Thomas Mandrup-Poulsen
Professor
- 2012
- Published
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines
Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, , 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes
Cavelti-Weder, C., Babians-Brunner, A., Keller, C., Stahel, M. A., Kurz-Levin, M., Zayed, H., Solinger, A. M., Mandrup-Poulsen, Thomas, Dinarello, C. A. & Donath, M. Y., 2012, In: Diabetes Care.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children
Lundh, M., Christensen, D. P., Damgaard Nielsen, M., Richardson, S. J., Dahllöf, M. S., Skovgaard, T., Berthelsen, J., Dinarello, C. A., Stevenazzi, A., Mascagni, P., Grunnet, Louise Groth, Morgan, N. G. & Mandrup-Poulsen, Thomas, 2012, In: Diabetologia. 55, 9, p. 2421-31Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin-1 antagonists and other cytokine blockade strategies for type 1 diabetes
Mandrup-Poulsen, Thomas, 2012, In: The review of diabetic studies : RDS. 9, 4, p. 338-47 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Perspective: Testing failures
Mandrup-Poulsen, Thomas, 2012, In: Nature Study. 485, 7398, p. S17Research output: Contribution to journal › Journal article › Commissioned
- Published
Response to Comment on: Ellervik et al. Elevated Transferrin Saturation and Risk of Diabetes: Three Population-Based Studies. Diabetes Care 2011;34:2256-2258
Ellervik, Christina, Mandrup-Poulsen, Thomas, Birgens, H. & Nordestgaard, Børge, 2012, In: Diabetes Care. 35, 6, p. e48Research output: Contribution to journal › Journal article › Research
- Published
Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation
Ablamunits, V., Henegariu, O., Hansen, J. B., Opare-Addo, L., Preston-Hurlburt, P., Santamaria, P., Mandrup-Poulsen, Thomas & Herold, K. C., 2012, In: Diabetes. 61, 1, p. 145-54 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptional and translational regulation of cytokine signaling in inflammatory ß-cell dysfunction and apoptosis
Novotny, G. W., Lundh, M., Backe, M. B., Christensen, D. P., Hansen, J. B., Dahllöf, M. S., Pallesen, E. & Mandrup-Poulsen, Thomas, 2012, In: Archives of Biochemistry and Biophysics. 528, 2, p. 171-84Research output: Contribution to journal › Review › Research › peer-review
- 2011
- Published
Apolipoprotein CIII reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the Akt prosurvival pathway.
Størling, Joachim, Juntti-Berggren, L., Olivecrona, G., Prause, Michala Cecilie Burstein, Berggren, P. & Mandrup-Poulsen, Thomas, Aug 2011, In: Endocrinology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
16 SKELETAL-MUSCLE LIPOPROTEIN EXPRESSION IS REGULATED BY TRAINING AND TYPE 2 DIABETES IN HUMANS AND IMPROVES INSULIN SENSITIVITY IN OBESE MICE
Bartels, E. M., Mandrup-Poulsen, Thomas & Nielsen, L. B., Jun 2011, In: Atherosclerosis. Supplement. 12, 1, p. 4 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet ß cells in vivo and in vitro
Lewis, E. C., Blaabjerg, L., Størling, Joachim, Ronn, S. G., Mascagni, P., Dinarello, C. A. & Mandrup-Poulsen, Thomas, May 2011, In: Molecular Medicine. 17, 5-6, p. 369-377 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up
Akerblom, H. K., Krischer, J., Virtanen, V. S., Berseth, C., Becker, D., Dupré, J., Ilonen, J., Trucco, M., Savilahti, E., Koski, K., Pajakkala, E., Fransiscus, M., Lough, G., Bradley, B., Koski, M., Knip, M., TRIGR Study Group, T. S. G. & Mandrup-Poulsen, Thomas, 1 Mar 2011, In: Diabetologica. 54, 3, p. 627-633 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique
Kulahin, N., Grunnet, L. G., Lundh, M., Christensen, D. P., Jorgensen, R., Heding, A., Billestrup, Nils, Berezin, V., Bock, E. & Mandrup-Poulsen, Thomas, 3 Jan 2011, In: FEBS Letters. 585, 1, p. 58-64 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Apolipoprotein CIII Reduces Proinflammatory Cytokine-Induced Apoptosis in Rat Pancreatic Islets via the Akt Prosurvival Pathway
