Jens Juul Holst
Professor
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
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Increased Hepatic Insulin Clearance After Roux-en-Y Gastric Bypass
Bojsen-Møller, K. N., Dirksen, C., Jørgensen, N. B., Jacobsen, S. H., Hansen, D. L., Worm, Dorte, Naver, L., Kristiansen, V. B., Holst, Jens Juul & Madsbad, Sten, 22 Apr 2013, In: Journal of Clinical Endocrinology and Metabolism. 98, 6, p. E1066-E1071 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Variable reliability of surrogate measures of insulin sensitivity after Roux-en-Y gastric bypass
Bojsen-Møller, K. N., Dirksen, C., Svane, M. S., Jørgensen, N. B., Holst, Jens Juul, Richter, Erik A. & Madsbad, Sten, 2017, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 312, 5, p. R797-R805 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations—Role of Carbohydrate and Energy Availability
Bojsen-Møller, K. N., Lundsgaard, Anne-Marie, Madsbad, Sten, Kiens, Bente & Holst, Jens Juul, Nov 2018, In: Diabetes. 67, 11, p. 2129-2136 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass
Bojsen-Møller, K. N., Dirksen, C., Jørgensen, N. B., Jacobsen, S. H., Serup, A. K. L., Albers, P. H., Hansen, D. L., Worm, D., Naver, L., Kristiansen, V. B., Wojtaszewski, Jørgen F P, Kiens, Bente, Holst, Jens Juul, Richter, Erik A. & Madsbad, Sten, 2014, In: Diabetes. 63, 5, p. 1725-1737 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Follistatin secretion is enhanced by protein, but not glucose or fat ingestion in obese persons independently of previous gastric bypass surgery
Bojsen-Møller, K. N., Svane, M. S., Jensen, Christian Zinck, Kjeldsen, Sasha Alexandra Sampson, Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer & Madsbad, Sten, 2021, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 320, 5, p. G753-G758Research output: Contribution to journal › Journal article › Research › peer-review
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Primary weight loss failure after Roux-en-Y gastric bypass is characterized by impaired gut-hormone mediated regulation of food intake
Bojsen-Møller, Kirstine Nyvold, Svane, M. S., Martinussen, C., Dirksen, Carsten Moro, Jørgensen, Nils Bruun, Jensen, Jens-Erik Beck, Jensen, Christian Zinck, Torekov, Signe Sørensen, Kristiansen, V. B., Rehfeld, Jens Frederik, Bork-Jensen, J., Grarup, Niels, Hansen, Torben, Hartmann, Bolette, Holst, Jens Juul & Madsbad, Sten, 2023, In: International Journal of Obesity. 47, 11, p. 1143-1151 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Selectivity of prandial glucose regulators: nateglinide, but not repaglinide, accelerates exocytosis in rat pancreatic A-cells
Bokvist, K., Høy, M., Buschard, K., Holst, Jens Juul, Thomsen, M. K. & Gromada, J. L., 1999, In: Eur. J. Pharmacol.. 386, p. 105-111Research output: Contribution to journal › Journal article › Research › peer-review
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Evaluation of commercially available glucagon receptor antibodies and glucagon receptor expression
Billeschou, Anna, Johansen, C. D., Christensen, J. B., Kjeldsen, Sasha Alexandra Sampson, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Serizawa, R., Hornum, Mads, Porrini, E., Pedersen, Jens, Ørskov, Cathrine, Gluud, Lise Lotte, Sorensen, Charlotte Mehlin, Holst, Jens Juul, Albrechtsen, Reidar & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Communications Biology . 5, 1, 13 p., 1278.Research output: Contribution to journal › Journal article › Research › peer-review
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Reduced postprandial GLP-1 responses in women with gestational diabetes mellitus
Bonde, L., Vilsbøll, Tina, Nielsen, T., Bagger, J. I., Svare, J. A., Holst, Jens Juul, Larsen, S. & Knop, Filip Krag, 13 Feb 2013, In: Diabetes, Obesity and Metabolism. 15, 8, p. 713-720 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Improved tolerance to sequential glucose loading (Staub-Traugott effect): size and mechanisms
