Jens Juul Holst

Jens Juul Holst

Professor


  1. 2016
  2. Published

    Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

    Adriaenssens, A. E., Svendsen, B., Lam, B. Y. H., Yeo, G. S. H., Holst, Jens Juul, Reimann, F. & Gribble, F. M., Oct 2016, In: Diabetologia. 59, 10, p. 2156-2165 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes.

    Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Windeløv, Johanne Agerlin, Ørgaard, A., Deacon, Carolyn F., Kissow, Hannelouise, Hartmann, Bolette & Holst, Jens Juul, 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 2, p. E302-E309 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes

    Albrechtsen, Nicolai Jacob Wewer, Albrechtsen, Reidar, Bremholm, L., Svendsen, B., Kuhre, Rune Ehrenreich, Poulsen, Steen Seier, Christiansen, Charlotte Bayer, Jensen, E. P., Janus, C., Hilsted, Linda, Deacon, Carolyn F., Hartmann, Bolette & Holst, Jens Juul, 2016, In: Cell Reports. 17, 11, p. 2845-2856 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The intestinal distribution pattern of appetite- and glucose regulatory peptides in mice, rats and pigs

    Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Toräng, S. & Holst, Jens Juul, 2 Feb 2016, In: BMC Research Notes. 9, 1, p. 1-6 6 p., 60.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Glucagon-like peptide-1 does not have acute effects on central or renal hemodynamics in patients with type 2 diabetes without nephropathy

    Asmar, A., Simonsen, L., Asmar, M., Madsbad, Sten, Holst, Jens Juul, Frandsen, E., Moro, C., Sorensen, Charlotte Mehlin, Jonassen, Thomas & Bulow, J., May 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 310, 9, p. E744-E753 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The blunted effect of glucose-dependent insulinotropic polypeptide in subcutaneous abdominal adipose tissue in obese subjects is partly reversed by weight loss

    Asmar, M., Arngrim, N., Simonsen, L., Asmar, A., Nordby, P., Holst, Jens Juul & Bülow, J., 2016, In: Nutrition and Diabetes. 6, 7 p., e208.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Insulin Plays a Permissive Role for the Vasoactive Effect of GIP Regulating Adipose Tissue Metabolism in Humans

    Asmar, M., Simonsen, L., rck626, rck626, Holst, Jens Juul, Dela, Flemming & Bülow, J., Aug 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 8, p. 3155-62 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Feedback suppression of meal-induced glucagon-like peptide-1 (GLP-1) secretion mediated through elevations in intact GLP-1 caused by dipeptidyl peptidase-4 inhibition: a randomized, prospective comparison of sitagliptin and vildagliptin treatment

    Baranov, O., Kahle, M., Deacon, Carolyn F., Holst, Jens Juul & Nauck, M. A., Nov 2016, In: Diabetes, Obesity and Metabolism. 18, 11, p. 1100-1109 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Secretion of glucagon-like peptide-2 responds to nutrient intake but not glucose provision in milk-fed calves

    Castro, J. J., Morrison, S. Y., Hosseinni, A., Loor, J. J., Drackley, J. K., Ipharraguerre, I. R., Holst, Jens Juul & Hartmann, Bolette, Jul 2016, In: Journal of Dairy Science. 99, 7, p. 5793–5807

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycaemic control (Lira-1): a randomised, double-blind, placebo-controlled trial

    Dejgaard, T. F., Frandsen, C. S., Hansen, T. S., Almdal, Thomas Peter, Urhammer, Søren Asger, Pedersen-Bjergaard, Ulrik, Jensen, T., Jensen, Andreas Kryger, Holst, Jens Juul, Tarnow, L., Knop, Filip Krag, Madsbad, Sten & Andersen, H. U., Mar 2016, In: The Lancet Diabetes & Endocrinology. 4, 3, p. 221–232 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Liraglutide for treating type 1 diabetes

    Dejgaard, T. F., Frandsen, C. S., Holst, Jens Juul & Madsbad, Sten, Apr 2016, In: Expert Opinion on Biological Therapy. 16, 4, p. 579-90 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    No Islet Cell Hyperfunction, but Altered Gut-Islet Regulation and Postprandial Hypoglycemia in Glucose-Tolerant Patients 3 Years After Gastric Bypass Surgery

    Dirksen, C., Eiken, A., Bojsen-Møller, K. N., Svane, M. S., Martinussen, C., Jørgensen, N. B., Holst, Jens Juul & Madsbad, Sten, Sep 2016, In: Obesity Surgery. 26, 9, p. 2263-7 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  14. Published

    Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels

    pjx571, pjx571, Iepsen, E. P. W., Galijatovic, E. A. A., Mahendran, Y., Lundgren, J. R., Jonsson, Anna Elisabet, Madsbad, Sten, Holst, Jens Juul, drb459, drb459, Hansen, Torben & Torekov, Signe Sørensen, Dec 2016, In: Metabolomics. 12, 12, p. 1-9 9 p., 181.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Insulin Resistance is Accompanied by Increased Fasting Glucagon and Delayed Glucagon Suppression in Individuals With Normal and Impaired Glucose Regulation

    Faerch, K., Vistisen, D., Pacini, G., Torekov, Signe Sørensen, Johansen, N. B., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Lauritzen, T., Jørgensen, M. E., Ahrén, B. & Holst, Jens Juul, 8 Aug 2016, In: Diabetes. 65, 11, p. 3473-3481 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Proteomics reveals the effects of sustained weight loss on the human plasma proteome

    Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Tyanova, S., Grassl, N., Iepsen, E. P. W., Lundgren, J., Madsbad, Sten, Holst, Jens Juul, Torekov, Signe Sørensen & Mann, Matthias, 22 Dec 2016, In: Molecular Systems Biology. 12, 16 p., 901.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Comparison of the long-term effects of LIiraglutide and Glimepiride monotherapy on bone mineral density in patients with type 2 diabetes

    Gilbert, M. P., Marre, M., Holst, Jens Juul, Garber, A., Baeres, F. M. M., Thomsen, H. & Pratley, R. E., Apr 2016, In: Endocrine Practice. 22, 4, p. 406-411 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Neurotensin Is Co-Expressed, Co-Released And Acts Together With Glp-1 And Pyy In Enteroendocrine Control Of Metabolism

    Grunddal, Kaare Villum, Ratner, C. F., Svendsen, B., Sommer, F., Engelstoft, M. S., Madsen, A. N., Pedersen, Jens, Nøhr, M. K., Egerod, Kristoffer Lihme, Nawrocki, A. R., Kowalski, T., Howard, A. D., Poulsen, Steen Seier, Offermanns, S., Bäckhed, G. F., Holst, Jens Juul, Holst, Birgitte & Schwartz, Thue W., Jan 2016, In: Endocrinology. 157, 1, p. 176-94 19 p., en20151600.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Disturbed postprandial glucose metabolism and gut hormone responses in non-diabetic patients with psoriasis

    Gyldenløve, M., Vilsbøll, Tina, Holst, Jens Juul, Zachariae, Claus, Skov, L. & Knop, Filip Krag, Nov 2016, In: British Journal of Dermatology. 175, 5, p. 1085–1088

    Research output: Contribution to journalLetterResearchpeer-review

  20. Published

    GLP-1 Restores Altered Insulin and Glucagon Secretion in Posttransplantation Diabetes

    Halden, T. A. S., Egeland, E. J., Åsberg, A., Hartmann, A., Midtvedt, K., Khiabani, H. Z., Holst, Jens Juul, Knop, Filip Krag, Hornum, Mads, Feldt-Rasmussen, Bo & Jenssen, T., 23 Feb 2016, In: Diabetes Care. 39, p. 617-24

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs

    Hansen, C. F., Thymann, Thomas, Andersen, A. D., Holst, Jens Juul, Hartmann, Bolette, Hilsted, Linda, Langhorn, L., Jelsing, J. & Sangild, Per Torp, 28 Jan 2016, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 310, 8, p. G550-560 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    N- and C-terminally truncated forms of glucose-dependent insulinotropic polypeptide are high-affinity competitive antagonists of the human GIP receptor

    Hansen, L. S., wbf943, wbf943, Christensen, M., Knop, Filip Krag, Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 826-838 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Effect of chenodeoxycholic acid and the bile acid sequestrant colesevelam on glucagon-like peptide-1 secretion

    Hansen, M., Scheltema, M. J., Sonne, David Peick, Hansen, J. S., Sperling, M., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jun 2016, In: Diabetes, Obesity and Metabolism. 18, 6, p. 571-80 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor

    Hassing, H. A., Engelstoft, M. S., Sichlau, R. M., Madsen, A. N., Rehfeld, Jens Frederik, Pedersen, Jens, Jones, R. M., Holst, Jens Juul, Schwartz, Thue W., Rosenkilde, Mette & Hansen, Harald S., 2016, In: BioFactors. 42, 6, p. 665-673

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published
  26. Published

    IDegLira Improves Both Fasting and Postprandial Glucose Control as Demonstrated Using Continuous Glucose Monitoring and a Standardized Meal Test

    Holst, Jens Juul, Buse, J. B., Rodbard, H. W., Linjawi, S., Woo, V. C., Boesgaard, T. W., Kvist, K. & Gough, S. C., Mar 2016, In: Journal of Diabetes Science and Technology. 10, 2, p. 389-97 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Gut hormones and gastric bypass

    Holst, Jens Juul, 2016, In: Cardiovascular Endocrinology. 5, 3, p. 69-74 6 p.