Størling, Joachim, Juntti-Berggren, L., Olivecrona, G., Prause, M. C., Berggren, P. & Mandrup-Poulsen, Thomas, 2011, In: Endocrinology. 152, 8, p. 3040-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cytokines and type 1 diabetes: a numbers game
Grunnet, L. G. & Mandrup-Poulsen, Thomas, 2011, In: Diabetes. 60, 3, p. 697-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR)
Knip, M., Virtanen, S. M., Becker, D., Dupré, J., Krischer, J. P., Åkerblom, H. K., TRIGR Study Group, T. S. G. & Mandrup-Poulsen, Thomas, 2011, In: American Journal of Clinical Nutrition. 94, 6 Suppl, p. 1814S-1820S 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elevated transferrin saturation and risk of diabetes: Three population-based studies
Ellervik, Christina, Mandrup-Poulsen, Thomas, Andersen, H. U., Tybjærg-Hansen, Anne, Frandsen, M., Birgens, H. & Nordestgaard, Børge, 2011, In: Diabetes Care. 34, 10, p. 2256-8 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Endothelial Progenitor Cells in Long-Standing Asymptomatic Type 1 Diabetic Patients with or without Diabetic Nephropathy
Reinhard, H., Jacobsen, P. K., Lajer, M., Tarnow, L., Astrup, A. S., Kim, W. Y., Pedersen, N., Billestrup, Nils, Mandrup-Poulsen, Thomas, Parving, H. & Rossing, Peter, 2011, In: Nephron Clinical Practice. 118, 3, p. c309-c314 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus
Christensen, D. P., Dahllöf, M. S., Lundh, M., Rasmussen, D. N., Nielsen, M. D., Billestrup, Nils, Grunnet, L. G. & Mandrup-Poulsen, Thomas, 2011, In: Molecular Medicine. 17, 5-6, p. 378-90 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines
Lundh, M., Christensen, D. P., Rasmussen, D. N., Mascagni, P., Dinarello, C. A., Billestrup, Nils, Grunnet, L. G. & Mandrup-Poulsen, Thomas, 1 Dec 2010, In: Diabetologia. 53, 12, p. 2569-78 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IL-1 family nomenclature
Dinarello, C., Arend, W., Sims, J., Smith, D., Blumberg, H., O'Neill, L., Goldbach-Mansky, R., Pizarro, T., Hoffman, H., Bufler, P., Nold, M., Ghezzi, P., Mantovani, A., Garlanda, C., Boraschi, D., Rubartelli, A., Netea, M., van der Meer, J., Joosten, L., Mandrup-Poulsen, T. & 14 others, , 1 Nov 2010, In: Nature Immunology. 11, 11, p. 973 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IAPP boosts islet macrophage IL-1 in type 2 diabetes
Mandrup-Poulsen, Thomas, 1 Oct 2010, In: Nature Immunology. 11, 10, p. 881-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multifactorial treatment increases endothelial progenitor cells in patients with type 2 diabetes
Reinhard, H., Jacobsen, P. K., Lajer, M., Pedersen, N., Billestrup, Nils, Mandrup-Poulsen, Thomas, Parving, H. & Rossing, Peter, 1 Oct 2010, In: Diabetologica. 53, 10, p. 2129-33 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of IL-1beta in type 2 diabetes
Dinarello, C. A., Donath, M. Y. & Mandrup-Poulsen, Thomas, 1 Aug 2010, In: Current Opinion in Endocrinology, Diabetes and Obesity. 17, 4, p. 314-21 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Blockade of Interleukin 1 in Type 1 diabetes mellitus
Mandrup-Poulsen, Thomas, Pickersgill, L. M. S. & Donath, M. Y., 2010, In: Nature Reviews Endocrinology. 6, p. 158-166 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DIFFERENTIAL TRANSCRIPTIONAL REGULATION OF EXTRA CELLULAR MATRIX MODULATING GENES BY PROINFLAMMATORY CYTOKINES IN INS-1 CELLS
Hansen, J. B., Tonnesen, M. F., Friberg, J., Brunner, N. & Mandrup-Poulsen, Thomas, 2010.Research output: Contribution to conference › Conference abstract for conference › Research
- Accepted/In press
Genetic deficiency of tissue inhibitor of metalloproteinase (TIMP) 1 does not affect apoptosis in cytokine-exposed mouse islets in vitro.