Bonuccelli, S., Muscelli, E., Gastaldelli, A., Barsotti, E., Astiarraga, B. D., Holst, Jens Juul, Mari, A. & Ferrannini, E., 2009, In: American Journal of Physiology: Endocrinology and Metabolism. 297, 2, p. E532-7Research output: Contribution to journal › Journal article › Research › peer-review
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Abscisic acid controls the release of insulin from beta-cells, Glucagon-Like Peptide-1 from intestinal L-cells and glucagon from alpha-cells
Booz, V., Christiansen, Charlotte Bayer, Kuhre, Rune Ehrenreich, Saltiel, M. Y., Sturla, L., Sociali, G., Zocchi, E., Holst, Jens Juul & Bruzzone, S., 2017, In: European Journal of Clinical Investigation. 47, p. 112-113Research output: Contribution to journal › Conference abstract in journal › Research
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Abscisic acid stimulates the release of insulin and of GLP-1 in the rat perfused pancreas and intestine
Booz, V., Christiansen, Charlotte Bayer, Kuhre, Rune Ehrenreich, Saltiel, M. Y., Sociali, G., Schaltenberg, N., Fischer, A. W., Heeren, J., Zocchi, E., Holst, Jens Juul & Bruzzone, S., 2019, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 35, 8 p., e3102.Research output: Contribution to journal › Journal article › Research › peer-review
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Restoration of enteroendocrine and pancreatic function after internal hernia and short bowel syndrome in a young woman with gastric bypass: a 2-year follow-up
Borghede, M., Vinter-Jensen, L., Rasmussen, H. H., Veedfald, Simon, Rehfeld, Jens Frederik, Hartmann, Bolette, Holst, Jens Juul, Knop, Filip Krag & Sonne, D. P., 2018, In: Physiological Reports. 6, 9, 6 p., e13686.Research output: Contribution to journal › Journal article › Research › peer-review
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Vasoactive intestinal peptide (VIP) stimulates androstenedione release in isolated perfused pig adrenals
Bornstein, S. R., Ehrhart-Bornstein, M., Stromeyer, H. G., Adler, G., Scherbaum, W. A. & Holst, Jens Juul, 1993, In: Life Sciences. 52, p. 135-140Research output: Contribution to journal › Journal article › Research › peer-review
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The effects of dietary fibre type on satiety-related hormones and voluntary food intake in dogs
Bosch, G., Verbrugghe, A., Hesta, M., Holst, Jens Juul, van der Poel, A. F. B., Janssens, G. P. J. & Hendriks, W. H., 2009, In: British Journal of Nutrition. 102, 2, p. 318-25 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes
Bowman, P., Patel, K. A., McDonald, T. J., Holst, Jens Juul, Hartmann, Bolette, Leveridge, M., Shields, B. M., Hammersley, S., Spaull, S. R., Knight, B. A., Flanagan, S. E., Shepherd, M. H., Andrews, R. C. & Hattersley, A. T., 2023, In: Journal of Diabetes Investigation. 14, 12, p. 1378-1382Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 and GLP-2 act in concert to inhibit fasted, but not fed, small bowel motility in the rat.
Bozkurt, A., Näslund, E., Holst, Jens Juul & Hellström, P. M., 2002, In: Regulatory Peptides. 107, 1-3, p. 129-35 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Acute effects of casein on postprandial lipemia and incretin responses in type 2 diabetic subjects
Brader, L. J., Holm, L., Mortensen, L., Thomsen, C., Astrup, A., Holst, Jens Juul, Vrese, M. D., Schrezenmeir, J. & Hermansen, K., 2010, In: Nutrition, Metabolism & Cardiovascular Diseases. 20, 2, p. 101-109 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Immunoneutralization of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycemia in moderately streptozotocin-diabetes rats
Brand, C. L., Rolin, B., Jørgensen, P. N., Svendsen, J. S. & Holst, Jens Juul, 1994, In: Diabetologia. 37, p. 985-993Research output: Contribution to journal › Journal article › Research › peer-review
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The role of glucagon in the maintenance of euglycemia in the fed and the fasted state. Monoclonal antibody treatment as a tool in glucagon physiology in rats.
