Thomas Mandrup-Poulsen

Thomas Mandrup-Poulsen

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    1. Published

      Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study

      Ullitz Thorsen, S., Liu, X., Kataria, Y., Mandrup-poulsen, T., Kaur, S., Uusitalo, U., Virtanen, S. M., Norris, J., Rewers, M., Hagopian, W., Yang, J., She, J., Akolkar, B., Rich, S. S., Aronsson, C. A., Lernmark, Å., Ziegler, A., Toppari, J., Krischer, J. P., Parikh, H. M. & 31 others, Ellervik, Christina, Svensson, Jannet, Rewers, M., Barbour, A., Bautista, K., Baxter, J., Felipe-morales, D., Frohnert, B. I., Stahl, M., Gesualdo, P., Hoffman, M., Karban, R., Liu, E., Munoz, A., Norris, J., O’donnell, H., Peacock, S., Shorrosh, H., Steck, A., Stern, M., Waugh, K., Toppari, J., Simell, O. G., Adamsson, A., Ahonen, S., Åkerlund, M., Anttila, S., Hakola, L., Hekkala, A., Agardh, D. & Environmental Determinants of Diabetes in the Young (TEDDY) Group, E. D. O. D. I. T. Y. (. G., 2023, In: Diabetes Care. 46, 5, p. 1-5

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans

      Spinas, G. A., Hansen, B. S., Linde, S., Kastern, W., Mølvig, J., Mandrup-Poulsen, Thomas, Dinarello, C. A., Nerup, J. & Nielsen, Jens Høiriis, Jul 1987, In: Diabetologia. 30, 7, p. 474-80 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Interleukin-1 antagonism: a sturdy companion for immune tolerance induction in type 1 diabetes?

      Mandrup-Poulsen, Thomas, Jun 2014, In: Diabetes. 63, 6, p. 1833-5 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

      Moran, A., Bundy, B., Becker, D. J., DiMeglio, L. A., Gitelman, S. E., Goland, R., Greenbaum, C. J., Herold, K. C., Marks, J. B., Raskin, P., Sanda, S., Schatz, D., Wherrett, D. K., Wilson, D. M., Krischer, J. P., Skyler, J. S., Pickersgill, L., de Koning, E., Ziegler, A-G., Böehm, B. & 12 others, Badenhoop, K., Schloot, N., Bak, J. F., Pozzilli, P., Mauricio, D., Donath, M. Y., Castaño, L., Wägner, A., Lervang, H. H., Perrild, Hans, Mandrup-Poulsen, Thomas & Type 1 Diabetes TrialNet Canakinumab Study Group, T. 1. D. T. C. S. G., 1 Jun 2013, In: Lancet. 381, 9881, p. 1905-15 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset

      Cabrera, S. M., Wang, X., Chen, Y., Jia, S., Kaldunski, M. L., Greenbaum, C. J., Mandrup-Poulsen, Thomas & Hessner, M. J., Apr 2016, In: European Journal of Immunology. 46, 4, p. 1030-1046 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Interleukin-1 antagonists and other cytokine blockade strategies for type 1 diabetes

      Mandrup-Poulsen, Thomas, 2012, In: The review of diabetic studies : RDS. 9, 4, p. 338-47 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Interleukin-1 antagonists for diabetes

      Mandrup-Poulsen, Thomas & AIDA study group, A. S. G., Aug 2013, In: Expert Opinion on Investigational Drugs. 22, 8, p. 965-79 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine

      Andersen, H. U., Mauricio, D., Karlsen, A. E., Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, Feb 1996, In: European Journal of Endocrinology. 134, 2, p. 251-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Interleukin-1 receptorantagonistbehandling af patienter med type 2-diabetes--sekundaerpublikation.

      Larsen, C. M., Faulenbach, M., Vaag, Allan, Vølund, A., Ehses, J., Seifert, B., Mandrup-Poulsen, Thomas & Donath, M., 2007, In: Ugeskrift for læger. 169, 45, p. 3868-71 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Interleukin-1-receptor antagonist in type 2 diabetes mellitus - Reply

      Mandrup-Poulsen, Thomas, Seifert, B. & Donath, M. Y., 2007, In: New England Journal of Medicine. 357, 3, p. 303-303

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Interleukin-1-receptor antagonist in type 2 diabetes mellitus.