Hansen, J. B., Tonnesen, M. F., Rømer, M. U. K., Billestrup, Nils, Brunner, N. & Mandrup-Poulsen, Thomas, 2010, (Accepted/In press).Research output: Contribution to conference › Conference abstract for conference › Research
- Published
High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression
Fred, R. G., Bang-Berthelsen, C. H., Mandrup-Poulsen, Thomas, Grunnet, L. G. & Welsh, N., 2010, In: PLoS ONE. 5, 5, p. e10843Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells
Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, Nils, Eizirik, D. L., Størling, Joachim & Mandrup-Poulsen, Thomas, Sep 2009, In: Endocrinology. 150, 9, p. 4094-103 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DIAMAP team group. Europe draws up a map to a better future: Diabetes Breakthrough
Mandrup-Poulsen, Thomas, 2009Research output: Other contribution › Communication
- Published
- Published
Differential transcriptional regulation of extra cellular matrix modulating genes by proinflammatory cytokines in ins-1 cells
Hansen, J. B., Tonnesen, M., Friberg, J., Brünner, N. & Mandrup-Poulsen, Thomas, 2009. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
Functional SOCS1 polymorphisms are associated with variation in obesity in whites
Gylvin, T., Ek, J., Nolsøe, R., Albrechtsen, A., Andersen, G., Bergholdt, R., Brorsson, C., Bang-Berthelsen, C. H., Hansen, T., Karlsen, A. E., Billestrup, N., Borch-Johnsen, K., Jørgensen, T., Pedersen, Oluf Borbye, Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 2009, In: Diabetes, Obesity and Metabolism. 11, 3, p. 196-203 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
Holst, Birgitte, Egerod, Kristoffer Lihme, Jin, C., Petersen, P. S., Østergaard, M. V., Hald, J., Sprinkel, A. M. E., Størling, J., Mandrup-Poulsen, Thomas, Holst, Jens Juul, Thams, P., Orskov, C., Wierup, N., Sundler, F., Madsen, O. D. & Schwartz, Thue W., 2009, In: Endocrinology. 150, 6, p. 2577-85 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IL-1 beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells
Jacobsen, M. L. B., Ronn, S. G., Bruun, C., Larsen, C. M., Eizirik, D. L., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2009, In: Diabetologia. 52, 2, p. 281-288 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes
Berchtold, L. A., Larsen, C. M., Vaag, Allan, Faulenbach, M., Workman, C. T., Kruhøffer, M., Donath, M. & Mandrup-Poulsen, Thomas, 2009, In: European Cytokine Network. 20, 2, p. 81-87 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of Nuclear Factor-kappa B or Bax Prevents Endoplasmic Reticulum Stress-But Not Nitric Oxide-Mediated Apoptosis in INS-1E Cells
Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, Nils, Eizirik, D. L., Storling, J. & Mandrup-Poulsen, Thomas, 2009, In: Endocrinology. 150, 9, p. 4094-4103 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proinflammatory Cytokines Inhibit TIMP-1 Expression but Induces PAI-1 and CD63 Expression in INS-1 Cells
Hansen, J. B., Brunner, N. & Mandrup-Poulsen, Thomas, 2009.Research output: Contribution to conference › Poster › Research
- Published
Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells
Grunnet, L. G., Aikin, R., Tonnesen, M. F., Paraskevas, S., Blaabjerg, L., Størling, J., Rosenberg, L., Billestrup, Nils, Maysinger, D. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes. 58, 8, p. 1807-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells
Bruun, C., Heding, P. E., Rønn, S. G., Frobøse, H., Rhodes, C. J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2009, In: Molecular and Cellular Endocrinology. 311, 1-2, p. 32-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes
Larsen, C. M., Faulenbach, M., Vaag, Allan, Ehses, J. A., Donath, M. Y. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes Care. 32, 9, p. 1663-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The anti-interleukin-1 in type 1 diabetes action trial - Background and rationale
Pickersgill, L. M. S. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 25, 4, p. 321-324 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation
Kolb, H. & Mandrup-Poulsen, Thomas, 2009, In: Diabetologia. 53, 1, p. 10-20 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Behandling af diabetes mellitus med biologiske laegemidler.
