Jens Juul Holst
Professor
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
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Reduced incretin effect precedes diabetes development following duodenopancreatectomy in individuals without diabetes
Di Giuseppe, G., Soldovieri, L., Ciccarelli, G., Ferraro, P. M., Quero, G., Cinti, F., Capece, U., Moffa, S., Nista, E. C., Gasbarrini, A., Mari, A., Alfieri, S., Tondolo, V., Pontecorvi, A., Holst, Jens Juul, Giaccari, A. & Mezza, T., 2024, In: Journal of Clinical Investigation. 134, 8, 3 p., e175133.Research output: Contribution to journal › Comment/debate › Research
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Fortifying a meal with oyster mushroom powder beneficially affects postprandial glucagon-like peptide-1, non-esterified free fatty acids and hunger sensation in adults with impaired glucose tolerance: a double-blind randomized controlled crossover trial
Dicks, L., Jakobs, L., Sari, M., Hambitzer, R., Ludwig, N., Simon, M., Stehle, P., Stoffel-Wagner, B., Helfrich, H., Ahlborn, J., Rühl, M., Hartmann, Bolette, Holst, Jens Juul & Ellinger, S., 2022, In: European Journal of Nutrition. 61, p. 687–701Research output: Contribution to journal › Journal article › Research › peer-review
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Fast pouch emptying, delayed small intestinal transit, and exaggerated gut hormone responses after Roux-en-Y gastric bypass
Dirksen, C., Damgaard, Morten, Bojsen-Møller, K. N., Jørgensen, N. B., Kielgast, U., Jacobsen, S. H., Naver, L. S., Worm, Dorte, Holst, Jens Juul, Madsbad, Sten, Hansen, D. L. & Madsen, J. L., Apr 2013, In: Neurogastroenterology and Motility. 25, 4, p. 346-e255 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass
Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Kielgast, U., Jacobsen, S. H., Clausen, T. R., Worm, Dorte, Hartmann, Bolette, Rehfeld, Jens Frederik, Damgaard, Morten, Madsen, J. L., Madsbad, Sten, Holst, Jens Juul & Hansen, D. L., 19 Feb 2013, In: International Journal of Obesity. 37, p. 1452-1459 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass
Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Jacobsen, S. H., Hansen, D. L., Worm, Dorte, Holst, Jens Juul & Madsbad, Sten, 2012, In: Diabetologia. 55, 7, p. 1890-901 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Energy intake, gastrointestinal transit, and gut hormone release in response to oral triglycerides and fatty acids in men with and without severe obesity
Dirksen, C., Graff, J., Fuglsang, S., Rehfeld, Jens Frederik, Holst, Jens Juul & Madsen, J. L., 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 3, p. G332-G337Research output: Contribution to journal › Journal article › Research › peer-review
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Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion: a case report
Dirksen, C., Hansen, D. L., Madsbad, Sten, Hvolris, L. E., Naver, L. S., Holst, Jens Juul & Worm, Dorte, 2010, In: Diabetes Care. 33, 2, p. 375-377Research output: Contribution to journal › Journal article › Research › peer-review
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Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass
Dirksen, C., Bojsen-Møller, K. N., Jørgensen, N. B., Jacobsen, S. H., Kristiansen, V. B., Naver, L. S., Hansen, D. L., Worm, Dorte, Holst, Jens Juul & Madsbad, Sten, 2013, In: Diabetologia. 56, 12, p. 2679-2687Research output: Contribution to journal › Journal article › Research › peer-review
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Reduction in cardiovascular risk factors and insulin dose, but no beta-cell regeneration 1 year after Roux-en-Y gastric bypass in an obese patient with type 1 diabetes: a case report
Dirksen, C., Jacobsen, S. H., Bojsen-Møller, K. N., Jørgensen, N. B., Naver, L. S., Hvolris, L. E., Worm, Dorte, Madsbad, Sten, Holst, Jens Juul & Hansen, D. L., 7 Dec 2013, In: Obesity Research & Clinical Practice. 7, 4, p. e269-74 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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No Islet Cell Hyperfunction, but Altered Gut-Islet Regulation and Postprandial Hypoglycemia in Glucose-Tolerant Patients 3 Years After Gastric Bypass Surgery
Dirksen, C., Eiken, A., Bojsen-Møller, K. N., Svane, M. S., Martinussen, C., Jørgensen, N. B., Holst, Jens Juul & Madsbad, Sten, Sep 2016, In: Obesity Surgery. 26, 9, p. 2263-7 5 p.Research output: Contribution to journal › Letter › Research › peer-review
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Feast or famine - are GLP-1 and ghrelin secretion intertwined?
