Z-score transformation of T-wave morphology values to a standardized scale

Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt

Standard

Z-score transformation of T-wave morphology values to a standardized scale. / Graff, C.; Nielsen, J.; Kanters, J. K.; Matz, J.; Schmidt, S. E.; Toft, E.; Struijk, J. J.

Computing in Cardiology 2011, CinC 2011. Bind 38 2011. s. 737-740 6164671.

Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt

Harvard

Graff, C, Nielsen, J, Kanters, JK, Matz, J, Schmidt, SE, Toft, E & Struijk, JJ 2011, Z-score transformation of T-wave morphology values to a standardized scale. i Computing in Cardiology 2011, CinC 2011. bind 38, 6164671, s. 737-740, Computing in Cardiology 2011, CinC 2011, Hangzhou, Kina, 18/09/2011.

APA

Graff, C., Nielsen, J., Kanters, J. K., Matz, J., Schmidt, S. E., Toft, E., & Struijk, J. J. (2011). Z-score transformation of T-wave morphology values to a standardized scale. I Computing in Cardiology 2011, CinC 2011 (Bind 38, s. 737-740). [6164671]

Vancouver

Graff C, Nielsen J, Kanters JK, Matz J, Schmidt SE, Toft E o.a. Z-score transformation of T-wave morphology values to a standardized scale. I Computing in Cardiology 2011, CinC 2011. Bind 38. 2011. s. 737-740. 6164671

Author

Graff, C. ; Nielsen, J. ; Kanters, J. K. ; Matz, J. ; Schmidt, S. E. ; Toft, E. ; Struijk, J. J. / Z-score transformation of T-wave morphology values to a standardized scale. Computing in Cardiology 2011, CinC 2011. Bind 38 2011. s. 737-740

Bibtex

@inproceedings{67d2838792e04a6fa2110eab82b2bfce,
title = "Z-score transformation of T-wave morphology values to a standardized scale",
abstract = "Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.",
author = "C. Graff and J. Nielsen and Kanters, {J. K.} and J. Matz and Schmidt, {S. E.} and E. Toft and Struijk, {J. J.}",
year = "2011",
month = dec,
day = "1",
language = "English",
isbn = "9781457706127",
volume = "38",
pages = "737--740",
booktitle = "Computing in Cardiology 2011, CinC 2011",
note = "Computing in Cardiology 2011, CinC 2011 ; Conference date: 18-09-2011 Through 21-09-2011",

}

RIS

TY - GEN

T1 - Z-score transformation of T-wave morphology values to a standardized scale

AU - Graff, C.

AU - Nielsen, J.

AU - Kanters, J. K.

AU - Matz, J.

AU - Schmidt, S. E.

AU - Toft, E.

AU - Struijk, J. J.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.

AB - Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.

UR - http://www.scopus.com/inward/record.url?scp=84859990662&partnerID=8YFLogxK

M3 - Article in proceedings

AN - SCOPUS:84859990662

SN - 9781457706127

VL - 38

SP - 737

EP - 740

BT - Computing in Cardiology 2011, CinC 2011

T2 - Computing in Cardiology 2011, CinC 2011

Y2 - 18 September 2011 through 21 September 2011

ER -

ID: 204298799