Gertrud Malene Hjortø
Associate Professor
Molecular and Translational Pharmacology
Blegdamsvej 3B
2200 København N
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Transcriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cells
Albrektsen, T., Sørensen, B. B., Hjortø, Gertrud Malene, Fleckner, J., Rao, L. V. M. & Petersen, L. C., Aug 2007, In: Journal of Thrombosis and Haemostasis. 5, 8, p. 1588-97 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tissue factor-dependent cellular responses of factor VII/VIIa in the absence and presence of factor X
Albrektsen, T., Petersen, L. C., Hjortø, Gertrud Malene, Kjalke, M., Roikjaer, R., Bjørn, S. E. & Sorensen, B. B., 2005, p. 550. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Probing Biased Signaling in Chemokine Receptors
Amarandi, R. M., Hjortø, Gertrud Malene, Rosenkilde, Mette & Karlshøj, S., 2016, Methods in Enzymology. Academic Press, Vol. 570. p. 155-186 32 p. (Methods in Enzymology, Vol. 570).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Ligand-selective small molecule modulators of the constitutively active vGPCR US28
Amarandi, R., Lückmann, Michael, Melynis, M., Jakobsen, M. H., Fallah, Z., Spiess, Katja, Hjortø, Gertrud Malene, Pui, A., Frimurer, Thomas Michael & Rosenkilde, Mette, 2018, In: European Journal of Medicinal Chemistry. 155, p. 244-254Research output: Contribution to journal › Journal article › Research › peer-review
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Signaling via G proteins mediates tumorigenic effects of GPR87
Arfelt, K. N., Fares, S., wbf943, wbf943, Hjortø, Gertrud Malene, Gasbjerg, Lærke Smidt, Molleskov-Jensen, A., Benned-Jensen, T. & Rosenkilde, Mette, Jan 2017, In: Cellular Signalling. 30, p. 9-18Research output: Contribution to journal › Journal article › Research › peer-review
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A method for rapid and easy identification of individual alpha- and beta-cells in intact pancreatic islets
Arhammar, P. O., Hjortø, Gertrud Malene, Terry, B. R. & Thastrup, O., 1997, p. 1051-1051. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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GPR183 is Dispensable for B1 cell Accumulation and Function, but Affects B2 cell Abundance, in the Omentum and Peritoneal Cavity
Barington, L., Christensen, Liv von Voss, Pedersen, K. K., Arfelt, K. N., Roumain, M., Jensen, Kristian HR, Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Kearney, J. F., Christensen, Jan Pravsgaard, Hjortø, Gertrud Malene, Muccioli, G. G., Holst, Peter Johannes & Rosenkilde, Mette, 2022, In: Cells. 11, 3, 19 p., 494.Research output: Contribution to journal › Journal article › Research › peer-review
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Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails
Brandum, E. P., Jørgensen, Astrid Sissel, Calvo, M. B., Spiess, Katja, Peterson, F. C., Yang, Zhang, Volkman, B. F., Veldkamp, C. T., Rosenkilde, Mette, Goth, C. K. & Hjortø, Gertrud Malene, 2022, In: International Journal of Molecular Sciences. 23, 3, 20 p., 1397.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation
Goth, C. K., Mehta, A. Y., McQuillan, A. M., Baker, K. J., Hanes, M. S., Park, S. S., Stavenhagen, K., Hjortø, Gertrud Malene, Heimburg-Molinaro, J., Chaikof, E. L., Rosenkilde, Mette & Cummings, R. D., 2023, In: Cell Chemical Biology. 30, 8, p. 893-905.e7Research output: Contribution to journal › Journal article › Research › peer-review
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Cell culture plastics with immobilized interleukin-4 for monocyte differentiation
Hansen, M., Hjortø, Gertrud Malene, Met, Ö., Jakobsen, M. H., Svane, Inge Marie & Larsen, N., 2011, In: Journal of Biomedical Materials Research. Part A. 96, 2, p. 372-83 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21
Hansen, M., Met, Özcan, Larsen, N. B., Rosenkilde, Mette, Andersen, Mads Hald, Svane, Inge Marie & Hjortø, Gertrud Malene, Sep 2016, In: Cytotherapy. 18, 9, p. 1187-1196Research output: Contribution to journal › Journal article › Research › peer-review
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Comparison of clinical grade type 1 polarized and standard matured dendritic cells for cancer immunotherapy
Hansen, M., Hjortø, Gertrud Malene, Donia, M., Met, Özcan, Larsen, N. B., Andersen, M. H., Thor Straten, P. & Svane, Inge Marie, 2013, In: Vaccine. 31, 4, p. 639-46 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell culture plastics with immobilized interleukin-4 for monocyte differentiation
Hansen, M., Hjortø, Gertrud Malene, Met, Özcan, Jakobsen, M. H., Svane, Inge Marie & Larsen, N. B., Feb 2011, In: Journal of Biomedical Materials Research. Part A. 96, 2, p. 372-83 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines
Hjortø, Gertrud Malene, Larsen, Olav, Steen, A., Daugvilaite, V., Berg, Christian, Fares, S., Hansen, M., Ali, S. & Rosenkilde, Mette, 9 Dec 2016, In: Frontiers in Immunology. 7, 568.Research output: Contribution to journal › Journal article › Research › peer-review
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Confinement dependent chemotaxis in two-photon polymerized linear migration constructs with highly definable concentration gradients
Hjortø, Gertrud Malene, Olsen, M. H., Svane, Inge Marie & Larsen, N. B., Apr 2015, In: Biomedical Microdevices. 17, 2, p. 1-10 10 p., 30.Research output: Contribution to journal › Journal article › Research › peer-review
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Factor VIIa binding and internalization in hepatocytes
Hjortø, Gertrud Malene, Sorensen, B. B., Petersen, L. C. & Rao, L. V. M., Oct 2005, In: Journal of Thrombosis and Haemostasis. 3, 10, p. 2264-73 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration
Hjortø, Gertrud Malene, Petersen, L. C., Albrektsen, T., Sorensen, B. B., Norby, P. L., Mandal, S. K., Pendurthi, U. R. & Rao, L. V. M., 15 Apr 2004, In: Blood. 103, 8, p. 3029-37 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elk3 from hamster--a ternary complex factor with strong transcriptional repressor activity
Hjortø, Gertrud Malene, Weilguny, D. & Willumsen, Berthe Marie, Jan 2005, In: D N A and Cell Biology. 24, 1, p. 35-42 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Human cytomegalovirus chemokine receptor US28 induces migration of cells on a CX3CL1-presenting surface
Hjortø, Gertrud Malene, Kiilerich-Pedersen, K., Selmeczi, D., Kledal, T. N. & Larsen, N. B., 2013, In: The Journal of general virology. 94, Pt 5, p. 1111-20 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Generating substrate bound functional chemokine gradients in vitro
Hjortø, Gertrud Malene, Hansen, M., Larsen, N. B. & Kledal, T. N., Oct 2009, In: Biomaterials. 30, 29, p. 5305-11 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional identification and monitoring of individual alpha and beta cells in cultured mouse islets of Langerhans
Hjortø, Gertrud Malene, Hagel, G. M., Terry, B. R., Thastrup, O. & Arkhammar, P. O., 1997, In: Acta Diabetologica. p. 185-193 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tissue factor/factor VIIa specific up-regulation of IL-8 expression in a human breast carcinoma cell line resulting in increased migration and invasion of tumor cells.
Hjortø, Gertrud Malene, 2003, p. 530-31. 2 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Increased adsorption of histidine-tagged proteins onto tissue culture polystyrene
Holmberg, M., Hansen, T. S., Lind, J. U. & Hjortø, Gertrud Malene, 1 Apr 2012, In: Colloids and Surfaces B: Biointerfaces. 92, p. 286-292 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rewiring host–microbe interactions and barrier function during gastrointestinal inflammation
Jensen, Sune K. , Pærregaard, S. I., Brandum, E. P., Jørgensen, Astrid Sissel, Hjortø, Gertrud Malene & Jensen, Benjamin Anderschou Holbech, 25 Jan 2022, In: Gastroenterology Report. 10, p. 1-15 goac008.Research output: Contribution to journal › Journal article › Research › peer-review
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CCL19 with CCL21-tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells
Jørgensen, Astrid Sissel, Adogamhe, P. E., Laufer, J. M., Legler, D. F., Veldkamp, C. T., Rosenkilde, M. M. & Hjortø, Gertrud Malene, 2018, In: Journal of Leukocyte Biology. 104, 2, p. 401-411Research output: Contribution to journal › Journal article › Research › peer-review
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Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization
Jørgensen, Astrid Sissel, Daugvilaite, V., De Filippo, K., Berg, Christian, Mavri, M., Benned-Jensen, T., Juzenaite, G., Hjortø, Gertrud Malene, Rankin, S., Vabeno, J. & Rosenkilde, Mette, 2021, In: Communications Biology . 4, 1, 12 p., 569.Research output: Contribution to journal › Journal article › Research › peer-review
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Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7
Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Frontiers in Immunology. 10, 14 p., 2156.Research output: Contribution to journal › Journal article › Research › peer-review
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The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus
Jørgensen, Astrid Sissel, Brandum, E. P., Mikkelsen, J. M., Orfin, K. A., Boilesen, D. R., Egerod, Kristoffer Lihme, Moussouras, N. A., Vilhardt, Frederik, Kalinski, P., Basse, P., Chen, Yen-Hsi, Yang, Zhang, Dwinell, M. B., Volkman, B. F., Veldkamp, C. T., Holst, Peter Johannes, Lahl, K., Goth, C. K., Rosenkilde, Mette & Hjortø, Gertrud Malene, 2021, In: Cellular and Molecular Life Sciences. 78, p. 6963-6978 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biased signaling of G protein-coupled receptors: rom a chemokine receptor CCR7 perspective