Djurhuus, C. B., Hansen, T. K., Holst, Jens Juul & Schmitz, O., Jul 2002, In: Hormone and Metabolic Research. Supplement. 34, 7, p. 353-4 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating levels of ghrelin and GLP-1 are inversely related during glucose ingestion
Djurhuus, C. B., Hansen, T. K., Gravholt, C., Ørskov, L., Hosoda, H., Kangawa, K., Jørgensen, J. O. L., Holst, Jens Juul & Schmitz, O., Jul 2002, In: Hormone and Metabolic Research. Supplement. 34, 7, p. 411-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity
Dollerup, O. L., Trammell, Sam, Hartmann, Bolette, Holst, Jens Juul, Christensen, B., Møller, N., Gillum, M. P., Treebak, Jonas Thue & Jessen, N., 1 Nov 2019, In: The Journal of clinical endocrinology and metabolism. 104, 11, p. 5703-5714 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery, characterization, and clinical development of the glucagon-like peptides
Drucker, D. J., Habener, J. F. & Holst, Jens Juul, 1 Dec 2017, In: The Journal of Clinical Investigation. 127, 12, p. 4217-4227 11 p.Research output: Contribution to journal › Review › Research › peer-review
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The expanding incretin universe: from basic biology to clinical translation
Drucker, D. J. & Holst, Jens Juul, 2023, In: Diabetologia. 66, p. 1765-1779Research output: Contribution to journal › Review › Research › peer-review
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Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monosaturated-fat, low-fat, and control diets
Due, A. P., Larsen, T. M., Hermansen, K., Stender, Steen, Holst, Jens Juul, Toubro, S., Martinussen, Torben & Astrup, A., 2008, In: American Journal of Clinical Nutrition. 87, 4, p. 855-862 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monounsaturated-fat, low-fat, and control diets
Due, A. P., Larsen, T. M., Hermansen, K., Stender, Steen, Holst, Jens Juul, Toubro, S., Martinussen, Torben & Astrup, A., 2008, In: American Journal of Clinical Nutrition. 87, 4, p. 855-862 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Atrial natriuretic peptide-like immunoreactive material (ANP-L1) is released from the adrenal gland by splanchnic nerve stimulation
Duntas, L., Bornstein, S. R., Scherbaum, W. & Holst, Jens Juul, 1994, In: Exp.Clin.Endocrinol.. 101, p. 371-373Research output: Contribution to journal › Journal article › Research › peer-review
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Meal-induced compositional changes in blood and saliva in persons with bulimia nervosa
Dynesen, A. W., Jensen, A. B., Astrup, A., Petersson, B., Holst, Jens Juul & Nauntofte, B., 2008, In: American Journal of Clinical Nutrition. 87, 1, p. 12-22 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-1 is a marker of systemic inflammation in patients treated with high-dose chemotherapy and autologous stem cell transplantation
Ebbesen, M. S., Kissow, Hannelouise, Hartmann, Bolette, Grell, Kathrine, Gørløv, J. S., Kielsen, K., Holst, Jens Juul & Muller, Klaus, 2019, In: Biology of Blood and Marrow Transplantation. 25, 6, p. 1085-1091 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-Like Peptide-1 Is Associated With Systemic Inflammation in Pediatric Patients Treated With Hematopoietic Stem Cell Transplantation
Sørum, Maria Ebbesen, Kissow, Hannelouise, Hartmann, Bolette, Kielsen, K., Sørensen, K., Stinson, Sara, Frithioff-Bojsoe, C., Fonvig, Cilius Esmann, Holm, Jens-Christian, Hansen, Torben, Holst, Jens Juul & Müller, K. G., 2021, In: Frontiers in Immunology. 12, 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucometabolic hormones and cardiovascular risk markers in antipsychotic-treated patients
