Gertrud Malene Hjortø

Gertrud Malene Hjortø

Associate Professor


Publication year:
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1 - 40 out of 40Page size: 100
  1. 2023
  2. Published

    Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation

    Goth, C. K., Mehta, A. Y., McQuillan, A. M., Baker, K. J., Hanes, M. S., Park, S. S., Stavenhagen, K., Hjortø, Gertrud Malene, Heimburg-Molinaro, J., Chaikof, E. L., Rosenkilde, Mette & Cummings, R. D., 2023, In: Cell Chemical Biology. 30, 8, p. 893-905.e7

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization

    Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Stepniewski, T. M., Madsen, C. M., Jørgensen, Astrid Sissel, Bhuskute, K. R., Inoue, A., Ulven, Trond, Benned-Jensen, T., Hjorth, Siv Annegrethe, Hjortø, Gertrud Malene, Moo, Ee Von, Selent, J. & Rosenkilde, Mette, 2023, In: Science Signaling. 16, 779, 13 p., eabl4283.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    “Glyco-sulfo barcodes” regulate chemokine receptor function

    Verhallen, L., Lackman, Jarkko Juhani, Wendt, R., Gustavsson, Martin, Yang, Zhang, Narimatsu, Yoshiki, Sørensen, Daniel Madriz, Lafferty, K. M., Gouwy, M., Marques, P. E., Hjortø, Gertrud Malene, Rosenkilde, Mette, Proost, P. & Goth, C. K., 2023, In: Cellular and Molecular Life Sciences. 80, 2, 18 p., 55.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2022
  6. Published

    Rewiring host–microbe interactions and barrier function during gastrointestinal inflammation

    Jensen, Sune K. , Pærregaard, S. I., Brandum, E. P., Jørgensen, Astrid Sissel, Hjortø, Gertrud Malene & Jensen, Benjamin Anderschou Holbech, 25 Jan 2022, In: Gastroenterology Report. 10, p. 1-15 goac008.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    GPR183 is Dispensable for B1 cell Accumulation and Function, but Affects B2 cell Abundance, in the Omentum and Peritoneal Cavity

    Barington, L., Christensen, Liv von Voss, Pedersen, K. K., Arfelt, K. N., Roumain, M., Jensen, Kristian HR, Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Kearney, J. F., Christensen, Jan Pravsgaard, Hjortø, Gertrud Malene, Muccioli, G. G., Holst, Peter Johannes & Rosenkilde, Mette, 2022, In: Cells. 11, 3, 19 p., 494.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails

    Brandum, E. P., Jørgensen, Astrid Sissel, Calvo, M. B., Spiess, Katja, Peterson, F. C., Yang, Zhang, Volkman, B. F., Veldkamp, C. T., Rosenkilde, Mette, Goth, C. K. & Hjortø, Gertrud Malene, 2022, In: International Journal of Molecular Sciences. 23, 3, 20 p., 1397.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 2021
  10. Published

    Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization

    Jørgensen, Astrid Sissel, Daugvilaite, V., De Filippo, K., Berg, Christian, Mavri, M., Benned-Jensen, T., Juzenaite, G., Hjortø, Gertrud Malene, Rankin, S., Vabeno, J. & Rosenkilde, Mette, 2021, In: Communications Biology . 4, 1, 12 p., 569.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

    van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus

    Jørgensen, Astrid Sissel, Brandum, E. P., Mikkelsen, J. M., Orfin, K. A., Boilesen, D. R., Egerod, Kristoffer Lihme, Moussouras, N. A., Vilhardt, Frederik, Kalinski, P., Basse, P., Chen, Yen-Hsi, Yang, Zhang, Dwinell, M. B., Volkman, B. F., Veldkamp, C. T., Holst, Peter Johannes, Lahl, K., Goth, C. K., Rosenkilde, Mette & Hjortø, Gertrud Malene, 2021, In: Cellular and Molecular Life Sciences. 78, p. 6963-6978 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. 2020
  14. Published

    Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21

    Moussouras, N. A., Hjortø, Gertrud Malene, Peterson, F. C., Szpakowska, M., Chevigné, A., Rosenkilde, Mette, Volkman, B. F. & Dwinell, M. B., 7 Apr 2020, In: Biochemistry. 59, 13, p. 1338-1350 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Three-Dimensional Explant Platform for Studies on Choroid Plexus Epithelium

    Petersen, N., Pedersen, Lola Julie Torz, Jensen, Kristian HR, Hjortø, Gertrud Malene, Spiess, Katja & Rosenkilde, Mette, 2020, In: Frontiers in Cellular Neuroscience. 14, 11 p., 108.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. 2019
  17. Published