    Research output: Contribution to journalReviewResearchpeer-review

  28. Published

    Incretin hormones as a target for therapy

    Holst, Jens Juul, 2016, Handbook of Incretin-based Therapies in Type 2 Diabetes. Gough, S. (ed.). Springer, p. 11-30

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  29. Published

    Mechanisms of surgical control of type 2 diabetes: GLP-1 is key factor

    Holst, Jens Juul & Madsbad, Sten, Jul 2016, In: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 12, 6, p. 1236-42 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Roles of the Gut in Glucose Homeostasis

    Holst, Jens Juul, Gribble, F., Horowitz, M. & Rayner, C. K., Jun 2016, In: Diabetes Care. 39, 6, p. 884-92 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Searching for the physiological role of glucose-dependent insulinotropic polypeptide

    Holst, Jens Juul, Windeløv, Johanne Agerlin, Boer, G. A., Pedersen, Jens, Svendsen, B., Christensen, M., Torekov, Signe Sørensen, Asmar, M., Hartmann, Bolette & Nissen, A., 1 Apr 2016, In: Journal of Diabetes Investigation. 7, S1, p. 8-12 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Safety and Efficacy of Liraglutide in Patients With Type 2 Diabetes and End-Stage Renal Disease: An Investigator-Initiated, Placebo-Controlled, Double-Blinded, Parallel Group, Randomized Trial

    Idorn, T., Knop, Filip Krag, Jørgensen, M. B., Jensen, T., Resuli, M., Hansen, P. M., Christensen, Karl Bang, Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, Feb 2016, In: Diabetes Care. 39, 2, p. 206-13 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3-36

    Iepsen, E. W., Lundgren, J., Holst, Jens Juul, Madsbad, Sten & Torekov, Signe Sørensen, Jun 2016, In: European Journal of Endocrinology. 174, 6, p. 775-784 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Atrial Natriuretic Peptide in the high normal range is associated with lower prevalence of insulin resistance

    Jujić, A., Nilsson, P. M., Persson, M., Holst, Jens Juul, Torekov, Signe Sørensen, Lyssenko, V., Groop, L., Melander, O. & Magnusson, M., 27 Jan 2016, In: The Journal of clinical endocrinology and metabolism. 101, 4, p. 1372-1380 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Diabetic and nondiabetic patients with nonalcoholic fatty liver disease have an impaired incretin effect and fasting hyperglucagonaemia

    Junker, A. E., Gluud, Lise Lotte, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, May 2016, In: Journal of Internal Medicine. 279, 5, p. 485–493 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Effects of glucagon-like peptide-1 on glucagon secretion in patients with non-alcoholic fatty liver disease

    Junker, A. E., Gluud, Lise Lotte, van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, Apr 2016, In: Journal of Hepatology. 64, 4, p. 908–915

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia

    Kristensen, P. L., Pedersen-Bjergaard, Ulrik, Due-Andersen, R., Høi-Hansen, T., Grimmeshave, L., Lyssenko, V., Groop, L., Holst, Jens Juul, Vaag, Allan & Thorsteinsson, B., 2016, In: Endocrine Connections. 5, 6, p. 53-60 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells.

    Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Balk-Møller, E., Rehfeld, Jens Frederik, Relman, F., Gribble, F. M. & Holst, Jens Juul, 2016, In: Journal of Molecular Endocrinology. 56, p. 201-211

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The regulation of function, growth and survival of GLP-1-producing L-cells.

    Kuhre, Rune Ehrenreich, Holst, Jens Juul & Kappe, C., 1 Jan 2016, In: Clinical Science. 130, 2, p. 79-91 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    Afferent Endocrine Control of Eating

    Langhans, W. & Holst, Jens Juul, 22 Aug 2016, Neuroendocrinology of Appetite. Dickson, S. L. & Mercer, J. G. (eds.). Wiley-Blackwell, p. 24-54 31 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  41. Published

    Pancreatic α-cell hyperplasia and hyperglucagonemia due to a mutation of the glucagon