Ebdrup, Bjørn, Knop, Filip Krag, Madsen, A., Mortensen, H. B., Søgaard, B., Holst, Jens Juul, Szecsi, P. B. & Lublin, H., Sep 2014, In: Journal of Clinical Psychiatry. 75, 9, p. e899-905 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis
Edholm, T., Degerblad, M., Grybäck, P., Hilsted, Linda, Holst, Jens Juul, Jacobsson, H., Efendic, S., Schmidt, P. T. & Hellström, P. M., 1 Nov 2010, In: Neurogastroenterology and Motility Online. 22, 11, p. 1191-200, e315 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Difference in postprandial GLP-1 response despite similar glucose kinetics after consumption of wheat breads with different particle size in healthy men
Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, Jens Juul, Deacon, Carolyn F., Rehfeld, Jens Frederik, Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., 2017, In: European Journal of Nutrition. 56, 3, p. 1063-1076 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The structure of wheat bread influences the postprandial metabolic response in healthy men
Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, Jens Juul, Deacon, Carolyn F., Rehfeld, Jens Frederik, Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., Oct 2015, In: Food & Function. 6, 10, p. 3236-48 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin
Egerod, Kristoffer Lihme, Engelstoft, M. S., Grunddal, Kaare Villum, Nøhr, M. K., Secher, A., Sakata, I., Pedersen, Jens, Windeløv, Johanne Agerlin, Füchtbauer, E., Olsen, Jørgen, Sundler, F., Christensen, Jan Pravsgaard, Wierup, N., Olsen, Jesper Velgaard, Holst, Jens Juul, Zigman, J. M., Poulsen, Steen Seier & Schwartz, Thue W., 1 Dec 2012, In: Endocrinology. 153, 12, p. 5782-95 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells
Egerod, Kristoffer Lihme, Engelstoft, M. S., Lund, M. L., Grunddal, Kaare Villum, Zhao, M., Barir-Jensen, D., Nygaard, E. B., Petersen, N., Holst, Jens Juul & Schwartz, Thue W., Nov 2015, In: Endocrinology. 156, 11, p. 3909-23 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sympathoadrenal regulation of adrenocortical steroidogenesis
Ehrhart-Bornstein, M., Bornstein, S. R., Gonzalez-Hernandez, J., Holst, Jens Juul, Watermann, M. R. & Scherbaum, W. A., 1995, In: Endocrine Research. 21, p. 13-24Research output: Contribution to journal › Journal article › Research › peer-review
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Sympathoadrenal regulation of adrenal androstenedione release
Ehrhart-Bornstein, M., Bornstein, S. R., Behling, H. G., Holst, Jens Juul, Strohmayer, H. G., Rasmussen, T. N., Scherbaum, W. A. & Adler, G., 1994, In: Neuroendocrinology. 59, p. 406-412Research output: Contribution to journal › Journal article › Research › peer-review
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Vasoactive intestinal peptide in the porcine adrenal gland
Ehrhart-Bornstein, M., Bornstein, S. R. & Holst, Jens Juul, 1991, In: Neuroendocrinology. 54, p. 623-628Research output: Contribution to journal › Journal article › Research › peer-review
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Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy
Eiken, A., Fuglsang, S., Eiken, M., Svane, M. S., Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hansen, S. H., Trammell, Sam, Svenningsen, J. S., Rehfeld, Jens Frederik, Bojsen-Møller, K. N., Jørgensen, N. B., Holst, Jens Juul, Madsbad, Sten, Madsen, J. L. & Dirkse, C., 2020, In: International Journal of Obesity. 44, p. 1872-1883Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of beta cell and incretin function in patients with MODY1 (HNF4A MODY) and MODY3 (HNF1A MODY) in a Swedish patient collection