Brand, C. L., Jørgensen, P. N., Svendsen, I., Kristensen, J. S., Knigge, U., Warberg, J. & Holst, Jens Juul, 1995, In: Am. J. Physiol.. 269, p. E469-E477Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of Glucagon-Like Peptide-2 on mesenteric blood flow and cardiac parameters in end-jejunostomy short bowel patients
Bremholm, L., Hornum, Mads, Andersen, U. B., Hartmann, Bolette, Holst, Jens Juul & Jeppesen, Palle Bekker, 2011, In: Regulatory Peptides. 168, 1-3, p. 32-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-2 increases mesenteric blood flow in humans
Bremholm, L., Hornum, Mads, Henriksen, B. M., Larsen, S. & Holst, Jens Juul, 2008, In: Scandinavian Journal of Gastroenterology. 44, 3, p. 314-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of glucagon-like peptide-2 on arterial blood flow and cardiac parameters
Bremholm, L., Hornum, Mads, Andersen, U. B. & Holst, Jens Juul, 8 Jan 2010, In: Regulatory Peptides. 159, 1-3, p. 67-71 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased meal-induced neurotensin response predicts successful maintenance of weight loss: Data from a randomized controlled trial
Brethvad, Annemette Overgaard, Zakariassen, Hannah Louise, Holt, Joachim, Lundgren, J. R., Jakobsen, A., Hartmann, Bolette, Lehmann, E. W., Kissow, Hannelouise, Holst, Jens Juul, Madsbad, Sten, Torekov, Signe Sørensen & Holst, Birgitte, 2023, In: Metabolism: Clinical and Experimental. 143, 8 p., 155534.Research output: Contribution to journal › Journal article › Research › peer-review
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Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors
Brighton, C. A., Rievaj, J., Kuhre, Rune Ehrenreich, Glass, L. L., Schoonjans, K., Holst, Jens Juul, Gribble, F. M. & Reimann, F., 2015, In: Endocrinology. 156, 11, p. 3961-1370 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Enteral nutrients potentiate glucagon-like peptide-2 action and reduce dependence on parenteral nutrition in a rat model of human intestinal failure
Brinkman, A. S., Murali, S. G., Hitt, S., Solverson, P. M., Holst, Jens Juul & Ney, D. M., 1 Sep 2012, In: A J P: Gastrointestinal and Liver Physiology (Online). 303, 5, p. G610-22Research output: Contribution to journal › Journal article › Research › peer-review
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Gastrointestinal Motility in Patients with End-Stage Renal Diease on Chronic Hemodialysis
Broberg, B., Madsen, J., Fuglsang, S., Holst, Jens Juul, Christensen, Karl Bang, Rydahl, C., Idorn, T., Feldt-Rasmussen, Bo & Hornum, Mads, 1 Feb 2018, In: Nephrology Dialysis Transplantation. 33, Supplement 1, p. 318 1 p., SaO009 .Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Gastrointestinal motility in patients with end-stage renal disease on chronic hemodialysis
Broberg, B., Madsen, J. L., Fuglsang, S., Holst, Jens Juul, Christensen, Karl Bang, Rydahl, C., Idorn, T., Feldt-Rasmussen, Bo & Hornum, Mads, 2019, In: Neurogastroenterology and Motility. 31, 4, e13554.Research output: Contribution to journal › Journal article › Research › peer-review
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Counter-regulatory hormone responses to spontaneous hypoglycaemia during treatment with insulin Aspart or human soluble insulin: a double-blinded randomized cross-over study
Brock Jacobsen, I., Vind, B. F., Korsholm, L., Flyvbjerg, A., Frystyk, J., Holst, Jens Juul, Beck-Nielsen, H. & Henriksen, J. E., 2011, In: Acta Physiologica (Print). 202, 3, p. 337-347 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY: A human-randomized cross-over trial
Brodersen, K., Mose, M., Ramer Mikkelsen, U., Jørgensen, J. O. L., Festersen Nielsen, M., Møller, N., Wegeberg, A., Brock, C., Hartmann, Bolette, Holst, Jens Juul & Rittig, N., 2022, In: Physiological Reports. 10, 18, 12 p., e15462.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparable Effects of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass on Basal Fuel Metabolism and Insulin Sensitivity in Individuals with Obesity and Type 2 Diabetes