    Arrestin-independent constitutive endocytosis of GPR125/ADGRA3

    Spiess, Katja, Bagger, Sofie Morsing, Pedersen, Lola Julie Torz, Jensen, Kristian HR, Walser, Anna Louise Silvia, Kvam, J. M., Mogelmose, A. K., Daugvilaite, V., Junnila, R. K., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Annals of the New York Academy of Sciences. 1456, p. 186–199

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

    Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Frontiers in Immunology. 10, 14 p., 2156.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. 2018
  20. Published

    Biased signaling of G protein-coupled receptors: rom a chemokine receptor CCR7 perspective

    Jørgensen, Astrid Sissel, Rosenkilde, Mette & Hjortø, Gertrud Malene, Mar 2018, In: General and Comparative Endocrinology. 258, SI, p. 4-14

    Research output: Contribution to journal › Review › Research › peer-review

  21. Published

    CCL19 with CCL21-tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells

    Jørgensen, Astrid Sissel, Adogamhe, P. E., Laufer, J. M., Legler, D. F., Veldkamp, C. T., Rosenkilde, M. M. & Hjortø, Gertrud Malene, 2018, In: Journal of Leukocyte Biology. 104, 2, p. 401-411

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Ligand-selective small molecule modulators of the constitutively active vGPCR US28

    Amarandi, R., Lückmann, Michael, Melynis, M., Jakobsen, M. H., Fallah, Z., Spiess, Katja, Hjortø, Gertrud Malene, Pui, A., Frimurer, Thomas Michael & Rosenkilde, Mette, 2018, In: European Journal of Medicinal Chemistry. 155, p. 244-254

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

    Miles, T. F., Spiess, Katja, Jude, K. M., Tsutsumi, N., Burg, J. S., Ingram, J. R., Waghray, D., Hjortø, Gertrud Malene, Larsen, Olav, Ploegh, H. L., Rosenkilde, Mette & Garcia, K. C., 2018, In: eLife. 7, 23 p., e35850 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. 2017
  25. Published

    Signaling via G proteins mediates tumorigenic effects of GPR87

    Arfelt, K. N., Fares, S., wbf943, wbf943, Hjortø, Gertrud Malene, Gasbjerg, Lærke Smidt, Molleskov-Jensen, A., Benned-Jensen, T. & Rosenkilde, Mette, Jan 2017, In: Cellular Signalling. 30, p. 9-18

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. 2016
  27. Published

    Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines

    Hjortø, Gertrud Malene, Larsen, Olav, Steen, A., Daugvilaite, V., Berg, Christian, Fares, S., Hansen, M., Ali, S. & Rosenkilde, Mette, 9 Dec 2016, In: Frontiers in Immunology. 7, 568.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21

    Hansen, M., Met, Özcan, Larsen, N. B., Rosenkilde, Mette, Andersen, Mads Hald, Svane, Inge Marie & Hjortø, Gertrud Malene, Sep 2016, In: Cytotherapy. 18, 9, p. 1187-1196

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Discovery and Characterization of Biased Allosteric Agonists of the Chemokine Receptor CXCR3

    Milanos, L., Brox, R., Frank, T., Poklukar, G., Palmisano, R., Waibel, R., Einsiedel, J., Dürr, M., Ivanović-Burmazović, I., Larsen, Olav, Hjortø, Gertrud Malene, Rosenkilde, M. M. & Tschammer, N., 2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2222-2243 22 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Probing Biased Signaling in Chemokine Receptors

    Amarandi, R. M., Hjortø, Gertrud Malene, Rosenkilde, Mette & Karlshøj, S., 2016, Methods in Enzymology. Academic Press, Vol. 570. p. 155-186 32 p. (Methods in Enzymology, Vol. 570).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  31. 2015
  32. Published

    Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

    Spiess, Katja, Jeppesen, M. G., Malmgaard-Clausen, M., Krzywkowski, K., Dulal, K., Cheng, T., Hjortø, Gertrud Malene, Larsen, Olav, Burg, J. S., Jarvis, M. A., Garcia, K. C., Zhu, H., Kledal, T. N. & Rosenkilde, Mette, Jul 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8427-8432 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Confinement dependent chemotaxis in two-photon polymerized linear migration constructs with highly definable concentration gradients

    Hjortø, Gertrud Malene, Olsen, M. H., Svane, Inge Marie & Larsen, N. B., Apr 2015, In: Biomedical Microdevices. 17, 2, p. 1-10 10 p., 30.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 2013
  35. Published

    In-chip fabrication of free-form 3D constructs for directed cell migration analysis

    Olsen, M. H., Hjortø, Gertrud Malene, Hansen, M., Met, Özcan, Svane, Inge Marie & Larsen, N. B., 21 Dec 2013, In: Lab On a Chip. 13, 24, p. 4800-4809 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Comparison of clinical grade type 1 polarized and standard matured dendritic cells for cancer immunotherapy

