Carolyn F. Deacon
Associate Professor
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Effects of the dipeptidyl peptidase IV inhibitor, vildagliptin, on glycemic, gut hormone, triglyceride, energy expenditure and energy intake responses to intraduodenal fat infusion in healthy males
Heruc, G., Horowitz, M., Deacon, Carolyn F., Feinle-Bisset, C., Rayner, C., Luscombe-Marsh, N. & Little, T. J., 2014, In: American Journal of Physiology: Endocrinology and Metabolism. 307, 9, p. E830-E837 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptidyl peptidase-4 inhibition increases portal concentrations of intact glucagon-like peptide-1 (GLP-1) to a greater extent than peripheral concentrations in anaesthetised pigs
Hjøllund, K. R., Deacon, Carolyn F. & Holst, Jens Juul, 2011, In: Diabetologia. 54, 8, p. 2206-8 3 p.Research output: Contribution to journal › Letter › Research › peer-review
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On the treatment of diabetes mellitus with glucagon-like peptide-1.
Holst, Jens Juul, Deacon, Carolyn F., Toft-Nielsen, M. & Bjerre-Knudsen, L., 1998, In: Annals of the New York Academy of Sciences. 865, p. 336-343Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes
Holst, Jens Juul & Deacon, Carolyn F., 1998, In: Diabetes. 47, p. 1663-1670Research output: Contribution to journal › Journal article › Research › peer-review
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New horizons in diabetes therapy
Holst, Jens Juul & Deacon, Carolyn F., 2007, In: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 7, 1, p. 49-55 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Role of GLP-1 analogues and DDP-IV inhibitors in the treatment of type 2 diabetes
Holst, Jens Juul & Deacon, Carolyn F., 2006, In: Avances en Diabetologia. 22, 2, p. 115-125 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Physiology of the Incretin Hormones, GIP and GLP-1-Regulation of Release and Posttranslational Modifications
Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Rosenkilde, Mette & Deacon, Carolyn F., 2019, In: Comprehensive Physiology. 9, 4, p. 1339-1381Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus.
Holst, Jens Juul & Deacon, Carolyn F., 2004, In: Current Opinion in Pharmacology. 4, 6, p. 589-96 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-1, glucose homeostasis and diabetes.
Holst, Jens Juul, Deacon, Carolyn F., Vilsbøll, Tina, Krarup, T. & Madsbad, Sten, 2008, In: Trends in Molecular Medicine. 14, 4, p. 161-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The incretin system and its role in type 2 diabetes mellitus
Holst, Jens Juul, Vilsbøll, Tina & Deacon, Carolyn F., 2008, In: Molecular and Cellular Endocrinology. 297, 1-2, p. 127-136 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-1 mediates the therapeutic actions of Dpp-IV inhibitors
Holst, Jens Juul & Deacon, Carolyn F., 2005, In: Diabetologia. 48, p. 612-615Research output: Contribution to journal › Journal article › Research › peer-review
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For debate: Are antidiabetic actions of DPP-IV inhibitors mediated by glucagon-like peptide- 1?
Holst, Jens Juul & Deacon, Carolyn F., 2005, In: Diabetologia. 48, p. 612-615Research output: Contribution to journal › Journal article › Research › peer-review
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Posttranslational processing of proglucagon and postsecretory fate of proglucagon products.
Holst, Jens Juul, Ørskov, C., Hartmann, B. & Deacon, Carolyn F., 1997, The Insulinotropic Gut Hormone Glucagon-like Peptide-1.. Basel: Karger, p. 24-48Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors
Holst, Jens Juul & Deacon, Carolyn F., Apr 2005, In: Diabetologia. 48, 4, p. 612-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Is there a place for incretin therapies in obesity and prediabetes?
