Mette Rosenkilde
Professor
- Published
Functional analysis of the murine cytomegalovirus chemokine receptor homologue M33: ablation of constitutive signaling is associated with an attenuated phenotype in vivo
Case, R., Sharp, E., Benned-Jensen, T., Rosenkilde, Mette, Davis-Poynter, N. & Farrell, H. E., 2007, In: Journal of Virology. 82, 4, p. 1884-98 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular Disulfide Bridges Serve Different Purposes in Two Homologous Chemokine Receptors, CCR1 and CCR5
Rummel, P. C., Thiele, S., Gasbjerg, Lærke Smidt, Petersen, T. P., wbf943, wbf943, Ulven, T. & Rosenkilde, Mette, 13 Jun 2013, In: Current Molecular Pharmacology. 84, 3, p. 335-345 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats.
Simonsen, L., Pilgaard, S., Orskov, C., Rosenkilde, Mette, Hartmann, B., Holst, Jens Juul & Deacon, Carolyn F., 2007, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 293, 1, p. G288-95Research output: Contribution to journal › Journal article › Research › peer-review
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Ex vivo treatment of cytomegalovirus in human donor lungs using a novel chemokine-based immunotoxin
Ribeiro, R. V. P., Ku, T., Wang, A., Pires, L., Ferreira, V. H., Michaelsen, V., Ali, A., Galasso, M., Moshkelgosha, S., Gazzalle, A., Jeppesen, Mads Gravers, Rosenkilde, Mette, Liu, M., Singer, L. G., Kumar, D., Keshavjee, S., Sinclair, J., Kledal, T. N., Humar, A. & Cypel, M., 2022, In: Journal of Heart and Lung Transplantation. 41, 3, p. 287-297Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists
Gasbjerg, Lærke Smidt, Bergmann, N. C., Stensen, S., Christensen, Mikkel Bring, Rosenkilde, Mette, Holst, Jens Juul, Nauck, M. & Knop, Filip Krag, 2020, In: Peptides. 125, 10 p., 170183.Research output: Contribution to journal › Review › Research › peer-review
- Published
Estrous Cycle Modulation of Feeding and Relaxin-3/Rxfp3 mRNA Expression: Implications for Estradiol Action
de Avila, C., Chometton, S., Calvez, J., Guevremont, G., Kania, A., Pedersen, Lola Julie Torz, Lenglos, C., Blasiak, A., Rosenkilde, Mette, Holst, Birgitte, Conrad, C. D., Fyer, J. D., Timofeeva, E., Gundlach, A. L. & Cifani, C., 2021, In: Neuroendocrinology. 111, 12, p. 1201–1218Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epstein-Barr virus-kodet BILF1 er en konstitutivt aktiv G-protein-koblede receptor
Paulsen, S. J., Rosenkilde, Mette, Eugen-Olsen, J. & Kledal, T. N., 2005, In: Journal of Virology. 79, 1, p. 536-46 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epstein-Barr Virus-Encoded BILF1 Orthologues From Porcine Lymphotropic Herpesviruses Display Common Molecular Functionality
Mavri, M., Kubale, V., Depledge, D. P., Zuo, J., Huang, C. A., Breuer, J., Vrecl, M., Jarvis, M. A., Jovičić, E. J., Petan, T., Ehlers, B., Rosenkilde, Mette & Spiess, Katja, 2022, In: Frontiers in Endocrinology. 13, 16 p., 862940.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epstein Barr Virus encoded BILF1 is a constitutively active G-protein coupled receptor
Paulsen, S., Rosenkilde, Mette, Eugen-Olsen, J. & Kledal, T. N., 2005, In: Journal of Virology. Vol. 79, no. 1, p. 536-46Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice
Gobron, B., Bouvard, B., Vyavahare, S., Blom, L. V. V., Pedersen, K. K., Windeløv, Johanne Agerlin, Boer, G. A., Harada, N., Zhang, S., Shimazu-Kuwahara, S., Wice, B., Inagaki, N., Legrand, E., Flatt, P. R., Chappard, D., Hartmann, Bolette, Holst, Jens Juul, Rosenkilde, Mette, Irwin, N. & Mabilleau, G., 2020, In: Journal of Bone and Mineral Research. 35, 7, p. 1363-1374 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system
Gabe, M. B. N., van der Velden, W. J. C., Gadgaard, S., Smit, F. X., Hartmann, Bolette, Bräuner, Hans & Rosenkilde, Mette, 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, p. 122-132Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Endogenous glucose-dependent insulinotropic polypeptide exerts diverging and tissue specific in obese patients with type 2 diabetes
Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., wbf943, wbf943, Skov-Jeppesen, Kirsa, Jensen, M. H., Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, M. B. & Knop, Filip Krag, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S270-S271 2 p., 560.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in Beta Cell Function in Patients with Type 2 Diabetes
Stensen, S., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Vilsbøll, Tina, Holst, Jens Juul, Hartmann, Bolette, Christensen, Mikkel Bring & Knop, Filip Krag, 2022, In: Diabetes. 71, 10, p. 2209-2221Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Effects of exogenous GIP and GLP-2 on bone turnover in individuals with type 2 diabetes
Skov-Jeppesen, Kirsa, Christiansen, Charlotte Bayer, Hansen, L. S., Windeløv, Johanne Agerlin, Hedbäck, N., Gasbjerg, Lærke Smidt, Hindsø, M., Svane, M. S., Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2024, (Accepted/In press) In: The Journal of clinical endocrinology and metabolism.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of endogenous GIP in patients with type 2 diabetes
Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., Skov-Jeppesen, Kirsa, wbf943, wbf943, Jensen, M. H., Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, Mikkel Bring & Knop, Filip Krag, Apr 2021, In: European Journal of Endocrinology. 185, 1, p. 33-45Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial
Ekeloef, S., Halladin, N., Fonnes, S., Jensen, S. E., Zaremba, T., Rosenberg, Jacob, Jonsson, G., Aarøe, J., Gasbjerg, Lærke Smidt, Rosenkilde, Mette & Gögenur, Ismail, Dec 2017, In: Journal of Cardiovascular Translational Research. 10, 5-6, p. 470-479 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
EBV, the Human Host, and the 7TM Receptors: Defense or Offense?
Arfelt, K. N., Fares, S. & Rosenkilde, Mette, 2015, The Molecular Basis of Viral Infection. Klasse, P. J. (ed.). Academic Press, Vol. 129. p. 395-427 (Progress in Molecular Biology and Translational Science, Vol. 129).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors
Nørregaard, K., Benned-Jensen, T. & Rosenkilde, Mette, 2011, In: Current Topics in Medicinal Chemistry. 11, 6, p. 618-28 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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EBI2 overexpression in mice leads to B1 B cell expansion and chronic lymphocytic leukemia-(CLL)-like B cell malignancies
Niss Arfelt, K., Barington, L., Benned-Jensen, T., Kubale, V., Kovalchuk, A. L., Daugvilaite, V., Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Egerod, Kristoffer Lihme, Bassi, Maria Rosaria, Spiess, Katja, Schwartz, Thue W., Wang, H., Morse, H. C., Holst, Peter Johannes & Rosenkilde, Mette, 2017, In: Blood. 129, 7, p. 866-878Research output: Contribution to journal › Journal article › Research › peer-review
- Published
EBI2 in splenic and local immune responses and in autoimmunity
Barington, L., Wanke, F., Niss Arfelt, K., Holst, Peter Johannes, Kurschus, F. C. & Rosenkilde, Mette, 2018, In: Journal of Leukocyte Biology. 104, 2, p. 313-322 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Dual treatment with a fixed ratio of glucagon and insulin increases the therapeutic window of insulin in diabetic rats
Pedersen, C., Bouman, S. D., Porsgaard, T., Rosenkilde, Mette & Roed, N. K., 2018, In: Physiological Reports. 6, 6, 9 p., e13657 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dose-dependent efficacy of the glucose-dependent insulinotropic polypeptide (GIP)receptor antagonistGIP(3-30)NH2 on GIP actions in humans
Gasbjerg, Lærke Smidt, Bari, E. J., Stensen, S., Hoe, B., Lanng, A. R., Mathiesen, D. S., Christensen, Mikkel Bring, Hartmann, Bolette, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2021, In: Diabetes, Obesity and Metabolism. 23, 1, p. 68-74Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants
Benned-Jensen, T. & Rosenkilde, Mette, Mar 2010, In: British Journal of Pharmacology. 159, 5, p. 1092-105 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation
Fares, S., Spiess, Katja, Olesen, Emma Tina Bisgaard, Zuo, J., Jackson, S., Kledal, T. N., Wills, M. R. & Rosenkilde, Mette, 2019, In: mBio. 10, 1, e01707-18.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of GPR183 Agonists Based on an Antagonist Scaffold
Kjær, Viktoria Madeline Skovgaard, Ieremias, L., Daugvilaite, V., Lückmann, Michael, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette & Våbenø, J., 2021, In: ChemMedChem. 16, 17, p. 2623-2627Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2
Zweemer, A. J. M., Bunnik, J., Veenhuizen, M., Miraglia, F., Lenselink, E. B., Vilums, M., de Vries, H., Gibert, A., Thiele, S., Rosenkilde, Mette, IJzerman, A. P. & Heitman, L. H., 2014, In: Molecular Pharmacology. 86, 4, p. 358-68 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential regulation of CXCR4 and CCR5 endocytosis
Signoret, N., Rosenkilde, Mette, Klasse, P. J., Schwartz, Thue W., Malim, M. H., Hoxie, J. A. & Marsh, M., 1998, In: Journal of Cell Science. 111, no. 18, p. 2819-2830Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines
Hjortø, Gertrud Malene, Larsen, Olav, Steen, A., Daugvilaite, V., Berg, Christian, Fares, S., Hansen, M., Ali, S. & Rosenkilde, Mette, 9 Dec 2016, In: Frontiers in Immunology. 7, 568.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of potent and proteolytically stable human neuromedin U receptor agonists
De Prins, A., Martin, C., Van Wanseele, Y., Skov, Louise Julie, Tömböly, C., Tourwé, D., Caveliers, V., Van Eeckhaut, A., Holst, Birgitte, Rosenkilde, Mette, Smolders, I. & Ballet, S., 20 Jan 2018, In: European Journal of Medicinal Chemistry. 144, p. 887-897 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes
Berg, Christian, Friis, M. B., Rosenkilde, Mette, Benfield, Thomas, Nielsen, L., Lüttichau, H. R. & Sundelin, T., 2019, In: PLoS ONE. 14, 9, 14 p., e0222053.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis
Thiele, S., Mungalpara, J., Steen, A., Rosenkilde, Mette & Våbenø, J., Dec 2014, In: British Journal of Pharmacology. 171, 23, p. 5313-29 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
Winther-Sørensen, Marie, Garcia, S. L., Bartholdy, Andreas, Ottenheijm, Maud Eline, Banasik, Karina, Brunak, Søren, Sorensen, Charlotte Mehlin, Gluud, Lise Lotte, Knop, Filip Krag, Holst, Jens Juul, Rosenkilde, Mette, Jensen, Majken Karoline & Albrechtsen, Nicolai Jacob Wewer, 6 May 2024, (E-pub ahead of print) In: Diabetologia.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Det chemokine system - en vigtig regulator af angiogenese i sundhed og sygdom
Rosenkilde, Mette & Schwartz, Thue W., 2004, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 112, 7-8, p. 481-95 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)
Zachariassen, Z. G., Thiele, S., Berg, E. A., Rasmussen, P., Fossen, T., Rosenkilde, Mette, Våbenø, J. & Haug, B. E., 1 Sep 2014, In: Bioorganic & Medicinal Chemistry. 22, 17, p. 4759-69 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Constitutive and regulated activities of virus-encoded 7TM receptors
Rosenkilde, Mette & Schwartz, Thue W., 2004, Handbook of Cellular Signalling. Chapter 29 ed. p. 173-76Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
- Published
Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V
Rosenkilde, Mette, David, R., Oerlecke, I., Benned-Jensen, T., Geumann, U., Beck-Sickinger, A. G. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 70, 6, p. 1892-901 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes
Mandøe, M. J., Hansen, K. B., Windeløv, Johanne Agerlin, Knop, Filip Krag, Rehfeld, Jens Frederik, Rosenkilde, Mette, Holst, Jens Juul & Hansen, Harald S., 2018, In: Nutrition and Diabetes. 8, 1, p. 1-10 2.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combined N-terminal and C-terminal truncations of Glucose dependent Insulinotropic Polypeptide (GIP) are potent and efficient GIP receptor antagonists