Ekholm, E., Shaat, N. & Holst, Jens Juul, Oct 2012, In: Acta Diabetologica. 49, 5, p. 349-54 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion
El-Ouaghlidi, A., Rehring, E., Holst, Jens Juul, Schweizer, A., Foley, J., Holmes, D. & Nauck, M. A., Nov 2007, In: The Journal of clinical endocrinology and metabolism. 92, 11, p. 4165-71 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations
Ellrichmann, M., Kapelle, M., Ritter, P. R., Holst, Jens Juul, Herzig, K. H., Schmidt, W. E., Schmitz, F. & Meier, J. J., 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 10, p. 3995-3998 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations
Ellrichmann, M., Kapelle, M., Ritter, P. R., Holst, Jens Juul, Herzig, K., Schmidt, W. E., Schmitz, F. & Meier, J. J., Oct 2008, In: The Journal of clinical endocrinology and metabolism. 93, 10, p. 3995-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells
Elmelund, E., Galsgaard, Katrine Douglas, Johansen, C. D., Trammell, Sam, Billeschou, Anna, Winther-Sørensen, Marie, Dal, Jenna Elizabeth Hunt, Sorensen, Charlotte Mehlin, Kruse, Thomas, Lau, J. F., Grevengoed, Trisha Jean, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: iScience. 25, 11, 20 p., 105296.Research output: Contribution to journal › Journal article › Research › peer-review
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Intestinal nutrient absorption in newborn pigs in response to enteral nutrition or treatment with glucagon-like peptide 2
Elnif, J., Buddington, R. K., Petersen, Y. M., Hartmann, B., Holst, Jens Juul, Schmidt, M., Burrin, D. G. & Sangild, Per Torp, 2001, Ikke angivet. Lindberg, J. E., Ogle & B. (eds.). CABI Publishing, p. 37-39 3 p.Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research
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Inhibition of gastric emptying by acarbose is correlated with GLP-1 response and accompanied by CCK release
Enc, F. Y., Imeryuz, N., Akin, L. & Holst, Jens Juul, 2001, In: Am J Physiol-Gastr L. 281, p. G752-G763Research output: Contribution to journal › Journal article › Research › peer-review
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Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses
pjx571, pjx571, Mahendran, Y., Jonsson, Anna Elisabet, Gjesing, A. P., Weeke, P. E., Jørgensen, M. E., Færch, K., Witte, D. R., Holst, Jens Juul, Jørgensen, T., Grarup, Niels, Pedersen, Oluf Borbye, drb459, drb459, Torekov, Signe Sørensen, Kanters, Jørgen K. & Hansen, Torben, 2018, In: B M C Genetics. 19, 1, p. 1-9 9 p., 15.Research output: Contribution to journal › Journal article › Research › peer-review
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Treatment with liraglutide may improve markers of CVD reflected by reduced levels of apoB
pjx571, pjx571, Lundgren, Jens, Albrechtsen, Nicolai Jacob Wewer, Mahendran, Y., Iepsen, E. P. W., Finocchietto, P., Jonsson, Anna Elisabet, Madsbad, Sten, Holst, Jens Juul, drb459, drb459, Hansen, Torben & Torekov, Signe Sørensen, 2017, In: Obesity Science & Practice. 3, 4, p. 425-433 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels
pjx571, pjx571, Iepsen, E. P. W., Galijatovic, E. A. A., Mahendran, Y., Lundgren, J. R., Jonsson, Anna Elisabet, Madsbad, Sten, Holst, Jens Juul, drb459, drb459, Hansen, Torben & Torekov, Signe Sørensen, Dec 2016, In: Metabolomics. 12, 12, p. 1-9 9 p., 181.Research output: Contribution to journal › Journal article › Research › peer-review
