Jens Juul Holst

Jens Juul Holst

Professor

ORCID: 0000-0001-6853-3805

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  1. Published

    Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects

    Hansen, K. B., Vilsbøll, Tina, Bagger, J. I., Holst, Jens Juul & Knop, Filip Krag, 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 4, p. 1363-70 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine

    Hansen, L., Deacon, Carolyn F., Ørskov, Cathrine & Holst, Jens Juul, Nov 1999, In: Molecular Endocrinology. 140, 11, p. 5356-63 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    N- and C-terminally truncated forms of glucose-dependent insulinotropic polypeptide are high-affinity competitive antagonists of the human GIP receptor

    Hansen, L. S., wbf943, wbf943, Christensen, M., Knop, Filip Krag, Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 826-838 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Somastostatin restrains the secretion of glucagon-like peptide-1 and 2 (GLP-1 and GLP-2) from isolated perfused porcine ileum

    Hansen, L., Hartmann, B., Bisgaard, T., Mineo, H., Jørgensen, P. N. & Holst, Jens Juul, 2000, In: Am. J. Physiol.. 278, p. E1010-E1018

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Glucagon-like peptide-1(7-36)amide is transformed to glucagon-like peptide-1 (9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the intestinal L-cells

    Hansen, L., Deacon, Carolyn F., Ørskov, C. & Holst, Jens Juul, 1999, In: Endokrinologiya. 140, p. 5356-5363

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Glucagon-like peptide- 1 secretion is influenced by perfusate glucose concentration and a feedback mechanism involving somatostatin in isolated perfused porcine ileum

    Hansen, L., Hartmann, B., Mineo, H. & Holst, Jens Juul, 2004, In: Regul. Pept.. 118, p. 11-18

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Neural regulation of glucagon-like peptide- 1 secretion in pigs

    Hansen, L., Lampert, S., Mineo, H. & Holst, Jens Juul, 2004, In: Am. J. Physiol.. 287, p. E939-E947

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Combined N-terminal and C-terminal truncations of Glucose dependent Insulinotropic Polypeptide (GIP) are potent and efficient GIP receptor antagonists

    Hansen, L. S., wbf943, wbf943, Svendsen, B., Christensen, M., Hartmann, Bolette, Knop, Filip Krag, Holst, Jens Juul & Rosenkilde, Mette, Sep 2015, In: Diabetologia. 58, 1 supplement, p. S276-S277 2 p., 569.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  9. Published

    Acute effects of glucagon-like peptide-1, GLP-19-36 amide, and exenatide on mesenteric blood flow, cardiovascular parameters, and biomarkers in healthy volunteers

    Hansen, Lasse Bremholm, Andersen, U. B., Hornum, Mads, Hilsted, L., Veedfald, S., Hartmann, Bolette & Holst, Jens Juul, Feb 2017, In: Physiological Reports. 5, 4, 12 p., e13102.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

    Hansen, L. B. S., Roager, H. M., Søndertoft, N. B., Gøbel, R. J., Kristensen, M. B., Vallès-Colomer, M., Vieira-Silva, S., Ibrügger, S., Lind, M. V., Mærkedahl, R. B., Bahl, M. I., Madsen, M. L., Havelund, J., Falony, G., Tetens, I., Nielsen, T., Allin, K. H., Frandsen, H. L., Hartmann, B., Holst, J. J. & 32 others, Sparholt, M. H., Holck, J., Blennow, Andreas, Moll, J. M., Meyer, A. S., Hoppe, C., Poulsen, J. H., Carvalho, V., Sagnelli, D., Dalgaard, M. D., Christensen, A. F., Lydolph, M., Ross, A. B., Villas-Bôas, S. G., Brix, S., Sicheritz-Pontén, T., Buschard, K., Linneberg, Allan René, Rumessen, J. J., Ekstrøm, Claus Thorn, Ritz, C., Kristiansen, Karsten, Nielsen, H. B., drb459, drb459, Færgeman, N. J., Raes, J., Frøkiær, Hanne, Hansen, Torben, Lauritzen, Lotte, Gupta, R., Licht, T. R. & Pedersen, Oluf Borbye, 2018, In: Nature Communications. 9, 13 p., 4630.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Neural regulation of glucagon-like peptide-1 secretion in pigs

    Hansen, L., Lampert, S., Mineo, H. & Holst, Jens Juul, Nov 2004, In: American Journal of Physiology: Endocrinology and Metabolism. 287, 5, p. E939-47

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Metabolism of glucagon-like peptide-2 in pigs: role of dipeptidyl peptidase IV.