Hansen, L. S., wbf943, wbf943, Svendsen, B., Christensen, M., Hartmann, Bolette, Knop, Filip Krag, Holst, Jens Juul & Rosenkilde, Mette, Sep 2015, In: Diabetologia. 58, 1 supplement, p. S276-S277 2 p., 569.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N. & 9 others, , Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation
Goth, C. K., Mehta, A. Y., McQuillan, A. M., Baker, K. J., Hanes, M. S., Park, S. S., Stavenhagen, K., Hjortø, Gertrud Malene, Heimburg-Molinaro, J., Chaikof, E. L., Rosenkilde, Mette & Cummings, R. D., 2023, In: Cell Chemical Biology. 30, 8, p. 893-905.e7Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5
Larsen, Olav, Schuermans, S., Walser, Anna Louise Silvia, Louka, S., Lillethorup, I. A., Våbenø, J., Qvortrup, K., Proost, P. & Rosenkilde, Mette, 2023, In: FEBS Letters. 597, 24, p. 3049-3060Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chapter 8. Activation mechanisms of chemokine receptors
Jensen, P. C. & Rosenkilde, Mette, 2009, In: Methods in Enzymology. 461, p. 171-90 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection
Klasse, P. J., Rosenkilde, Mette, Signoret, N., Pelchen-Matthews, A., Schwartz, Thue W. & Marsh, M., 1999, In: Journal of Virology. 73, no. 9, p. 7453-7466Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, Olav, Jepsen, Sara Lind, Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biased small-molecule ligands for selective inhibition of HIV-1 cell entry via CCR5
Berg, Christian, Spiess, Katja, von Lüttichau, H. R. & Rosenkilde, Mette, Dec 2016, In: Pharmacology Research & Perspectives. 4, 6, 14 p., e00262.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119
Hassing, H. A., Fares, S., Larsen, Olav, Pad, H., Pedersen, M. H., Jones, R. M., Schwartz, Thue W., Hansen, Harald S. & Rosenkilde, Mette, 26 Aug 2016, In: Biochemical Pharmacology. 119, 1, p. 66-75 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biased signaling of G protein-coupled receptors: rom a chemokine receptor CCR7 perspective
Jørgensen, Astrid Sissel, Rosenkilde, Mette & Hjortø, Gertrud Malene, Mar 2018, In: General and Comparative Endocrinology. 258, SI, p. 4-14Research output: Contribution to journal › Review › Research › peer-review
- Published
Biased and g protein-independent signaling of chemokine receptors
Steen, A., Larsen, O., Thiele, S. & Rosenkilde, Mette, 2014, In: Frontiers in Immunology. 5, p. 1-13 13 p., 277.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biased and Constitutive Signaling in the CC-Chemokine Receptor CCR5 by manipulating the Interface between Transmembrane Helix 6 and 7
Steen, A., Thiele, S., Guo, D., Gasbjerg, Lærke Smidt, Frimurer, Thomas Michael & Rosenkilde, Mette, 3 May 2013, In: Journal of Biological Chemistry. 288, 18, p. 12511-12521 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biased agonism and allosteric modulation of GPR183- a 7TM receptor also known as EBV-induced EBI2
Daugvilaite, V., Madsen, C. M., Lückmann, Michael, Castello Echeverria, C., Sailer, A. W., Frimurer, Thomas Michael, Rosenkilde, Mette & Benned-Jensen, T., 2017, In: British Journal of Pharmacology. 174, 13, p. 2031–2042Research output: Contribution to journal › Journal article › Research › peer-review
ID: 3361
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Pharmacokinetics of oral and intravenous melatonin in healthy volunteers
Research output: Contribution to journal › Journal article › Research › peer-review
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442
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Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines
Research output: Contribution to journal › Journal article › Research › peer-review
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375
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Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119
Research output: Contribution to journal › Journal article › Research › peer-review
Published