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Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects
Enç, F. Y., Ones, T., Akin, H. L., Dede, F., Turoglu, H. T., Ulfer, G., Bekiroglu, N., Haklar, G., Rehfeld, Jens Frederik, Holst, Jens Juul, Ulusoy, N. B. & Imeryüz, N., 2008, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 296, 3, p. G482-9Research output: Contribution to journal › Journal article › Research › peer-review
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Reduction of insulinotropic properties of GLP-1 and GIP after glucocorticoid-induced insulin resistance
Eriksen, M., Jensen, D. H., Tribler, S., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 2015, In: Diabetologia. 58, 5, p. 920-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Counterregulatory hormone and symptom responses to hypoglycaemia in people with type 1 diabetes, insulin-treated type 2 diabetes or without diabetes: the Hypo-RESOLVE hypoglycaemic clamp study
Fabricius, T. W., Verhulst, C. E. M., Kristensen, Peter Lommer, Holst, Jens Juul, Tack, C. J., McCrimmon, R. J., Heller, S. R., Evans, M. L., de Galan, B. E., Pedersen-Bjergaard, Ulrik & Hypo-RESOLVE Consortium, H. C., 2024, In: Acta Diabetologica. 61, 5, p. 623-633Research output: Contribution to journal › Journal article › Research › peer-review
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Impaired fasting glycaemia vs impaired glucose tolerance: similar impairment of pancreatic alpha and beta cell function but differential roles of incretin hormones and insulin action
Faerch, K., Vaag, Allan, Holst, Jens Juul, Glümer, C., Pedersen, Oluf Borbye & Borch-Johnsen, K., 2008, In: Diabetologia. 51, 5, p. 853-61 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pathophysiology and aetiology of impaired fasting glycaemia and impaired glucose tolerance: does it matter for prevention and treatment of type 2 diabetes?
Faerch, K., Borch-Johnsen, K., Holst, Jens Juul & Vaag, Allan, 2009, In: Diabetologia. 52, 9, p. 1714-23 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Progression from normal glucose tolerance to impaired fasting glycaemia and impaired glucose tolerance: differential roles of insulin resistance and beta cell dysfunction
Faerch, K., Vaag, Allan, Holst, Jens Juul, Pedersen, O., Glumer, C. & Borch-Johnsen, K., 2008, In: Diabetologia. 51, Suppl. 1, p. S85-S86Research output: Contribution to journal › Journal article › Research › peer-review
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Determinants of glycemic charges in normoglycemic individuals
Faerch, K., Vaag, Allan, Holst, Jens Juul, Hansen, T., Glumer, C. & Borch-Johnsen, K., 2008, In: Diabetes. Suppl. 1, p. A659-A659 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele
Faerch, K., Pilgaard, K., Knop, Filip Krag, Hansen, Torben, Pedersen, Oluf Borbye, Jørgensen, T. & Holst, Jens Juul, 2012, In: Diabetes, Obesity and Metabolism Online. 15, 1, p. 91-95 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Insulin Resistance is Accompanied by Increased Fasting Glucagon and Delayed Glucagon Suppression in Individuals With Normal and Impaired Glucose Regulation
Faerch, K., Vistisen, D., Pacini, G., Torekov, Signe Sørensen, Johansen, N. B., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Lauritzen, T., Jørgensen, M. E., Ahrén, B. & Holst, Jens Juul, 8 Aug 2016, In: Diabetes. 65, 11, p. 3473-3481 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
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