Mette Rosenkilde

Mette Rosenkilde

Professor

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    ORCID: 0000-0001-9600-3254

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    1. Published

      The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus

      Jørgensen, Astrid Sissel, Brandum, E. P., Mikkelsen, J. M., Orfin, K. A., Boilesen, D. R., Egerod, Kristoffer Lihme, Moussouras, N. A., Vilhardt, Frederik, Kalinski, P., Basse, P., Chen, Yen-Hsi, Yang, Zhang, Dwinell, M. B., Volkman, B. F., Veldkamp, C. T., Holst, Peter Johannes, Lahl, K., Goth, C. K., Rosenkilde, Mette & Hjortø, Gertrud Malene, 2021, In: Cellular and Molecular Life Sciences. 78, p. 6963-6978 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      The CCR5 receptor acts as an alloantigen in CCR5¿32 homozygous individuals: Identification of chemokine- and HIV-1 blocking human antibodies

      Ditzel, H. J., Rosenkilde, Mette, Garred, P., Wang, M., Pedersen, C., Burton, D. R. & Schwartz, Thue W., 1998, In: Proceedings of the National Academy of Science of the United States of America. 95, no. 9, p. 5241-5245

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins

      Rosenkilde, Mette, McLean, K. A., Holst, Peter Johannes & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 31, p. 32524-33 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      The Dual GLP-1/GIP Receptor Agonist DA4-JC Shows Superior Protective Properties Compared to the GLP-1 Analogue Liraglutide in the APP/PS1 Mouse Model of Alzheimer's Disease

      Maskery, M., Goulding, E. M., Gengler, S., Melchiorsen, J. U., Rosenkilde, Mette & Holscher, C., 2020, In: American Journal of Alzheimer's Disease and Other Dementias. 35, 11 p., 1533317520953041.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling

      Benned-Jensen, T., Mokrosinski, J. & Rosenkilde, Mette, 2011, In: P L o S One. 6, 9, p. e24644

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling

      Sommer, M. E., Selent, J., Carlsson, J., De Graaf, C., Gloriam, David E., Keseru, G. M., Kosloff, M., Mordalski, S., Rizk, A., Rosenkilde, Mette, Sotelo, E., Tiemann, Johanna Katarina Sofie, Tobin, A., Vardjan, N., Waldhoer, M. & Kolb, P., 2020, In: ACS Pharmacology & Translational Science. 3, 2, p. 361-370 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      The Glucagon Receptor Antagonist LY2409021 has No Effect on Postprandial Glucose in Type 2 Diabetes

      Hædersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Forman, Julie Lyng, van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: European Journal of Endocrinology. 186, 2, p. 207-221 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor

      Asmar, M., Asmar, A., Simonsen, L., Gasbjerg, Lærke Smidt, wbf943, wbf943, Rosenkilde, Mette, Hartmann, Bolette, Dela, Flemming, Holst, Jens Juul & Bülow, J., Sep 2017, In: Diabetes. 66, 9, p. 2363-2371 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      The Gβγ-subunit interacts directly with aquaporin-2 (AQP2) and regulates its membrane targeting

      Olesen, Emma Tina Bisgaard, Poulsen, S. B., Rosenkilde, Mette, Sorensen, Charlotte Mehlin & Fenton, R. A., 2018.

      Research output: Contribution to conference › Conference abstract for conference › Research

    10. Published

      The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection

      Lindquist, Peter, Gasbjerg, Lærke Smidt, Mokrosinski, J., Holst, Jens Juul, Hauser, Alexander Sebastian & Rosenkilde, Mette, 2022, In: Frontiers in Endocrinology. 13, 14 p., 891586.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      The Novel Dual GLP-1/GIP Receptor Agonist DA-CH5 Is Superior to Single GLP-1 Receptor Agonists in the MPTP Model of Parkinson's Disease

      Zhang, L., Zhang, L., Li, Y., Li, L., Melchiorsen, J. U., Rosenkilde, Mette & Holscher, C., 2020, In: Journal of Parkinson's Disease. 10, 2, p. 523-542

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      The Secretome of Parental and Bone Metastatic Breast Cancer Elicits Distinct Effects in Human Osteoclast Activity after Activation of β2 Adrenergic Signaling

      Conceição, F., Sousa, D. M., Tojal, S., Lourenço, C., Carvalho-Maia, C., Estevão-Pereira, H., Lobo, J., Couto, M., Rosenkilde, Mette, Jerónimo, C. & Lamghari, M., 2023, In: Biomolecules. 13, 4, 25 p., 622.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      The anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in vivo.