    Larger, E., Albrechtsen, Nicolai Jacob Wewer, Hansen, L. H., Gelling, R. W., Capeau, J., Deacon, Carolyn F., Madsen, O. D., Yakushiji, F., Meyts, P. D., Holst, Jens Juul & Nishimura, E., 2016, In: Endocrinology, Diabetes & Metabolism Case Reports. 2016, 6 p., EDM160081.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Erratum: Evidence of extrapancreatic glucagon secretion in man. Diabetes 2016;65:585-597

    Lund, Asger Bach, Bagger, J. I., Albrechtsen, Nicolai Jacob Wewer, Christensen, M., Grøndahl, M., Hartmann, Bolette, Mathiesen, Elisabeth, Hansen, C. P., Storkholm, J. H., van Hall, Gerrit, Rehfeld, Jens Frederik, Hornburg, D., Meissner, F., Mann, Matthias, Larsen, S., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Jun 2016, In: Diabetes. 65, 6, p. 1752 1 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  43. Published

    Evidence of Extrapancreatic Glucagon Secretion in Man

    Lund, Asger Bach, Bagger, J. I., Albrechtsen, Nicolai Jacob Wewer, Christensen, M., Grøndahl, M., Hartmann, Bolette, Mathiesen, Elisabeth, Hansen, C. P., Storkholm, J. H., van Hall, Gerrit, Rehfeld, Jens Frederik, Hornburg, D., Meissner, F., Mann, Matthias, Larsen, S., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Mar 2016, In: Diabetes. 65, 3, p. 585-597 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Higher Endogenous Glucose Production during OGTT vs Isoglycemic Intravenous Glucose Infusion

    Lund, Asger Bach, Bagger, J. I., Christensen, Mikkel Bring, Grøndahl, M., van Hall, Gerrit, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Nov 2016, In: The Journal of Clinical Endocrinology & Metabolism. 101, 11, p. 4377-4384

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Jejunal feeding is followed by a greater rise in plasma cholecystokinin, peptide YY, glucagon-like peptide 1, and glucagon-like peptide 2 concentrations compared with gastric feeding in vivo in humans: a randomized trial

    Luttikhold, J., van Norren, K., Rijna, H., Buijs, N., Ankersmit, M., Heijboer, A. C., Gootjes, J., Hartmann, Bolette, Holst, Jens Juul, van Loon, L. J. & van Leeuwen, P. A., Feb 2016, In: The American Journal of Clinical Nutrition. 103, 2, p. 435-43 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Guidelines: Surgical or medical therapy for patients with obesity and T2DM?

    Madsbad, Sten & Holst, Jens Juul, 1 Sep 2016, In: Nature Reviews Endocrinology. 12, 9, p. 500-502 3 p.

    Research output: Contribution to journalComment/debateCommunication

  47. Published

    Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men

    Matikainen, N., Björnson, E., Söderlund, S., Borén, C., Eliasson, B., Pietiläinen, K. H., Bogl, L. H., Hakkarainen, A., Lundbom, N., Rivellese, A., Riccardi, G., Després, J., Alméras, N., Holst, Jens Juul, Deacon, Carolyn F., Borén, J. & Taskinen, M., 2016, In: PLOS ONE. 11, 1, p. 1-15 15 p., e0145890.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Glucose-dependent insulinotropic polypeptide (GIP) is associated with lower LDL but unhealthy fat distribution, independent of insulin: The ADDITION-PRO study

    Møller, C. L., Vistisen, D., Færch, K., Johansen, N. B., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Lauritzen, T., Jørgensen, M. E., Torekov, Signe Sørensen & Holst, Jens Juul, Feb 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 2, p. 485– 493 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Quantification of the contribution of GLP-1 to mediating insulinotropic effects of DPP-4 inhibition with vildagliptin in healthy subjects and type 2-diabetic patients using exendin [9-39] as a GLP-1 receptor antagonist.

    Nauck, M. A., Kind, J., Köthe, L. D., Holst, Jens Juul, Deacon, Carolyn F., Broschag, M., He, Y., Kjems, L. & Foley, J., 2016, In: Diabetes. 65, 8, p. 2440-2447 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Regulation of Pancreatic Alpha Cell Function and Proliferation by Bone Morphogenetic Protein 4 (BMP4) in vitro.

    Nielsen, S. S., Christensen, G. L., Holst, Jens Juul & Billestrup, Nils, Oct 2016, In: Endocrinology. 157, 10, p. 3809-3820 12 p., 27479530 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Regulation of Pancreatic α-Cell Function and Proliferation by Bone Morphogenetic Protein 4 (BMP4) In Vitro

    Nielsen, S. S., Christensen, G. L., Holst, Jens Juul & Billestrup, Nils, Oct 2016, In: Endocrinology. 157, 10, p. 3809-3820 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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