Thomas Mandrup-Poulsen
Professor
- 1985
- Published
Cytokines cause functional and structural damage to isolated islets of Langerhans
Mandrup-Poulsen, Thomas, Bendtzen, K., Bendixen, G., Nerup, J. & Nielsen, Jens Høiriis, Aug 1985, In: Allergy. 40, 6, p. 424-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1986
- Published
Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans
Bendtzen, K., Mandrup-Poulsen, Thomas, Nerup, J., Dinarello, C. A., Svenson, M. & Nielsen, Jens Høiriis, 20 Jun 1986, In: Science (New York, N.Y.). 232, 4757, p. 1545-7 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans
Mandrup-Poulsen, Thomas, Bendtzen, K., Nerup, J., Dinarello, C. A., Svenson, M. & Nielsen, Jens Høiriis, Jan 1986, In: Diabetologia. 29, 1, p. 63-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct effects of cyclosporin A on human pancreatic beta-cells
Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, Sep 1986, In: Diabetes. 35, 9, p. 1049-52 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanisms of pancreatic islet cell destruction. Dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans
Mandrup-Poulsen, Thomas, Bendtzen, K., Nerup, J., Egeberg, J. & Nielsen, Jens Høiriis, May 1986, In: Allergy. 41, 4, p. 250-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1987
- Published
Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics
Mandrup-Poulsen, Thomas, Spinas, G. A., Prowse, S. J., Hansen, B. S., Jørgensen, D. W., Bendtzen, K., Nerup, J. & Nielsen, Jens Høiriis, May 1987, In: Diabetes. 36, 5, p. 641-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ultrastructural studies of time-course and cellular specificity of interleukin-1 mediated islet cytotoxicity
Mandrup-Poulsen, Thomas, Egeberg, J., Nerup, J., Bendtzen, K., Dinarello, C. A. & Nielsen, Jens Høiriis, Apr 1987, In: Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology. 95, 2, p. 55-63 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans
Spinas, G. A., Hansen, B. S., Linde, S., Kastern, W., Mølvig, J., Mandrup-Poulsen, Thomas, Dinarello, C. A., Nerup, J. & Nielsen, Jens Høiriis, Jul 1987, In: Diabetologia. 30, 7, p. 474-80 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1988
- Published
Effect of interleukin-1 on the biosynthesis of proinsulin and insulin in isolated rat pancreatic islets
Hansen, B. S., Linde, S., Spinas, G. A., Welinder, B. S., Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, 1988, In: Biomedica Biochimica Acta. 47, 4-5, p. 305-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The bimodal effect of interleukin 1 on rat pancreatic beta-cells--stimulation followed by inhibition--depends upon dose, duration of exposure, and ambient glucose concentration
Spinas, G. A., Palmer, J. P., Mandrup-Poulsen, Thomas, Andersen, Heine, Nerup, J. & Nielsen, Jens Høiriis, Oct 1988, In: Acta Endocrinologica. 119, 2, p. 307-11 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1996
- Published
Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine
Andersen, H. U., Mauricio, D., Karlsen, A. E., Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, Feb 1996, In: European Journal of Endocrinology. 134, 2, p. 251-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females
Kristiansen, O. P., Nolsøe, R. L., Larsen, L., Gjesing, A. M. P., Johannesen, J., Larsen, Z. M. E., Lykkesfeldt, A. E., Karlsen, A. E., Pociot, Flemming, Mandrup-Poulsen, Thomas & DIEGG, D., 15 May 2003, In: Human Molecular Genetics. 12, 10, p. 1101-10 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Type 1 database mellitus: an inflammatory disease of the islet.
Bergholdt, R., Heding, P., Nielsen, K., Nolsøe, R., Sparre, T., Størling, J., Nerup, J., Pociot, Flemming & Mandrup-Poulsen, Thomas, 2004, In: Advances in Experimental Medicine and Biology. 552, p. 129-53 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity
Gylvin, T., Nolsøe, R., Hansen, Torben, Nielsen, E. M. D., Bergholdt, R., Karlsen, A. E., Billestrup, Nils, Borch-Johnsen, K., Pedersen, O., Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 1 Jul 2004, In: Diabetologia. 47, 7, p. 1273-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways
Karlsen, A. E., Heding, P. E., Frobøse, H., Rønn, S. G., Kruhøffer, M., Orntoft, T. F., Darville, M., Eizirik, D. L., Pociot, Flemming, Nerup, J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 1 Nov 2004, In: Diabetologia. 47, 11, p. 1998-2011 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity
Kristiansen, O. P., Karlsen, A. E., Larsen, Z. M., Johannesen, Jesper, Pociot, Flemming, Mandrup-Poulsen, Thomas & Danish IDDM Epidemiology and Genetics Group and Danish Study Group of IDDM in Childhood, D. I. E. A. G. G. A. D. S. G. O. I. I. C., 1 Jun 2004, In: Scandinavian Journal of Immunology. 59, 6, p. 582-91 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.