Jørgensen, Astrid Sissel, Rosenkilde, Mette & Hjortø, Gertrud Malene, Mar 2018, In: General and Comparative Endocrinology. 258, SI, p. 4-14Research output: Contribution to journal › Review › Research › peer-review
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Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization
Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Stepniewski, T. M., Madsen, C. M., Jørgensen, Astrid Sissel, Bhuskute, K. R., Inoue, A., Ulven, Trond, Benned-Jensen, T., Hjorth, Siv Annegrethe, Hjortø, Gertrud Malene, Moo, Ee Von, Selent, J. & Rosenkilde, Mette, 2023, In: Science Signaling. 16, 779, 13 p., eabl4283.Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery and Characterization of Biased Allosteric Agonists of the Chemokine Receptor CXCR3
Milanos, L., Brox, R., Frank, T., Poklukar, G., Palmisano, R., Waibel, R., Einsiedel, J., Dürr, M., Ivanović-Burmazović, I., Larsen, Olav, Hjortø, Gertrud Malene, Rosenkilde, M. M. & Tschammer, N., 2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2222-2243 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy
Miles, T. F., Spiess, Katja, Jude, K. M., Tsutsumi, N., Burg, J. S., Ingram, J. R., Waghray, D., Hjortø, Gertrud Malene, Larsen, Olav, Ploegh, H. L., Rosenkilde, Mette & Garcia, K. C., 2018, In: eLife. 7, 23 p., e35850 .Research output: Contribution to journal › Journal article › Research › peer-review
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Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21
Moussouras, N. A., Hjortø, Gertrud Malene, Peterson, F. C., Szpakowska, M., Chevigné, A., Rosenkilde, Mette, Volkman, B. F. & Dwinell, M. B., 7 Apr 2020, In: Biochemistry. 59, 13, p. 1338-1350 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In-chip fabrication of free-form 3D constructs for directed cell migration analysis
Olsen, M. H., Hjortø, Gertrud Malene, Hansen, M., Met, Özcan, Svane, Inge Marie & Larsen, N. B., 21 Dec 2013, In: Lab On a Chip. 13, 24, p. 4800-4809 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Factor VIIa/tissue factor-dependent gene regulation and pro-coagulant activity: effect of factor VIIa concentration
Petersen, L. C., Albrektsen, T., Hjortø, Gertrud Malene, Kjalke, M., Bjørn, S. E. & Sørensen, B. L., Oct 2007, In: Thrombosis and Haemostasis. 98, 4, p. 909-11 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Three-Dimensional Explant Platform for Studies on Choroid Plexus Epithelium
Petersen, N., Pedersen, Lola Julie Torz, Jensen, Kristian HR, Hjortø, Gertrud Malene, Spiess, Katja & Rosenkilde, Mette, 2020, In: Frontiers in Cellular Neuroscience. 14, 11 p., 108.Research output: Contribution to journal › Journal article › Research › peer-review
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Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo
Spiess, Katja, Jeppesen, M. G., Malmgaard-Clausen, M., Krzywkowski, K., Dulal, K., Cheng, T., Hjortø, Gertrud Malene, Larsen, Olav, Burg, J. S., Jarvis, M. A., Garcia, K. C., Zhu, H., Kledal, T. N. & Rosenkilde, Mette, Jul 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8427-8432 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Arrestin-independent constitutive endocytosis of GPR125/ADGRA3
Spiess, Katja, Bagger, Sofie Morsing, Pedersen, Lola Julie Torz, Jensen, Kristian HR, Walser, Anna Louise Silvia, Kvam, J. M., Mogelmose, A. K., Daugvilaite, V., Junnila, R. K., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Annals of the New York Academy of Sciences. 1456, p. 186–199Research output: Contribution to journal › Journal article › Research › peer-review
- Published
“Glyco-sulfo barcodes” regulate chemokine receptor function
Verhallen, L., Lackman, Jarkko Juhani, Wendt, R., Gustavsson, Martin, Yang, Zhang, Narimatsu, Yoshiki, Sørensen, Daniel Madriz, Lafferty, K. M., Gouwy, M., Marques, P. E., Hjortø, Gertrud Malene, Rosenkilde, Mette, Proost, P. & Goth, C. K., 2023, In: Cellular and Molecular Life Sciences. 80, 2, 18 p., 55.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats
van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 113657078
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Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
149
downloads
Arrestin-independent constitutive endocytosis of GPR125/ADGRA3
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
124
downloads
Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7
Research output: Contribution to journal › Journal article › Research › peer-review
Published