Holst, Jens Juul & Deacon, Carolyn F., 13 Feb 2013, In: Trends in Endocrinology and Metabolism. 24, 3, p. 145-152 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Activation of GLP-1 receptors on vascular smooth muscle cells reduces the autoregulatory response in afferent arterioles and increases renal blood flow
Jensen, E. P., Poulsen, Steen Seier, Kissow, Hannelouise, von Holstein-Rathlou, Niels-Henrik, Deacon, Carolyn F., Jensen, B. L., Holst, Jens Juul & Sorensen, Charlotte Mehlin, 15 Apr 2015, In: A J P: Renal Physiology (Online). 308, 8, p. F867-F877 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner
Jepsen, Sara Lind, Albrechtsen, Nicolai Jacob Wewer, Windeløv, Johanne Agerlin, Galsgaard, Katrine Douglas, Dal, Jenna Elizabeth Hunt, Farb, T. B., Kissow, Hannelouise, Pedersen, J., Deacon, Carolyn F., Martin, R. E. & Holst, Jens Juul, 2021, In: JCI insight. 6, 4, 15 p., e143228.Research output: Contribution to journal › Journal article › Research › peer-review
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Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice
Jepsen, Sara Lind, Grunddal, Kaare Villum, Albrechtsen, Nicolai Jacob Wewer, Engelstoft, M. S., Gabe, M. B. N., Jensen, E. P., Ørskov, Cathrine, Poulsen, Steen Seier, Rosenkilde, M. M., Pedersen, J., Gribble, F. M., Reimann, F., Deacon, Carolyn F., Schwartz, Thue W., Christ, A. D., Martin, R. E. & Holst, Jens Juul, 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 317, 6, p. E1081-E1093Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice
Jolivalt, C., Fineman, M., Deacon, Carolyn F., Carr, R. & Calcutt, N., Nov 2011, In: Diabetes, Obesity and Metabolism. 13, 11, p. 990-1000 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism
Kjeldsen, Sasha Alexandra Sampson, Hansen, L. H., Esser, N., Mongovin, S., Winther-Sørensen, Marie, Galsgaard, Katrine Douglas, Dal, Jenna Elizabeth Hunt, Kissow, Hannelouise, Ceutz, F. R., Terzic, D., Mark, P. D., Plomgaard, Peter Stendahl, Goetze, Jens P. , Goossens, G. H., Blaak, E. E., Deacon, Carolyn F., Rosenkilde, Mette, Zraika, S., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Endocrine Research. 5, 9, 15 p., bvab084.Research output: Contribution to journal › Journal article › Research › peer-review
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Do sodium-glucose transporter-2 inhibitors increase plasma glucagon by direct actions on the alpha-cell? - and does the increase matter for the associated increase in endogenous glucose production?
Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2021, In: Diabetes, Obesity and Metabolism. 23, 9, p. 2009-2019Research output: Contribution to journal › Review › Research › peer-review
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What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?
Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Holst, Jens Juul & Petersen, N., 2021, In: Frontiers in Endocrinology. 12, 19 p., 694284.Research output: Contribution to journal › Review › Research › peer-review
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Measurement of the incretin hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic peptide
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, Apr 2015, In: Journal of Diabetes and its Complications. 29, 3, p. 445-450 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, Olav, Jepsen, Sara Lind, Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells.
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Balk-Møller, E., Rehfeld, Jens Frederik, Relman, F., Gribble, F. M. & Holst, Jens Juul, 2016, In: Journal of Molecular Endocrinology. 56, p. 201-211Research output: Contribution to journal › Journal article › Research › peer-review
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Pancreatic α-cell hyperplasia and hyperglucagonemia due to a mutation of the glucagon
Larger, E., Albrechtsen, Nicolai Jacob Wewer, Hansen, L. H., Gelling, R. W., Capeau, J., Deacon, Carolyn F., Madsen, O. D., Yakushiji, F., Meyts, P. D., Holst, Jens Juul & Nishimura, E., 2016, In: Endocrinology, Diabetes & Metabolism Case Reports. 2016, 6 p., EDM160081.Research output: Contribution to journal › Journal article › Research › peer-review
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Valine pyrrolidide preserves intact glucose-dependent insulinotropic peptide and improves abnormal glucose tolerance in minipigs with reduced beta-cell mass.
Larsen, M. O., Rolin, B., Ribel, U., Wilken, M., Deacon, Carolyn F., Svendsen, O., Gotfredsen, C. F. & Carr, R. D., 2003, In: Experimental Diabesity Research. 4, 2, p. 93-105 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dissociated incretin hormone response to protein versus fat ingestion in obese subjects
Lindgren, O., Carr, R., Holst, Jens Juul, Deacon, Carolyn F. & Ahren, B., Jul 2011, In: Diabetes, Obesity and Metabolism Online. 13, 9, p. 863-865 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men
Lindgren, O., Mari, A., Deacon, Carolyn F., Carr, R. D., Winzell, M. S., Vikman, J. & Ahrén, B., 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 8, p. 2887-92 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Incretin effect after oral amino Acid ingestion in humans
Lindgren, O., Pacini, G., Tura, A., Holst, Jens Juul, Deacon, Carolyn F. & Ahrén, B., Mar 2015, In: The Journal of clinical endocrinology and metabolism. 100, 3, p. 1172-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans
Lindgren, O., Carr, R. D., Deacon, Carolyn F., Holst, Jens Juul, Pacini, G., Mari, A. & Ahrén, B., Aug 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 8, p. 2519-2524 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An overview of once-weekly glucagon-like peptide-1 receptor agonists--available efficacy and safety data and perspectives for the future