Maedler, K., Størling, J., Sturis, J., Zuellig, R. A., Spinas, G. A., Arkhammar, P. O. G., Mandrup-Poulsen, Thomas & Donath, M. Y., 2004, In: Diabetes. 53, 7, p. 1706-13 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transplantation mellem enaeggede tvillinger
Mandrup-Poulsen, Thomas, 26 Jan 2004, In: Ugeskrift for Laeger. 166, 5, p. 398-9; author reply 399Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antitumorigenic effect of proteasome inhibitors on insulinoma cells.
Størling, J., Allaman-Pillet, N., Karlsen, A. E., Billestrup, N., Bonny, C. & Mandrup-Poulsen, Thomas, 2004, In: Endocrinology. 146, 4, p. 1718-26 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
Cardozo, A. K., Ortis, F., Storling, J., Feng, Y., Rasschaert, J., Tonnesen, M., Van Eylen, F., Mandrup-Poulsen, Thomas, Herchuelz, A. & Eizirik, D. L., 2005, In: Diabetes. 54, 2, p. 452-61 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Poor pregnancy outcome in women with type 2 diabetes
Clausen, Tine Dalsgaard, Mathiesen, E., Ekbom, P., Hellmuth, E., Mandrup-Poulsen, Thomas & Damm, Peter, 2005, In: Diabetes Care. 28, 2, p. 323-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Is puberty an accelerator of type 1 diabetes in IL6-174CC females?
Gillespie, K. M., Nolsøe, R., Betin, V. M., Kristiansen, O. P., Bingley, P. J., Mandrup-Poulsen, Thomas & Gale, E. A. M., 2005, In: Diabetes. 54, 4, p. 1245-8 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes
Hamid, Y. H., Rose, C. S., Urhammer, S. A., Glümer, C., Nolsøe, R., Kristiansen, O. P., Mandrup-Poulsen, Thomas, Borch-Johnsen, K., Jorgensen, T., Hansen, Torben & Pedersen, O., 1 Feb 2005, In: Diabetologia. 48, 2, p. 251-60 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An immune origin of type 2 diabetes?
Kolb, H. & Mandrup-Poulsen, Thomas, 1 Jun 2005, In: Diabetologia. 48, 6, p. 1038-50 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin-6 and diabetes: the good, the bad, or the indifferent?
Kristiansen, O. P. & Mandrup-Poulsen, Thomas, 2005, In: Diabetes. 54 Suppl 2, p. S114-24Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells
Larsen, L., Størling, Joachim, Darville, M., Eizirik, D. L., Bonny, C., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 Dec 2005, In: Diabetologia. 48, 12, p. 2582-90 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia
Nolsøe, R. L., Kelly, J. A., Pociot, Flemming, Moser, K., Kristiansen, O. P., Mandrup-Poulsen, Thomas & Harley, J. B., 1 Dec 2005, In: Genes and Immunity. 6, 8, p. 699-706 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Er der dokumentation for Lyrica til behandling af smertende diabetisk neuropati?
Persson, F., Mogensen, C. E. & Mandrup-Poulsen, Thomas, 2005, In: Ugeskrift for læger. 167, 16, p. 1768-9; author reply 1769-70Research output: Contribution to journal › Journal article › Research › peer-review
- Published
European Nicotinamide Diabetes Intervention Trial (ENDIT)--sekundaerpublikation. En randomiseret, placebokontrolleret undersøgelse af intervention før debut af type 1-diabetes.
Reimers, J. I., Larsen, C. M., Mandrup-Poulsen, Thomas & European Nicotinamide Diabetes Intervention Trial Group, E. N. D. I. T. G., 2005, In: Ugeskrift for læger. 167, 3, p. 293-6 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt
Størling, Joachim, Binzer, J., Andersson, A., Züllig, R. A., Tonnesen, M., Knudsen, R. L. P., Spinas, G. A., Sandler, S., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 Oct 2005, In: Diabetologia. 48, 10, p. 2039-50 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.
Størling, J., Zaitsev, S. V., Kapelioukh, I. L., Karlsen, A. E., Billestrup, N., Berggren, P. & Mandrup-Poulsen, Thomas, 2005, In: Endocrinology. 146, 7, p. 3026-36 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes
Alizadeh, B. Z., Hanifi-Moghaddam, P., Eerligh, P., van der Slik, A. R., Kolb, H., Kharagjitsingh, A. V., Pereira Arias, A. M., Ronkainen, M., Knip, M., Bonfanti, R., Bonifacio, E., Prasad, D., Wilkin, T., Giphart, M. J., Koeleman, B. P. C., Nolsøe, R., Mandrup-Poulsen, Thomas, Schloot, N. C., Roep, B. O. & DIABMARKER Study Group, D. S. G., 1 Sep 2006, In: Clinical and Experimental Immunology. 145, 3, p. 480-4 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex.
