Jens Juul Holst

Jens Juul Holst

Professor


  1. Published

    Short term insulin treatment prevents the diabetogenic action of streptozotocin in rats

    Thulesen, J., Ørskov, Cathrine, Holst, Jens Juul & Poulsen, Steen Seier, 1997, In: Endokrinologiya. Vol. 138, No. 1, p. 62-68

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Glucagon-like peptide 2 treatment may improve intestinal adaptation during weaning

    Thymann, Thomas, Le Huërou-Luron, I., Petersen, Y. M., Hedemann, M. S., Elinf, J., Jensen, B. B., Holst, Jens Juul, Hartmann, Bolette & Sangild, Per Torp, 2014, In: Journal of Animal Science. 92, 5, p. 2070-2079 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Glucagon-like peptide 2 (Glp-2) stimulates intestinal function during weaning

    Thymann, Thomas, Huërou-Luron, I. L., Petersen, Y. M., Hedemann, M. S., Elnif, J., Jensen, B. B., Hartmann, Bolette, Holst, Jens Juul & Sangild, Per Torp, 2011, 44th annual meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition, 2011: programme and abstract booklet. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), p. 202 1 p.

    Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearch

  4. Published

    Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids: A Preview study

    Tischmann, L., Drummen, M., Gatta-Cherifi, B., Raben, Anne, Fogelholm, M., Hartmann, Bolette, Holst, Jens Juul, Matias, I., Cota, D., Mensink, R. P., Peters, J., Westerterp-Plantenga, M. S. & Adam, T. C., 2019, In: Nutrients. 11, 16 p., 2269.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Exaggerated secretion of glucagon-like peptide-1 (GLP-1) could cause reactive hypoglycaemia

    Toft-Nielsen, M., Madsbad, Sten & Holst, Jens Juul, 1998, In: Diabetologia. 41, 10, p. 1180-1186 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients

    Toft-Nielsen, M. B., Damholt, M. B., Madsbad, Sten, Hilsted, L. M., Hughes, T. E., Michelsen, B. K. & Holst, Jens Juul, 2001, In: Journal of Clinical Endocrinology and Metabolism. 86, 8, p. 3717-3723 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Determinants of the effectiveness of glucagon-like peptide- 1 in type 2 diabetes

    Toft-Nielsen, M. B., Madsbad, S. & Holst, Jens Juul, 2001, In: J Clin Endocr Metab. 86, p. 3853-3860

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Continuous subcutaneous infusion of Glucagon-like Peptide-1 (GLP-1) lowers plasma glucose and reduces appetite in type II diabetic patients

    Toft-Nielsen, M. B., Madsbad, S. & Holst, Jens Juul, 1999, In: Diabetes Care. 22, p. 1137-1143

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Glucagon-like peptide-1 retards gastric emptying and small bowel transit in the rat: Effect mediated through central or enteric nervous mechanisms

    Tolessa, T., Gutniak, M. K., Holst, Jens Juul, Efendic, S. & Hellstrom, P. M., 1998, In: Dig. Dis. Sci.. 43, p. 2284-2290

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Inhibitory effect of glucagon-like peptide-1 on small bowel motility. Fasting but not fed motility inhibited via nitric oxide independently of insulin and somatostatin

    Tolessa, T., Gutniak, M. K., Holst, Jens Juul, Efendic, S. & Hellstrom, P. M., 1998, In: J. Clin. Invest.. 102, p. 764-774

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Leptin Serum Levels are Associated With GLP-1 Receptor Agonist-Mediated Effects on Glucose Metabolism in Clozapine-or Olanzapine-Treated, Prediabetic, Schizophrenia Patients

    Tomasik, J., Rustogi, N., Larsen, J. R., Jakobsen, M. I., Svensson, C. K., Vedtofte, L., Jakobsen, M. S. L., Jespersen, H. R., Koyuncu, K., Schjerning, O., Nielsen, Jimmi, Ekstrøm, Claus Thorn, Correll, C. U., Holst, Jens Juul, Vilsbøll, Tina, Bahn, S. & Fink-Jensen, Anders, 2020, In: Schizophrenia Bulletin Open. 1, 1, 11 p., sgaa044.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1

    Torekov, S. S., Ma, L., Grarup, N., Hartmann, B., Hainerová, I. A., Kielgast, U., Kissow, H., Rosenkilde, M., Lebl, J., Witte, D. R., Jørgensen, T., Sandbaek, A., Lauritzen, T., Madsen, O. D., Wang, J., Linneberg, A., Madsbad, S., Holst, J. J., Hansen, T., Pedersen, O. & 1 others, GIANT Consortium, G. C., 2011, In: Diabetologia. 54, 11, p. 2820-31 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Obesity - an indication for GLP-1 treatment? Obesity pathophysiology and GLP-1 treatment potential