    Hansen, L., Hare, K. J., Hartmann, B., Deacon, Carolyn F., Ugleholdt, Randi Kjærsgaard, Plamboeck, A. & Holst, Jens Juul, 2006, In: Regulatory Peptides. 138, 2-3, p. 126-32 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop?

    Hansen, L. & Holst, Jens Juul, 31 Dec 2002, In: Regulatory Peptides. 110, 1, p. 39-45 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum

    Hansen, L., Hartmann, Bolette, Mineo, H. & Holst, Jens Juul, 15 Apr 2004, In: Regulatory Peptides. 118, 1-2, p. 11-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Important species differences regarding lymph contribution to gut hormone responses

    Hansen, M., Hjøllund, K. R., Hartmann, Bolette, Plamboeck, A., Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, Sep 2015, In: Peptides. 71, p. 28-31 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Inhibition de la sécrétion du glucagon par les antagonistes du GLP-1 et les inhibiteurs de la DPP-4

    Hansen, M., Knop, Filip Krag & Holst, Jens Juul, Apr 2011, In: Medecine des Maladies Metaboliques. 5, 2

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Inhibition of glucagon secretion by GLP-1 agonists and DPP4 inhibitors

    Hansen, M., Juul Hare, K., Holst, Jens Juul & Knop, Filip Krag, Jun 2011, In: Journal of Clinical Metabolism & Diabetes. 2, 2, p. 7-13 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Effect of chenodeoxycholic acid and the bile acid sequestrant colesevelam on glucagon-like peptide-1 secretion

    Hansen, M., Scheltema, M. J., Sonne, David Peick, Hansen, J. S., Sperling, M., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jun 2016, In: Diabetes, Obesity and Metabolism. 18, 6, p. 571-80 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Glucagon-Like Peptide 2 Inhibits Postprandial Gallbladder Emptying in Man: A Randomized, Double-Blinded, Crossover Study

    Hansen, N. L., Brønden, Andreas, Nexoe-Larsen, C. C., Christensen, A. S., Sonne, D. P., Rehfeld, Jens Frederik, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 2020, In: Clinical and Translational Gastroenterology. 11, 12, 9 p., e00257.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Novel Mody3 Mutations in the Hepatocyte Factor-1a Gene. Evidence for a Hyperexcitabillity of Pancreatic ß-cells to Intravenous Secretagogues in a Glucosetolerant Carrier of a P447L Mutation

    Hansen, T., Eiberg, Hans Rudolf Lytchoff, Rouard, M., Vaxillaire, M., Møller, A. M., Rasmussen, S. K., Fridberg, M. & Holst, Jens Juul, 1997, In: Diabetes. 46, p. 726-730

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors

    Hansotia, T., Baggio, L. L., Delmeire, D., Hinke, S. A., Yamada, Y., Tsukiyama, K., Seino, Y., Holst, Jens Juul, Schuit, F. & Drucker, D. J., 2004, In: Diabetes. 53, p. 1326-1335

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors

    Hansotia, T., Baggio, L. L., Delmeire, D., Hinke, S. A., Yamada, Y., Tsukiyama, K., Seino, Y., Holst, Jens Juul, Schuit, F. & Drucker, D. J., May 2004, In: Diabetes. 53, 5, p. 1326-35 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Effect of IL-6 on the insulin sensitivity in patients with type 2 diabetes

    Harder-Lauridsen, N. M., Krogh-Madsen, Rikke, Holst, Jens Juul, Plomgaard, P., Leick, L., Pedersen, Bente Klarlund & Fischer, C. P., 1 Apr 2014, In: American Journal of Physiology: Endocrinology and Metabolism. 306, 7, p. E769-78 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus

    Hare, K. J., Knop, Filip Krag, Asmar, M., Madsbad, Sten, Deacon, Carolyn F., Holst, Jens Juul & Vilsbøll, Tina, 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 12, p. 4679-87 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Inappropriate glucagon response after oral compared with isoglycemic intravenous glucose administration in patients with type 1 diabetes

    Hare, K. J., Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 1 Apr 2010, In: American Journal of Physiology: Endocrinology and Metabolism. 298, 4, p. E832-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action

    Hare, K. J., Vilsbøll, Tina, Asmar, M., Deacon, Carolyn F., Knop, Filip Krag & Holst, Jens Juul, 1 Jul 2010, In: Diabetes. 59, 7, p. 1765-70 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    The intestinotrophic peptide, glp-2, counteracts intestinal atrophy in mice induced by the epidermal growth factor receptor inhibitor, gefitinib.