Frobøse, H., Rønn, S. G., Heding, P. E., Mendoza, H., Cohen, P., Mandrup-Poulsen, Thomas & Billestrup, N., 2006, In: Molecular Endocrinology. 20, 7, p. 1587-96 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Plasma cytokine levels in young and elderly twins: genes versus environment and relation to in vivo insulin action
Grunnet, Louise Groth, Poulsen, P., Pedersen, Bente Klarlund, Mandrup-Poulsen, Thomas & Vaag, A., 1 Feb 2006, In: Diabetologia. 49, 2, p. 343-50 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells
Larsen, C. M., Døssing, M. G., Papa, S., Franzoso, G., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 May 2006, In: Diabetologia. 49, 5, p. 980-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.
Ortis, F., Cardozo, A. K., Crispim, D., Störling, J., Mandrup-Poulsen, Thomas & Eizirik, D. L., 2006, In: Molecular Endocrinology. 20, 8, p. 1867-79 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line
Petersen, L. G., Størling, Joachim, Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, Nils, Bock, E. & Mandrup-Poulsen, Thomas, 2006, In: Diabetologia. 49, 8, p. 1864-75 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IL-1β-induced pro-apoptotic signaling is facilitated by NCAM/FGF receptor signaling and inhibited by the C3d ligand in the INS-1E rat beta cell line
Petersen, L. G., Størling, J., Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, N., Bock, E. M. & Mandrup-Poulsen, Thomas, 2006, In: Diabetologia. 49, p. 1864-75Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines.
Zaitseva, I. I., Sharoyko, V., Størling, J., Efendic, S., Guerin, C., Mandrup-Poulsen, Thomas, Nicotera, P., Berggren, P. & Zaitsev, S. V., 2006, In: Biochemical and Biophysical Research Communications. 347, 4, p. 1121-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Ætiologi og patogenese, Type 1
Bergholdt, R., Larsen, C. M., Pociot, Flemming, Mandrup-Poulsen, Thomas, Hilsted, J. C., Christensen, J. S. & Borch-Johnsen, K., 2007, Diabetes. 1 ed. København: Handelshøjskolens Forlag, Vol. 6. p. -Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Cytokines and beta-cell biology: from concept to clinical translation
Donath, M. Y., Storling, J., Berchtold, L. A., Billestrup, N. & Mandrup-Poulsen, Thomas, 2007, In: Endocrine Reviews. 29, 3, p. 334-50 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lost in translation
Frank, L. & Mandrup-Poulsen, Thomas, 2007, In: Weekendavisen. 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin-1-receptor antagonist in type 2 diabetes mellitus.
Larsen, C. M., Faulenbach, M., Vaag, Allan, Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, Thomas & Donath, M. Y., 2007, In: New England Journal of Medicine. 356, 15, p. 1517-26 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin-1 receptorantagonistbehandling af patienter med type 2-diabetes--sekundaerpublikation.
Larsen, C. M., Faulenbach, M., Vaag, Allan, Vølund, A., Ehses, J., Seifert, B., Mandrup-Poulsen, Thomas & Donath, M., 2007, In: Ugeskrift for læger. 169, 45, p. 3868-71 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells
Larsen, L., Tonnesen, M., Ronn, S. G., Størling, Joachim, Jørgensen, S., Mascagni, P., Dinarello, C. A., Billestrup, Nils & Mandrup-Poulsen, Thomas, Apr 2007, In: Diabetologia. 50, 4, p. 779-89 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells
Larsen, L., Tonnesen, M. F., Ronn, S. G., Storling, J., Jørgensen, S., Mascagni, P., Dinarello, C. A., Billestrup, N. & Mandrup-Poulsen, Thomas, 2007, In: Diabetologia. 50, 4, p. 779-789 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glutaminsyre-decarboxylase-antistoffer og diabetes.
Mandrup-Poulsen, Thomas, 2007, In: Ugeskrift for læger. 169, 4, p. 300-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin-1-receptor antagonist in type 2 diabetes mellitus - Reply
Mandrup-Poulsen, Thomas, Seifert, B. & Donath, M. Y., 2007, In: New England Journal of Medicine. 357, 3, p. 303-303Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Type 1 diabetes - the copenhagen model
Mandrup-Poulsen, Thomas, Binder, C., Deckert, T. & Nerup, J., 2007, Diabetes og Danmark. 1 ed. Gad, p. 184-195 11 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Diabetes and suppressors of cytokine signaling proteins.
Rønn, S. G., Billestrup, N. & Mandrup-Poulsen, Thomas, 2007, In: Diabetes. 56, 2, p. 541-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 923693
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Tissue inhibitor of matrix metalloproteinase-1 is required for high-fat diet-induced glucose intolerance and hepatic steatosis in mice
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
212
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JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1 beta-Induced Apoptosis Associated with Abrogated Myc Expression
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A Placebo-Controlled Study on the Effects of the Glucagon-Like Peptide-1 Mimetic, Exenatide, on Insulin Secretion, Body Composition and Adipokines in Obese, Client-Owned Cats
Research output: Contribution to journal › Journal article › Research › peer-review
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