Triangulation of the monophasic action potential causes flattening of the electrocardiographic T-wave

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Triangulation of the monophasic action potential causes flattening of the electrocardiographic T-wave. / Bhuiyan, Tanveer Ahmed; Graff, Claus; Thomsen, Morten Bækgaard; Struijk, Johannes J.

Computing in Cardiology. Bind 39 2012. s. 757-760.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskning

Harvard

Bhuiyan, TA, Graff, C, Thomsen, MB & Struijk, JJ 2012, Triangulation of the monophasic action potential causes flattening of the electrocardiographic T-wave. i Computing in Cardiology. bind 39, s. 757-760.

APA

Bhuiyan, T. A., Graff, C., Thomsen, M. B., & Struijk, J. J. (2012). Triangulation of the monophasic action potential causes flattening of the electrocardiographic T-wave. I Computing in Cardiology (Bind 39, s. 757-760)

Vancouver

Bhuiyan TA, Graff C, Thomsen MB, Struijk JJ. Triangulation of the monophasic action potential causes flattening of the electrocardiographic T-wave. I Computing in Cardiology. Bind 39. 2012. s. 757-760

Author

Bhuiyan, Tanveer Ahmed ; Graff, Claus ; Thomsen, Morten Bækgaard ; Struijk, Johannes J. / Triangulation of the monophasic action potential causes flattening of the electrocardiographic T-wave. Computing in Cardiology. Bind 39 2012. s. 757-760

Bibtex

@inbook{105e7becff054bb587458c4c9fa6ea57,
title = "Triangulation of the monophasic action potential causes flattening of the electrocardiographic T-wave",
abstract = "It has been proposed that triangulation on the cardiac action potential manifests as a broadened, more flat and notched T-wave on the ECG but to what extent such morphology characteristics are indicative of triangulation is more unclear. In this paper, we have analyzed the morphological changes of the action potential under the effect of the IKr blocker sertindole and associated these changes to concurrent changes in the morphology of electrocardiographic T-waves in dogs. We show that, under the effect of sertindole, the peak changes in the morphology of action potentials occur at time points similar to those observed for the peak changes in T-wave morphology on the ECG. We further show that the association between action potential shape and ECG shape is dose-dependent and most prominent at the time corresponding to phase 3 of the action potential.",
author = "Bhuiyan, {Tanveer Ahmed} and Claus Graff and Thomsen, {Morten B{\ae}kgaard} and Struijk, {Johannes J.}",
year = "2012",
month = "1",
day = "1",
language = "English",
isbn = "9781467320740",
volume = "39",
pages = "757--760",
booktitle = "Computing in Cardiology",

}

RIS

TY - CHAP

T1 - Triangulation of the monophasic action potential causes flattening of the electrocardiographic T-wave

AU - Bhuiyan, Tanveer Ahmed

AU - Graff, Claus

AU - Thomsen, Morten Bækgaard

AU - Struijk, Johannes J.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - It has been proposed that triangulation on the cardiac action potential manifests as a broadened, more flat and notched T-wave on the ECG but to what extent such morphology characteristics are indicative of triangulation is more unclear. In this paper, we have analyzed the morphological changes of the action potential under the effect of the IKr blocker sertindole and associated these changes to concurrent changes in the morphology of electrocardiographic T-waves in dogs. We show that, under the effect of sertindole, the peak changes in the morphology of action potentials occur at time points similar to those observed for the peak changes in T-wave morphology on the ECG. We further show that the association between action potential shape and ECG shape is dose-dependent and most prominent at the time corresponding to phase 3 of the action potential.

AB - It has been proposed that triangulation on the cardiac action potential manifests as a broadened, more flat and notched T-wave on the ECG but to what extent such morphology characteristics are indicative of triangulation is more unclear. In this paper, we have analyzed the morphological changes of the action potential under the effect of the IKr blocker sertindole and associated these changes to concurrent changes in the morphology of electrocardiographic T-waves in dogs. We show that, under the effect of sertindole, the peak changes in the morphology of action potentials occur at time points similar to those observed for the peak changes in T-wave morphology on the ECG. We further show that the association between action potential shape and ECG shape is dose-dependent and most prominent at the time corresponding to phase 3 of the action potential.

UR - http://www.scopus.com/inward/record.url?scp=84875684588&partnerID=8YFLogxK

M3 - Book chapter

SN - 9781467320740

VL - 39

SP - 757

EP - 760

BT - Computing in Cardiology

ER -

ID: 106949594