Jens Juul Holst

Jens Juul Holst

Professor

ORCID: 0000-0001-6853-3805

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  1. Published

    Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels

    pjx571, pjx571, Iepsen, E. P. W., Galijatovic, E. A. A., Mahendran, Y., Lundgren, J. R., Jonsson, Anna Elisabet, Madsbad, Sten, Holst, Jens Juul, drb459, drb459, Hansen, Torben & Torekov, Signe Sørensen, Dec 2016, In: Metabolomics. 12, 12, p. 1-9 9 p., 181.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    WITHDRAWN: Glucagon processing

    Steiner, D. F., Albrechtsen, Nicolai Jacob Wewer, Rehfeld, Jens Frederik & Holst, Jens Juul, 2016, The Curated Reference Collection in Neuroscience and Biobehavioral Psychology. Elsevier

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  3. Published

    Use of anesthesia dramatically alters the oral glucose tolerance and insulin secretion in C57Bl/6 mice

    Windeløv, Johanne Agerlin, Pedersen, Jens & Holst, Jens Juul, Jun 2016, In: Physiological Reports. 4, 11, 6 p., e12824.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

    Adriaenssens, A. E., Svendsen, B., Lam, B. Y. H., Yeo, G. S. H., Holst, Jens Juul, Reimann, F. & Gribble, F. M., Oct 2016, In: Diabetologia. 59, 10, p. 2156-2165 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    The regulation of function, growth and survival of GLP-1-producing L-cells.

    Kuhre, Rune Ehrenreich, Holst, Jens Juul & Kappe, C., 1 Jan 2016, In: Clinical Science. 130, 2, p. 79-91 13 p.

    Research output: Contribution to journal › Review › Research › peer-review

  6. Published

    The intestinal distribution pattern of appetite- and glucose regulatory peptides in mice, rats and pigs

    Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Toräng, S. & Holst, Jens Juul, 2 Feb 2016, In: BMC Research Notes. 9, 1, p. 1-6 6 p., 60.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The insulinotropic effect of exogenous GLP-1 is not affected by acute vagotomy in anaesthetized pigs

    Veedfald, Simon, Hansen, M., Christensen, L. W., Larsen, S. A. H., Hjøllund, K. R., Plamboeck, A., Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, 30 Mar 2016, In: Experimental Physiology. 101, 7, p. 895-912 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The blunted effect of glucose-dependent insulinotropic polypeptide in subcutaneous abdominal adipose tissue in obese subjects is partly reversed by weight loss

    Asmar, M., Arngrim, N., Simonsen, L., Asmar, A., Nordby, P., Holst, Jens Juul & Bülow, J., 2016, In: Nutrition and Diabetes. 6, 7 p., e208.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The biology of glucagon and the consequences of hyperglucagonemia

    Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Pedersen, Jens, Knop, Filip Krag & Holst, Jens Juul, 9 Sep 2016, In: Biomarkers in Medicine. 10, 11, p. 1141-1151 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3-36

    Iepsen, E. W., Lundgren, J., Holst, Jens Juul, Madsbad, Sten & Torekov, Signe Sørensen, Jun 2016, In: European Journal of Endocrinology. 174, 6, p. 775-784 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Species-specific action of (Pro3)GIP - an efficacious agonist on human GIP receptor, but partial agonist and competitive antagonist on rat and mouse GIP receptors

    wbf943, wbf943, Gasbjerg, Lærke Smidt, Svendsen, B., Christensen, M., Knop, Filip Krag, Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, Jan 2016, In: British Journal of Pharmacology. 173, 1, p. 27-38 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Short-term effects of liraglutide on kidney function and vasoactive hormones in type 2 diabetes: a randomized clinical trial

    Skov, J., Pedersen, M., Holst, Jens Juul, Madsen, B., Goetze, Jens P. , Rittig, S., Jonassen, Thomas, Frøkiær, J., Dejgaard, A. & Christiansen, J. S., 22 Feb 2016, In: Diabetes, Obesity and Metabolism Online. 18, 6, p. 581-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Serum lipase activity and concentration during intravenous infusions of GLP-1 and PYY3-36 and after ad libitum meal ingestion in overweight men

    Schmidt, J. B., Sjödin, Anders Mikael, Stevner, L. S., Ritz, C., Michaelsen, N. B., Thomsen, A. B., Holst, Jens Juul & Astrup, A., 2016, In: Physiological Reports. 4, 18, 7 p., e12980.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Secretion of glucagon-like peptide-2 responds to nutrient intake but not glucose provision in milk-fed calves