Madsbad, Sten, Kielgast, U., Asmar, M., Deacon, Carolyn F., Torekov, Signe Sørensen & Holst, Jens Juul, May 2011, In: Diabetes, Obesity and Metabolism. 13, 5, p. 394-407 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials
Madsbad, Sten, Krarup, T., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Krarup, T., Deacon, C. F. & Holst, J. J., 2008, In: Current Opinion in Clinical Nutrition and Metabolic Care. 11, 4, p. 491-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials
Madsbad, Sten, Krarup, T., Deacon, Carolyn F. & Holst, Jens Juul, Jul 2008, In: Current Opinion in Clinical Nutrition and Metabolic Care. 11, 4, p. 491-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetes
Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Dunning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., Aug 2005, In: The Journal of clinical endocrinology and metabolism. 90, 8, p. 4888-94 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Vildagliptin, a dipeptidyl peptidase-IV inhibitor improves model-assessed beta-cell function in patients with type 2 diabetes
Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Duning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., 2005, In: J. Clin. Endocrinol. Metab.. 90, p. 4888-4894Research output: Contribution to journal › Journal article › Research
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The incretin enhancer vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed -cell function in patients with type 2 diabetes
Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Dunning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, p. 4888-4894Research output: Contribution to journal › Journal article › Research
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Incretin-based therapies– review of the physiology, pharmacology and emerging clinical experience
Martin, J., Deacon, Carolyn F., Gorrell, M. & Prins, J., 2011, In: Internal Medicine Journal (Online). 41, p. 299-307 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men
Matikainen, N., Söderlund, S., Björnson, E., Bogl, L. H., Pietiläinen, K. H., Hakkarainen, A., Lundbom, N., Eliasson, B., Räsänen, S. M., Rivellese, A., Patti, L., Prinster, A., Riccardi, G., Després, J., Alméras, N., Holst, Jens Juul, Deacon, Carolyn F., Borén, J. & Taskinen, M., Jun 2017, In: Nutrition, Metabolism & Cardiovascular Diseases. 27, 6, p. 534-542 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men
Matikainen, N., Björnson, E., Söderlund, S., Borén, C., Eliasson, B., Pietiläinen, K. H., Bogl, L. H., Hakkarainen, A., Lundbom, N., Rivellese, A., Riccardi, G., Després, J., Alméras, N., Holst, Jens Juul, Deacon, Carolyn F., Borén, J. & Taskinen, M., 2016, In: PLOS ONE. 11, 1, p. 1-15 15 p., e0145890.Research output: Contribution to journal › Journal article › Research › peer-review
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Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery
McLaughlin, T., Peck, M., Holst, Jens Juul & Deacon, Carolyn F., Apr 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 4, p. 1851-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia
Meier, J. J., Gallwitz, B., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., Jun 2003, In: Diabetologia. 46, 6, p. 798-801 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Secretion of incretin hormones and the insulinotropic effect of gastric inhibitory polypeptide in women with a history of gestational diabetes
Meier, J. J., Gallwitz, B., Askenas, M., Vollmer, K., Deacon, Carolyn F., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., Sep 2005, In: Diabetologia. 48, 9, p. 1872-81 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Insulinotropic effect of gastric inhibitory polypeptide (GIP) in women with a history of gestational diabetes
Meier, J. J., Gallwitz, B., Askenas, M., Vollmer, K., Deacon, Carolyn F., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., 2005, In: Diabetologia. 48, p. 1872-1881Research output: Contribution to journal › Journal article › Research
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Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia
Meier, J. J., Gallwitz, N., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., 2003, In: Diabetologia. 46, p. 798-801Research output: Contribution to journal › Journal article › Research › peer-review
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Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects
Meier, J. J., Deacon, Carolyn F., Schmidt, W. E., Holst, Jens Juul & Nauck, M. A., 2007, In: Diabetologia. 50, 4, p. 806-813 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes
Meier, J. J., Huking, K., Holst, Jens Juul, Deacon, Carolyn F., Schmiegel, W. H. & Nauck, M. A., 2001, In: Diabetes. 50, p. 2497-2504Research output: Contribution to journal › Journal article › Research › peer-review
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Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls.
Meier, J. J., Nauck, M. A., Kask, B., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Gallwitz, B., 2006, In: World Journal of Gastroenterology. 12, 12, p. 1874-80 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric inhibitory polypeptide (GIP).
Meier, J. J., Gallwitz, B., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., 2003, In: Regulatory Peptides. 113, 1-3, p. 95-100 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects.
Meier, J. J., Nauck, M. A., Kranz, D., Holst, Jens Juul, Deacon, Carolyn F., Gaeckler, D., Schmidt, W. E. & Gallwitz, B., 2004, In: Diabetes. 53, 3, p. 654-62 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes
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Acute effects of dietary carbohydrate restriction on glycemia, lipemia and appetite regulating hormones in normal-weight to obese subjects
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302
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Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
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