      Larsen, C. M., Faulenbach, M., Vaag, Allan, Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, Thomas & Donath, M. Y., 2007, In: New England Journal of Medicine. 356, 15, p. 1517-26 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue

      Ballak, D. B., Li, S., Cavalli, G., Stahl, J. L., Tengesdal, I. W., van Diepen, J. A., Kluck, V., Swartzwelter, B., Azam, T., Tack, C. J., Stienstra, R., Mandrup-Poulsen, Thomas, Seals, D. R. & Dinarello, C. A., 2018, In: Journal of Biological Chemistry. 293, 37, p. 14224-14236

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Interleukin-6 and diabetes: the good, the bad, or the indifferent?

      Kristiansen, O. P. & Mandrup-Poulsen, Thomas, 2005, In: Diabetes. 54 Suppl 2, p. S114-24

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Interleukin-6 receptor blockade or TNF alpha inhibition for reducing glycaemia in patients with RA and diabetes: post hoc analyses of three randomised, controlled trials

      Genovese, M. C., Burmester, G. R., Hagino, O., Thangavelu, K., Iglesias-Rodriguez, M., John, G. S., Gonzalez-Gay, M. A., Mandrup-Poulsen, Thomas & Fleischmann, R., 2020, In: Arthritis Research & Therapy. 22, 1, 12 p., 206.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Iron: the hard player in diabetes pathophysiology

      Hansen, J. B., Moen, I. W. & Mandrup-Poulsen, Thomas, Apr 2014, In: Acta Physiologica (Print). 210, 4, p. 717-32 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Iron Regulation of Pancreatic Beta-Cell Functions and Oxidative Stress

      Backe, M. B., Moen, I. W., Ellervik, Christina, Hansen, J. B. & Mandrup-Poulsen, Thomas, 17 Jul 2016, In: Annual Review of Nutrition. 36, p. 241-273 33 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Iron Status and Gestational Diabetes: A Meta-Analysis

      Kataria, Y., Wu, Y., Horskjaer, P. D. H., Mandrup-Poulsen, Thomas & Ellervik, Christina, 2018, In: Nutrients. 10, 5, 15 p., 621 .

      Research output: Contribution to journal › Review › Research › peer-review

    18. Published

      Is puberty an accelerator of type 1 diabetes in IL6-174CC females?

      Gillespie, K. M., Nolsøe, R., Betin, V. M., Kristiansen, O. P., Bingley, P. J., Mandrup-Poulsen, Thomas & Gale, E. A. M., 2005, In: Diabetes. 54, 4, p. 1245-8 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics

      Mandrup-Poulsen, Thomas, Spinas, G. A., Prowse, S. J., Hansen, B. S., Jørgensen, D. W., Bendtzen, K., Nerup, J. & Nielsen, Jens Høiriis, May 1987, In: Diabetes. 36, 5, p. 641-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1 beta-Induced Apoptosis Associated with Abrogated Myc Expression

      Prause, Michala Cecilie Burstein, Mayer, C. M., Brorsson, C., Frederiksen, K. S., Billestrup, Nils, Størling, Joachim & Mandrup-Poulsen, Thomas, 2016, In: Journal of Diabetes Research. 2016, 15 p., 1312705.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis

      Prause, Michala Cecilie Burstein, Christensen, D. P., Billestrup, Nils & Mandrup-Poulsen, Thomas, 2014, In: PLOS ONE. 9, 1, p. 1-11 11 p., e87067.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Large-scale prospective T cell function assays in shipped, unfrozen blood samples: experiences from the multicenter TRIGR trial

      Hadley, D., Cheung, R. K., Becker, D. J., Girgis, R., Palmer, J. P., Cuthbertson, D., Krischer, J. P., Dosch, H., TRIGR North America Investigators, T. N. A. I. & Mandrup-Poulsen, Thomas, Feb 2014, In: Clinical and Vaccine Immunology (Online). 21, 2, p. 203-11 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Limited benefit of haemoglobin glycation index as risk factor for cardiovascular disease in type 2 diabetes patients

      Østergaard, H. B., Mandrup-Poulsen, Thomas, Berkelmans, G. F. N., van der Graaf, Y., Visseren, F. L. J. & Westerink, J., 2019, In: Diabetes and Metabolism. 45, 3, p. 254-260 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Lost in translation

      Frank, L. & Mandrup-Poulsen, Thomas, 2007, In: Weekendavisen. 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