    Castro, J. J., Morrison, S. Y., Hosseinni, A., Loor, J. J., Drackley, J. K., Ipharraguerre, I. R., Holst, Jens Juul & Hartmann, Bolette, Jul 2016, In: Journal of Dairy Science. 99, 7, p. 5793–5807

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Searching for the physiological role of glucose-dependent insulinotropic polypeptide

    Holst, Jens Juul, Windeløv, Johanne Agerlin, Boer, G. A., Pedersen, Jens, Svendsen, B., Christensen, M., Torekov, Signe Sørensen, Asmar, M., Hartmann, Bolette & Nissen, A., 1 Apr 2016, In: Journal of Diabetes Investigation. 7, S1, p. 8-12 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Safety and Efficacy of Liraglutide in Patients With Type 2 Diabetes and End-Stage Renal Disease: An Investigator-Initiated, Placebo-Controlled, Double-Blinded, Parallel Group, Randomized Trial

    Idorn, T., Knop, Filip Krag, Jørgensen, M. B., Jensen, T., Resuli, M., Hansen, P. M., Christensen, Karl Bang, Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, Feb 2016, In: Diabetes Care. 39, 2, p. 206-13 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota

    Palleja, A., Kashani, A., Allin, K. H., Nielsen, T., Zhang, C., Li, Y., Brach, Thorsten, Liang, S., Feng, Q., Jørgensen, N. B., Bojsen-Møller, K. N., Dirksen, C., Burgdorf, Kristoffer Sølvsten, Holst, Jens Juul, Madsbad, Sten, Wang, J., Pedersen, Oluf Borbye, Hansen, Torben & Arumugam, Mani, 2016, In: Genome Medicine. 8, 13 p., 67.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Roles of the Gut in Glucose Homeostasis

    Holst, Jens Juul, Gribble, F., Horowitz, M. & Rayner, C. K., Jun 2016, In: Diabetes Care. 39, 6, p. 884-92 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Regulation of gut hormone secretion. Studies using isolated perfused intestines.

    Svendsen, B. & Holst, Jens Juul, Mar 2016, In: Peptides. 77, p. 47-53 7 p.

    Research output: Contribution to journal › Review › Research › peer-review

  20. Published

    Regulation of Pancreatic α-Cell Function and Proliferation by Bone Morphogenetic Protein 4 (BMP4) In Vitro

    Nielsen, S. S., Christensen, G. L., Holst, Jens Juul & Billestrup, Nils, Oct 2016, In: Endocrinology. 157, 10, p. 3809-3820 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Regulation of Pancreatic Alpha Cell Function and Proliferation by Bone Morphogenetic Protein 4 (BMP4) in vitro.

    Nielsen, S. S., Christensen, G. L., Holst, Jens Juul & Billestrup, Nils, Oct 2016, In: Endocrinology. 157, 10, p. 3809-3820 12 p., 27479530 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs

    Hansen, C. F., Thymann, Thomas, Andersen, A. D., Holst, Jens Juul, Hartmann, Bolette, Hilsted, Linda, Langhorn, L., Jelsing, J. & Sangild, Per Torp, 28 Jan 2016, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 310, 8, p. G550-560 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Quantification of the contribution of GLP-1 to mediating insulinotropic effects of DPP-4 inhibition with vildagliptin in healthy subjects and type 2-diabetic patients using exendin [9-39] as a GLP-1 receptor antagonist.

    Nauck, M. A., Kind, J., Köthe, L. D., Holst, Jens Juul, Deacon, Carolyn F., Broschag, M., He, Y., Kjems, L. & Foley, J., 2016, In: Diabetes. 65, 8, p. 2440-2447 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Proteomics reveals the effects of sustained weight loss on the human plasma proteome

    Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Tyanova, S., Grassl, N., Iepsen, E. P. W., Lundgren, J., Madsbad, Sten, Holst, Jens Juul, Torekov, Signe Sørensen & Mann, Matthias, 22 Dec 2016, In: Molecular Systems Biology. 12, 16 p., 901.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells.

    Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Balk-Møller, E., Rehfeld, Jens Frederik, Relman, F., Gribble, F. M. & Holst, Jens Juul, 2016, In: Journal of Molecular Endocrinology. 56, p. 201-211

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Peptide YY3-36 and glucagon-like peptide-1 in functional dyspepsia. Secretion and role in symptom generation

    Witte, A., Hilsted, Linda, Holst, Jens Juul & Schmidt, P. T., Apr 2016, In: Scandinavian Journal of Gastroenterology. 51, 4, p. 400-409 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Peptide YY and glucagon-like peptide-1 contribute to decreased food intake after Roux-en-Y gastric bypass surgery

