Unconventional insulins from predators and pathogens

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Unconventional insulins from predators and pathogens. / Laugesen, Sophie Heiden; Chou, Danny Hung Chieh; Safavi-Hemami, Helena.

I: Nature Chemical Biology, Bind 18, Nr. 7, 2022, s. 688-697.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Laugesen, SH, Chou, DHC & Safavi-Hemami, H 2022, 'Unconventional insulins from predators and pathogens', Nature Chemical Biology, bind 18, nr. 7, s. 688-697. https://doi.org/10.1038/s41589-022-01068-6

APA

Laugesen, S. H., Chou, D. H. C., & Safavi-Hemami, H. (2022). Unconventional insulins from predators and pathogens. Nature Chemical Biology, 18(7), 688-697. https://doi.org/10.1038/s41589-022-01068-6

Vancouver

Laugesen SH, Chou DHC, Safavi-Hemami H. Unconventional insulins from predators and pathogens. Nature Chemical Biology. 2022;18(7):688-697. https://doi.org/10.1038/s41589-022-01068-6

Author

Laugesen, Sophie Heiden ; Chou, Danny Hung Chieh ; Safavi-Hemami, Helena. / Unconventional insulins from predators and pathogens. I: Nature Chemical Biology. 2022 ; Bind 18, Nr. 7. s. 688-697.

Bibtex

@article{c545184031934d1ea17382dd2b884754,

title = "Unconventional insulins from predators and pathogens",

abstract = "Insulin and its related peptides are found throughout the animal kingdom, in which they serve diverse functions. This includes regulation of glucose homeostasis, neuronal development and cognition. The surprising recent discovery that venomous snails evolved specialized insulins to capture fish demonstrated the nefarious use of this hormone in nature. Because of their streamlined role in predation, these repurposed insulins exhibit unique characteristics that have unraveled new aspects of the chemical ecology and structural biology of this important hormone. Recently, insulins were also reported in other venomous predators and pathogenic viruses, demonstrating the broader use of insulin by one organism to manipulate the physiology of another. In this Review, we provide an overview of the discovery and biomedical application of repurposed insulins and other hormones found in nature and highlight several unique insights gained from these unusual compounds. [Figure not available: see fulltext.]",

author = "Laugesen, {Sophie Heiden} and Chou, {Danny Hung Chieh} and Helena Safavi-Hemami",

note = "Publisher Copyright: {\textcopyright} 2022, Springer Nature America, Inc.",

year = "2022",

doi = "10.1038/s41589-022-01068-6",

language = "English",

volume = "18",

pages = "688--697",

journal = "Nature Chemical Biology",

issn = "1552-4450",

publisher = "nature publishing group",

number = "7",

}

RIS

TY - JOUR

T1 - Unconventional insulins from predators and pathogens

AU - Laugesen, Sophie Heiden

AU - Chou, Danny Hung Chieh

AU - Safavi-Hemami, Helena

PY - 2022

Y1 - 2022

N2 - Insulin and its related peptides are found throughout the animal kingdom, in which they serve diverse functions. This includes regulation of glucose homeostasis, neuronal development and cognition. The surprising recent discovery that venomous snails evolved specialized insulins to capture fish demonstrated the nefarious use of this hormone in nature. Because of their streamlined role in predation, these repurposed insulins exhibit unique characteristics that have unraveled new aspects of the chemical ecology and structural biology of this important hormone. Recently, insulins were also reported in other venomous predators and pathogenic viruses, demonstrating the broader use of insulin by one organism to manipulate the physiology of another. In this Review, we provide an overview of the discovery and biomedical application of repurposed insulins and other hormones found in nature and highlight several unique insights gained from these unusual compounds. [Figure not available: see fulltext.]

AB - Insulin and its related peptides are found throughout the animal kingdom, in which they serve diverse functions. This includes regulation of glucose homeostasis, neuronal development and cognition. The surprising recent discovery that venomous snails evolved specialized insulins to capture fish demonstrated the nefarious use of this hormone in nature. Because of their streamlined role in predation, these repurposed insulins exhibit unique characteristics that have unraveled new aspects of the chemical ecology and structural biology of this important hormone. Recently, insulins were also reported in other venomous predators and pathogenic viruses, demonstrating the broader use of insulin by one organism to manipulate the physiology of another. In this Review, we provide an overview of the discovery and biomedical application of repurposed insulins and other hormones found in nature and highlight several unique insights gained from these unusual compounds. [Figure not available: see fulltext.]

U2 - 10.1038/s41589-022-01068-6

DO - 10.1038/s41589-022-01068-6

M3 - Review

C2 - 35761080

AN - SCOPUS:85132960522

VL - 18

SP - 688

EP - 697

JO - Nature Chemical Biology

JF - Nature Chemical Biology

SN - 1552-4450

IS - 7

ER -

ID: 313871489