      Toräng, S., Veedfald, Simon, Rosenkilde, Mette, Hartmann, Bolette & Holst, Jens Juul, 20 Jul 2015, In: Physiological Reports. 3, 7, p. 1-8 8 p., e12455.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism - a randomized crossover study

      Skov-Jeppesen, Kirsa, Hepp, N., Oeke, J., Hansen, M. S., Jafari Kermani, Abbas, Svane, M. S., Balenga, N., Olson, J. A., Frost, M., Kassem, Moustapha Saad El-Deen, Madsbad, Sten, Jensen, Jens-Erik Beck, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2021, In: Journal of Bone and Mineral Research. 36, 8, p. 1448-1458 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis

      Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. 278, 21, p. 19473-82 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endoytosis

      Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. Vol. 278 (21), p. 19473-82

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      The chemokine system - a major regulator of angiogenesis in health and disease

      Rosenkilde, Mette & Schwartz, Thue W., 2004, In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. Vol. 112, 7-8, p. 481-95

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      The frequency of cytomegalovirus non-ELR UL146 genotypes in neonates with congenital CMV disease is comparable to strains in the background population

      Berg, Christian, Rosenkilde, Mette, Benfield, Thomas, Nielsen, L., Sundelin, T. & Luttichau, H. R., 2021, In: BMC Infectious Diseases. 21, 1, 12 p., 386.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      The future of antiviral immunotoxins

      Spiess, Katja, Jakobsen, M. H., Kledal, T. N. & Rosenkilde, Mette, Jun 2016, In: Journal of Leukocyte Biology. 99, 6, p. 911-925 15 p.

      Research output: Contribution to journal › Review › Research › peer-review

    20. Published

      The glucagon-like peptide 2 receptor is expressed in enteric neurons and not in the epithelium of the intestine

      Pedersen, Jens, B. Pedersen, N., Brix, S. W., Grunddal, Kaare Villum, Rosenkilde, Mette, Hartmann, Bolette, Ørskov, Cathrine, Poulsen, Steen Seier & Holst, Jens Juul, May 2015, In: Peptides. 67, p. 20-28 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      The impact of short chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon

      Christiansen, Charlotte Bayer, Gabe, M. B. N., Svendsen, B., Dragsted, Lars Ove, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 315, 1, p. G53-G65 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      The importance of endogenously secreted GLP-1 and GIP for postprandial glucose tolerance and β-cell function after Roux-en-Y gastric bypass and sleeve gastrectomy surgery

      Hindsø, M., Hedbäck, N., Svane, M. S., Møller, A., Martinussen, C., Jørgensen, N. B., Dirksen, C., Gasbjerg, Lærke Smidt, Kristiansen, V. B., Hartmann, Bolette, Rosenkilde, Mette, Holst, Jens Juul, Madsbad, Sten & Bojsen-Møller, K. N., 2023, In: Diabetes. 72, 3, p. 336–347

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      The importance of glucose-dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide

      Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Meier, J. J., Holst, Jens Juul & Knop, Filip Krag, 2023, In: Diabetes, Obesity and Metabolism. 25, 11, p. 3079-3092

      Research output: Contribution to journal › Review › Research › peer-review

    24. Published

      The minor binding pocket: a major player in 7TM receptor activation

      Rosenkilde, Mette, Benned-Jensen, T., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Trends in Pharmacological Sciences. 31, 12, p. 567-574 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans

      Krogh, L. S. L., Henriksen, K., Stensen, S., Skov-Jeppesen, Kirsa, Bergmann, N. C., Størling, Joachim, Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2023, In: European Journal of Endocrinology. 188, 1, lvac015.

      Research output: Contribution to journal › Journal article › Research › peer-review

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