    Svane, M. S., Jørgensen, N. B., Bojsen-Møller, K. N., Dirksen, C., Nielsen, S., Kristiansen, V. B., Toräng, S., Albrechtsen, Nicolai Jacob Wewer, Rehfeld, Jens Frederik, Hartmann, Bolette, Madsbad, Sten & Holst, Jens Juul, 30 Aug 2016, In: International Journal of Obesity. 40, p. 1699–1706

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Pancreatic α-cell hyperplasia and hyperglucagonemia due to a mutation of the glucagon

    Larger, E., Albrechtsen, Nicolai Jacob Wewer, Hansen, L. H., Gelling, R. W., Capeau, J., Deacon, Carolyn F., Madsen, O. D., Yakushiji, F., Meyts, P. D., Holst, Jens Juul & Nishimura, E., 2016, In: Endocrinology, Diabetes & Metabolism Case Reports. 2016, 6 p., EDM160081.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma

    Albrechtsen, Nicolai Jacob Wewer, Hornburg, D., Albrechtsen, Reidar, Svendsen, B., Toräng, S., Jepsen, Sara Lind, Kuhre, Rune Ehrenreich, Hansen, M., Janus, C., Floyd, A., Lund, Asger Bach, Vilsbøll, Tina, Knop, Filip Krag, drb459, drb459, Deacon, Carolyn F., Meissner, F., Mann, Matthias, Holst, Jens Juul & Hartmann, Bolette, May 2016, In: EBioMedicine. 7, p. 112-120 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor

    Hassing, H. A., Engelstoft, M. S., Sichlau, R. M., Madsen, A. N., Rehfeld, Jens Frederik, Pedersen, Jens, Jones, R. M., Holst, Jens Juul, Schwartz, Thue W., Rosenkilde, Mette & Hansen, Harald S., 2016, In: BioFactors. 42, 6, p. 665-673

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    No Islet Cell Hyperfunction, but Altered Gut-Islet Regulation and Postprandial Hypoglycemia in Glucose-Tolerant Patients 3 Years After Gastric Bypass Surgery

    Dirksen, C., Eiken, A., Bojsen-Møller, K. N., Svane, M. S., Martinussen, C., Jørgensen, N. B., Holst, Jens Juul & Madsbad, Sten, Sep 2016, In: Obesity Surgery. 26, 9, p. 2263-7 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  32. Published

    Neurotensin Is Co-Expressed, Co-Released And Acts Together With Glp-1 And Pyy In Enteroendocrine Control Of Metabolism

    Grunddal, Kaare Villum, Ratner, C. F., Svendsen, B., Sommer, F., Engelstoft, M. S., Madsen, A. N., Pedersen, Jens, Nøhr, M. K., Egerod, Kristoffer Lihme, Nawrocki, A. R., Kowalski, T., Howard, A. D., Poulsen, Steen Seier, Offermanns, S., Bäckhed, G. F., Holst, Jens Juul, Holst, Birgitte & Schwartz, Thue W., Jan 2016, In: Endocrinology. 157, 1, p. 176-94 19 p., en20151600.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    N- and C-terminally truncated forms of glucose-dependent insulinotropic polypeptide are high-affinity competitive antagonists of the human GIP receptor

    Hansen, L. S., wbf943, wbf943, Christensen, M., Knop, Filip Krag, Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 826-838 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men

    Matikainen, N., Björnson, E., Söderlund, S., Borén, C., Eliasson, B., Pietiläinen, K. H., Bogl, L. H., Hakkarainen, A., Lundbom, N., Rivellese, A., Riccardi, G., Després, J., Alméras, N., Holst, Jens Juul, Deacon, Carolyn F., Borén, J. & Taskinen, M., 2016, In: PLOS ONE. 11, 1, p. 1-15 15 p., e0145890.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Mechanisms of surgical control of type 2 diabetes: GLP-1 is key factor

    Holst, Jens Juul & Madsbad, Sten, Jul 2016, In: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 12, 6, p. 1236-42 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Major rapid weight loss induces changes in cardiac repolarization

    Vedel-Larsen, E., Iepsen, E. P. W., Lundgren, J., Graff, C., Struijk, J. J., Hansen, Torben, Holst, Jens Juul, Madsbad, Sten, Torekov, Signe Sørensen & Kanters, Jørgen K., 10 Feb 2016, In: Journal of Electrocardiology. 49, 3, p. 467-472 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Liraglutide for treating type 1 diabetes

    Dejgaard, T. F., Frandsen, C. S., Holst, Jens Juul & Madsbad, Sten, Apr 2016, In: Expert Opinion on Biological Therapy. 16, 4, p. 579-90 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Jejunal feeding is followed by a greater rise in plasma cholecystokinin, peptide YY, glucagon-like peptide 1, and glucagon-like peptide 2 concentrations compared with gastric feeding in vivo in humans: a randomized trial