    Torekov, Signe Sørensen, Madsbad, Sten & Holst, Jens Juul, 2011, In: Obesity Reviews. 12, 8, p. 593-601 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Evidence of an association between the Arg72-allele of the peptide YY (PYY) and increased risk of type 2 diabetes

    Torekov, S. S., Larsen, L. H., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Holst, Jens Juul, Madsen, O. D., Hansen, T. & Pedersen, O., 2005, In: Diabetes. 54, p. 2261-2265

    Research output: Contribution to journalJournal articleResearch

  15. Published

    KCNQ1 Long QT syndrome patients have hyperinsulinemia and symptomatic hypoglycemia

    Torekov, Signe Sørensen, Iepsen, E., Christiansen, M., Linneberg, Allan René, Pedersen, Oluf Borbye, Holst, Jens Juul, Kanters, Jørgen K. & Hansen, Torben, Apr 2014, In: Diabetes. 63, 4, p. 1315-1325 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes

    Torekov, Signe Sørensen, Larsen, L. H., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Holst, Jens Juul, Madsen, O. D., Hansen, Torben & Pedersen, Oluf Borbye, 2005, In: Diabetes. 54, 7, p. 2261-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Dose response of subcutaneous GLP-1 infusion in patients with type 2 diabetes

    Torekov, Signe Sørensen, Kipnes, M. S., Harley, R. E., Holst, Jens Juul & Ehlers, M. R., 2011, In: Diabetes, Obesity and Metabolism. 13, 7, p. 639-43 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Dose response of continuous subcutaneous infusion of recombinant glucagon-like peptide-1 in combination with metformin and sulphonylurea over 12 weeks in patients with type 2 diabetes mellitus

    Torekov, Signe Sørensen, Holst, Jens Juul & Ehlers, M. R., May 2014, In: Diabetes, Obesity and Metabolism. 16, 5, p. 451-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk

    Torekov, Signe Sørensen, Harsløf, T., Rejnmark, L., Eiken, P., Jensen, Jens-Erik Beck, Herman, A. P., Hansen, Torben, Pedersen, Oluf Borbye, Holst, Jens Juul & Langdahl, B. L., Apr 2014, In: The Journal of clinical endocrinology and metabolism. 99, 4, p. E729-33 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    PACAP 1-38 as neurotransmitter in the porcine antrum

    Tornoe, K., Hannibal, J., Georg, B. & Holst, Jens Juul, 2001, In: Regulatory Peptides. 101, p. 109-121

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    PACAP 1-38 as neurotransmitter in porcine adrenal glands

    Tornøe, K., Hannibal, J., Rickelt, L. F., Bolding Jensen, M., Børglum, J. T., Fahrenkrug, J. & Holst, Jens Juul, 2000, In: American Journal of Physiology: Endocrinology and Metabolism. 279, p. E1412-E1425

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    PACAP 1-38 as neurotransmitter in the pig pancreas: PACAP-receptor activation revealed by the antagonist PACAP 6-38.

    Tornøe, K., Hannibal, J., Fahrenkrug, J. & Holst, Jens Juul, 1997, In: Am. J. Physiol.. 273, p. G436-G446

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    In vivo and in vitro degradation of peptide YY3-36 to inactive peptide YY3-34 in humans

    Toräng, S., Bojsen-Møller, K. N., Svane, M. S., Hartmann, Bolette, Rosenkilde, Mette, Madsbad, Sten & Holst, Jens Juul, 27 Jan 2016, In: A J P: Regulatory, Integrative and Comparative Physiology (Online). 310, 1, p. R866-R874 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    The anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in vivo.

    Toräng, S., Veedfald, Simon, Rosenkilde, Mette, Hartmann, Bolette & Holst, Jens Juul, 20 Jul 2015, In: Physiological Reports. 3, 7, p. 1-8 8 p., e12455.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5

    Trammell, Sam, Svenningsen, J. S., Holst, Jens Juul, Gillum, M. P. & Kuhre, Rune Ehrenreich, 2020, In: Molecules. 25, 14 p., 2371.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Neutral endopeptidase 24.11 is important for the degradation of both endogenous and exogenous glucagon in anesthetized pigs.

    Trebbien, R., Klarskov, L., Olesen, M., Holst, Jens Juul, Carr, R. D. & Deacon, Carolyn F., 2004, In: American Journal of Physiology: Endocrinology and Metabolism. 287, 3, p. E431-8

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Impaired beta cell sensitivity to incretins in type 2 diabetes is insufficiently compensated by higher incretin response

    Tura, A., Bagger, J. I., Ferrannini, E., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina & Mari, A., Dec 2017, In: Nutrition, Metabolism and Cardiovascular Diseases. 27, 12, p. 1123-1129 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1.

