Clare Louise Hawkins
Professor MSO
Inflammation, Metabolism and Oxidation
Blegdamsvej 3
2200 København N.
- 2017
CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis
Ridiandries, A., Tan, J. T. M., Ravindran, D., Williams, H., Medbury, H. J., Lindsay, L., Hawkins, Clare Louise, Prosser, H. C. G. & Bursill, C. A., Mar 2017, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31, 3, p. 1179-1192 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes
Carroll, L., Pattison, D. I., Fu, S., Schiesser, C. H., Davies, Michael J. & Hawkins, Clare Louise, 2017, In: Redox Biology. 12, p. 872-882 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction
Abdo, A., Rayner, B. S., van Reyk, D. M. & Hawkins, Clare Louise, 2017, In: Redox Biology. 13, p. 623-632 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function
Indo, H. P., Hawkins, Clare Louise, Nakanishi, I., Matsumoto, K., Matsui, H., Suenaga, S., Davies, Michael J., St Clair, D. K., Ozawa, T. & Majima, H. J., 2017, Pharmacology of Mitochondria. Springer, Vol. 240. p. 439-456 18 p. (Handbook of Experimental Pharmacology, Vol. 240).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2016
A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity
Lok, H. C., Sahni, S., Jansson, P. J., Kovacevic, Z., Hawkins, Clare Louise & Richardson, D. R., 30 Dec 2016, In: The Journal of Biological Chemistry. 291, 53, p. 27042-27061 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space
Indo, H. P., Majima, H. J., Terada, M., Suenaga, S., Tomita, K., Yamada, S., Higashibata, A., Ishioka, N., Kanekura, T., Nonaka, I., Hawkins, Clare Louise, Davies, Michael J., Clair, D. K. S. & Mukai, C., 16 Dec 2016, In: Scientific Reports. 6, 10 p., 39015.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cross-linking of lens crystallin proteins induced by tryptophan metabolites and metal ions: implications for cataract development
Tweeddale, H. J., Hawkins, Clare Louise, Janmie, J. F., Truscott, R. J. W. & Davies, Michael J., Oct 2016, In: Free Radical Research. 50, 10, p. 1116-1130 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia
Karimi Galougahi, K., Liu, C., Garcia, A., Gentile, C., Fry, N. A., Hamilton, E. J., Hawkins, Clare Louise & Figtree, G. A., 19 Feb 2016, In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 5, 2, e002824.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages
Love, D., Barrett, T. J., White, M. Y., Cordwell, S. J., Davies, Michael J. & Hawkins, Clare Louise, 2016, In: Free Radical Biology & Medicine. 94, p. 88-98 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?
Ismael, F. O., Barrett, T. J., Sheipouri, D., Brown, B. E., Davies, Michael J. & Hawkins, Clare Louise, 2016, In: P L o S One. 11, 12, 16 p., e0168844.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin and enhances rat gastric tumor cell invasion
Indo, H. P., Matsui, H., Chen, J., Zhu, H., Hawkins, Clare Louise, Davies, Michael J., Yarana, C., Clair, D. K. S. & Majima, H. J., 1 Jul 2015, In: Journal of Clinical Biochemistry and Nutrition. 57, 1, p. 13-20 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reactivity of selenium-containing compounds with myeloperoxidase-derived chlorinating oxidants: Second-order rate constants and implications for biological damage
Carroll, L., Pattison, D. I., Fu, S., Schiesser, C. H., Davies, Michael J. & Hawkins, Clare Louise, Jul 2015, In: Free Radical Biology & Medicine. 84, p. 279-288 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
Tryptophan oxidation in proteins exposed to thiocyanate-derived oxidants
Bonifay, V., Barrett, T. J., Pattison, D. I., Davies, Michael J., Hawkins, Clare Louise & Ashby, M. T., 15 Dec 2014, In: Archives of Biochemistry and Biophysics. 564, p. 1-11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?
