Thomas Mandrup-Poulsen
Professor
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A Placebo-Controlled Study on the Effects of the Glucagon-Like Peptide-1 Mimetic, Exenatide, on Insulin Secretion, Body Composition and Adipokines in Obese, Client-Owned Cats
Hoelmkjaer, K. M., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Cronin, A. M., Nielsen, Dorte Hald, Mandrup-Poulsen, Thomas & Bjørnvad, Charlotte Reinhard, 2 May 2016, In: P L o S One. 11, 5, 18 p., e0154727.Research output: Contribution to journal › Journal article › Research › peer-review
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FK506-Binding Protein 2 Participates in Proinsulin Folding
Hoefner, C., Bryde, T. H., Pihl, C., Tiedemann, S. N., Bresson, S. E., Hotiana, H. A., Khilji, M. S., Santos, T. D., Puglia, M., Pisano, P., Majewska, M., Durzynska, J., Klindt, K., Klusek, J., Perone, M. J., Bucki, R., Hägglund, P. M., Gourdon, P. E., Gotfryd, K., Urbaniak, E. & 5 others, , 2023, In: Biomolecules. 13, 1, 20 p., 152.Research output: Contribution to journal › Journal article › Research › peer-review
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DIFFERENTIAL TRANSCRIPTIONAL REGULATION OF EXTRA CELLULAR MATRIX MODULATING GENES BY PROINFLAMMATORY CYTOKINES IN INS-1 CELLS
Hansen, J. B., Tonnesen, M. F., Friberg, J., Brunner, N. & Mandrup-Poulsen, Thomas, 2010.Research output: Contribution to conference › Conference abstract for conference › Research
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Differential transcriptional regulation of extra cellular matrix modulating genes by proinflammatory cytokines in ins-1 cells
Hansen, J. B., Tonnesen, M., Friberg, J., Brünner, N. & Mandrup-Poulsen, Thomas, 2009. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research
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Glucolipotoxic conditions induce beta-cell iron import, cytosolic ROS formation and apoptosis
Hansen, J. B., Dos Santos, L. R. B., Liu, Y., Prentice, K. J., Teudt, F., Tonnesen, M., Jonas, J., Wheeler, M. B. & Mandrup-Poulsen, Thomas, 2018, In: Journal of Molecular Endocrinology. 61, 2, p. 69-77Research output: Contribution to journal › Journal article › Research › peer-review
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Iron: the hard player in diabetes pathophysiology
Hansen, J. B., Moen, I. W. & Mandrup-Poulsen, Thomas, Apr 2014, In: Acta Physiologica (Print). 210, 4, p. 717-32 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Genetic deficiency of tissue inhibitor of metalloproteinase (TIMP) 1 does not affect apoptosis in cytokine-exposed mouse islets in vitro.
Hansen, J. B., Tonnesen, M. F., Rømer, M. U. K., Billestrup, Nils, Brunner, N. & Mandrup-Poulsen, Thomas, 2010, (Accepted/In press).Research output: Contribution to conference › Conference abstract for conference › Research
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Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines
Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, , 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proinflammatory Cytokines Inhibit TIMP-1 Expression but Induces PAI-1 and CD63 Expression in INS-1 Cells
Hansen, J. B., Brunner, N. & Mandrup-Poulsen, Thomas, 2009.Research output: Contribution to conference › Poster › Research
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Beta-Cell Specific DMT1 KO Protects Islets from Cytokine Induced ROS and Apoptosis
Hansen, J. B., Heller, S., Madsen, A. N., Holst, Birgitte, Tonnesen, M. F. & Mandrup-Poulsen, Thomas, 2012.Research output: Contribution to conference › Poster › Research › peer-review
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Effect of interleukin-1 on the biosynthesis of proinsulin and insulin in isolated rat pancreatic islets
Hansen, B. S., Linde, S., Spinas, G. A., Welinder, B. S., Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, 1988, In: Biomedica Biochimica Acta. 47, 4-5, p. 305-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes
Hamid, Y. H., Rose, C. S., Urhammer, S. A., Glümer, C., Nolsøe, R., Kristiansen, O. P., Mandrup-Poulsen, Thomas, Borch-Johnsen, K., Jorgensen, T., Hansen, Torben & Pedersen, O., 1 Feb 2005, In: Diabetologia. 48, 2, p. 251-60 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Large-scale prospective T cell function assays in shipped, unfrozen blood samples: experiences from the multicenter TRIGR trial
Hadley, D., Cheung, R. K., Becker, D. J., Girgis, R., Palmer, J. P., Cuthbertson, D., Krischer, J. P., Dosch, H., TRIGR North America Investigators, T. N. A. I. & Mandrup-Poulsen, Thomas, Feb 2014, In: Clinical and Vaccine Immunology (Online). 21, 2, p. 203-11 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional SOCS1 polymorphisms are associated with variation in obesity in whites