    Luttikhold, J., van Norren, K., Rijna, H., Buijs, N., Ankersmit, M., Heijboer, A. C., Gootjes, J., Hartmann, Bolette, Holst, Jens Juul, van Loon, L. J. & van Leeuwen, P. A., Feb 2016, In: The American Journal of Clinical Nutrition. 103, 2, p. 435-43 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells

    Schmidt, S. F., Madsen, J. G. S., Frafjord, K. Ø., Poulsen, L. L. C., Salö, S., Boergesen, M., Loft, A., Larsen, B. D., Madsen, M. S., Holst, Jens Juul, Maechler, P., Dalgaard, L. T. & Mandrup, S., 30 Aug 2016, In: Cell Reports. 16, 9, p. 2359-72 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Insulin Resistance is Accompanied by Increased Fasting Glucagon and Delayed Glucagon Suppression in Individuals With Normal and Impaired Glucose Regulation

    Faerch, K., Vistisen, D., Pacini, G., Torekov, Signe Sørensen, Johansen, N. B., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Lauritzen, T., Jørgensen, M. E., Ahrén, B. & Holst, Jens Juul, 8 Aug 2016, In: Diabetes. 65, 11, p. 3473-3481 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Insulin Plays a Permissive Role for the Vasoactive Effect of GIP Regulating Adipose Tissue Metabolism in Humans

    Asmar, M., Simonsen, L., rck626, rck626, Holst, Jens Juul, Dela, Flemming & Bülow, J., Aug 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 8, p. 3155-62 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Incretin hormones as a target for therapy

    Holst, Jens Juul, 2016, Handbook of Incretin-based Therapies in Type 2 Diabetes. Gough, S. (ed.). Springer, p. 11-30

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  43. Published

    Inability of Some Commercial Assays to Measure Suppression of Glucagon Secretion

    Albrechtsen, Nicolai Jacob Wewer, Veedfald, Simon, Plamboeck, A., Deacon, Carolyn F., Hartmann, Bolette, Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 2016, In: Journal of Diabetes Research. 2016, 5 p., 8352957.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    In vivo and in vitro degradation of peptide YY3-36 to inactive peptide YY3-34 in humans

    Toräng, S., Bojsen-Møller, K. N., Svane, M. S., Hartmann, Bolette, Rosenkilde, Mette, Madsbad, Sten & Holst, Jens Juul, 27 Jan 2016, In: A J P: Regulatory, Integrative and Comparative Physiology (Online). 310, 1, p. R866-R874 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia

    Kristensen, P. L., Pedersen-Bjergaard, Ulrik, Due-Andersen, R., Høi-Hansen, T., Grimmeshave, L., Lyssenko, V., Groop, L., Holst, Jens Juul, Vaag, Allan & Thorsteinsson, B., 2016, In: Endocrine Connections. 5, 6, p. 53-60 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    IDegLira Improves Both Fasting and Postprandial Glucose Control as Demonstrated Using Continuous Glucose Monitoring and a Standardized Meal Test

    Holst, Jens Juul, Buse, J. B., Rodbard, H. W., Linjawi, S., Woo, V. C., Boesgaard, T. W., Kvist, K. & Gough, S. C., Mar 2016, In: Journal of Diabetes Science and Technology. 10, 2, p. 389-97 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Higher Endogenous Glucose Production during OGTT vs Isoglycemic Intravenous Glucose Infusion

    Lund, Asger Bach, Bagger, J. I., Christensen, Mikkel Bring, Grøndahl, M., van Hall, Gerrit, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Nov 2016, In: The Journal of Clinical Endocrinology & Metabolism. 101, 11, p. 4377-4384

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Gut hormones and gastric bypass

    Holst, Jens Juul, 2016, In: Cardiovascular Endocrinology. 5, 3, p. 69-74 6 p.

    Research output: Contribution to journal › Review › Research › peer-review

  49. Published

    Guidelines: Surgical or medical therapy for patients with obesity and T2DM?

    Madsbad, Sten & Holst, Jens Juul, 1 Sep 2016, In: Nature Reviews Endocrinology. 12, 9, p. 500-502 3 p.

    Research output: Contribution to journal › Comment/debate › Communication

  50. Published

    Glucose-dependent insulinotropic polypeptide (GIP) is associated with lower LDL but unhealthy fat distribution, independent of insulin: The ADDITION-PRO study

    Møller, C. L., Vistisen, D., Færch, K., Johansen, N. B., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Lauritzen, T., Jørgensen, M. E., Torekov, Signe Sørensen & Holst, Jens Juul, Feb 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 2, p. 485– 493 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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