    Ugleholdt, Randi Kjærsgaard, Zhu, X., Deacon, Carolyn F., Ørskov, Cathrine, Steiner, D. F. & Holst, Jens Juul, 2003, In: Endocrinology. 145, 3, p. 1349-55 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain

    Ugleholdt, Randi Kjærsgaard, Pedersen, Jens, Bassi, Maria Rosaria, Füchtbauer, E., Jørgensen, S. M., Kissow, Hannelouise, Nytofte, N., Poulsen, Steen Seier, Rosenkilde, Mette, Seino, Y., Thams, P., Holst, Peter Johannes & Holst, Jens Juul, Dec 2011, In: The Journal of Biological Chemistry. 286, 52, p. 44632-44645 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor

    Ugleholdt, Randi Kjærsgaard, Poulsen, M. H., Holst, Peter Johannes, Irminger, J., Orskov, C., Pedersen, Jens, Rosenkilde, Mette, Zhu, X., Steiner, D. F. & Holst, Jens Juul, 2006, In: Journal of Biological Chemistry. 281, 16, p. 11050-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Type 2 Diabetes risk alleles in Peptidyl-glycine Alpha-amidating Monooxygenase influence GLP-1 levels and response to GLP-1 Receptor Agonists

    Umapathysivam, M. M., Araldi, E., Hastoy, B., Dawed, A. Y., Vatandaslar, H., Sengupta, S., Kaufmann, A., Thomsen, S., Hartmann, B., Jonsson, A. E., Kabakci, H., Thaman, S., Grarup, N., Have, C. T., Færch, K., Gjesing, A. P., Nawaz, S., Cheeseman, J., Neville, M. J., Pedersen, O. & 12 others, Walker, M., Jennison, C., Hattersley, A. T., Hansen, Torben, Karpe, F., Holst, Jens Juul, Jones, A. G., Ristow, M., McCarthy, M. I., Pearson, E. R., Stoffel, M. & Gloyn, A. L., 2023, medRxiv, 35 p.

    Research output: Working paperPreprintResearch

  32. Published

    Gastric emptying of orally administered glucose solutions and incretin hormone responses are unaffected by laparoscopic adjustable gastric banding

    Usinger, Lotte, Hansen, K. B., Kristiansen, V. B., Larsen, S., Holst, Jens Juul & Knop, Filip Krag, 2011, In: Obesity Surgery. 21, 5, p. 625-32 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose

    Utzschneider, K. M., Tong, J., Montgomery, B., Udayasankar, J., Gerchman, F., Marcovina, S. M., Watson, C. E., Ligueros-Saylan, M. A., Foley, J. E., Holst, Jens Juul, Deacon, Carolyn F. & Kahn, S. E., 2007, In: Diabetes Care. 31, 1, p. 108-113 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Metabolic Dysregulation in Adult Survivors of Pediatric Hematopoietic Stem Cell Transplantation: The Role of Incretins

    Vadmand, A. C., Nissen, A. A., Mathiesen, S., Ebbesen, M. S., Gerbek, T., Fridh, M. K., Sørensen, K., Hartmann, Bolette, Holst, Jens Juul & Muller, Klaus, 2023, In: Journal of Clinical Endocrinology and Metabolism. 108, 2, p. 453–462

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Plasma glucagon-like peptide 1 and peptide YY levels are not altered in symptomatic fructose-sorbitol malabsorption.

    Valeur, J., Øines, E., Morken, M. H., Holst, Jens Juul & Berstad, A., 2008, In: Scandinavian Journal of Gastroenterology. 43, 10, p. 1212-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Effects of sitagliptin and metformin treatment on incretin hormone and insulin secretory responses to oral and "isoglycemic" intravenous glucose

    Vardarli, I., Arndt, E., Deacon, Carolyn F., Holst, Jens Juul & Nauck, M. A., Feb 2014, In: Diabetes. 63, 2, p. 663-74 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Inhibition of DPP-4 with vildagliptin improved insulin secretion in response to oral as well as "isoglycemic" intravenous glucose without numerically changing the incretin effect in patients with type 2 diabetes

    Vardarli, I., Nauck, M. A., Köthe, L. D., Deacon, Carolyn F., Holst, Jens Juul, Schweizer, A. & Foley, J. E., 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 4, p. 945-954 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Major rapid weight loss induces changes in cardiac repolarization

    Vedel-Larsen, E., Iepsen, E. P. W., Lundgren, J., Graff, C., Struijk, J. J., Hansen, Torben, Holst, Jens Juul, Madsbad, Sten, Torekov, Signe Sørensen & Kanters, Jørgen K., 10 Feb 2016, In: Journal of Electrocardiology. 49, 3, p. 467-472 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    One Year's Treatment with the Glucagon-Like Peptide 1 Receptor Agonist Liraglutide Decreases Hepatic Fat Content in Women with Nonalcoholic Fatty Liver Disease and Prior Gestational Diabetes Mellitus in a Randomized, Placebo-Controlled Trial