Hawkins, Clare Louise, Nov 2014, In: Kidney International. 86, 5, p. 875-7 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells
Rayner, B. S., Love, D. T. & Hawkins, Clare Louise, Jun 2014, In: Free Radical Biology & Medicine. 71, p. 240-55 16 p.Research output: Contribution to journal › Journal article › Commissioned › peer-review
Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides
Kajer, T. B., Fairfull-Smith, K. E., Yamasaki, T., Yamada, K., Fu, S., Bottle, S. E., Hawkins, Clare Louise & Davies, Michael J., May 2014, In: Free Radical Biology & Medicine. 70, p. 96-105 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Detection and characterisation of radicals in biological materials using EPR methodology
Hawkins, Clare Louise & Davies, Michael J., Feb 2014, In: B B A - Reviews on Cancer. 1840, 2, p. 708-21 14 p.Research output: Contribution to journal › Review › Research › peer-review
Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction
Galougahi, K. K., Liu, C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N. A. S., Davies, Michael J., Hawkins, Clare Louise, Rasmussen, H. H. & Figtree, G. A., 2014, In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 3, 2, p. e000731Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MODULATION OF ENDOTHELIAL CELL FUNCTION BY THE MYELOPEROXIDASE-DERIVED OXIDANT HYPOCHLOROUS ACID (HOCl) AND ITS CONTRIBUTION TO ATHEROSCLEROSIS
Rayner, B. S., Lloyd, M. M., Summers, F. A., Davies, Michael J. & Hawkins, Clare Louise, 2014, In: Hypertension.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells
Lloyd, M. M., Grima, M. A., Rayner, B. S., Hadfield, K. A., Davies, Michael J. & Hawkins, Clare Louise, Dec 2013, In: Free Radical Biology & Medicine. 65, p. 1352-62 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)
Hadfield, K. A., Pattison, D. I., Brown, B. E., Hou, L., Rye, K., Davies, Michael J. & Hawkins, Clare Louise, 15 Jan 2013, In: Biochemical Journal. 449, 2, p. 531-42 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
Identification of proteins susceptible to thiol oxidation in endothelial cells exposed to hypochlorous acid and N-chloramines
Summers, F. A., Forsman Quigley, A. & Hawkins, Clare Louise, 24 Aug 2012, In: Biochemical and Biophysical Research Communications. 425, 2, p. 157-61 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids
Pattison, D. I., Davies, Michael J. & Hawkins, Clare Louise, Aug 2012, In: Free Radical Research. 46, 8, p. 975-95 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome
Boon, A., Hawkins, Clare Louise, Bisht, K., Coombes, J. S., Bakrania, B., Wagner, K. & Bulmer, A. C., 15 May 2012, In: Free Radical Biology & Medicine. 52, 10, p. 2120-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates
Barrett, T. J., Pattison, D. I., Leonard, S. E., Carroll, K. S., Davies, Michael J. & Hawkins, Clare Louise, 15 Mar 2012, In: Free Radical Biology & Medicine. 52, 6, p. 1075-85 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Hypothiocyanous acid - benign or deadly?
Barrett, T. J. & Hawkins, Clare Louise, 20 Feb 2012, In: Chemical Research in Toxicology. 25, 2, p. 263-73 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes
Lok, H. C., Suryo Rahmanto, Y., Hawkins, Clare Louise, Kalinowski, D. S., Morrow, C. S., Townsend, A. J., Ponka, P. & Richardson, D. R., 2 Jan 2012, In: The Journal of Biological Chemistry. 287, 1, p. 607-18 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase
Morgan, P. E., Pattison, D. I., Talib, J., Summers, F. A., Harmer, J. A., Celermajer, D. S., Hawkins, Clare Louise & Davies, Michael J., 1 Nov 2011, In: Free Radical Biology & Medicine. 51, 9, p. 1815-22 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity
Yu, Y., Suryo Rahmanto, Y., Hawkins, Clare Louise & Richardson, D. R., Jun 2011, In: Molecular Pharmacology. 79, 6, p. 921-31 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome
Gracanin, M., Lam, M. A., Morgan, P. E., Rodgers, K. J., Hawkins, Clare Louise & Davies, Michael J., 15 Jan 2011, In: Free Radical Biology & Medicine. 50, 2, p. 389-99 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
Cellular effects of photogenerated oxidants and long-lived, reactive, hydroperoxide photoproducts
Rahmanto, A. S., Morgan, P. E., Hawkins, Clare Louise & Davies, Michael J., 30 Nov 2010, In: Free Radical Biology & Medicine. 49, 10, p. 1505-15 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation - an EPR study
Jansson, P. J., Hawkins, Clare Louise, Lovejoy, D. B. & Richardson, D. R., Nov 2010, In: Journal of Inorganic Biochemistry. 104, 11, p. 1224-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages
Lane, A. E., Tan, J. T. M., Hawkins, Clare Louise, Heather, A. K. & Davies, Michael J., 15 Aug 2010, In: Biochemical Journal. 430, 1, p. 161-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Ability of hypochlorous acid and N-chloramines to chlorinate DNA and its constituents