    Hare, K. J., Hartmann, B., Kissow, Hannelouise, Holst, Jens Juul & Poulsen, Steen Seier, 2007, In: Clinical Cancer Research. 13, 17, p. 5170-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Galanin and vasoactive intestinal polypeptide: coexistence and corelease from the vascularly perfused pig ileum during distension and chemical stimulation of the mucosa

    Harling, H., Messell, T., Poulsen, Steen Seier & Holst, Jens Juul, 1991, In: Digestion. 50, 2, p. 61-71 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Galanin: Distribution and Effect on Contractile Activity and Release of Vasoactive Intestinal Polypeptide from the Isolated Perfused Porcine Ileum

    Harling, H., Gregersen, H., Rasmussen, T. N., Holst, Jens Juul & Poulsen, S. S., 1990, In: Digestion. 47, p. 191-199

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Circulating galanin: origin, metabolism, and pharmacokinetics in anesthetized pigs

    Harling, H. & Holst, Jens Juul, 1992, In: Am. J. of Physiology. 262, p. E52-E57

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Galanin and vasoactive intestinal polypeptide: Release during intraluminal, chemical irritation and distension of the isolated perfused porcine ileum

    Harling, M., Messel, T., Holst, Jens Juul & Poulsen, S. S., 1991, In: Digestion. 50, p. 61-71

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Distal gastrectomy in pancreaticoduodenectomy is associated with accelerated gastric emptying, enhanced postprandial release of GLP-1, and improved insulin sensitivity

    Harmuth, S., Wewalka, M., Holst, Jens Juul, Nemecek, R., Thalhammer, S., Schmid, R., Sahora, K., Gnant, M. & Miholić, J., Jan 2014, In: Journal of Gastrointestinal Surgery. 18, 1, p. 52-9 8 p.

    Research output: Contribution to journal › Conference article › Research › peer-review

  33. Published

    Dipeptidyl peptidase IV inhibition enhances the intestinotrophic effect of glucagon-like peptide-2 in rats and mice

    Hartmann, Bolette, Thulesen, J., Kissow, Hannelouise, Thulesen, S., Ørskov, Cathrine, Ropke, C., Poulsen, Steen Seier & Holst, Jens Juul, 2000, In: Endocrinology. 141, 11, p. 4013-20 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    In vivo and in vitro degradation of glucagon-like peptide-2 in humans

    Hartmann, B., Harr, M. B., Jeppesen, P. B., Wojdemann, M., Deacon, Carolyn F., Mortensen, P. B. & Holst, Jens Juul, 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, p. 2884-2888

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Immunoneutralization of endogenous glucagon-like peptide-2 reduces adaptive intestinal growth in diabetic rats.

    Hartmann, B., Thulesen, J., Hare, K. J., Kissow, Hannelouise, Orskov, C., Poulsen, Steen Seier & Holst, Jens Juul, 2002, In: Regulatory Peptides. 105, 3, p. 173-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Signs of a Glucose- and Insulin-Independent Gut-Bone Axis and Aberrant Bone Homeostasis in Type 1 Diabetes

    Hartmann, Bolette, Longo, M., Mathiesen, D. S., Hare, Kristine Juul, Jørgensen, Niklas Rye, Esposito, K., Deacon, Carolyn F., Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 1, p. e259-e265 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Postprandial effects of test meals including concentrated arabinoxylan and whole grain rye in subjects with the metabolic syndrome: a randomised study

    Hartvigsen, M. L., Lærke, H. N., Overgaard, A., Holst, Jens Juul, Bach Knudsen, K. E. & Hermansen, K., May 2014, In: European Journal of Clinical Nutrition. 68, 5, p. 567-74 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Effects of concentrated arabinoxylan and β-glucan compared with refined wheat and whole grain rye on glucose and appetite in subjects with the metabolic syndrome: a randomized study

    Hartvigsen, M. L., Gregersen, S., Lærke, H. N., Holst, Jens Juul, Bach Knudsen, K. E. & Hermansen, K., Jan 2014, In: European Journal of Clinical Nutrition. 68, 1, p. 84-90 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor

    Hassing, H. A., Engelstoft, M. S., Sichlau, R. M., Madsen, A. N., Rehfeld, Jens Frederik, Pedersen, Jens, Jones, R. M., Holst, Jens Juul, Schwartz, Thue W., Rosenkilde, Mette & Hansen, Harald S., 2016, In: BioFactors. 42, 6, p. 665-673

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Defective glucose and lipid metabolism in human immunodeficiency virus-infected patients with lipodystrophy involve liver, muscle tissue and pancreatic beta-cells

    Haugaard, Steen Bendix, Andersen, Ove, Dela, Flemming, Holst, Jens Juul, Storgaard, H., Fenger, M., Iversen, J. & Madsbad, Sten, Jan 2005, In: European Journal of Endocrinology. Supplement. 152, 1, p. 103-12 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Defective glucose and lipid metabolism in human immunodeficiency virus-infected patients with lipodystrophy involve liver, muscle tissue and pancreatic beta-cells.

