 4153-4162 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    TRPV1: A Potential Therapeutic Target in Type 2 Diabetes and Comorbidities?

    Gram, D. X., Holst, Jens Juul & Szallasi, A., Nov 2017, In: Trends in Molecular Medicine. 23, 11, p. 1002-1013 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  16. Published

    Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals

    Mumme, L., Breuer, T. G. K., Rohrer, S., Schenker, N., Menge, B. A., Holst, Jens Juul, Nauck, M. A. & Meier, J. J., Oct 2017, In: Diabetes Care. 40, 10, p. 1314-1322 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

    Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., Knop, F. K., Blaak, E. E., Zhao, J., Smidt, H., Harms, A. C., Hankemeijer, T., Bergman, J. J. G. H. M., Romijn, H. A., Schaap, F. G., Olde Damink, S. W. M. & 8 others, Ackermans, M. T., Dallinga-Thie, G. M., Zoetendal, E., de Vos, W. M., Serlie, M. J., Stroes, E. S. G., Groen, A. K. & Nieuwdorp, M., Oct 2017, In: Cell Metabolism. 26, 4, p. 611-619.e6 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Mathematical Modelling of Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide-1 following Ingestion of Glucose

    Røge, R. M., Bagger, J. I., Alskär, O., Kristensen, N. R., Klim, S., Holst, Jens Juul, Ingwersen, S. H., Karlsson, M. O., Knop, Filip Krag, Vilsbøll, Tina & Kjellsson, M. C., Oct 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 4, p. 290-297 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Short-term effects of a low carbohydrate diet on glycaemic variables and cardiovascular risk markers in patients with type 1 diabetes: A randomized open-label crossover trial

    Ranjan, A., Schmidt, S., Damm-Frydenberg, C., Holst, Jens Juul, Madsbad, Sten & Nørgaard, Kirsten, Oct 2017, In: Diabetes, Obesity and Metabolism. 19, 10, p. 1479-1484

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Why is it so difficult to measure glucagon-like peptide-1 in a mouse?

    Windeløv, Johanne Agerlin, Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Hornburg, D., Pedersen, Jens, Jensen, E. P., Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Ørgaard, A., Deacon, Carolyn F., Mann, Matthias, Kissow, Hannelouise, Hartmann, Bolette & Holst, Jens Juul, Oct 2017, In: Diabetologia. 60, 10, p. 2066-2075 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    A sandwich ELISA for measurement of the primary glucagon-like peptide-1 metabolite

    Albrechtsen, Nicolai Jacob Wewer, Asmar, A., Jensen, F., Törang, S., Simonsen, L., Kuhre, Rune Ehrenreich, Asmar, M., Veedfald, Simon, Plamboeck, A., Knop, Filip Krag, Vilsbøll, Tina, Madsbad, Sten, Nauck, M. A., Deacon, Carolyn F., Bülow, J., Holst, Jens Juul & Hartmann, Bolette, 1 Sep 2017, In: American Journal of Physiology: Endocrinology and Metabolism. 313, 3, p. E284-E291

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    High-Intensity Interval Training, Appetite, and Reward Value of Food in the Obese

    Martins, C., Aschehoug, I., Ludviksen, M., Holst, Jens Juul, Finlayson, G., Wisloff, U., Morgan, L., King, N. & Kulseng, B., Sep 2017, In: Medicine and Science in Sports and Exercise. 49, 9, p. 1851-1858 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor

    Asmar, M., Asmar, A., Simonsen, L., Gasbjerg, Lærke Smidt, wbf943, wbf943, Rosenkilde, Mette, Hartmann, Bolette, Dela, Flemming, Holst, Jens Juul & Bülow, J., Sep 2017, In: Diabetes. 66, 9, p. 2363-2371 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    The role of somatostatin in GLP-1-induced inhibition of glucagon secretion in mice

    Ørgaard, A. & Holst, Jens Juul, Sep 2017, In: Diabetologia. 60, 9, p. 1731-1739 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Pancreatic and Intestinal Function Post Roux-en-Y Gastric Bypass Surgery for Obesity

    O'Keefe, S. J. D., Rakitt, T., Ou, J., El Hajj, I. I., Blaney, E., Vipperla, K., Holst, Jens Juul & Rehlfeld, J., 3 Aug 2017, In: Clinical and Translational Gastroenterology. 8, 11 p., e112.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Glucose ingestion causes cardiac repolarization disturbances in type 1 long QT syndrome patients and healthy subjects

    Hyltén-Cavallius, L., Iepsen, E. W., Christiansen, M., Graff, C., Linneberg, Allan René, Pedersen, Oluf Borbye, Holst, Jens Juul, Hansen, Torben, Torekov, Signe Sørensen & Kanters, Jørgen K., Aug 2017, In: Heart Rhythm. 14, 8, p. 1165-1170 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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