    Hansen, M., Hjortø, Gertrud Malene, Donia, M., Met, Özcan, Larsen, N. B., Andersen, M. H., Thor Straten, P. & Svane, Inge Marie, 2013, In: Vaccine. 31, 4, p. 639-46 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Human cytomegalovirus chemokine receptor US28 induces migration of cells on a CX3CL1-presenting surface

    Hjortø, Gertrud Malene, Kiilerich-Pedersen, K., Selmeczi, D., Kledal, T. N. & Larsen, N. B., 2013, In: The Journal of general virology. 94, Pt 5, p. 1111-20 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. 2012

  39. Increased adsorption of histidine-tagged proteins onto tissue culture polystyrene

    Holmberg, M., Hansen, T. S., Lind, J. U. & Hjortø, Gertrud Malene, 1 Apr 2012, In: Colloids and Surfaces B: Biointerfaces. 92, p. 286-292 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. 2011
  41. Published

    Cell culture plastics with immobilized interleukin-4 for monocyte differentiation

    Hansen, M., Hjortø, Gertrud Malene, Met, Özcan, Jakobsen, M. H., Svane, Inge Marie & Larsen, N. B., Feb 2011, In: Journal of Biomedical Materials Research. Part A. 96, 2, p. 372-83 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Cell culture plastics with immobilized interleukin-4 for monocyte differentiation

    Hansen, M., Hjortø, Gertrud Malene, Met, Ö., Jakobsen, M. H., Svane, Inge Marie & Larsen, N., 2011, In: Journal of Biomedical Materials Research. Part A. 96, 2, p. 372-83 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. 2009
  44. Published

    Generating substrate bound functional chemokine gradients in vitro

    Hjortø, Gertrud Malene, Hansen, M., Larsen, N. B. & Kledal, T. N., Oct 2009, In: Biomaterials. 30, 29, p. 5305-11 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. 2007
  46. Published

    Factor VIIa/tissue factor-dependent gene regulation and pro-coagulant activity: effect of factor VIIa concentration

    Petersen, L. C., Albrektsen, T., Hjortø, Gertrud Malene, Kjalke, M., Bjørn, S. E. & Sørensen, B. L., Oct 2007, In: Thrombosis and Haemostasis. 98, 4, p. 909-11 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Transcriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cells

    Albrektsen, T., Sørensen, B. B., Hjortø, Gertrud Malene, Fleckner, J., Rao, L. V. M. & Petersen, L. C., Aug 2007, In: Journal of Thrombosis and Haemostasis. 5, 8, p. 1588-97 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. 2005
  49. Published

    Factor VIIa binding and internalization in hepatocytes

    Hjortø, Gertrud Malene, Sorensen, B. B., Petersen, L. C. & Rao, L. V. M., Oct 2005, In: Journal of Thrombosis and Haemostasis. 3, 10, p. 2264-73 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Elk3 from hamster--a ternary complex factor with strong transcriptional repressor activity

    Hjortø, Gertrud Malene, Weilguny, D. & Willumsen, Berthe Marie, Jan 2005, In: D N A and Cell Biology. 24, 1, p. 35-42 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Tissue factor-dependent cellular responses of factor VII/VIIa in the absence and presence of factor X

    Albrektsen, T., Petersen, L. C., Hjortø, Gertrud Malene, Kjalke, M., Roikjaer, R., Bjørn, S. E. & Sorensen, B. B., 2005, p. 550. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  52. 2004
  53. Published

    Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration

    Hjortø, Gertrud Malene, Petersen, L. C., Albrektsen, T., Sorensen, B. B., Norby, P. L., Mandal, S. K., Pendurthi, U. R. & Rao, L. V. M., 15 Apr 2004, In: Blood. 103, 8, p. 3029-37 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. 2003
  55. Published

    Tissue factor/factor VIIa specific up-regulation of IL-8 expression in a human breast carcinoma cell line resulting in increased migration and invasion of tumor cells.

    Hjortø, Gertrud Malene, 2003, p. 530-31. 2 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  56. 1997
  57. Published

    A method for rapid and easy identification of individual alpha- and beta-cells in intact pancreatic islets

    Arhammar, P. O., Hjortø, Gertrud Malene, Terry, B. R. & Thastrup, O., 1997, p. 1051-1051. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  58. Published

    Functional identification and monitoring of individual alpha and beta cells in cultured mouse islets of Langerhans

    Hjortø, Gertrud Malene, Hagel, G. M., Terry, B. R., Thastrup, O. & Arkhammar, P. O., 1997, In: Acta Diabetologica. p. 185-193 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 113657078