Brodersen, K., Nielsen, M. F., Richelsen, B., Lauritzen, E. S., Pahle, E., Abrahamsen, J., Hartmann, Bolette, Holst, Jens Juul & Møller, N., 2022, In: Journal of Diabetes Research. 2022, 9 p., 5476454.Research output: Contribution to journal › Journal article › Research › peer-review
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Liraglutide decreases postprandial fibroblast growth factor 19 and glucagon-like peptide 2, and increases postprandial cholecystokinin in individuals with obesity
Bronden, A., Nerild, H. H., Nexoe-Larsen, C. C., Hellmann, P. H., Baekdal, M., Gether, I. M., Gillum, M. P., Hartmann, Bolette, Knudsen, L. B., Jacobsen, L. V., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina, Sonne, D. P. & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 94-94 177.Research output: Contribution to journal › Conference abstract in journal › Research
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Metformin potentiates bile acid-induced GLP-1 secretion in patients with type 2 diabetes
Bronden, A., Alber, A., Rohde, U., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2017, In: Diabetologia. 60, p. 113-113 242.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Relationships among tonic and episodic aspects of motivation to eat, gut peptides, and weight before and after bariatric surgery
Bryant, E. J., King, N. A., Falkén, Y., Hellström, P. M., Holst, Jens Juul, Blundell, J. E. & Näslund, E., 12 Oct 2012, In: Surgery for Obesity and Related Diseases.Research output: Contribution to journal › Journal article › Research › peer-review
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The bile acid-sequestering resin sevelamer eliminates the acute GLP-1 stimulatory effect of endogenously released bile acids in patients with type 2 diabetes
Brønden, A., Albér, A., Rohde, U., Gasbjerg, Lærke Smidt, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Feb 2018, In: Diabetes, Obesity and Metabolism. 20, 2, p. 362-369Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose-lowering effects and mechanisms of the bile acid-sequestering resin sevelamer
Brønden, A., Mikkelsen, K., Sonne, D. P., Hansen, M., Våben, C., Gabe, M. N., Rosenkilde, Mette, Tremaroli, V., Wu, H., Bäckhed, F., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jul 2018, In: Diabetes, Obesity and Metabolism. 20, 7, p. 1623-1631Research output: Contribution to journal › Journal article › Research › peer-review
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Single-Dose Metformin Enhances Bile Acid-Induced Glucagon-Like Peptide-1 Secretion in Patients With Type 2 Diabetes
Brønden, A., Albér, A., Rohde, U., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Nov 2017, In: The Journal of clinical endocrinology and metabolism. 102, 11, p. 4153-4162 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide-1 in the rat
Bucinskaite, V., Tolessa, T., Pedersen, J., Rydqvist, B., Zerihun, L., Holst, Jens Juul & Hellström, P. M., 2009, In: Neurogastroenterology and Motility. 21, 9, p. 978-e78Research output: Contribution to journal › Journal article › Research › peer-review
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Possible role of adiponectin and insulin sensitivity in mediating the favorable effects of lower body fat mass on blood lipids
Buemann, B., Astrup, A., Pedersen, O., Black, E., Holst, C., Toubro, S., Echwald, S., Holst, Jens Juul, Rasmussen, C. & Sørensen, Thorkild I.A., 2006, In: Journal of Clinical Endocrinology and Metabolism. 91, 5, p. 1698-1704 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lower-body fat mass as an independent marker of insulin sensitivity - the role of adiponectin?