Larsen, C. M. & Mandrup-Poulsen, Thomas, 2008, In: Ugeskrift for læger. 170, 24, p. 2134-7 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Circulating endothelial progenitor cell number in long-standing type 1 diabetic patients
Reinhard, H., Jacobsen, P. K., Tarnov, L., Astrup, A. S., Lajer, M., Pedersen, N., Billestrup, N., Mandrup-Poulsen, Thomas, Kastrup, J., Parving, H. H. & Rossing, P., 2008, In: Diabetologia. 51, Suppl. 1, p. S531-S531Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells
Jacobsen, M. L. B., Rønn, S. G., Bruun, C., Larsen, C. M., Eizirik, D. L., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2008, In: Diabetologia. 52, 2, p. 281-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MicroRNAs are potential posttranscriptional regulators of Bcl-2 family members after cytokine stimulation in INS-1 cells
Bang-Berthelsen, C. H., Grunnet, L. G., Kutlu, B., Johansson, F., Eizirik, D., Pociot, F. & Mandrup-Poulsen, Thomas, 2008, In: FEBS Journal. 275, Suppl. 1, p. 152-152Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes.
Greenbaum, C. J., Mandrup-Poulsen, Thomas, McGee, P. F., Battelino, T., Haastert, B., Ludvigsson, J., Pozzilli, P., Lachin, J. M., Kolb, H., Type 1 Diabetes Trial Net Research Group, T. 1. D. T. N. R. G. & European C-Peptide Trial Study Group, E. C. T. S. G., 2008, In: Diabetes Care. 31, 10, p. 1966-71 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proliferation of sorted human and rat beta cells
Parnaud, G., Bosco, D., Berney, T., Pattou, F., Kerr-Conte, J., Donath, M. Y., Bruun, C., Mandrup-Poulsen, Thomas, Billestrup, Nils & Halban, P. A., 2008, In: Diabetologia. 51, 1, p. 91-100 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection
Rønn, S. G., Börjesson, A., Bruun, C., Heding, P. E., Frobøse, H., Mandrup-Poulsen, Thomas, Karlsen, A. E., Rasschaert, J., Sandler, S. & Billestrup, Nils, 2008, In: Diabetologia. 51, 10, p. 1873-1882 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 923693
Most downloads
-
780
downloads
Tissue inhibitor of matrix metalloproteinase-1 is required for high-fat diet-induced glucose intolerance and hepatic steatosis in mice
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
210
downloads
JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1 beta-Induced Apoptosis Associated with Abrogated Myc Expression
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
199
downloads
A Placebo-Controlled Study on the Effects of the Glucagon-Like Peptide-1 Mimetic, Exenatide, on Insulin Secretion, Body Composition and Adipokines in Obese, Client-Owned Cats
Research output: Contribution to journal › Journal article › Research › peer-review
Published