    Haugaard, S. B., Andersen, Ove, Dela, Flemming, Holst, Jens Juul, Storgaard, H., Fenger, M., Iversen, J., Madsbad, Sten, Haugaard, S. B., Andersen, Ove, Dela, F., Holst, J. J., Storgaard, H., Fenger, M., Iversen, J. & Madsbad, Sten, 2005, In: European Journal of Endocrinology. 152, 1, p. 103-112 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Glucose-stimulated prehepatic insulin secretion is associated with circulating alanine, triglyceride, glucagons, lactate and TNF-alfa in patients with HIV-lipodystrophy

    Haugaard, S. B., Andersen, Ove, Pedersen, S., Dela, Flemming, Holst, Jens Juul, Deacon, Carolyn F., Iversen, J. & Madsbad, Sten, 2006, In: HIV Medicine. 7, p. 163-172 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Insulin secretion in lipodystrophic HIV-infected patients is associated with high levels of nonglucose secretagogues and insulin resistance of beta-cells.

    Haugaard, S. B., Andersen, Ove, Storgaard, H., Dela, Flemming, Holst, Jens Juul, Iversen, J., Nielsen, J. O. & Madsbad, Sten, 2004, In: American Journal of Physiology: Endocrinology and Metabolism. 287, 4, p. E677-85 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Pharmacodynamics of vildagliptin in patients with type 2 diabetes during OGTT.

    He, Y., Wang, Y., Bullock, J. M., Deacon, Carolyn F., Holst, Jens Juul, Dunning, B. E., Ligueros-Saylan, M. & Foley, J. E., 2007, In: Journal of Clinical Pharmacology. 47, 5, p. 633-41 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus.

    He, Y., Serra, D., Wang, Y., Campestrini, J., Riviere, G., Deacon, Carolyn F., Holst, Jens Juul, Schwartz, S., Nielsen, J. C. & Ligueros-Saylan, M., 2007, In: Clinical Pharmacokinetics. 46, 7, p. 577-88 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Effect of meal texture on glucose excursions after bariatric surgery

    Hedbäck, N., Hindso, M., Linddal, A. K., Bojsen-Moller, K. N., Jorgensen, N. B., Dirksen, C., Moller, A., Kristiansen, V. B., Holst, Jens Juul, Svane, M. S. & Madsbad, Sten, 2020, In: Diabetologia. 63, Suppl. 1, p. S203 1 p., 411.

    Research output: Contribution to journal › Conference abstract in journal › Research

  47. Published

    Effect of Meal Texture on Postprandial Glucose Excursions and Gut Hormones After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy

    Hedbäck, N., Hindsø, M., Bojsen-Møller, K. N., Linddal, A. K., Jørgensen, N. B., Dirksen, C., Møller, A., Kristiansen, V. B., Hartmann, Bolette, Holst, Jens Juul, Svane, M. S. & Madsbad, Sten, 2022, In: Frontiers in Nutrition. 9, 889710.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Effect of glucagon-like peptide 1 (7-356) amide in insulin treated patients with diabetes mellitus secondary to chronic pancreatitis

    Hedetoft, C., Larsen, S., Sheikh, S. & Holst, Jens Juul, 2000, In: Pancreas. 20, p. 25-31

    Research output: Contribution to journal › Journal article › Research

  49. Published

    Six-day subcutaneous GIP infusion increases glycaemic time in range in patients with type 1 diabetes

    Heimbuerger, S. M. N., Hoe, B., Nielsen, C. N., Bergmann, N. C., Hartmann, Bolette, Holst, Jens Juul, Størling, Joachim, Vilsbøll, Tina, Dejgaard, T. F., Christensen, Mikkel Bring & Knop, Filip Krag, 2020, In: Diabetologia. 63, SUPPL 1, p. S73 1 p., 145.

    Research output: Contribution to journal › Conference abstract in journal › Research

  50. Published

    Six-day sc GIP infusion increases plasma NEFA without altering the adipose tissue transcriptome, GIPR levels or plasma markers of inflammation in patients with type 1 diabetes

    Heimburger, S. M. N., Hoe, B., Nielsen, C. N., Hartmann, Bolette, Holst, Jens Juul, Dela, Flemming, Overgaard, J., Størling, Joachim, Vilsbøll, Tina, Dejgaard, T. F., Pyke, C., Christensen, M. B. & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 258-258 494.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

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