Stanley, N. R., Pattison, D. I. & Hawkins, Clare Louise, 19 Jul 2010, In: Chemical Research in Toxicology. 23, 7, p. 1293-302 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations
Koelsch, M., Mallak, R., Graham, G. G., Kajer, T., Milligan, M. K., Nguyen, L. Q., Newsham, D. W., Keh, J. S., Kettle, A. J., Scott, K. F., Ziegler, J. B., Pattison, D. I., Fu, S., Hawkins, Clare Louise, Rees, M. D. & Davies, Michael J., 15 Apr 2010, In: Biochemical Pharmacology. 79, 8, p. 1156-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cellular effects of peptide and protein hydroperoxides
Rahmanto, A. S., Morgan, P. E., Hawkins, Clare Louise & Davies, Michael J., 15 Apr 2010, In: Free Radical Biology & Medicine. 48, 8, p. 1071-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
The role of hypothiocyanous acid (HOSCN) in biological systems
Hawkins, Clare Louise, Dec 2009, In: Free Radical Research. 43, 12, p. 1147-58 12 p.Research output: Contribution to journal › Journal article › Commissioned › peer-review
Singlet-oxygen-mediated amino acid and protein oxidation: formation of tryptophan peroxides and decomposition products
Gracanin, M., Hawkins, Clare Louise, Pattison, D. I. & Davies, Michael J., 1 Jul 2009, In: Free Radical Biology & Medicine. 47, 1, p. 92-102 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
What are the plasma targets of the oxidant hypochlorous acid? A kinetic modeling approach
Pattison, D. I., Hawkins, Clare Louise & Davies, Michael J., May 2009, In: Chemical Research in Toxicology. 22, 5, p. 807-17 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quantification of protein modification by oxidants
Hawkins, Clare Louise, Morgan, P. E. & Davies, Michael J., 15 Apr 2009, In: Free Radical Biology & Medicine. 46, 8, p. 965-88 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation
Hawkins, Clare Louise, Pattison, D. I., Stanley, N. R. & Davies, Michael J., 15 Dec 2008, In: Biochemical Journal. 416, 3, p. 441-52 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Separation, detection, and quantification of hydroperoxides formed at side-chain and backbone sites on amino acids, peptides, and proteins
Morgan, P. E., Pattison, D. I., Hawkins, Clare Louise & Davies, Michael J., 1 Nov 2008, In: Free Radical Biology & Medicine. 45, 9, p. 1279-89 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin
Szuchman-Sapir, A. J., Pattison, D. I., Ellis, N. A., Hawkins, Clare Louise, Davies, Michael J. & Witting, P. K., 15 Sep 2008, In: Free Radical Biology & Medicine. 45, 6, p. 789-98 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid
Lloyd, M. M., van Reyk, D. M., Davies, Michael J. & Hawkins, Clare Louise, 1 Sep 2008, In: Biochemical Journal. 414, 2, p. 271-80 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines
Summers, F. A., Morgan, P. E., Davies, Michael J. & Hawkins, Clare Louise, Sep 2008, In: Chemical Research in Toxicology. 21, 9, p. 1832-40 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mammalian heme peroxidases: from molecular mechanisms to health implications
Davies, Michael J., Hawkins, Clare Louise, Pattison, D. I. & Rees, M. D., Jul 2008, In: Antioxidants & Redox Signaling. 10, 7, p. 1199-234 36 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
Hypochlorous acid-mediated protein oxidation: how important are chloramine transfer reactions and protein tertiary structure?
Pattison, D. I., Hawkins, Clare Louise & Davies, Michael J., 28 Aug 2007, In: Biochemistry. 46, 34, p. 9853-64 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
Sensitizer-mediated photooxidation of histidine residues: evidence for the formation of reactive side-chain peroxides
Agon, V. V., Bubb, W. A., Wright, A., Hawkins, Clare Louise & Davies, Michael J., 15 Feb 2006, In: Free Radical Biology & Medicine. 40, 4, p. 698-710 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
The role of aromatic amino acid oxidation, protein unfolding, and aggregation in the hypobromous acid-induced inactivation of trypsin inhibitor and lysozyme
Hawkins, Clare Louise & Davies, Michael J., Nov 2005, In: Chemical Research in Toxicology. 18, 11, p. 1669-77 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
The role of reactive N-bromo species and radical intermediates in hypobromous acid-induced protein oxidation
Hawkins, Clare Louise & Davies, Michael J., 1 Oct 2005, In: Free Radical Biology & Medicine. 39, 7, p. 900-12 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 173742266
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Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
181
downloads
Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
154
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Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space
Research output: Contribution to journal › Journal article › Research › peer-review
Published