Gylvin, T., Ek, J., Nolsøe, R., Albrechtsen, A., Andersen, G., Bergholdt, R., Brorsson, C., Bang-Berthelsen, C. H., Hansen, T., Karlsen, A. E., Billestrup, N., Borch-Johnsen, K., Jørgensen, T., Pedersen, Oluf Borbye, Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 2009, In: Diabetes, Obesity and Metabolism. 11, 3, p. 196-203 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity
Gylvin, T., Nolsøe, R., Hansen, Torben, Nielsen, E. M. D., Bergholdt, R., Karlsen, A. E., Billestrup, Nils, Borch-Johnsen, K., Pedersen, O., Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 1 Jul 2004, In: Diabetologia. 47, 7, p. 1273-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cytokines and type 1 diabetes: a numbers game
Grunnet, L. G. & Mandrup-Poulsen, Thomas, 2011, In: Diabetes. 60, 3, p. 697-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells
Grunnet, L. G., Aikin, R., Tonnesen, M. F., Paraskevas, S., Blaabjerg, L., Størling, J., Rosenberg, L., Billestrup, Nils, Maysinger, D. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes. 58, 8, p. 1807-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of NCAM signaling in the pancreatic beta-cell
Grunnet, L. G., Storling, J., Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, N., Bock, E. & Mandrup-Poulsen, Thomas, 2008, In: FEBS Journal. 275, Suppl. 1Research output: Contribution to journal › Journal article › Research › peer-review
Plasma cytokine levels in young and elderly twins: genes versus environment and relation to in vivo insulin action
Grunnet, Louise Groth, Poulsen, P., Pedersen, Bente Klarlund, Mandrup-Poulsen, Thomas & Vaag, A., 1 Feb 2006, In: Diabetologia. 49, 2, p. 343-50 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes.
Greenbaum, C. J., Mandrup-Poulsen, Thomas, McGee, P. F., Battelino, T., Haastert, B., Ludvigsson, J., Pozzilli, P., Lachin, J. M., Kolb, H., Type 1 Diabetes Trial Net Research Group, T. 1. D. T. N. R. G. & European C-Peptide Trial Study Group, E. C. T. S. G., 2008, In: Diabetes Care. 31, 10, p. 1966-71 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Is puberty an accelerator of type 1 diabetes in IL6-174CC females?
Gillespie, K. M., Nolsøe, R., Betin, V. M., Kristiansen, O. P., Bingley, P. J., Mandrup-Poulsen, Thomas & Gale, E. A. M., 2005, In: Diabetes. 54, 4, p. 1245-8 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The No-Go and Nonsense-Mediated RNA Decay Pathways Are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival
Ghiasi, S. M., Krogh, Nicolai, Tyrberg, B. & Mandrup-Poulsen, Thomas, 2018, In: Diabetes. 67, 10, p. 2019-2037 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of the beta-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis
Ghiasi, S. M., Dahllöf, M. S., Osmai, Y., Osmai, M., Jakobsen, K. K., Aivazidis, A., Tyrberg, B., Perruzza, L., Prause, Michala Cecilie Burstein, Christensen, D. P., Fog-Tonnesen, M., Lundh, M., Grassi, F., Chatenoud, L. & Mandrup-Poulsen, Thomas, 2018, In: Molecular and Cellular Endocrinology. 478, p. 106-114Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets
Ghiasi, S. M., Hansen, J. B., Christensen, D. P., Tyrberg, B. & Mandrup-Poulsen, Thomas, 2020, In: International Journal of Molecular Sciences (Online). 21, 12, 15 p., 4311.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling
Ghiasi, S. M., Dahlby, T., Hede Andersen, C., Haataja, L., Petersen, S., Omar-Hmeadi, M., Yang, M., Pihl, Celina, Bresson, S. E., Khilji, Muhammad Saad, Klindt, K., Cheta, O., Perone, M. J., Tyrberg, B., Prats, C., Barg, S., Tengholm, A., Arvan, P., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, Apr 2019, In: Diabetes. 68, 4, p. 747-760 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 923693
Most downloads
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780
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Tissue inhibitor of matrix metalloproteinase-1 is required for high-fat diet-induced glucose intolerance and hepatic steatosis in mice
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
211
downloads
JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1 beta-Induced Apoptosis Associated with Abrogated Myc Expression
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
199
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A Placebo-Controlled Study on the Effects of the Glucagon-Like Peptide-1 Mimetic, Exenatide, on Insulin Secretion, Body Composition and Adipokines in Obese, Client-Owned Cats
Research output: Contribution to journal › Journal article › Research › peer-review
Published