    Vedtofte, L., Bahne, E., Foghsgaard, S., Bagger, J. I., Andreasen, C., Strandberg, C., Gortz, P. M., Holst, Jens Juul, Gronbaek, H., Svare, J. A., Clausen, Tine Dalsgaard, Mathiesen, Elisabeth, Damm, Peter, Gluud, Lise Lotte, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Journal of Clinical Medicine. 9, 10, 14 p., 3213.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Ghrelin secretion in humans - a role for the vagus nerve?

    Veedfald, Simon, Plamboeck, A., Hartmann, Bolette, Vilsbøll, Tina, Knop, Filip Krag, Deacon, Carolyn F., Svendsen, Lars Bo & Holst, Jens Juul, Jun 2018, In: Neurogastroenterology and Motility. 30, 6, e13295.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Hyperosmolar Duodenal Saline Infusion Lowers Circulating Ghrelin and Stimulates Intestinal Hormone Release in Young Men

    Veedfald, Simon, Wu, T., Bound, M., Grivell, J., Hartmann, Bolette, Rehfeld, Jens Frederik, Deacon, Carolyn F., Horowitz, M., Holst, Jens Juul & Rayner, C. K., 2018, In: Journal of Clinical Endocrinology & Metabolism. 103, 12, p. 4409-4418

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Entero-pancreatic hormone secretion, gastric emptying and glucose absorption after frequently sampled meal tests

    Veedfald, Simon, Rehfeld, Jens Frederik, van Hall, Gerrit, Svendsen, Lars Bo & Holst, Jens Juul, 2022, In: Journal of Clinical Endocrinology and Metabolism. 107, 1, p. e188-e204 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    The insulinotropic effect of exogenous GLP-1 is not affected by acute vagotomy in anaesthetized pigs

    Veedfald, Simon, Hansen, M., Christensen, L. W., Larsen, S. A. H., Hjøllund, K. R., Plamboeck, A., Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, 30 Mar 2016, In: Experimental Physiology. 101, 7, p. 895-912 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Glucose-Dependent Insulinotropic Polypeptide Is a Pancreatic Polypeptide Secretagogue in Humans

    Veedfald, Simon, Vedtofte, L., Skov-Jeppesen, Kirsa, Deacon, Carolyn F., Hartmann, Bolette, Vilsbøll, Tina, Knop, Filip Krag, Christensen, Mikkel Bring & Holst, Jens Juul, 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 3, p. e502-e510

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Glucose homeostasis and the gastrointestinal tract

    Veedfald, Simon, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, Molecular Nutrition Carbohydrates. Elsevier, p. 3-19 17 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  46. Published

    Pancreatic polypeptide responses to isoglycemic oral and intravenous glucose in humans with and without intact vagal innervation

    Veedfald, Simon, Plamboeck, A., Hartmann, Bolette, Svendsen, Lars Bo, Vilsbøll, T., Knop, Filip Krag & Holst, Jens Juul, Sep 2015, In: Peptides. 71, p. 229-31 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Pancreatic polypeptide: A potential biomarker of glucose-dependent insulinotropic polypeptide receptor activation in vivo

    Veedfald, Simon, Bergmann, N. C., Vilsbøll, Tina, Christensen, Mikkel Bring, Holst, Jens Juul & Knop, Filip Krag, May 2021, In: Diabetic Medicine Online. 38, 8, e14592.

    Research output: Contribution to journalLetterResearchpeer-review

  48. Published

    Gut hormone secretion, gastric emptying and glucose absorption after frequently sampled oral glucose and liquid mixed meal tests in young men: [Meeting Abstract]

    Veedfald, Simon, Rehfeld, Jens Frederik, vanHall, G., Svendsen, Lars Bo & Holst, Jens Juul, 2020, In: Neurogastroenterology and Motility. 32, SI, p. 56 1 p., 146.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  49. Published

    Cephalic phase secretion of insulin and other enteropancreatic hormones in humans

    Veedfald, Simon, Plamboeck, A., Deacon, Carolyn F., Hartmann, Bolette, Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 1 Jan 2016, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 310, 1, p. G43-51

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates

    Vegge, A., Thymann, Thomas, Lund, P., Stoll, B., Bering, S. B., Hartmann, Bolette, Jelsing, J., Qvist, N., Burrin, D. G., Jeppesen, Palle Bekker, Holst, Jens Juul & Sangild, Per Torp, 2013, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 305, 4, p. G277-G285 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 4207