      Christensen, D. P., Gysemans, C., Lundh, M., Dahllöf, M. S., Noesgaard, D., Schmidt, S. F., Mandrup, S., Birkbak, N., Workman, C., Piemonti, L., Blaabjerg, L., Monzani, V., Fossati, G., Mascagni, P., Paraskevas, S., Aikin, R. A., Billestrup, N., Grunnet, L. G., Dinarello, C. A., Mathieu, C. & 1 others, Mandrup-Poulsen, Thomas, 6 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. 1055-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

      Lundh, M., Christensen, D. P., Rasmussen, D. N., Mascagni, P., Dinarello, C. A., Billestrup, Nils, Grunnet, L. G. & Mandrup-Poulsen, Thomas, 1 Dec 2010, In: Diabetologia. 53, 12, p. 2569-78 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

      Backe, M. B., Andersson, J. L., Bacos, K., Christensen, D. P., Hansen, J. B., Dorosz, J. J., Gajhede, Michael, Dahlby, T., Bysani, M., Kristensen, L. H., Ling, C., Olsen, L. & Mandrup-Poulsen, Thomas, 15 Jan 2018, In: Molecular and Cellular Endocrinology. 460, p. 47-56 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Mechanisms of pancreatic islet cell destruction. Dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans

      Mandrup-Poulsen, Thomas, Bendtzen, K., Nerup, J., Egeberg, J. & Nielsen, Jens Høiriis, May 1986, In: Allergy. 41, 4, p. 250-9 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage

      Vestergaard, A. L., Bang-Berthelsen, C. H., Floyel, T., Stahl, J. L., Christen, L., Sotudeh, F. T., Horskjaer, P. D. H., Frederiksen, K. S., Kofod, F. G., Bruun, C., Berchtold, L. A., Storling, J., Regazzi, R., Kaur, S., Pociot, Flemming & Mandrup-Poulsen, Thomas, 27 Sep 2018, In: PLOS ONE. 13, 9, p. 1-22 22 p., e0203713 .

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      MicroRNAs are potential posttranscriptional regulators of Bcl-2 family members after cytokine stimulation in INS-1 cells

      Bang-Berthelsen, C. H., Grunnet, L. G., Kutlu, B., Johansson, F., Eizirik, D., Pociot, F. & Mandrup-Poulsen, Thomas, 2008, In: FEBS Journal. 275, Suppl. 1, p. 152-152

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      MicroRNAs as regulators of beta-cell function and dysfunction

      Osmai, M., Osmai, Y., Bang-Berthelsen, C. H., Pallesen, E. M. H., Vestergaard, A. L., Novotny, G. W., Pociot, Flemming & Mandrup-Poulsen, Thomas, May 2016, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 32, 4, p. 334–349 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Mitophagy protects beta cells from inflammatory damage in diabetes

      Sidarala, V., Pearson, G. L., Parekh, V. S., Thompson, B., Christen, L., Gingerich, M. A., Zhu, J., Stromer, T., Ren, J., Reck, E. C., Chai, B., Corbett, J. A., Mandrup-Poulsen, Thomas, Satin, L. S. & Soleimanpour, S. A., 2020, In: JCI insight. 5, 24, 15 p., 141138.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes.

      Greenbaum, C. J., Mandrup-Poulsen, Thomas, McGee, P. F., Battelino, T., Haastert, B., Ludvigsson, J., Pozzilli, P., Lachin, J. M., Kolb, H., Type 1 Diabetes Trial Net Research Group, T. 1. D. T. N. R. G. & European C-Peptide Trial Study Group, E. C. T. S. G., 2008, In: Diabetes Care. 31, 10, p. 1966-71 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Multifactorial treatment increases endothelial progenitor cells in patients with type 2 diabetes

      Reinhard, H., Jacobsen, P. K., Lajer, M., Pedersen, N., Billestrup, Nils, Mandrup-Poulsen, Thomas, Parving, H. & Rossing, Peter, 1 Oct 2010, In: Diabetologica. 53, 10, p. 2129-33 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

      Gylvin, T., Nolsøe, R., Hansen, Torben, Nielsen, E. M. D., Bergholdt, R., Karlsen, A. E., Billestrup, Nils, Borch-Johnsen, K., Pedersen, O., Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 1 Jul 2004, In: Diabetologia. 47, 7, p. 1273-7 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Need for Reclassification of Diabetes Secondary to Iron Overload in the ADA and WHO Classifications

      Ellervik, Christina, Birgens, H. & Mandrup-Poulsen, Thomas, Jun 2014, In: Diabetes Care. 37, 6, p. e137-e138 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Neuromedin U Does Not Act as a Decretin in Rats

      Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Ghiasi, S. M., Gabe, M. B. N., Skat-Rørdam, P. A., Modvig, Ida Marie, Mandrup-Poulsen, Thomas, Albrechtsen, Reidar, Rosenkilde, Mette, Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, In: Cell Metabolism. 29, 3, p. 719-726.e1-e5 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt

      Størling, Joachim, Binzer, J., Andersson, A., Züllig, R. A., Tonnesen, M., Knudsen, R. L. P., Spinas, G. A., Sandler, S., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 Oct 2005, In: Diabetologia. 48, 10, p. 2039-50 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      No direct effect of SGLT2 activity on glucagon secretion

      Kuhre, Rune Ehrenreich, Ghiasi, S. M., Adriaenssens, A. E., Albrechtsen, Nicolai Jacob Wewer, Andersen, Daniel Bjørklund, Aivazidis, A., Chen, L., Mandrup-Poulsen, Thomas, Ørskov, Cathrine, Gribble, F. M., Reimann, F., Wierup, N., Tyrberg, B. & Holst, Jens Juul, 2019, In: Diabetologia. 62, 6, p. 1011-1023

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Obesity related differences in MCP-1 and adiponectin expression in subcutaneous adipose tissue in cats.

      Jensen, Kathrine Stenberg, Novotny, G. W., Mandrup-Poulsen, Thomas & Bjørnvad, Charlotte Reinhard, 2015.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    41. Published

      Obesity related differences in MCP-1 and adiponectin expression in subcutaneous adipose tissue in cats.

      Jensen, Kathrine Stenberg, Novotny, G. W., Mandrup-Poulsen, Thomas & Bjørnvad, Charlotte Reinhard, 2014.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    42. Published

      Obesity-induced changes in gene expression in feline adipose and skeletal muscle tissue

      Jensen, Kathrine Stenberg, Novotny, G. W., Lutz, T. A., Mandrup-Poulsen, Thomas & Bjørnvad, Charlotte Reinhard, 2023, In: Journal of Animal Physiology and Animal Nutrition. 107, 5, p. 1262 - 1278

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice

      Besançon, A., Goncalves, T., Valette, F., Dahllöf, M. S., Mandrup-Poulsen, Thomas, Chatenoud, L. & You, S., 1 Feb 2018, In: Diabetologia. 61, 2, p. 389-398 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice

      Brandt, C., Hansen, R. H., Hansen, J. B., Olsen, C. H., Galle, P., Mandrup-Poulsen, Thomas, Gehl, Julie, Pedersen, Bente Klarlund & Hojman, P., Feb 2015, In: Metabolism. 64, 2, p. 283-295 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Pancreatic beta-cells respond to fuel pressure with an early metabolic switch

      Malinowski, R. M., Ghiasi, S. M., Mandrup-Poulsen, Thomas, Meier, S., Lerche, M. H., Ardenkjaer-Larsen, J. H. & Jensen, P. R., 2020, In: Scientific Reports. 10, 1, 11 p., 15413.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Perspective: Testing failures

      Mandrup-Poulsen, Thomas, 2012, In: Nature Study. 485, 7398, p. S17

      Research output: Contribution to journal › Journal article › Commissioned

    47. Plasma cytokine levels in young and elderly twins: genes versus environment and relation to in vivo insulin action

      Grunnet, Louise Groth, Poulsen, P., Pedersen, Bente Klarlund, Mandrup-Poulsen, Thomas & Vaag, A., 1 Feb 2006, In: Diabetologia. 49, 2, p. 343-50 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Poor pregnancy outcome in women with type 2 diabetes

      Clausen, Tine Dalsgaard, Mathiesen, E., Ekbom, P., Hellmuth, E., Mandrup-Poulsen, Thomas & Damm, Peter, 2005, In: Diabetes Care. 28, 2, p. 323-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Proinflammatory Cytokines Inhibit TIMP-1 Expression but Induces PAI-1 and CD63 Expression in INS-1 Cells

      Hansen, J. B., Brunner, N. & Mandrup-Poulsen, Thomas, 2009.

      Research output: Contribution to conference › Poster › Research

    50. Published

      Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells

      Grunnet, L. G., Aikin, R., Tonnesen, M. F., Paraskevas, S., Blaabjerg, L., Størling, J., Rosenberg, L., Billestrup, Nils, Maysinger, D. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes. 58, 8, p. 1807-15 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 923693