Buemann, B., Black, E., Sørensen, Thorkild I.A., Holst, C., Toubro, S., Pedersen, O., Holst, Jens Juul, Rasmussen, C. & Astrup, A., 2005, In: International Journal of Obesity. 29, p. 624-631Research output: Contribution to journal › Journal article › Research › peer-review
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Naturally occurring products of proglucagon 111-160 in the porcine and human small intestine
Buhl, T., Thim, L., Kofod, H., Ørskov, Cathrine, Harling, H. & Holst, Jens Juul, 25 Jun 1988, In: Journal of Biological Chemistry. 263, 18, p. 8621-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide 2 stimulates intestinal growth by decreasing proteolysis and apoptosis in parenterally fed premature piglets
Burrin, D. G., Stoll, B., Jiang, R., Petersen, Y., Elnif, J., Buddington, R. K., Schmidt, M., Holst, Jens Juul, Hartmann, B. & Sangild, Per Torp, 2001, Ikke angivet. Lindberg, J. E., Ogle & B. (eds.). CABI Publishing, p. 40-42 3 p.Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research
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Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: how much is enough?
Burrin, D. G., Stoll, B., Jiang, R., Chang, X., Hartmann, B., Holst, Jens Juul, Greeley, G. H. & Reeds, P. J., 2000, In: Am. J. Clin. Nutr.. 71, p. 1603-1610Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-2 dose-dependently activates intestinal cell survival and proliferation in neonatal piglets
Burrin, D. G., Stoll, B., Guan, X., Cui, L., Chang, X. & Holst, Jens Juul, 2005, In: Endokrinologiya. 146, p. 22-32Research output: Contribution to journal › Journal article › Research
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GLP-2 stimulates intestinal growth by suppressing proteolysis and apoptosis in TNP-fed premature pigs
Burrin, D. G., Stoll, B., Jiang, R., Petersen, Y., Elnif, J., Buddington, R. K., Schmidt, M., Holst, Jens Juul, Hartmann, B. & Sangild, P. T., 2000, In: Am. J. Physiol.. 279, p. G1249-G1256Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-2 stimulates intestinal growth in premature TPN-fed pigs by suppressing proteolysis and apoptosis
Burrin, D. G., Stoll, B., Jiang, R. & Holst, Jens Juul, 2001, In: Am J Physiol-Gastr L. 279, p. G1249-G1256Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide 2 dose-dependently activates intestinal cell survival and proliferation in neonatal piglets
Burrin, D. G., Stoll, B., Guan, X., Cui, L., Chang, X. & Holst, Jens Juul, Jan 2005, In: Endocrinology. 146, 1, p. 22-32 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Influence of short term verapamil treatment on glucose metabolism in patients with non-insulin dependent diabetes mellitus
Busch Sørensen, M., Sjøstrand, H., Holst, Jens Juul, Sengeløv, H., Tiefenthal Thrane, M. & Lyngsøe, J., 1991, In: EUR. J. Clin. Pharmacol.. 41, p. 401-404Research output: Contribution to journal › Journal article › Research › peer-review
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Liraglutide Treatment Is Associated with a Low Frequency and Magnitude of Antibody Formation with No Apparent Impact on Glycemic Response or Increased Frequency of Adverse Events: Results from the Liraglutide Effect and Action in Diabetes (LEAD) trials
Buse, J. B., Garber, A., Rosenstock, J., Schmidt, W. E., Brett, J. H., Videbæk, N., Holst, Jens Juul & Nauck, M., 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 6, p. 1695-702 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity
Böhm, A., Wagner, R., Machicao, F., Holst, Jens Juul, Gallwitz, B., Stefan, N., Fritsche, A., Häring, H. & Staiger, H., 2017, In: PloS one. 12, 7, 13 p., e0181880.Research output: Contribution to journal › Journal article › Research › peer-review
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
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